Details for: BPI

Gene ID: 671

Symbol: BPI

Ensembl ID: ENSG00000101425

Description: bactericidal permeability increasing protein

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3173
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.86
    Marker Score: 804
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.56
    Marker Score: 3228
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.14
    Marker Score: 7572
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.14
    Marker Score: 2679
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71829
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48053
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1
    Marker Score: 2534
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.61
    Marker Score: 1157
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.6
    Marker Score: 1506
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.58
    Marker Score: 381
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.56
    Marker Score: 955
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.54
    Marker Score: 140
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.52
    Marker Score: 1048
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.47
    Marker Score: 299.5
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.45
    Marker Score: 187
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.41
    Marker Score: 133
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.38
    Marker Score: 170
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.38
    Marker Score: 187
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.37
    Marker Score: 217
  • Cell Name: immature neutrophil (CL0000776)
    Fold Change: 0.35
    Marker Score: 119
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.31
    Marker Score: 4846
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.31
    Marker Score: 187
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.31
    Marker Score: 161
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.3
    Marker Score: 80
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.29
    Marker Score: 287
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.28
    Marker Score: 178
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.26
    Marker Score: 116
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.25
    Marker Score: 79
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.23
    Marker Score: 101
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.22
    Marker Score: 70
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.21
    Marker Score: 98
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.2
    Marker Score: 103
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.2
    Marker Score: 118
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.18
    Marker Score: 90
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.17
    Marker Score: 78
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.16
    Marker Score: 98
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.16
    Marker Score: 58
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.16
    Marker Score: 113
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.15
    Marker Score: 56
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.15
    Marker Score: 52
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.15
    Marker Score: 144
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.15
    Marker Score: 92
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.14
    Marker Score: 384
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.13
    Marker Score: 211
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.13
    Marker Score: 140
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.13
    Marker Score: 6995
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.11
    Marker Score: 108
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.11
    Marker Score: 62
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.1
    Marker Score: 90
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.1
    Marker Score: 109
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.1
    Marker Score: 115
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.1
    Marker Score: 125
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.1
    Marker Score: 125
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.09
    Marker Score: 50
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.09
    Marker Score: 37
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.09
    Marker Score: 377
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.09
    Marker Score: 22
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.08
    Marker Score: 19
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.08
    Marker Score: 22
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.07
    Marker Score: 51
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.07
    Marker Score: 188
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.07
    Marker Score: 254
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.07
    Marker Score: 83
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.07
    Marker Score: 189
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.07
    Marker Score: 224
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.06
    Marker Score: 46
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.06
    Marker Score: 43
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.06
    Marker Score: 272
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.06
    Marker Score: 45
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.06
    Marker Score: 45
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.06
    Marker Score: 72
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.06
    Marker Score: 62
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.06
    Marker Score: 58
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: eosinophil (CL0000771)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.06
    Marker Score: 17

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Other Information

**Key characteristics:** - The protein is a transmembrane protein with a molecular weight of approximately 120 kDa. - It is a member of the BPI family of proteins, which are characterized by a conserved cysteine-rich domain. - The protein is expressed in high levels in response to infection. - It is involved in the regulation of the inflammatory response to Gram-negative bacteria. **Pathways and functions:** - BPI binds to lipopolysaccharide (LPS), a molecule found on the surface of Gram-negative bacteria. - Binding to LPS triggers a signaling cascade that involves the activation of toll-like receptor 4 (TLR4). - TLR4 is a pattern recognition receptor that is expressed on macrophages, dendritic cells, and other immune cells. - Activation of TLR4 by LPS leads to the production of cytokines and chemokines, which recruit immune cells to the site of infection. - BPI is also involved in the regulation of inflammation and cell death. **Clinical significance:** - Mutations in the BPI gene have been linked to a number of human diseases, including sepsis, meningitis, and tuberculosis. - BPI inhibitors are being investigated as potential treatments for these diseases. - The development of BPI inhibitors could provide new treatment options for patients with infections. **Conclusion:** The BPI gene is a key regulator of innate immune responses. It is expressed in a variety of cell types and is involved in the regulation of the inflammatory response to Gram-negative bacteria. Mutations in the BPI gene have been linked to a number of human diseases, including sepsis, meningitis, and tuberculosis.

