Details for: Pycard

Gene ID: 66824

Symbol: Pycard

Ensembl ID: ENSMUSG00000030793

Description: PYD and CARD domain containing

Associated with

  • C-type lectin receptors (clrs)
    (R-MMU-5621481)
  • Clec7a (dectin-1) signaling
    (R-MMU-5607764)
  • Clec7a/inflammasome pathway
    (R-MMU-5660668)
  • Immune system
    (R-MMU-168256)
  • Inflammasomes
    (R-MMU-622312)
  • Innate immune system
    (R-MMU-168249)
  • Neutrophil degranulation
    (R-MMU-6798695)
  • Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
    (R-MMU-168643)
  • The nlrp3 inflammasome
    (R-MMU-844456)
  • Activation of cysteine-type endopeptidase activity
    (GO:0097202)
  • Activation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0006919)
  • Activation of innate immune response
    (GO:0002218)
  • Apoptotic process
    (GO:0006915)
  • Bmp receptor binding
    (GO:0070700)
  • Cellular response to interleukin-1
    (GO:0071347)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Cellular response to tumor necrosis factor
    (GO:0071356)
  • Defense response to gram-negative bacterium
    (GO:0050829)
  • Defense response to gram-positive bacterium
    (GO:0050830)
  • Defense response to virus
    (GO:0051607)
  • Enzyme binding
    (GO:0019899)
  • Identical protein binding
    (GO:0042802)
  • Immune system process
    (GO:0002376)
  • Inflammatory response
    (GO:0006954)
  • Innate immune response
    (GO:0045087)
  • Interleukin-1 beta production
    (GO:0032611)
  • Interleukin-6 receptor binding
    (GO:0005138)
  • Intrinsic apoptotic signaling pathway by p53 class mediator
    (GO:0072332)
  • Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
    (GO:0042771)
  • Macrophage cytokine production
    (GO:0010934)
  • Macropinocytosis
    (GO:0044351)
  • Myeloid dendritic cell activation
    (GO:0001773)
  • Myeloid dendritic cell activation involved in immune response
    (GO:0002277)
  • Myosin i binding
    (GO:0017024)
  • Negative regulation of canonical nf-kappab signal transduction
    (GO:0043124)
  • Negative regulation of cytokine production involved in inflammatory response
    (GO:1900016)
  • Negative regulation of interferon-beta production
    (GO:0032688)
  • Negative regulation of nf-kappab transcription factor activity
    (GO:0032088)
  • Negative regulation of protein serine/threonine kinase activity
    (GO:0071901)
  • Nlrp3 inflammasome complex assembly
    (GO:0044546)
  • Osmosensory signaling pathway
    (GO:0007231)
  • Pattern recognition receptor signaling pathway
    (GO:0002221)
  • Peptidase activator activity involved in apoptotic process
    (GO:0016505)
  • Positive regulation of actin filament polymerization
    (GO:0030838)
  • Positive regulation of activated t cell proliferation
    (GO:0042104)
  • Positive regulation of adaptive immune response
    (GO:0002821)
  • Positive regulation of antigen processing and presentation of peptide antigen via mhc class ii
    (GO:0002588)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of chemokine production
    (GO:0032722)
  • Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043280)
  • Positive regulation of defense response to virus by host
    (GO:0002230)
  • Positive regulation of dna-binding transcription factor activity
    (GO:0051091)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of inflammatory response
    (GO:0050729)
  • Positive regulation of interleukin-1 beta production
    (GO:0032731)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-8 production
    (GO:0032757)
  • Positive regulation of interleukin-10 production
    (GO:0032733)
  • Positive regulation of jnk cascade
    (GO:0046330)
  • Positive regulation of macrophage cytokine production
    (GO:0060907)
  • Positive regulation of nf-kappab transcription factor activity
    (GO:0051092)
  • Positive regulation of non-canonical nf-kappab signal transduction
    (GO:1901224)
  • Positive regulation of phagocytosis
    (GO:0050766)
  • Positive regulation of release of cytochrome c from mitochondria
    (GO:0090200)
  • Positive regulation of t cell activation
    (GO:0050870)
  • Positive regulation of tumor necrosis factor production
    (GO:0032760)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Protease binding
    (GO:0002020)
  • Protein binding
    (GO:0005515)
  • Protein dimerization activity
    (GO:0046983)
  • Protein homodimerization activity
    (GO:0042803)
  • Protein homooligomerization
    (GO:0051260)
  • Pyrin domain binding
    (GO:0032090)
  • Pyroptosis
    (GO:0070269)
  • Regulation of apoptotic process
    (GO:0042981)
  • Regulation of autophagy
    (GO:0010506)
  • Regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043281)
  • Regulation of gtpase activity
    (GO:0043087)
  • Regulation of inflammatory response
    (GO:0050727)
  • Regulation of protein stability
    (GO:0031647)
  • Regulation of tumor necrosis factor-mediated signaling pathway
    (GO:0010803)
  • Response to bacterium
    (GO:0009617)
  • Transmembrane transporter binding
    (GO:0044325)
  • Tropomyosin binding
    (GO:0005523)
  • Tumor necrosis factor-mediated signaling pathway
    (GO:0033209)

