Details for: BPHL

Gene ID: 670

Symbol: BPHL

Ensembl ID: ENSG00000137274

Description: biphenyl hydrolase like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 113.2790
    Cell Significance Index: -17.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 66.7078
    Cell Significance Index: -16.9200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 44.7508
    Cell Significance Index: -18.4400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 37.4147
    Cell Significance Index: -15.2000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 16.2033
    Cell Significance Index: -15.4700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.8180
    Cell Significance Index: -18.2700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.3385
    Cell Significance Index: -16.9800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.6718
    Cell Significance Index: -18.4400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.2162
    Cell Significance Index: -12.9500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.9509
    Cell Significance Index: 117.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5137
    Cell Significance Index: 149.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4342
    Cell Significance Index: 74.5000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.3674
    Cell Significance Index: 10.9200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.0599
    Cell Significance Index: 210.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8692
    Cell Significance Index: 18.8300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8619
    Cell Significance Index: 11.7600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.8590
    Cell Significance Index: 7.9100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.7975
    Cell Significance Index: 8.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7854
    Cell Significance Index: 127.7400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7326
    Cell Significance Index: 50.6700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.7276
    Cell Significance Index: 15.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6978
    Cell Significance Index: 24.2500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5859
    Cell Significance Index: 15.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5250
    Cell Significance Index: 105.3100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4717
    Cell Significance Index: 12.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4611
    Cell Significance Index: 20.9000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4499
    Cell Significance Index: 81.1100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.4218
    Cell Significance Index: 7.1100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4183
    Cell Significance Index: 228.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3962
    Cell Significance Index: 142.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3132
    Cell Significance Index: 38.5100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2818
    Cell Significance Index: 38.7000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2398
    Cell Significance Index: 12.4900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2171
    Cell Significance Index: 12.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2134
    Cell Significance Index: 94.3300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2029
    Cell Significance Index: 14.3500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1671
    Cell Significance Index: 7.7900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1599
    Cell Significance Index: 20.5000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1592
    Cell Significance Index: 3.3900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1562
    Cell Significance Index: 4.6000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.1546
    Cell Significance Index: 2.2200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1380
    Cell Significance Index: 8.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1367
    Cell Significance Index: 10.1900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1303
    Cell Significance Index: 16.8400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1080
    Cell Significance Index: 3.4600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0952
    Cell Significance Index: 85.9300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0680
    Cell Significance Index: 1.9000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0663
    Cell Significance Index: 2.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0595
    Cell Significance Index: 2.6300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0522
    Cell Significance Index: 1.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0471
    Cell Significance Index: 8.9600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0264
    Cell Significance Index: 1.0000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0187
    Cell Significance Index: 2.2100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0133
    Cell Significance Index: 0.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0125
    Cell Significance Index: 23.5700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0101
    Cell Significance Index: 18.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0100
    Cell Significance Index: 15.3200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0089
    Cell Significance Index: 6.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0038
    Cell Significance Index: 5.1200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0013
    Cell Significance Index: 0.0600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0007
    Cell Significance Index: 0.1200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0087
    Cell Significance Index: -0.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0115
    Cell Significance Index: -7.2900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0184
    Cell Significance Index: -13.9100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0192
    Cell Significance Index: -14.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0213
    Cell Significance Index: -9.6600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0277
    Cell Significance Index: -15.6400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0306
