Details for: Sppl2a

Gene ID: 66552

Symbol: Sppl2a

Ensembl ID: ENSMUSG00000027366

Description: signal peptide peptidase like 2A

Associated with

Other Information

Genular Protein ID: 1657209043

Symbol: SPP2A_MOUSE

Name: Presenilin-like protein 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21896273

Title: Signal-peptide-peptidase-like 2a (SPPL2a) is targeted to lysosomes/late endosomes by a tyrosine motif in its C-terminal tail.

PubMed ID: 21896273

DOI: 10.1016/j.febslet.2011.08.043

PubMed ID: 30127434

Title: Disruption of an antimycobacterial circuit between dendritic and helper T cells in human SPPL2a deficiency.

PubMed ID: 30127434

DOI: 10.1038/s41590-018-0178-z

PubMed ID: 33239420

Title: Deficiency of the Intramembrane Protease SPPL2a Alters Antimycobacterial Cytokine Responses of Dendritic Cells.

PubMed ID: 33239420

DOI: 10.4049/jimmunol.2000151

Sequence Information:

  • Length: 523
  • Mass: 58129
  • Checksum: A15109A71FCF25C4
  • Sequence:
  • MGLLHSLHAP AAALLWSCLL GLAAAQEAIL HASTNGVSSL SKDYCMYYNN NWTRLPSSLE 
    NATSLSLMNL TGTALCHLSD IPPDGIRNKA VVVHWGPCHF LEKARIAQEG GAAALLIANN 
    SVLIPSSRNK STFQNVTVLI AVITQKDFKD MKETLGDDIT VKMYSPSWPN FDYTLVVIFV 
    IAVFTVALGG YWSGLIELEN MKSVEDAEDR ETRKKKDDYL TFSPLTVVVF VVICCIMIVL 
    LYFFYRWLVY VMIAIFCIAS SMSLYNCLSA LIHRMPCGQC TILCCGKNIK VSLIFLSGLC 
    ISVAVVWAVF RNEDRWAWIL QDILGIAFCL NLIKTMKLPN FMSCVILLGL LLIYDVFFVF 
    ITPFITKNGE SIMVELAAGP FENAEKLPVV IRVPKLMGYS VMSVCSVPVS VLGFGDIIVP 
    GLLIAYCRRF DVQTGSSIYY ISSTIAYAVG MIITFVVLMV MKTGQPALLY LVPCTLITVS 
    VVAWSRKEMK KFWKGSSYQV MDHLDYSTNE ENPVTTDEQI VQQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.