Details for: BOK

Gene ID: 666

Symbol: BOK

Ensembl ID: ENSG00000176720

Description: BCL2 family apoptosis regulator BOK

Associated with

  • Activation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0006919)
  • Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
    (GO:0008635)
  • Apoptotic process
    (GO:0006915)
  • Bh domain binding
    (GO:0051400)
  • Cellular component disassembly involved in execution phase of apoptosis
    (GO:0006921)
  • Cis-golgi network membrane
    (GO:0033106)
  • Cytoplasm
    (GO:0005737)
  • Early endosome membrane
    (GO:0031901)
  • Endoplasmic reticulum
    (GO:0005783)
  • Endoplasmic reticulum membrane
    (GO:0005789)
  • Extrinsic apoptotic signaling pathway in absence of ligand
    (GO:0097192)
  • Golgi apparatus
    (GO:0005794)
  • Intrinsic apoptotic signaling pathway by p53 class mediator
    (GO:0072332)
  • Intrinsic apoptotic signaling pathway in response to dna damage
    (GO:0008630)
  • Male gonad development
    (GO:0008584)
  • Mitochondrial inner membrane
    (GO:0005743)
  • Mitochondrial membrane
    (GO:0031966)
  • Mitochondrial outer membrane
    (GO:0005741)
  • Mitochondrion
    (GO:0005739)
  • Negative regulation of mitochondrial depolarization
    (GO:0051902)
  • Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
    (GO:1901029)
  • Negative regulation of necroptotic process
    (GO:0060546)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Neuron apoptotic process
    (GO:0051402)
  • Nuclear outer membrane
    (GO:0005640)
  • Nucleus
    (GO:0005634)
  • Oligodendrocyte differentiation
    (GO:0048709)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
    (GO:1902237)
  • Positive regulation of execution phase of apoptosis
    (GO:1900119)
  • Positive regulation of intrinsic apoptotic signaling pathway
    (GO:2001244)
  • Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
    (GO:1901030)
  • Positive regulation of perk-mediated unfolded protein response
    (GO:1903899)
  • Protein-containing complex binding
    (GO:0044877)
  • Protein binding
    (GO:0005515)
  • Protein complex oligomerization
    (GO:0051259)
  • Protein heterodimerization activity
    (GO:0046982)
  • Protein homodimerization activity
    (GO:0042803)
  • Recycling endosome membrane
    (GO:0055038)
  • Regulation of autophagy
    (GO:0010506)
  • Regulation of chorionic trophoblast cell proliferation
    (GO:1901382)
  • Regulation of cytosolic calcium ion concentration
    (GO:0051480)
  • Regulation of granulosa cell apoptotic process
    (GO:1904708)
  • Release of cytochrome c from mitochondria
    (GO:0001836)
  • Signaling receptor binding
    (GO:0005102)
  • Trans-golgi network membrane
    (GO:0032588)
  • Ubiquitin protein ligase binding
    (GO:0031625)

Other Information

Genular Protein ID: 4252464404

Symbol: BOK_HUMAN

Name: Bcl-2-like protein 9

UniProtKB Accession Codes:

Q9UMX3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 47 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11034351

Title: Evolutionarily conserved Bok proteins in the Bcl-2 family.

PubMed ID: 11034351

DOI: 10.1016/s0014-5793(00)01921-9

PubMed ID: 15775999

Title: A novel Mtd splice isoform is responsible for trophoblast cell death in pre-eclampsia.

PubMed ID: 15775999

DOI: 10.1038/sj.cdd.4401593

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9535847

Title: Mtd, a novel Bcl-2 family member activates apoptosis in the absence of heterodimerization with Bcl-2 and Bcl-XL.

PubMed ID: 9535847

DOI: 10.1074/jbc.273.15.8705

PubMed ID: 15102863

Title: BOK and NOXA are essential mediators of p53-dependent apoptosis.

PubMed ID: 15102863

DOI: 10.1074/jbc.m313526200

PubMed ID: 15868100

Title: Membrane translocation and oligomerization of hBok are triggered in response to apoptotic stimuli and Bnip3.

PubMed ID: 15868100

DOI: 10.1007/s00018-005-4543-3

PubMed ID: 16302269

Title: Nuclear translocation of the pro-apoptotic Bcl-2 family member Bok induces apoptosis.

PubMed ID: 16302269

DOI: 10.1002/mc.20156

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19942931

Title: Mtd/Bok takes a swing: proapoptotic Mtd/Bok regulates trophoblast cell proliferation during human placental development and in preeclampsia.

PubMed ID: 19942931

DOI: 10.1038/cdd.2009.167

PubMed ID: 20673843

Title: Regulation of cell death in human fetal and adult ovaries--role of Bok and Bcl-X(L).

PubMed ID: 20673843

DOI: 10.1016/j.mce.2010.07.020

PubMed ID: 24113155

Title: Placental autophagy regulation by the BOK-MCL1 rheostat.

PubMed ID: 24113155

DOI: 10.4161/auto.26452

PubMed ID: 23884412

Title: The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage.

PubMed ID: 23884412

DOI: 10.1074/jbc.m113.496570

PubMed ID: 27076518

Title: Bok is a genuine multi-BH-domain protein that triggers apoptosis in the absence of Bax and Bak.

PubMed ID: 27076518

DOI: 10.1242/jcs.181727

Sequence Information:

  • Length: 212
  • Mass: 23280
  • Checksum: 053ED605FF8EF5B2
  • Sequence:
    • MEVLRRSSVF AAEIMDAFDR SPTDKELVAQ AKALGREYVH ARLLRAGLSW SAPERAAPVP 
GRLAEVCAVL LRLGDELEMI RPSVYRNVAR QLHISLQSEP VVTDAFLAVA GHIFSAGITW 
GKVVSLYAVA AGLAVDCVRQ AQPAMVHALV DCLGEFVRKT LATWLRRRGG WTDVLKCVVS 
TDPGLRSHWL VAALCSFGRF LKAAFFVLLP ER

Genular Protein ID: 3920721375

Symbol: A0A481T0W6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A481T0W6

Database IDs:

AlphaFoldDB 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 RefSeq 1 SUPFAM 1

Sequence Information:

  • Length: 117
  • Mass: 12869
  • Checksum: ADA05B252CC084C4
  • Sequence:
    • MEVLRRSSVF AAEIMDAFDR SPTDKELVAQ AKALGREYVH ARLLRAGLSW SAPERAAPVP 
GRLAEVCAVL LRLGDELEMI RPSVYRNVAR QLHISLQSEP VVTDAFLAVA GHIFSAD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.