Lrrk2 | ENSMUSG00000036273 | NCBI 66725

Details for: Lrrk2

Gene ID: 66725

Symbol: Lrrk2

Ensembl ID: ENSMUSG00000036273

Description: leucine-rich repeat kinase 2

Associated with

Ptk6 promotes hif1a stabilization
(R-MMU-8857538)
Signaling by non-receptor tyrosine kinases
(R-MMU-9006927)
Signaling by ptk6
(R-MMU-8848021)
Actin binding
(GO:0003779)
Atp binding
(GO:0005524)
Autophagy
(GO:0006914)
Beta-catenin destruction complex binding
(GO:1904713)
Calcium-mediated signaling
(GO:0019722)
Cell differentiation
(GO:0030154)
Cellular response to oxidative stress
(GO:0034599)
Cellular response to reactive oxygen species
(GO:0034614)
Cellular response to starvation
(GO:0009267)
Clathrin binding
(GO:0030276)
Determination of adult lifespan
(GO:0008340)
Endocytosis
(GO:0006897)
Endoplasmic reticulum organization
(GO:0007029)
Exploration behavior
(GO:0035640)
Golgi organization
(GO:0007030)
Gtp-dependent protein kinase activity
(GO:0034211)
Gtpase activator activity
(GO:0005096)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Intracellular signal transduction
(GO:0035556)
Jnk cascade
(GO:0007254)
Jun kinase kinase kinase activity
(GO:0004706)
Kinase activity
(GO:0016301)
Locomotory exploration behavior
(GO:0035641)
Lysosome organization
(GO:0007040)
Magnesium ion binding
(GO:0000287)
Mapk cascade
(GO:0000165)
Map kinase kinase kinase activity
(GO:0004709)
Mitochondrion organization
(GO:0007005)
Negative regulation of gtpase activity
(GO:0034260)
Negative regulation of macroautophagy
(GO:0016242)
Negative regulation of neuron projection development
(GO:0010977)
Negative regulation of protein binding
(GO:0032091)
Negative regulation of protein phosphorylation
(GO:0001933)
Negative regulation of protein processing
(GO:0010955)
Neuromuscular junction development
(GO:0007528)
Nucleotide binding
(GO:0000166)
Olfactory bulb development
(GO:0021772)
Peptidyl-serine phosphorylation
(GO:0018105)
Peptidyl-threonine phosphorylation
(GO:0018107)
Peroxidase inhibitor activity
(GO:0036479)
Phosphorylation
(GO:0016310)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of programmed cell death
(GO:0043068)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Positive regulation of protein binding
(GO:0032092)
Positive regulation of protein kinase activity
(GO:0045860)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of protein ubiquitination
(GO:0031398)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein import into nucleus
(GO:0006606)
Protein kinase a binding
(GO:0051018)
Protein kinase activity
(GO:0004672)
Protein localization
(GO:0008104)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Regulation of autophagy
(GO:0010506)
Regulation of gene expression
(GO:0010468)
Regulation of kidney size
(GO:0035564)
Regulation of locomotion
(GO:0040012)
Regulation of lysosomal lumen ph
(GO:0035751)
Regulation of membrane potential
(GO:0042391)
Regulation of neuron maturation
(GO:0014041)
Regulation of protein kinase a signaling
(GO:0010738)
Regulation of protein stability
(GO:0031647)
Response to oxidative stress
(GO:0006979)
Rho protein signal transduction
(GO:0007266)
Signaling receptor complex adaptor activity
(GO:0030159)
Signal transduction
(GO:0007165)
Small gtpase binding
(GO:0031267)
Snare binding
(GO:0000149)
Synaptic vesicle recycling
(GO:0036465)
Syntaxin-1 binding
(GO:0017075)
Tangential migration from the subventricular zone to the olfactory bulb
(GO:0022028)
Transferase activity
(GO:0016740)
Transmembrane transporter binding
(GO:0044325)
Tubulin binding
(GO:0015631)

Other Information

Proteins

Leucine-rich repeat serine/threonine-protein kinase 2
Q9CQG8_MOUSE

Genular Protein ID: 121773259

Symbol: LRRK2_MOUSE

Name: Leucine-rich repeat serine/threonine-protein kinase 2

UniProtKB Accession Codes:

Q5S006 E9QNJ2 Q8BWG7 Q8BZJ6 Q8CI84 Q8K062

Database IDs:

Citations:

PubMed ID: 15541309

Title: Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology.

PubMed ID: 15541309

DOI: 10.1016/j.neuron.2004.11.005

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16532471

Title: LRRK2 expression linked to dopamine-innervated areas.

PubMed ID: 16532471

DOI: 10.1002/ana.20808

PubMed ID: 17120249

Title: Localization of LRRK2 to membranous and vesicular structures in mammalian brain.

PubMed ID: 17120249

DOI: 10.1002/ana.21019

PubMed ID: 16487147

Title: LRRK2 is expressed in areas affected by Parkinson's disease in the adult mouse brain.

PubMed ID: 16487147

DOI: 10.1111/j.1460-9568.2006.04616.x

PubMed ID: 16504409

Title: Anatomical localization of leucine-rich repeat kinase 2 in mouse brain.

