Details for: Khdc3

Gene ID: 66991

Symbol: Khdc3

Ensembl ID: ENSMUSG00000092622

Description: KH domain containing 3, subcortical maternal complex member

Associated with

Other Information

Genular Protein ID: 3633775082

Symbol: KHDC3_MOUSE

Name: KH domain-containing protein 3

UniProtKB Accession Codes:

Q9CWU5 A7YIL2 Q9CRD6

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 2 CDD 1 CORUM 1 CPTAC 1 CTD 1 DNASU 1 EMBL 12 Ensembl 3 ExpressionAtlas 1 GO 21 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 REPRODUCTION-2DPAGE 1 RNAct 1 RefSeq 2 SAM 1 SMR 1 STRING 1 TreeFam 1 UCSC 2 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 18057100

Title: Maternally derived FILIA-MATER complex localizes asymmetrically in cleavage-stage mouse embryos.

PubMed ID: 18057100

DOI: 10.1242/dev.011445

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17913455

Title: Atypical structure and phylogenomic evolution of the new eutherian oocyte- and embryo-expressed KHDC1/DPPA5/ECAT1/OOEP gene family.

PubMed ID: 17913455

DOI: 10.1016/j.ygeno.2007.06.003

PubMed ID: 18804437

Title: A subcortical maternal complex essential for preimplantation mouse embryogenesis.

PubMed ID: 18804437

DOI: 10.1016/j.devcel.2008.07.010

PubMed ID: 19376971

Title: Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesis.

PubMed ID: 19376971

DOI: 10.1073/pnas.0900519106

PubMed ID: 25208553

Title: The subcortical maternal complex controls symmetric division of mouse zygotes by regulating F-actin dynamics.

PubMed ID: 25208553

DOI: 10.1038/ncomms5887

PubMed ID: 25936915

Title: Filia Is an ESC-Specific Regulator of DNA Damage Response and Safeguards Genomic Stability.

PubMed ID: 25936915

DOI: 10.1016/j.stem.2015.03.017

PubMed ID: 29125140

Title: Mouse embryonic stem cells have increased capacity for replication fork restart driven by the specific Filia-Floped protein complex.

PubMed ID: 29125140

DOI: 10.1038/cr.2017.139

PubMed ID: 28992324

Title: Zbed3 participates in the subcortical maternal complex and regulates the distribution of organelles.

PubMed ID: 28992324

DOI: 10.1093/jmcb/mjx035

PubMed ID: 31575650

Title: The subcortical maternal complex protein Nlrp4f is involved in cytoplasmic lattice formation and organelle distribution.

PubMed ID: 31575650

DOI: 10.1242/dev.183616

PubMed ID: 33115731

Title: Genome integrity and neurogenesis of postnatal hippocampal neural stem/progenitor cells require a unique regulator Filia.

PubMed ID: 33115731

DOI: 10.1126/sciadv.aba0682

PubMed ID: 20823540

Title: Preliminary crystallographic analysis of the N-terminal domain of FILIA, a protein essential for embryogenesis.

PubMed ID: 20823540

DOI: 10.1107/s1744309110031994

PubMed ID: 22276159

Title: The N-terminus of FILIA forms an atypical KH domain with a unique extension involved in interaction with RNA.

PubMed ID: 22276159

DOI: 10.1371/journal.pone.0030209

Sequence Information:

  • Length: 440
  • Mass: 47995
  • Checksum: 19C1B93DACC42851
  • Sequence:
    • MASLKRFQTL VPLDHKQGTL FEIIGEPKLP KWFHVECLED PKRLYVEPRL LEIMFGKDGE 
HIPHLESMLH TLIHVNVWGP ERRAEIWIFG PPPFRRDVDR MLTDLAHYCR MKLMEIEALE 
AGVERRRMAA HKAATQPAPV KVREAAPRPA SVKVPETATQ PAPVKVREAA PQPAPVQEVR 
EAAPQQASVQ EEVREAATEQ APVQEVREAA TEQAPVQEVS EAATEQAPVQ EVNEAATEQA 
SVQAVREAAT RPAPGKVRKA ATQPAPVQVC QEATQLAPVK VREAATQPAS GKVREAATQL 
APVKVRKAAT QLAPVKVHEA ATQPAPGKVS DAATQSASVQ VREAATQLSP VEATDTSQLA 
QVKADEAFAQ HTSGEAHQVA NGQSPIEVCE TATGQHSLDV SRALSQKCPE VFEWETQSCL 
DGSYVIVQPP RDAWESFIIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.