    Cell Significance Index: -3.1300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0310
    Cell Significance Index: -19.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0358
    Cell Significance Index: -2.4100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0439
    Cell Significance Index: -6.3800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0500
    Cell Significance Index: -14.4000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0531
    Cell Significance Index: -0.9100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0562
    Cell Significance Index: -1.2300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0563
    Cell Significance Index: -6.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0582
    Cell Significance Index: -4.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0633
    Cell Significance Index: -5.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0685
    Cell Significance Index: -1.8300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0774
    Cell Significance Index: -8.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0902
    Cell Significance Index: -19.0000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1147
    Cell Significance Index: -2.7500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1172
    Cell Significance Index: -7.5600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1253
    Cell Significance Index: -1.8500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1299
    Cell Significance Index: -1.3500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1354
    Cell Significance Index: -7.1100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1525
    Cell Significance Index: -9.6100
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1562
    Cell Significance Index: -2.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1635
    Cell Significance Index: -17.0300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1785
    Cell Significance Index: -3.8200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.1842
    Cell Significance Index: -2.3200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1962
    Cell Significance Index: -5.3400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2229
    Cell Significance Index: -5.7300
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.2250
    Cell Significance Index: -1.7200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2321
    Cell Significance Index: -4.5300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2442
    Cell Significance Index: -6.9700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2454
    Cell Significance Index: -6.5700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2545
    Cell Significance Index: -5.8800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2867
    Cell Significance Index: -17.5800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2940
    Cell Significance Index: -6.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2996
    Cell Significance Index: -9.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Biphenyl Hydrolase-Like Activity:** The BPHL gene encodes an enzyme that exhibits biphenyl hydrolase-like activity, which is crucial for the degradation of xenobiotics and environmental pollutants. 2. **Multifaceted Metabolic Pathways:** BPHL is involved in various metabolic processes, including amino acid metabolic process, biological oxidations, and metabolism, underscoring its central role in maintaining cellular homeostasis. 3. **Significant Expression in Diverse Cell Types:** The gene is expressed in multiple cell types, including pulmonary interstitial fibroblasts, epithelial cells, and neurons, indicating its widespread importance in maintaining cellular function. 4. **Phase I Functionalization:** BPHL enzyme participates in phase I functionalization of compounds, a critical step in the metabolic activation and detoxification of xenobiotics. **Pathways and Functions:** 1. **Alpha-Amino-Acid Esterase Activity:** BPHL exhibits alpha-amino-acid esterase activity, which is essential for the degradation of amino acids and the regulation of cellular metabolism. 2. **Amino Acid Metabolic Process:** The gene is involved in the amino acid metabolic process, which is critical for maintaining protein synthesis, degradation, and other cellular functions. 3. **Biological Oxidations:** BPHL participates in biological oxidations, which are essential for the regulation of cellular metabolism and the detoxification of xenobiotics. 4. **Mitochondrial Outer Membrane and Mitochondrion:** The gene is expressed in mitochondrial outer membrane and mitochondrion, highlighting its role in maintaining mitochondrial function and regulating cellular energy metabolism. 5. **Xenobiotic Metabolic Process:** BPHL is involved in the xenobiotic metabolic process, which is critical for the detoxification and regulation of environmental pollutants. **Clinical Significance:** 1. **Detoxification and Metabolic Regulation:** The BPHL gene plays a critical role in maintaining cellular homeostasis and regulating metabolic processes, including xenobiotic metabolism and amino acid processing. 2. **Environmental Pollution:** The enzyme's ability to degrade biphenyl and other environmental pollutants makes it an attractive target for understanding the mechanisms of detoxification and environmental remediation. 3. **Neurological Disorders:** The gene's expression in neurons and peripheral nervous system cells highlights its potential role in neurological disorders, such as neurodegenerative diseases and neurotoxicity. 4. **Cancer Research:** The BPHL enzyme's involvement in phase I functionalization of compounds makes it an attractive target for understanding the mechanisms of carcinogenesis and developing novel therapeutic strategies. In conclusion, the BPHL gene is a multifaceted enzyme that plays a critical role in various metabolic pathways, including xenobiotic metabolism, amino acid processing, and mitochondrial function. Its widespread expression in diverse cell types and its involvement in phase I functionalization of compounds make it an attractive target for understanding the intricate mechanisms of detoxification and metabolic regulation. Further research is necessary to fully elucidate the clinical significance of the BPHL gene and its potential applications in environmental pollution, neurological disorders, and cancer research.

