Details for: BPGM

Gene ID: 669

Symbol: BPGM

Ensembl ID: ENSG00000172331

Description: bisphosphoglycerate mutase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 67.4175
    Cell Significance Index: -17.1000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 45.8553
    Cell Significance Index: -18.8900
  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 40.1169
    Cell Significance Index: -6.2400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 39.0153
    Cell Significance Index: -18.4200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 38.7932
    Cell Significance Index: -15.7600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 34.5461
    Cell Significance Index: -17.7700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 16.6013
    Cell Significance Index: -15.8500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.0473
    Cell Significance Index: -16.2000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.8352
    Cell Significance Index: -19.0800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.0469
    Cell Significance Index: -12.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.7682
    Cell Significance Index: 174.9100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.3846
    Cell Significance Index: 12.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1891
    Cell Significance Index: 31.7500
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.0871
    Cell Significance Index: 11.5500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0136
    Cell Significance Index: 70.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9847
    Cell Significance Index: 51.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9316
    Cell Significance Index: 151.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8599
    Cell Significance Index: 776.4300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8255
    Cell Significance Index: 22.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7791
    Cell Significance Index: 99.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7502
    Cell Significance Index: 35.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5544
    Cell Significance Index: 29.1100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5138
    Cell Significance Index: 7.0100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.4665
    Cell Significance Index: 3.7300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4553
    Cell Significance Index: 27.3400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3248
    Cell Significance Index: 9.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3137
    Cell Significance Index: 19.7700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3028
    Cell Significance Index: 54.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2823
    Cell Significance Index: 36.4800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2742
    Cell Significance Index: 33.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2057
    Cell Significance Index: 9.5900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1992
    Cell Significance Index: 6.9200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1734
    Cell Significance Index: 3.6300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.1699
    Cell Significance Index: 2.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1498
    Cell Significance Index: 66.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1490
    Cell Significance Index: 81.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1284
    Cell Significance Index: 24.4400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1233
    Cell Significance Index: 9.1900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1168
    Cell Significance Index: 2.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1134
    Cell Significance Index: 22.7400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0911
    Cell Significance Index: 4.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0832
    Cell Significance Index: 11.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0501
    Cell Significance Index: 9.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0465
    Cell Significance Index: 1.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0424
    Cell Significance Index: 7.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0382
    Cell Significance Index: 13.7000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0262
    Cell Significance Index: 0.6700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0146
    Cell Significance Index: 10.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0066
    Cell Significance Index: 12.5100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0047
    Cell Significance Index: 0.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0014
    Cell Significance Index: 2.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0005
    Cell Significance Index: -0.9500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0027
    Cell Significance Index: -3.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0029
    Cell Significance Index: -2.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0035
    Cell Significance Index: -0.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0036
    Cell Significance Index: -0.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0040
    Cell Significance Index: -2.9900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0092
    Cell Significance Index: -6.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0122
    Cell Significance Index: -7.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0126
    Cell Significance Index: -7.1100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0141
    Cell Significance Index: -8.9700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0280
    Cell Significance Index: -12.7000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0286
    Cell Significance Index: -2.9200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0327
    Cell Significance Index: -2.1100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0378
    Cell Significance Index: -2.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0403
    Cell Significance Index: -11.6000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0409
    Cell Significance Index: -0.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0442
    Cell Significance Index: -9.3200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0445
    Cell Significance Index: -2.3200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0512
    Cell Significance Index: -1.3500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0543
    Cell Significance Index: -6.2200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0545
    Cell Significance Index: -0.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0638
    Cell Significance Index: -7.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0685
    Cell Significance Index: -9.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0718
    Cell Significance Index: -1.5300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0735
    Cell Significance Index: -8.6700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0922
    Cell Significance Index: -3.2400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0923
    Cell Significance Index: -2.5800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0928
    Cell Significance Index: -10.5900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1122
    Cell Significance Index: -8.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1193
    Cell Significance Index: -3.8200
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1537
    Cell Significance Index: -1.4600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1616
    Cell Significance Index: -9.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1633
    Cell Significance Index: -10.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1713
    Cell Significance Index: -9.6100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1749
    Cell Significance Index: -13.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1750
    Cell Significance Index: -18.2200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2194
    Cell Significance Index: -2.6200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2452
    Cell Significance Index: -6.5700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2785
    Cell Significance Index: -7.4500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2834
    Cell Significance Index: -3.2200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2972
    Cell Significance Index: -8.7600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3026
    Cell Significance Index: -4.8000
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.3179
    Cell Significance Index: -2.1100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3237
    Cell Significance Index: -8.3200
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: -0.3269
    Cell Significance Index: -2.3600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.3398
    Cell Significance Index: -2.9200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3431
    Cell Significance Index: -5.1700
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3431
    Cell Significance Index: -5.7700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3515
    Cell Significance Index: -15.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BPGM is a bifunctional enzyme that catalyzes the reversible conversion of 2,3-bisphosphoglycerate (2,3-BPG) to 3-phosphoglycerate (3-PGA) and vice versa. This reaction is essential for regulating oxygen transport and metabolism in erythrocytes. BPGM is highly expressed in erythroid lineage cells, cardiac endothelial cells, and other cell types involved in immune response and metabolism. **Pathways and Functions:** BPGM plays a pivotal role in several metabolic and immune-related pathways: 1. **Glycolysis and Glucose Metabolism:** BPGM is involved in the regulation of glycolytic flux, ensuring optimal glucose metabolism and energy production in erythrocytes and other cells. 2. **Oxygen Transport and Respiration:** By converting 2,3-BPG to 3-PGA, BPGM facilitates the release of oxygen from hemoglobin, enabling efficient oxygen transport in erythrocytes. 3. **Immune Response:** BPGM is expressed in immune cells, including innate lymphoid cells, and plays a role in modulating immune responses, particularly in the context of protozoan infections. 4. **Erythropoiesis and Blood-Brain Barrier Establishment:** BPGM is essential for erythropoiesis, the process of red blood cell production, and is also involved in the establishment of the blood-brain barrier. **Clinical Significance:** Dysregulation of BPGM has been implicated in various diseases, including: 1. **Anemia and Hypoxia:** Altered BPGM activity can lead to anemia, hypoxia, and impaired oxygen delivery to tissues. 2. **Immune Disorders:** Dysregulation of BPGM in immune cells can contribute to immune dysfunction and disease, such as autoimmune disorders and cancer. 3. **Neurological Disorders:** BPGM has been linked to neuroinflammatory responses and the establishment of the blood-brain barrier, highlighting its potential role in neurological disorders, such as multiple sclerosis and stroke. In conclusion, BPGM is a multifunctional enzyme that plays a critical role in regulating metabolic homeostasis, immune response, and oxygen transport. Further research on BPGM is essential to elucidate its precise mechanisms of action and its implications in human disease.

