Details for: Oma1

Gene ID: 67013

Symbol: Oma1

Ensembl ID: ENSMUSG00000035069

Description: OMA1 zinc metallopeptidase

Associated with

Other Information

Genular Protein ID: 2750705537

Symbol: OMA1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24550258

Title: Stress-induced OMA1 activation and autocatalytic turnover regulate OPA1-dependent mitochondrial dynamics.

PubMed ID: 24550258

DOI: 10.1002/embj.201386474

PubMed ID: 20038678

Title: Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1.

PubMed ID: 20038678

DOI: 10.1083/jcb.200906084

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22433842

Title: Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice.

PubMed ID: 22433842

DOI: 10.1038/emboj.2012.70

PubMed ID: 24719224

Title: Membrane depolarization activates the mitochondrial protease OMA1 by stimulating self-cleavage.

PubMed ID: 24719224

DOI: 10.1002/embr.201338240

PubMed ID: 24616225

Title: The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission.

PubMed ID: 24616225

DOI: 10.1083/jcb.201308006

PubMed ID: 26785494

Title: Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice.

PubMed ID: 26785494

DOI: 10.1126/science.aad0116

PubMed ID: 26365306

Title: metalloprotease OMA1 fine-tunes mitochondrial bioenergetic function and respiratory supercomplex stability.

PubMed ID: 26365306

DOI: 10.1038/srep13989

PubMed ID: 26783299

Title: Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria.

PubMed ID: 26783299

DOI: 10.1083/jcb.201507022

PubMed ID: 29593106

Title: Ablation of the stress protease OMA1 protects against heart failure in mice.

PubMed ID: 29593106

DOI: 10.1126/scitranslmed.aan4935

PubMed ID: 31819158

Title: Prohibitin levels regulate OMA1 activity and turnover in neurons.

PubMed ID: 31819158

DOI: 10.1038/s41418-019-0469-4

Sequence Information:

  • Length: 521
  • Mass: 58878
  • Checksum: 80BCBFA70C9E2D5F
  • Sequence:
  • MSLLYGLQST RINRFLSGVN NLANRRQWTP PASCPLAPKL RAVNAYWGLN TVSHCHSVTL 
    LPRNFLFCRT LNHKKSRCLS SAQSKELGVL TYRCTVRGDS VLRQGARKVA GVPALAASCS 
    PSCPAVIEAR SFRTSARVQA APVPLLLLIL KPVQKLLAII VGRGIRKWWQ ALPPNKKELF 
    KDSVRKNKWR LLLGLSAFGL LFVVFYFTHL EVSPVTGRSK LLLVGKEHFR LLSDLEYEVW 
    MEEFKNDLLP ERDPRYLTVK EMVYHLTQCN RDVPGISETN WVVHVVDSPA VNAFVLPNGQ 
    VFIFTGLLNS VTDVHQLSFL LGHEIAHAVL GHAAEKASLV HLLDFLGMIF LTMIWAICPR 
    DSLAVLGQWI QSKLQEYMFD RPYSRTLEAE ADKVGLQLAA KACADVRASS VFWQQMEFSE 
    SLHGYPKLPE WLSTHPSHGN RAEYLDRLIP QALKLREVCN CPPLSGPDPR LLFRLTVKRF 
    LEDSEKEDLN ITVKKQKTDA LPMQKQEQIP LTYVLEKRTA G

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.