BPI | ENSG00000101425 | NCBI 671

Details for: BPI

Gene ID: 671

Symbol: BPI

Ensembl ID: ENSG00000101425

Description: bactericidal permeability increasing protein

Associated with

Antimicrobial peptides
(R-HSA-6803157)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Neutrophil degranulation
(R-HSA-6798695)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Azurophil granule lumen
(GO:0035578)
Defense response to gram-negative bacterium
(GO:0050829)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Innate immune response
(GO:0045087)
Lipopolysaccharide-mediated signaling pathway
(GO:0031663)
Lipopolysaccharide binding
(GO:0001530)
Membrane
(GO:0016020)
Negative regulation of interleukin-6 production
(GO:0032715)
Negative regulation of interleukin-8 production
(GO:0032717)
Negative regulation of macrophage activation
(GO:0043031)
Negative regulation of tumor necrosis factor production
(GO:0032720)
Specific granule lumen
(GO:0035580)

Other Information

Proteins

Bactericidal permeability-increasing protein

Genular Protein ID: 3082875698

Symbol: BPI_HUMAN

Name: Bactericidal permeability-increasing protein

UniProtKB Accession Codes:

P17213 B2RCY2 Q1ZZU8 Q5JRW0 Q8IW58 Q9BYZ9 Q9H1L2 Q9H1M8 Q9H203 Q9UCT4 Q9UD65

Database IDs:

Citations:

PubMed ID: 2722846

Title: Cloning of the cDNA of a human neutrophil bactericidal protein. Structural and functional correlations.

PubMed ID: 2722846

DOI: 10.1016/s0021-9258(18)60560-5

PubMed ID: 7517398

Title: Bactericidal/permeability-increasing protein and lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS-mediated cell activation.

PubMed ID: 7517398

DOI: 10.1016/s0021-9258(17)32454-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1937776

Title: Comparison of granule proteins from human polymorphonuclear leukocytes which are bactericidal toward Pseudomonas aeruginosa.

PubMed ID: 1937776

DOI: 10.1128/iai.59.11.4193-4200.1991

PubMed ID: 2501794

Title: Antibiotic proteins of human polymorphonuclear leukocytes.

PubMed ID: 2501794

DOI: 10.1073/pnas.86.14.5610

PubMed ID: 3667613

Title: A 25-kDa NH2-terminal fragment carries all the antibacterial activities of the human neutrophil 60-kDa bactericidal/permeability-increasing protein.

PubMed ID: 3667613

DOI: 10.1016/s0021-9258(18)48110-0

PubMed ID: 8812832

Title: Expression and characterization of cysteine-modified variants of an amino-terminal fragment of bactericidal/permeability-increasing protein.

PubMed ID: 8812832

DOI: 10.1006/prep.1996.0071

PubMed ID: 9188532

Title: Crystal structure of human BPI and two bound phospholipids at 2.4-A resolution.

PubMed ID: 9188532

DOI: 10.1126/science.276.5320.1861

PubMed ID: 10843855

Title: The 1.7 A crystal structure of BPI: a study of how two dissimilar amino acid sequences can adopt the same fold.

PubMed ID: 10843855

DOI: 10.1006/jmbi.2000.3805

Sequence Information:

Length: 487
Mass: 53900
Checksum: 30BC73B1B465B62D
Sequence:

MRENMARGPC NAPRWASLMV LVAIGTAVTA AVNPGVVVRI SQKGLDYASQ QGTAALQKEL 
KRIKIPDYSD SFKIKHLGKG HYSFYSMDIR EFQLPSSQIS MVPNVGLKFS ISNANIKISG 
KWKAQKRFLK MSGNFDLSIE GMSISADLKL GSNPTSGKPT ITCSSCSSHI NSVHVHISKS 
KVGWLIQLFH KKIESALRNK MNSQVCEKVT NSVSSELQPY FQTLPVMTKI DSVAGINYGL 
VAPPATTAET LDVQMKGEFY SENHHNPPPF APPVMEFPAA HDRMVYLGLS DYFFNTAGLV 
YQEAGVLKMT LRDDMIPKES KFRLTTKFFG TFLPEVAKKF PNMKIQIHVS ASTPPHLSVQ 
PTGLTFYPAV DVQAFAVLPN SSLASLFLIG MHTTGSMEVS AESNRLVGEL KLDRLLLELK 
HSNIGPFPVE LLQDIMNYIV PILVLPRVNE KLQKGFPLPT PARVQLYNVV LQPHQNFLLF 
GADVVYK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: BPI

Associated with

Other Information

Cloning of the cDNA of a human neutrophil bactericidal protein. Structural and functional correlations. PubMed ID: 2722846

Bactericidal/permeability-increasing protein and lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS-mediated cell activation. PubMed ID: 7517398

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 20. PubMed ID: 11780052

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Comparison of granule proteins from human polymorphonuclear leukocytes which are bactericidal toward Pseudomonas aeruginosa. PubMed ID: 1937776

Antibiotic proteins of human polymorphonuclear leukocytes. PubMed ID: 2501794

A 25-kDa NH2-terminal fragment carries all the antibacterial activities of the human neutrophil 60-kDa bactericidal/permeability-increasing protein. PubMed ID: 3667613

Expression and characterization of cysteine-modified variants of an amino-terminal fragment of bactericidal/permeability-increasing protein. PubMed ID: 8812832

Crystal structure of human BPI and two bound phospholipids at 2.4-A resolution. PubMed ID: 9188532

The 1.7 A crystal structure of BPI: a study of how two dissimilar amino acid sequences can adopt the same fold. PubMed ID: 10843855