PubMed ID: 16504409

DOI: 10.1016/j.neuroscience.2006.01.017

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23395371

Title: RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk.

PubMed ID: 23395371

DOI: 10.1016/j.neuron.2012.11.033

PubMed ID: 25201882

Title: Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export.

PubMed ID: 25201882

DOI: 10.15252/embj.201487807

PubMed ID: 26824392

Title: Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases.

PubMed ID: 26824392

DOI: 10.7554/elife.12813

PubMed ID: 29125462

Title: Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

PubMed ID: 29125462

DOI: 10.7554/elife.31012

PubMed ID: 28720718

Title: Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease.

PubMed ID: 28720718

DOI: 10.1126/scisignal.aam6790

PubMed ID: 30398148

Title: A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain.

PubMed ID: 30398148

DOI: 10.7554/elife.40202

PubMed ID: 29212815

Title: Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.

PubMed ID: 29212815

DOI: 10.15252/embj.201798099

PubMed ID: 23526378

Title: Targeted disruption of leucine-rich repeat kinase 1 but not leucine-rich repeat kinase 2 in mice causes severe osteopetrosis.

PubMed ID: 23526378

DOI: 10.1002/jbmr.1935

Sequence Information:

Length: 2527
Mass: 284732
Checksum: 706E25C173E36F98
Sequence:

MASGACQGCE EEEEEEALKK LIVRLNNVQE GKQIETLLQL LEDMLVFTYS DRASKLFEDK 
NFHVPLLIVL DSYMRVASVQ QAGWSLLCKL IEVCPGTLQS LIGPQDIGND WEVLGIHRLI 
LKMLTVHHAN VNLSIVGLKA LDLLLDSGKL TLLILDEECD IFLLIFDAMH RYSANDEVQK 
LGCKALHVLF ERVSEEQLTE FVENKDYTIL LSTFGSFRRD KEIVYHVLCC LHSLAVTCSN 
VEVLMSGNVR CYNLVVEAMK AFPTNENIQE VSCSLFQKLT LGNFFNILVL NEVHVFVVKA 
VRQYPENAAL QISALSCLAL LTETIFLNQD LEERSETQEQ SEEEDSEKLF WLEPCYKALV 
RHRKDKHVQE AACWALNNLL MYQNSLHEKI GDEDGQFPAH REVMLSMLMH SSSKDVFQAA 
AHALSTLLEQ NVNFRKILLA KGVYLNVLEL MQKHAHAPEV AESGCKMLSH LFEGSNPSLD 
TMAAVVPKIL TVMKAHGTSL SVQLEALRAI LHFVVPGLLE ESREDSQCRP NVLRKQCFRT 
DIHKLVLVAL NRFIGNPGIQ KCGLKVISSL AHLPDATETL SLQGAVDSVL HTLQMYPDDQ 
EIQCLGLHLM GCLMTKKNFC IGTGHLLAKI LASTLQRFKD VAEVQTTGLQ TTLSILELSV 
SFSKLLVHYS FDVVIFHQMS SSVVEQKDEQ FLNLCCKCFA KVAVDDELKN TMLERACDQN 
NSIMVECLLL LGADANQVKG ATSLIYQVCE KESSPKLVEL LLNGGCREQD VRKALTVSIQ 
KGDSQVISLL LRKLALDLAN NSICLGGFGI GKIDPSWLGP LFPDKSSNLR KQTNTGSVLA 
RKVLRYQMRN TLQEGVASGS DGKFSEDALA KFGEWTFIPD SSMDSVFGQS DDLDSEGSES 
SFLVKRKSNS ISVGEVYRDL ALQRCSPNAQ RHSNSLGPVF DHEDLLRRKR KILSSDESLR 
SSRLPSHMRQ SDSSSSLASE REHITSLDLS ANELKDIDAL SQKCCLSSHL EHLTKLELHQ 
NSLTSFPQQL CETLKCLIHL DLHSNKFTSF PSFVLKMPRI TNLDASRNDI GPTVVLDPAM 
KCPSLKQLNL SYNQLSSIPE NLAQVVEKLE QLLLEGNKIS GICSPLSLKE LKILNLSKNH 
IPSLPGDFLE ACSKVESFSA RMNFLAAMPA LPSSITSLKL SQNSFTCIPE AIFSLPHLRS 
LDMSHNNIEC LPGPAHWKSL NLRELIFSKN QISTLDFSEN PHVWSRVEKL HLSHNKLKEI 
PPEIGCLENL TSLDVSYNLE LRSFPNEMGK LSKIWDLPLD GLHLNFDFKH VGCKAKDIIR 
FLQQRLKKAV PYNRMKLMIV GNTGSGKTTL LQQLMKMKKP ELGMQGATVG IDVRDWSIQI 
RGKRRKDLVL NVWDFAGREE FYSTHPHFMT QRALYLAVYD LSKGQAEVDA MKPWLFNIKA 
RASSSPVILV GTHLDVSDEK QRKACISKIT KELLNKRGFP TIRDYHFVNA TEESDALAKL 
RKTIINESLN FKIRDQPVVG QLIPDCYVEL EKIILSERKA VPTEFPVINR KHLLQLVNEH 
QLQLDENELP HAVHFLNESG VLLHFQDPAL QLSDLYFVEP KWLCKVMAQI LTVKVDGCLK 
HPKGIISRRD VEKFLSKKKR FPKNYMMQYF KLLEKFQIAL PIGEEYLLVP SSLSDHRPVI 
ELPHCENSEI IIRLYEMPYF PMGFWSRLIN RLLEISPFML SGRERALRPN RMYWRQGIYL 
NWSPEAYCLV GSEVLDNRPE SFLKITVPSC RKGCILLGRV VDHIDSLMEE WFPGLLEIDI 
CGEGETLLKK WALYSFNDGE EHQKILLDEL MKKAEEGDLL INPDQPRLTI PISQIAPDLI 
LADLPRNIML NNDELEFEEA PEFLLGDGSF GSVYRAAYEG EEVAVKIFNK HTSLRLLRQE 
LVVLCHLHHP SLISLLAAGI RPRMLVMELA SKGSLDRLLQ QDKASLTRTL QHRIALHVAD 
GLRYLHSAMI IYRDLKPHNV LLFTLYPNAA IIAKIADYGI AQYCCRMGIK TSEGTPGFRA 
PEVARGNVIY NQQADVYSFG LLLHDIWTTG SRIMEGLRFP NEFDELAIQG KLPDPVKEYG 
CAPWPMVEKL ITKCLKENPQ ERPTSAQVFD ILNSAELICL MRHILIPKNI IVECMVATNL 
NSKSATLWLG CGNTEKGQLS LFDLNTERYS YEEVADSRIL CLALVHLAAE KESWVVCGTQ 
SGALLVINVE EETKRHTLEK MTDSVTCLHC NSLAKQSKQS NFLLVGTADG NLMIFEDKAV 
KCKGAAPLKT LHIGDVSTPL MCLSESLNSS ERHITWGGCG TKVFSFSNDF TIQKLIETKT 
NQLFSYAAFS DSNIIALAVD TALYIAKKNS PVVEVWDKKT EKLCELIDCV HFLKEVMVKL 
NKESKHQLSY SGRVKALCLQ KNTALWIGTG GGHILLLDLS TRRVIRTIHN FCDSVRAMAT 
AQLGSLKNVM LVLGYKRKST EGIQEQKEIQ SCLSIWDLNL PHEVQNLEKH IEVRTELADK 
MRKTSVE