Genular Protein ID: 3004489553

Symbol: PARG_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q86W56 A5YBK3 B2RC24 B4DIU5 B4DYR4 I6RUV3 Q6E4P6 Q6E4P7 Q7Z742 Q9Y4W7

Database IDs:

AGR 2 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 2 BioMuta 1 CCDS 1 CTD 2 ChEBI 3 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 2 DrugCentral 1 EC 1 EMBL 11 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 GeneCards 1 GeneTree 1 GeneWiki 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 25 PDBsum 25 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 5 Rhea 4 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14527731

Title: Human poly(ADP-ribose) glycohydrolase (PARG) gene and the common promoter sequence it shares with inner mitochondrial membrane translocase 23 (TIM23).

PubMed ID: 14527731

DOI: 10.1016/s0378-1119(03)00738-8

PubMed ID: 15212953

Title: Human poly(ADP-ribose) glycohydrolase is expressed in alternative splice variants yielding isoforms that localize to different cell compartments.

PubMed ID: 15212953

DOI: 10.1016/j.yexcr.2004.03.050

PubMed ID: 10449915

Title: Assignment of the poly(ADP-ribose) glycohydrolase gene (PARG) to human chromosome 10q11.23 and mouse chromosome 14B by in situ hybridization.

PubMed ID: 10449915

DOI: 10.1159/000015310

PubMed ID: 17509564

Title: Two small enzyme isoforms mediate mammalian mitochondrial poly(ADP-ribose) glycohydrolase (PARG) activity.

PubMed ID: 17509564

DOI: 10.1016/j.yexcr.2007.03.043

PubMed ID: 22433848

Title: ADP-ribosylhydrolase 3 (ARH3), not poly(ADP-ribose) glycohydrolase (PARG) isoforms, is responsible for degradation of mitochondrial matrix-associated poly(ADP-ribose).

PubMed ID: 22433848

DOI: 10.1074/jbc.m112.349183

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15450800

Title: A nonradiometric, high-throughput assay for poly(ADP-ribose) glycohydrolase (PARG): application to inhibitor identification and evaluation.

PubMed ID: 15450800

DOI: 10.1016/j.ab.2004.04.032

PubMed ID: 16460818

Title: Dynamic relocation of poly(ADP-ribose) glycohydrolase isoforms during radiation-induced DNA damage.

PubMed ID: 16460818

DOI: 10.1016/j.bbamcr.2005.11.015

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19105632

Title: Proteomic investigation of phosphorylation sites in poly(ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase.

PubMed ID: 19105632

DOI: 10.1021/pr800810n

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21892188

Title: The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase.

PubMed ID: 21892188

DOI: 10.1038/nature10404

PubMed ID: 21398629

Title: PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms.

PubMed ID: 21398629

DOI: 10.1093/nar/gkr099

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23102699

Title: Poly (ADP-ribose) glycohydrolase regulates retinoic acid receptor-mediated gene expression.

PubMed ID: 23102699

DOI: 10.1016/j.molcel.2012.09.021

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23481255

Title: Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease.

PubMed ID: 23481255

DOI: 10.1038/emboj.2013.51

PubMed ID: 23474714

Title: Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases.

PubMed ID: 23474714

DOI: 10.1038/nsmb.2521

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24906880

Title: PARG is dispensable for recovery from transient replicative stress but required to prevent detrimental accumulation of poly(ADP-ribose) upon prolonged replicative stress.

PubMed ID: 24906880

DOI: 10.1093/nar/gku505

PubMed ID: 27257257

Title: ADP-ribose-derived nuclear ATP synthesis by NUDIX5 is required for chromatin remodeling.

PubMed ID: 27257257

DOI: 10.1126/science.aad9335

PubMed ID: 33186521

Title: An HPF1/PARP1-based chemical biology strategy for exploring ADP-ribosylation.

PubMed ID: 33186521

DOI: 10.1016/j.cell.2020.09.055

PubMed ID: 34019811

Title: Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease.

PubMed ID: 34019811

DOI: 10.1016/j.molcel.2021.04.028

PubMed ID: 34321462

Title: Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal.

PubMed ID: 34321462

DOI: 10.1038/s41467-021-24723-3

PubMed ID: 23251397

Title: Structures of the human poly (ADP-ribose) glycohydrolase catalytic domain confirm catalytic mechanism and explain inhibition by ADP-HPD derivatives.

PubMed ID: 23251397

DOI: 10.1371/journal.pone.0050889

PubMed ID: 30472116

Title: (ADP-ribosyl)hydrolases: Structural Basis for Differential Substrate Recognition and Inhibition.

PubMed ID: 30472116

DOI: 10.1016/j.chembiol.2018.11.001

Sequence Information:

