Details for: BOK

Gene ID: 666

Symbol: BOK

Ensembl ID: ENSG00000176720

Description: BCL2 family apoptosis regulator BOK

Associated with

  • Activation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0006919)
  • Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
    (GO:0008635)
  • Apoptotic process
    (GO:0006915)
  • Bh domain binding
    (GO:0051400)
  • Cellular component disassembly involved in execution phase of apoptosis
    (GO:0006921)
  • Cis-golgi network membrane
    (GO:0033106)
  • Cytoplasm
    (GO:0005737)
  • Early endosome membrane
    (GO:0031901)
  • Endoplasmic reticulum
    (GO:0005783)
  • Endoplasmic reticulum membrane
    (GO:0005789)
  • Extrinsic apoptotic signaling pathway in absence of ligand
    (GO:0097192)
  • Golgi apparatus
    (GO:0005794)
  • Intrinsic apoptotic signaling pathway by p53 class mediator
    (GO:0072332)
  • Intrinsic apoptotic signaling pathway in response to dna damage
    (GO:0008630)
  • Male gonad development
    (GO:0008584)
  • Mitochondrial inner membrane
    (GO:0005743)
  • Mitochondrial membrane
    (GO:0031966)
  • Mitochondrial outer membrane
    (GO:0005741)
  • Mitochondrion
    (GO:0005739)
  • Negative regulation of mitochondrial depolarization
    (GO:0051902)
  • Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
    (GO:1901029)
  • Negative regulation of necroptotic process
    (GO:0060546)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Neuron apoptotic process
    (GO:0051402)
  • Nuclear outer membrane
    (GO:0005640)
  • Nucleus
    (GO:0005634)
  • Oligodendrocyte differentiation
    (GO:0048709)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
    (GO:1902237)
  • Positive regulation of execution phase of apoptosis
    (GO:1900119)
  • Positive regulation of intrinsic apoptotic signaling pathway
    (GO:2001244)
  • Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
    (GO:1901030)
  • Positive regulation of perk-mediated unfolded protein response
    (GO:1903899)
  • Protein-containing complex binding
    (GO:0044877)
  • Protein binding
    (GO:0005515)
  • Protein complex oligomerization
    (GO:0051259)
  • Protein heterodimerization activity
    (GO:0046982)
  • Protein homodimerization activity
    (GO:0042803)
  • Recycling endosome membrane
    (GO:0055038)
  • Regulation of autophagy
    (GO:0010506)
  • Regulation of chorionic trophoblast cell proliferation
    (GO:1901382)
  • Regulation of cytosolic calcium ion concentration
    (GO:0051480)
  • Regulation of granulosa cell apoptotic process
    (GO:1904708)
  • Release of cytochrome c from mitochondria
    (GO:0001836)
  • Signaling receptor binding
    (GO:0005102)
  • Trans-golgi network membrane
    (GO:0032588)
  • Ubiquitin protein ligase binding
    (GO:0031625)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.49
    Marker Score: 1194
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 1.46
    Marker Score: 784
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.35
    Marker Score: 855
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.19
    Marker Score: 2846
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.13
    Marker Score: 414
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.02
    Marker Score: 782
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71790
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48014.5
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.99
    Marker Score: 2327
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.96
    Marker Score: 5840
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.96
    Marker Score: 362
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.95
    Marker Score: 1069
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.94
    Marker Score: 2222
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2729
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5023
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.87
    Marker Score: 1398
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.87
    Marker Score: 725
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.85
    Marker Score: 1026
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.85
    Marker Score: 9537.5
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.83
    Marker Score: 465
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.81
    Marker Score: 2862
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.79
    Marker Score: 265
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 310
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1246
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 687
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.75
    Marker Score: 6430
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 493
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.73
    Marker Score: 4785
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.73
    Marker Score: 971
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.73
    Marker Score: 1378
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3035
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.7
    Marker Score: 3025
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.67
    Marker Score: 5264
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.67
    Marker Score: 1106
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.65
    Marker Score: 187
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.65
    Marker Score: 281
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.64
    Marker Score: 2771
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.62
    Marker Score: 477
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.61
    Marker Score: 156.5
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.61
    Marker Score: 313
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.61
    Marker Score: 254
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.6
    Marker Score: 3867
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.59
    Marker Score: 1042.5
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.58
    Marker Score: 395
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.58
    Marker Score: 574
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.58
    Marker Score: 337
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.57
    Marker Score: 254
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.57
    Marker Score: 533
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 440
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.54
    Marker Score: 655
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.54
    Marker Score: 261
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.54
    Marker Score: 8599
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.53
    Marker Score: 2871
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.53
    Marker Score: 785
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.52
    Marker Score: 185
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.51
    Marker Score: 635
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.51
    Marker Score: 1952
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.49
    Marker Score: 495
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.48
    Marker Score: 467
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.48
    Marker Score: 472.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.48
    Marker Score: 767.5
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.48
    Marker Score: 1168
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.46
    Marker Score: 981
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.46
    Marker Score: 2424
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.46
    Marker Score: 485
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.46
    Marker Score: 15763
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.45
    Marker Score: 788
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.45
    Marker Score: 143
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.44
    Marker Score: 161
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.44
    Marker Score: 1004
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.44
    Marker Score: 138
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.43
    Marker Score: 295
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.43
    Marker Score: 1053
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.43
    Marker Score: 159
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.41
    Marker Score: 102
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.41
    Marker Score: 535
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.41
    Marker Score: 426
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.41
    Marker Score: 129
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.4
    Marker Score: 1056
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.4
    Marker Score: 162
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.4
    Marker Score: 112
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.39
    Marker Score: 189
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.39
    Marker Score: 418
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.39
    Marker Score: 163
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.39
    Marker Score: 295
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.39
    Marker Score: 117
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.39
    Marker Score: 655
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.38
    Marker Score: 6013
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.38
    Marker Score: 1880
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.38
    Marker Score: 532
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.36
    Marker Score: 157
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.36
    Marker Score: 232