Genular Protein ID: 4244470702

Symbol: Q9CQG8_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q9CQG8

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 561
Mass: 62834
Checksum: 8EB2B26C99F1D293
Sequence:

MLGAIFERPI PPDTRPWYLH SAMIIYRDLK PHNVLLFTLY PNAAIIAKIA DYGIAQYCCR 
MGIKTSEGTP GFRAPEVARG NVIYNQQADV YSFGLLLHDI WTTGSRIMEG LRFPNEFDEL 
AIQGKLPDPV KEYGCAPWPM VEKLITKCLK ENPQERPTSA QVFDILNSAE LICLMRHILI 
PKNIIVECMV ATNLNSKSAT LWLGCGNTEK GQLSLFDLNT ERYSYEEVAD SRILCLALVH 
LAAEKESWVV CGTQSGALLV INVEEETKRH TLEKMTDSVT CLHCNSLAKQ SKQSNFLLVG 
TADGNLMIFE DKAVKCKGAA PLKTLHIGDV STPLMCLSES LNSSERHITW GGCGTKVFSF 
SNDFTIQKLI ETKTNQLFSY AAFSDSNIIA LAVDTALYIA KKNSPVVEVW DKKTEKLCEL 
IDCVHFLKEV MVKLNKESKH QLSYSGRVKA LCLQKNTALW IGTGGGHILL LDLSTRRVIR 
TIHNFCDSVR AMATAQLGSL KNVMLVLGYK RKSTEGIQEQ KEIQSCLSIW DLNLPHEVQN 
LEKHIEVRTE LADKMRKTSV E

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Lrrk2

Associated with

Other Information

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. PubMed ID: 15541309

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

LRRK2 expression linked to dopamine-innervated areas. PubMed ID: 16532471

Localization of LRRK2 to membranous and vesicular structures in mammalian brain. PubMed ID: 17120249

LRRK2 is expressed in areas affected by Parkinson's disease in the adult mouse brain. PubMed ID: 16487147

Anatomical localization of leucine-rich repeat kinase 2 in mouse brain. PubMed ID: 16504409

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk. PubMed ID: 23395371

Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export. PubMed ID: 25201882

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases. PubMed ID: 26824392

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis. PubMed ID: 29125462

Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease. PubMed ID: 28720718

A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain. PubMed ID: 30398148

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase. PubMed ID: 29212815

Targeted disruption of leucine-rich repeat kinase 1 but not leucine-rich repeat kinase 2 in mice causes severe osteopetrosis. PubMed ID: 23526378

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073