  • Length: 976
  • Mass: 111110
  • Checksum: D6646353C6D0180E
  • Sequence:
    • MNAGPGCEPC TKRPRWGAAT TSPAASDARS FPSRQRRVLD PKDAHVQFRV PPSSPACVPG 
RAGQHRGSAT SLVFKQKTIT SWMDTKGIKT AESESLDSKE NNNTRIESMM SSVQKDNFYQ 
HNVEKLENVS QLSLDKSPTE KSTQYLNQHQ TAAMCKWQNE GKHTEQLLES EPQTVTLVPE 
QFSNANIDRS PQNDDHSDTD SEENRDNQQF LTTVKLANAK QTTEDEQARE AKSHQKCSKS 
CDPGEDCASC QQDEIDVVPE SPLSDVGSED VGTGPKNDNK LTRQESCLGN SPPFEKESEP 
ESPMDVDNSK NSCQDSEADE ETSPGFDEQE DGSSSQTANK PSRFQARDAD IEFRKRYSTK 
GGEVRLHFQF EGGESRTGMN DLNAKLPGNI SSLNVECRNS KQHGKKDSKI TDHFMRLPKA 
EDRRKEQWET KHQRTERKIP KYVPPHLSPD KKWLGTPIEE MRRMPRCGIR LPLLRPSANH 
TVTIRVDLLR AGEVPKPFPT HYKDLWDNKH VKMPCSEQNL YPVEDENGER TAGSRWELIQ 
TALLNKFTRP QNLKDAILKY NVAYSKKWDF TALIDFWDKV LEEAEAQHLY QSILPDMVKI 
ALCLPNICTQ PIPLLKQKMN HSITMSQEQI ASLLANAFFC TFPRRNAKMK SEYSSYPDIN 
FNRLFEGRSS RKPEKLKTLF CYFRRVTEKK PTGLVTFTRQ SLEDFPEWER CEKPLTRLHV 
TYEGTIEENG QGMLQVDFAN RFVGGGVTSA GLVQEEIRFL INPELIISRL FTEVLDHNEC 
LIITGTEQYS EYTGYAETYR WSRSHEDGSE RDDWQRRCTE IVAIDALHFR RYLDQFVPEK 
MRRELNKAYC GFLRPGVSSE NLSAVATGNW GCGAFGGDAR LKALIQILAA AAAERDVVYF 
TFGDSELMRD IYSMHIFLTE RKLTVGDVYK LLLRYYNEEC RNCSTPGPDI KLYPFIYHAV 
ESCAETADHS GQRTGT

Genular Protein ID: 1350870542

Symbol: BPHL_HUMAN

Name: Valacyclovir hydrolase

UniProtKB Accession Codes:

Q86WA6 Q00306 Q13855 Q3KP51

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 6 ESTHER 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 6 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7759552

Title: Cloning and expression analysis of a novel human serine hydrolase with sequence similarity to prokaryotic enzymes involved in the degradation of aromatic compounds.

PubMed ID: 7759552

DOI: 10.1074/jbc.270.21.12926

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2393862

Title: Cloning and sequencing of a complementary DNA encoding a M(r) 70,000 human breast epithelial mucin-associated antigen.

PubMed ID: 2393862

PubMed ID: 12732646

Title: Identification of a human valacyclovirase: biphenyl hydrolase-like protein as valacyclovir hydrolase.

PubMed ID: 12732646

DOI: 10.1074/jbc.m302055200

PubMed ID: 9721218

Title: Structural characterization and chromosomal localization of the gene encoding human biphenyl hydrolase-related protein (BPHL).

PubMed ID: 9721218

DOI: 10.1006/geno.1998.5351

PubMed ID: 15832508

Title: A novel nucleoside prodrug-activating enzyme: substrate specificity of biphenyl hydrolase-like protein.

PubMed ID: 15832508

DOI: 10.1021/mp0499757

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 18256025

Title: Molecular basis of prodrug activation by human valacyclovirase, an alpha-amino acid ester hydrolase.

PubMed ID: 18256025

DOI: 10.1074/jbc.m709530200

Sequence Information:

  • Length: 291
  • Mass: 32543
  • Checksum: 830B948492160244
  • Sequence:
    • MVAVLGGRGV LRLRLLLSAL KPGIHVPRAG PAAAFGTSVT SAKVAVNGVQ LHYQQTGEGD 
HAVLLLPGML GSGETDFGPQ LKNLNKKLFT VVAWDPRGYG HSRPPDRDFP ADFFERDAKD 
AVDLMKALKF KKVSLLGWSD GGITALIAAA KYPSYIHKMV IWGANAYVTD EDSMIYEGIR 
DVSKWSERTR KPLEALYGYD YFARTCEKWV DGIRQFKHLP DGNICRHLLP RVQCPALIVH 
GEKDPLVPRF HADFIHKHVK GSRLHLMPEG KHNLHLRFAD EFNKLAEDFL Q

Genular Protein ID: 4284508385

Symbol: Q49AI2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q49AI2

Database IDs:

ARBA 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 ESTHER 1 Ensembl 2 GO 1 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 2 RefSeq 2 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 194
  • Mass: 21532
  • Checksum: 544E78D231E6C81B
  • Sequence:
    • MPRNLLYSLL SSHLSPHFST SVTSAKVAVN GVQLHYQQTG EGDHAVLLLP GMLGSGETDF 
GPQLKNLNKK LFTVVAWDPR GYGHSRPPDR DFPADFFERD AKDAVDLMKA LKFKKVSLLG 
WSDGGITALI AAAKYPSYIH KMVIWGANAY VTDEDSMIYE GIRDVSKWSE RTRKPLEALY 
GWSLTLSPGW NAMA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.