Wwp2 | ENSMUSG00000031930 | NCBI 66894

Details for: Wwp2

Gene ID: 66894

Symbol: Wwp2

Ensembl ID: ENSMUSG00000031930

Description: WW domain containing E3 ubiquitin protein ligase 2

Associated with

Intracellular signaling by second messengers
(R-MMU-9006925)
Notch3 activation and transmission of signal to the nucleus
(R-MMU-9013507)
Pip3 activates akt signaling
(R-MMU-1257604)
Pten regulation
(R-MMU-6807070)
Regulation of pten stability and activity
(R-MMU-8948751)
Rho gtpase cycle
(R-MMU-9012999)
Rhoq gtpase cycle
(R-MMU-9013406)
Rhou gtpase cycle
(R-MMU-9013420)
Signaling by notch
(R-MMU-157118)
Signaling by notch3
(R-MMU-9012852)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
Cytoplasm
(GO:0005737)
Extracellular transport
(GO:0006858)
Negative regulation of dna-binding transcription factor activity
(GO:0043433)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of protein transport
(GO:0051224)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of transporter activity
(GO:0032410)
Nucleus
(GO:0005634)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein autoubiquitination
(GO:0051865)
Protein binding
(GO:0005515)
Protein k63-linked ubiquitination
(GO:0070534)
Protein ubiquitination
(GO:0016567)
Regulation of membrane potential
(GO:0042391)
Regulation of monoatomic ion transmembrane transport
(GO:0034765)
Regulation of potassium ion transmembrane transporter activity
(GO:1901016)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Transcription by rna polymerase ii
(GO:0006366)
Transcription factor binding
(GO:0008134)
Transferase activity
(GO:0016740)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin protein ligase activity
(GO:0061630)

Other Information

Proteins

NEDD4-like E3 ubiquitin-protein ligase WWP2
Q3TXI7_MOUSE

Genular Protein ID: 2254864001

Symbol: WWP2_MOUSE

Name: NEDD4-like E3 ubiquitin-protein ligase WWP2

UniProtKB Accession Codes:

Q9DBH0 Q8BTG4 Q923F6

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17526739

Title: Wwp2-mediated ubiquitination of the RNA polymerase II large subunit in mouse embryonic pluripotent stem cells.

PubMed ID: 17526739

DOI: 10.1128/mcb.01667-06

PubMed ID: 18776082

Title: Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2.

PubMed ID: 18776082

DOI: 10.1182/blood-2008-04-150953

PubMed ID: 19651900

Title: The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination.

PubMed ID: 19651900

DOI: 10.1128/mcb.00407-09

PubMed ID: 19997087

Title: Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dosage-dependent manner.

PubMed ID: 19997087

DOI: 10.1038/cr.2009.136

Sequence Information:

Length: 870
Mass: 98761
Checksum: 72B34A1B727A7FB3
Sequence:

MASASSSRAG VALPFEKSQL TLKVVSAKPK VHNRQPRINS YVEVAVDGLP SETKKTGKRI 
GSSELLWNEI IVLNVTAQSH LDLKVWSCHT LRNELLGTAS VNLSNVLKNN GGKMENTQLT 
LNLQTENKGS VVSGGELTIF LDGPTVDLGS VPNGSAVTDG SQPPSRESSG TAIAPETRHQ 
PPSTNCFGGR SRTHRHSGGS ARTATAASEQ SPGARNRHRQ PVKNSSSSGL ANGTVNEEPT 
PASEPEESSV VGVTSLPAAA LSVSSNPNTT SLPAQSTPAE GEEASTSGTQ QLPAAAQAPD 
ALPAGWEQRE LPNGRVYYVD HNTKTTTWER PLPPGWEKRT DPRGRFYYVD HNTRTTTWQR 
PTAEYVRNYE QWQSQRNQLQ GAMQHFSQRF LYQSSSASTD HDPLGPLPPG WEKRQDNGRV 
YYVNHNTRTT QWEDPRTQGM IQEPALPPGW EMKYTSEGVR YFVDHNTRTT TFKDPRPGFE 
SGTKQGSPGA YDRSFRWKYH QFRFLCHSNA LPSHVKISVS RQTLFEDSFQ QIMNMKPYDL 
RRRLYIIMRG EEGLDYGGIA REWFFLLSHE VLNPMYCLFE YAGKNNYCLQ INPASSINPD 
HLTYFRFIGR FIAMALYHGK FIDTGFTLPF YKRMLNKRPT LKDLESIDPE FYNSIVWIKE 
NNLEECGLEL FFIQDMEILG KVTTHELKEG GENIRVTEEN KEEYIMLLTD WRFTRGVEEQ 
TKAFLDGFNE VAPLEWLRYF DEKELELMLC GMQEIDMSDW QKNAIYRHYT KSSKQIQWFW 
QVVKEMDNEK RIRLLQFVTG TCRLPVGGFA ELIGSNGPQK FCIDRVGKET WLPRSHTCFN 
RLDLPPYKSY EQLKEKLLYA IEETEGFGQE

Genular Protein ID: 3192970755

Symbol: Q3TXI7_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3TXI7

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 431
Mass: 51060
Checksum: 27C41A9A0FBDA50E
Sequence:

MIQEPALPPG WEMKYTSEGV RYFVDHNTRT TTFKDPRPGF ESGTKQGSPG AYDRSFRWKY 
HQFRFLCHSN ALPSHVKISV SRQTLFEDSF QQIMNMKPYD LRRRLYIIMR GEEGLDYGGI 
AREWFFLLSH EVLNPMYCLF EYAGKNNYCL QINPASSINP DHLTYFRFIG RFIAMALYHG 
KFIDTGFTLP FYKRMLNKRP TLKDLESIDP EFYNSIVWIK ENNLEECGLE LFFIQDMEIL 
GKVTTHELKE GGENIRVTEE NKEEYIMLLT DWRFTRGVEE QTKAFLDGFN EVAPLEWLRY 
FDEKELELML CGMQEIDMSD WQKNAIYRHY TKSSKQIQWF WQVVKEMDNE KRIRLLQFVT 
GTCRLPVGGF AELIGSNGPQ KFCIDRVGKE TWLPRSHTCF NRLDLPPYKS YEQLKEKLLY 
AIEETEGFGQ E

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Wwp2

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Wwp2-mediated ubiquitination of the RNA polymerase II large subunit in mouse embryonic pluripotent stem cells. PubMed ID: 17526739

Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2. PubMed ID: 18776082

The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination. PubMed ID: 19651900

Wwp2 mediates Oct4 ubiquitination and its own auto-ubiquitination in a dosage-dependent manner. PubMed ID: 19997087

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303