Genular Protein ID: 1432720608

Symbol: PMGE_HUMAN

Name: Bisphosphoglycerate mutase

UniProtKB Accession Codes:

P07738 A4D1N9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 5 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 7 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 12 PDBsum 12 PIR 1 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 4 Rhea 2 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2542247

Title: Isolation, characterization, and structure of a mutant 89 ArgTO: bisphosphoglycerate mutase. Implication of the active site in the mutation.

PubMed ID: 2542247

DOI: 10.1016/s0021-9258(18)83118-0

PubMed ID: 6313356

Title: The complete amino acid sequence of human erythrocyte diphosphoglycerate mutase.

PubMed ID: 6313356

DOI: 10.1002/j.1460-2075.1983.tb01569.x

PubMed ID: 3023066

Title: Molecular cloning and sequencing of the human erythrocyte 2,3-bisphosphoglycerate mutase cDNA: revised amino acid sequence.

PubMed ID: 3023066

DOI: 10.1002/j.1460-2075.1986.tb04495.x

PubMed ID: 3036106

Title: Molecular cloning of the human 2,3-bisphosphoglycerate mutase cDNA and revised amino acid sequence.

PubMed ID: 3036106

PubMed ID: 2844822

Title: Isolation and characterization of the human 2,3-bisphosphoglycerate mutase gene.

PubMed ID: 2844822

DOI: 10.1016/s0021-9258(19)37657-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9832630

Title: Human erythrocyte bisphosphoglycerate mutase: inactivation by glycation in vivo and in vitro.

PubMed ID: 9832630

DOI: 10.1093/oxfordjournals.jbchem.a022243

PubMed ID: 8440681

Title: The platelet-activating factor acetylhydrolase from human erythrocytes. Purification and properties.

PubMed ID: 8440681

DOI: 10.1016/s0021-9258(18)53552-3

PubMed ID: 10477269

Title: Model of 2,3-bisphosphoglycerate metabolism in the human erythrocyte based on detailed enzyme kinetic equations: equations and parameter refinement.

PubMed ID: 10477269

DOI: 10.1042/bj3420581

PubMed ID: 16246416

Title: Novel placental expression of 2,3-bisphosphoglycerate mutase.

PubMed ID: 16246416

DOI: 10.1016/j.placenta.2005.08.010

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 1387804

Title: Structural modeling of the human erythrocyte bisphosphoglycerate mutase.

PubMed ID: 1387804

DOI: 10.1016/0300-9084(92)90149-9

PubMed ID: 15258155

Title: Crystal structure of human bisphosphoglycerate mutase.

PubMed ID: 15258155

DOI: 10.1074/jbc.m405982200

PubMed ID: 17052986

Title: Seeing the process of histidine phosphorylation in human bisphosphoglycerate mutase.

PubMed ID: 17052986

DOI: 10.1074/jbc.m606421200

PubMed ID: 21045285

Title: Unliganded structure of human bisphosphoglycerate mutase reveals side-chain movements induced by ligand binding.

PubMed ID: 21045285

DOI: 10.1107/s1744309110035475

PubMed ID: 1421379

Title: Compound heterozygosity in a complete erythrocyte bisphosphoglycerate mutase deficiency.

PubMed ID: 1421379

PubMed ID: 15054810

Title: Erythrocytosis due to bisphosphoglycerate mutase deficiency with concurrent glucose-6-phosphate dehydrogenase (G-6-PD) deficiency.

PubMed ID: 15054810

DOI: 10.1002/ajh.20014

Sequence Information:

  • Length: 259
  • Mass: 30005
  • Checksum: A2AF1D6F2985A3B5
  • Sequence:
    • MSKYKLIMLR HGEGAWNKEN RFCSWVDQKL NSEGMEEARN CGKQLKALNF EFDLVFTSVL 
NRSIHTAWLI LEELGQEWVP VESSWRLNER HYGALIGLNR EQMALNHGEE QVRLWRRSYN 
VTPPPIEESH PYYQEIYNDR RYKVCDVPLD QLPRSESLKD VLERLLPYWN ERIAPEVLRG 
KTILISAHGN SSRALLKHLE GISDEDIINI TLPTGVPILL ELDENLRAVG PHQFLGDQEA 
IQAAIKKVED QGKVKQAKK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.