Other Information

Genular Protein ID: 1890211885

Symbol: ASC_MOUSE

Name: Apoptosis-associated speck-like protein containing a CARD

UniProtKB Accession Codes:

Q9EPB4 Q9D2W9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 2 CORUM 1 CPTAC 1 CTD 1 ChEMBL 1 ComplexPortal 3 DIP 1 DNASU 1 EMBL 6 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 87 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 1 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 11139337

Title: Murine ortholog of ASC, a CARD-containing protein, self-associates and exhibits restricted distribution in developing mouse embryos.

PubMed ID: 11139337

DOI: 10.1006/excr.2000.5078

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15507117

Title: ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules.

PubMed ID: 15507117

DOI: 10.1111/j.1365-2443.2004.00789.x

PubMed ID: 15190255

Title: Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf.

PubMed ID: 15190255

DOI: 10.1038/nature02664

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21892172

Title: The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization.

PubMed ID: 21892172

DOI: 10.1038/ni.2095

PubMed ID: 22555457

Title: AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages.

PubMed ID: 22555457

DOI: 10.1038/cdd.2012.51

PubMed ID: 28314590

Title: Inflammasome activation triggers caspase-1-mediated cleavage of cGAS to regulate responses to DNA virus infection.

PubMed ID: 28314590

DOI: 10.1016/j.immuni.2017.02.011

PubMed ID: 30487600

Title: PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation.

PubMed ID: 30487600

DOI: 10.1038/s41586-018-0761-3

PubMed ID: 32424362

Title: Deubiquitination of NLRP6 inflammasome by Cyld critically regulates intestinal inflammation.

PubMed ID: 32424362

DOI: 10.1038/s41590-020-0681-x

PubMed ID: 34678144

Title: Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome.

PubMed ID: 34678144

DOI: 10.1016/j.cell.2021.09.032

PubMed ID: 34471287

Title: AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence.

PubMed ID: 34471287

DOI: 10.1038/s41586-021-03875-8

Sequence Information:

  • Length: 193
  • Mass: 21459
  • Checksum: 2A4EA40194870B31
  • Sequence:
    • MGRARDAILD ALENLSGDEL KKFKMKLLTV QLREGYGRIP RGALLQMDAI DLTDKLVSYY 
LESYGLELTM TVLRDMGLQE LAEQLQTTKE ESGAVAAAAS VPAQSTARTG HFVDQHRQAL 
IARVTEVDGV LDALHGSVLT EGQYQAVRAE TTSQDKMRKL FSFVPSWNLT CKDSLLQALK 
EIHPYLVMDL EQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.