Mcm8 | ENSMUSG00000027353 | NCBI 66634

Details for: Mcm8

Gene ID: 66634

Symbol: Mcm8

Ensembl ID: ENSMUSG00000027353

Description: minichromosome maintenance 8 homologous recombination repair factor

Associated with

Activation of atr in response to replication stress
(R-MMU-176187)
Activation of the pre-replicative complex
(R-MMU-68962)
Assembly of the pre-replicative complex
(R-MMU-68867)
Cdc6 association with the orc:origin complex
(R-MMU-68689)
Cell cycle, mitotic
(R-MMU-69278)
Cell cycle checkpoints
(R-MMU-69620)
Dna replication pre-initiation
(R-MMU-69002)
G1/s transition
(R-MMU-69206)
G2/m checkpoints
(R-MMU-69481)
Mitotic g1 phase and g1/s transition
(R-MMU-453279)
Orc1 removal from chromatin
(R-MMU-68949)
S phase
(R-MMU-69242)
Switching of origins to a post-replicative state
(R-MMU-69052)
Synthesis of dna
(R-MMU-69239)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Cell cycle
(GO:0007049)
Chromatin binding
(GO:0003682)
Chromosome
(GO:0005694)
Dna binding
(GO:0003677)
Dna damage response
(GO:0006974)
Dna duplex unwinding
(GO:0032508)
Dna repair
(GO:0006281)
Dna replication
(GO:0006260)
Double-strand break repair via homologous recombination
(GO:0000724)
Enzyme binding
(GO:0019899)
Female gamete generation
(GO:0007292)
Helicase activity
(GO:0004386)
Hydrolase activity
(GO:0016787)
Male gamete generation
(GO:0048232)
Mcm8-mcm9 complex
(GO:0097362)
Mcm complex
(GO:0042555)
Mutlbeta complex binding
(GO:0032406)
Mutsalpha complex binding
(GO:0032407)
Mutsbeta complex binding
(GO:0032408)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Protein localization to chromatin
(GO:0071168)
Protein stabilization
(GO:0050821)
Recombinational interstrand cross-link repair
(GO:0036298)
Single-stranded dna binding
(GO:0003697)
Single-stranded dna helicase activity
(GO:0017116)

Other Information

Proteins

DNA helicase MCM8

Genular Protein ID: 4057277718

Symbol: MCM8_MOUSE

Name: DNA helicase MCM8

UniProtKB Accession Codes:

Q9CWV1 A2AVM8 A2AVM9 Q3UZG5 Q80US2 Q80VI0

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22771120

Title: MCM8- and MCM9-deficient mice reveal gametogenesis defects and genome instability due to impaired homologous recombination.

PubMed ID: 22771120

DOI: 10.1016/j.molcel.2012.05.048

Sequence Information:

Length: 833
Mass: 92371
Checksum: B45385BFB778B9E0
Sequence:

MSGAYRGRGF GRGRFQSWKR GRGGGNFSGR WRERENRVDL NEASGKHASA QASQPLLQQS 
TLDQFIPYKG WKLYFSEVYS NNSPFIEKIQ AFEKFFTRHI DLYDKDEIER KGSILVDFKE 
LTKADEITNL IPDIENALRD APEKTLACMG LAIHQVLTKD LERHAAELQA QEGLSNGGET 
MVNVPHIYAR VYNYEPLTHL KNIRATCYGK YISIRGTVVR VSNIKPLCTN MAFQCAACGE 
IQSFPLPDGK YTLPTKCPVP ACRGRSFAPL RSSPLTVTLD WQLIKIQELM SDAQREAGRI 
PRTIECELVH DLVDSCVPGD TVTVTGIVKV SNSEEGSRNK NDKCMFLLYI EANSVSNSKG 
PKAQTAEDGC KHGTLMEFSL KDLYAIREIQ AEENLLKLVV NSLCPVIFGH ELVKAGLTLA 
LFGGSQKYAD DKNRIPIRGD PHVLIVGDPG LGKSQMLQAA CNVAPRGVYV CGNTTTSSGL 
TVTLSKDSSS GDFALEAGAL VLGDQGICGI DEFDKMGNQH QALLEAMEQQ SISLAKAGVV 
CSLPARTSII AAANPVGGHY NKARTVSENL KMGSALLSRF DLVFILLDTP NEQHDHLLSE 
HVIAIRAGKQ KAVSSATVTR VLSQDSNTSV LEVVSEKPLS ERLKVAPGEQ TDPIPHQLLR 
KYIGYARQYV HPRLSTDAAQ ALQDFYLELR KQSQRVGSSP ITTRQLESLI RLTEARARLE 
LREEATREDA EDIIEIMKHS MLGTYSDEFG NLDFERSQHG SGMSNRSTAK RFISALNSIA 
ERTYNNIFQY HQLRQIAKEL NIQVADFENF IGSLNDQGYL LKKGPKIYQL QTM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Mcm8

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

MCM8- and MCM9-deficient mice reveal gametogenesis defects and genome instability due to impaired homologous recombination. PubMed ID: 22771120

Database document:

PubMed ID: 16141072

PubMed ID: 19468303

PubMed ID: 15489334

PubMed ID: 22771120