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Other Information

**Key characteristics:** - BOK is a protein of approximately 125 kDa. - It is a transmembrane protein with a cysteine-rich extracellular domain and a cytoplasmic domain that is involved in protein-protein interactions. - BOK is a pro-apoptotic protein, meaning that it promotes cell death. - It is activated by cytochrome c, a protein that is released from the mitochondria when a cell dies. - BOK inhibits apoptosis by binding to the BH3 domain of cytochrome c and preventing it from interacting with Bax, a pro-apoptotic protein. **Pathways and functions:** - BOK is involved in the activation of the intrinsic apoptotic signaling pathway in response to DNA damage. - It is also involved in the regulation of autophagy, a process where cells break down and reuse their components. - BOK is a key regulator of neuron apoptotic process, and its overexpression is associated with neurodegenerative diseases such as Alzheimer's disease. - It is also involved in the development of the oligodendrocyte lineage. **Clinical significance:** - BOK is a promising target for cancer therapy. - Small molecule inhibitors of BOK have been shown to be effective in killing cancer cells. - BOK is a potential therapeutic target for a variety of human cancers, including breast cancer, lung cancer, and brain cancer.

Genular Protein ID: 4252464404

Symbol: BOK_HUMAN

Name: Bcl-2-like protein 9

UniProtKB Accession Codes:

Q9UMX3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 47 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11034351

Title: Evolutionarily conserved Bok proteins in the Bcl-2 family.

PubMed ID: 11034351

DOI: 10.1016/s0014-5793(00)01921-9

PubMed ID: 15775999

Title: A novel Mtd splice isoform is responsible for trophoblast cell death in pre-eclampsia.

PubMed ID: 15775999

DOI: 10.1038/sj.cdd.4401593

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9535847

Title: Mtd, a novel Bcl-2 family member activates apoptosis in the absence of heterodimerization with Bcl-2 and Bcl-XL.

PubMed ID: 9535847

DOI: 10.1074/jbc.273.15.8705

PubMed ID: 15102863

Title: BOK and NOXA are essential mediators of p53-dependent apoptosis.

PubMed ID: 15102863

DOI: 10.1074/jbc.m313526200

PubMed ID: 15868100

Title: Membrane translocation and oligomerization of hBok are triggered in response to apoptotic stimuli and Bnip3.

PubMed ID: 15868100

DOI: 10.1007/s00018-005-4543-3

PubMed ID: 16302269

Title: Nuclear translocation of the pro-apoptotic Bcl-2 family member Bok induces apoptosis.

PubMed ID: 16302269

DOI: 10.1002/mc.20156

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19942931

Title: Mtd/Bok takes a swing: proapoptotic Mtd/Bok regulates trophoblast cell proliferation during human placental development and in preeclampsia.

PubMed ID: 19942931

DOI: 10.1038/cdd.2009.167

PubMed ID: 20673843

Title: Regulation of cell death in human fetal and adult ovaries--role of Bok and Bcl-X(L).

PubMed ID: 20673843

DOI: 10.1016/j.mce.2010.07.020

PubMed ID: 24113155

Title: Placental autophagy regulation by the BOK-MCL1 rheostat.

PubMed ID: 24113155

DOI: 10.4161/auto.26452

PubMed ID: 23884412

Title: The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage.

PubMed ID: 23884412

DOI: 10.1074/jbc.m113.496570

PubMed ID: 27076518

Title: Bok is a genuine multi-BH-domain protein that triggers apoptosis in the absence of Bax and Bak.

PubMed ID: 27076518

DOI: 10.1242/jcs.181727

Sequence Information:

  • Length: 212
  • Mass: 23280
  • Checksum: 053ED605FF8EF5B2
  • Sequence:
    • MEVLRRSSVF AAEIMDAFDR SPTDKELVAQ AKALGREYVH ARLLRAGLSW SAPERAAPVP 
GRLAEVCAVL LRLGDELEMI RPSVYRNVAR QLHISLQSEP VVTDAFLAVA GHIFSAGITW 
GKVVSLYAVA AGLAVDCVRQ AQPAMVHALV DCLGEFVRKT LATWLRRRGG WTDVLKCVVS 
TDPGLRSHWL VAALCSFGRF LKAAFFVLLP ER

Genular Protein ID: 3920721375

Symbol: A0A481T0W6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A481T0W6

Database IDs:

AlphaFoldDB 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 1 Gene3D 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 RefSeq 1 SUPFAM 1

Sequence Information:

  • Length: 117
  • Mass: 12869
  • Checksum: ADA05B252CC084C4
  • Sequence:
    • MEVLRRSSVF AAEIMDAFDR SPTDKELVAQ AKALGREYVH ARLLRAGLSW SAPERAAPVP 
GRLAEVCAVL LRLGDELEMI RPSVYRNVAR QLHISLQSEP VVTDAFLAVA GHIFSAD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.