Lamtor1 | ENSMUSG00000030842 | NCBI 66508

Details for: Lamtor1

Gene ID: 66508

Symbol: Lamtor1

Ensembl ID: ENSMUSG00000030842

Description: late endosomal/lysosomal adaptor, MAPK and MTOR activator 1

Associated with

Amino acids regulate mtorc1
(R-MMU-9639288)
Autophagy
(R-MMU-9612973)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to starvation
(R-MMU-9711097)
Energy dependent regulation of mtor by lkb1-ampk
(R-MMU-380972)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Intracellular signaling by second messengers
(R-MMU-9006925)
Macroautophagy
(R-MMU-1632852)
Mtorc1-mediated signalling
(R-MMU-166208)
Mtor signalling
(R-MMU-165159)
Neutrophil degranulation
(R-MMU-6798695)
Pip3 activates akt signaling
(R-MMU-1257604)
Pten regulation
(R-MMU-6807070)
Rac1 gtpase cycle
(R-MMU-9013149)
Rac2 gtpase cycle
(R-MMU-9013404)
Rac3 gtpase cycle
(R-MMU-9013423)
Regulation of pten gene transcription
(R-MMU-8943724)
Rhog gtpase cycle
(R-MMU-9013408)
Rho gtpase cycle
(R-MMU-9012999)
Rhoh gtpase cycle
(R-MMU-9013407)
Rhoq gtpase cycle
(R-MMU-9013406)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
Tp53 regulates metabolic genes
(R-MMU-5628897)
Transcriptional regulation by tp53
(R-MMU-3700989)
Cellular response to amino acid stimulus
(GO:0071230)
Cellular response to nutrient levels
(GO:0031669)
Cholesterol homeostasis
(GO:0042632)
Endosomal transport
(GO:0016197)
Endosome
(GO:0005768)
Endosome organization
(GO:0007032)
Fnip-folliculin ragc/d gap
(GO:1990877)
Gtpase binding
(GO:0051020)
Guanyl-nucleotide exchange factor activity
(GO:0005085)
Late endosome membrane
(GO:0031902)
Lysosomal membrane
(GO:0005765)
Lysosome
(GO:0005764)
Lysosome localization
(GO:0032418)
Lysosome organization
(GO:0007040)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Molecular adaptor activity
(GO:0060090)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of protein localization to lysosome
(GO:0150032)
Positive regulation of torc1 signaling
(GO:1904263)
Positive regulation of tor signaling
(GO:0032008)
Protein-membrane adaptor activity
(GO:0043495)
Protein binding
(GO:0005515)
Protein localization
(GO:0008104)
Protein localization to membrane
(GO:0072657)
Ragulator complex
(GO:0071986)
Regulation of cell growth
(GO:0001558)
Regulation of cholesterol efflux
(GO:0010874)
Regulation of cholesterol import
(GO:0060620)
Regulation of receptor recycling
(GO:0001919)
Torc1 signaling
(GO:0038202)

Other Information

Proteins

Ragulator complex protein LAMTOR1

Genular Protein ID: 3898488218

Symbol: LTOR1_MOUSE

Name: Ragulator complex protein LAMTOR1

UniProtKB Accession Codes:

Q9CQ22 Q9CYS0

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15345747

Title: Phosphoproteomic analysis of the developing mouse brain.

PubMed ID: 15345747

DOI: 10.1074/mcp.m400085-mcp200

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19177150

Title: The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes.

PubMed ID: 19177150

DOI: 10.1038/emboj.2008.308

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 29644770

Title: TMEM55B contributes to lysosomal homeostasis and amino acid-induced mTORC1 activation.

PubMed ID: 29644770

DOI: 10.1111/gtc.12583

PubMed ID: 30595499

Title: Lysosomal signaling licenses embryonic stem cell differentiation via inactivation of Tfe3.

PubMed ID: 30595499

DOI: 10.1016/j.stem.2018.11.021

PubMed ID: 29158492

Title: Structural basis for the assembly of the Ragulator-Rag GTPase complex.

PubMed ID: 29158492

DOI: 10.1038/s41467-017-01762-3

PubMed ID: 30020076

Title: UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity.

PubMed ID: 30020076

DOI: 10.7554/elife.37993

Sequence Information:

Length: 161
Mass: 17749
Checksum: D50CC6C05C36B457
Sequence:

MGCCYSSENE DSDQDREERK LLLDPSSTPT KALNGAEPNY HSLPSARTDE QALLSSILAK 
TASNIIDVSA ADSQGMEQHE YMDRARQYST RLAVLSSSLT HWKKLPPLPS LTSQPHQVLA 
SEPIPFSDLQ QVSRIAAYAY SALSQIRVDA KEELVVQFGI P

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Lamtor1

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Phosphoproteomic analysis of the developing mouse brain. PubMed ID: 15345747

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes. PubMed ID: 19177150

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

TMEM55B contributes to lysosomal homeostasis and amino acid-induced mTORC1 activation. PubMed ID: 29644770

Lysosomal signaling licenses embryonic stem cell differentiation via inactivation of Tfe3. PubMed ID: 30595499

Structural basis for the assembly of the Ragulator-Rag GTPase complex. PubMed ID: 29158492

UBE3A-mediated p18/LAMTOR1 ubiquitination and degradation regulate mTORC1 activity and synaptic plasticity. PubMed ID: 30020076