Genular Protein ID: 3082875698

Symbol: BPI_HUMAN

Name: Bactericidal permeability-increasing protein

UniProtKB Accession Codes:

P17213 B2RCY2 Q1ZZU8 Q5JRW0 Q8IW58 Q9BYZ9 Q9H1L2 Q9H1M8 Q9H203 Q9UCT4 Q9UD65

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CDD 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 9 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 2 PIR 1 PIRSF 1 PRIDE 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2722846

Title: Cloning of the cDNA of a human neutrophil bactericidal protein. Structural and functional correlations.

PubMed ID: 2722846

DOI: 10.1016/s0021-9258(18)60560-5

PubMed ID: 7517398

Title: Bactericidal/permeability-increasing protein and lipopolysaccharide (LPS)-binding protein. LPS binding properties and effects on LPS-mediated cell activation.

PubMed ID: 7517398

DOI: 10.1016/s0021-9258(17)32454-7

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11780052

Title: The DNA sequence and comparative analysis of human chromosome 20.

PubMed ID: 11780052

DOI: 10.1038/414865a

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1937776

Title: Comparison of granule proteins from human polymorphonuclear leukocytes which are bactericidal toward Pseudomonas aeruginosa.

PubMed ID: 1937776

DOI: 10.1128/iai.59.11.4193-4200.1991

PubMed ID: 2501794

Title: Antibiotic proteins of human polymorphonuclear leukocytes.

PubMed ID: 2501794

DOI: 10.1073/pnas.86.14.5610

PubMed ID: 3667613

Title: A 25-kDa NH2-terminal fragment carries all the antibacterial activities of the human neutrophil 60-kDa bactericidal/permeability-increasing protein.

PubMed ID: 3667613

DOI: 10.1016/s0021-9258(18)48110-0

PubMed ID: 8812832

Title: Expression and characterization of cysteine-modified variants of an amino-terminal fragment of bactericidal/permeability-increasing protein.

PubMed ID: 8812832

DOI: 10.1006/prep.1996.0071

PubMed ID: 9188532

Title: Crystal structure of human BPI and two bound phospholipids at 2.4-A resolution.

PubMed ID: 9188532

DOI: 10.1126/science.276.5320.1861

PubMed ID: 10843855

Title: The 1.7 A crystal structure of BPI: a study of how two dissimilar amino acid sequences can adopt the same fold.

PubMed ID: 10843855

DOI: 10.1006/jmbi.2000.3805

Sequence Information:

  • Length: 487
  • Mass: 53900
  • Checksum: 30BC73B1B465B62D
  • Sequence:
    • MRENMARGPC NAPRWASLMV LVAIGTAVTA AVNPGVVVRI SQKGLDYASQ QGTAALQKEL 
KRIKIPDYSD SFKIKHLGKG HYSFYSMDIR EFQLPSSQIS MVPNVGLKFS ISNANIKISG 
KWKAQKRFLK MSGNFDLSIE GMSISADLKL GSNPTSGKPT ITCSSCSSHI NSVHVHISKS 
KVGWLIQLFH KKIESALRNK MNSQVCEKVT NSVSSELQPY FQTLPVMTKI DSVAGINYGL 
VAPPATTAET LDVQMKGEFY SENHHNPPPF APPVMEFPAA HDRMVYLGLS DYFFNTAGLV 
YQEAGVLKMT LRDDMIPKES KFRLTTKFFG TFLPEVAKKF PNMKIQIHVS ASTPPHLSVQ 
PTGLTFYPAV DVQAFAVLPN SSLASLFLIG MHTTGSMEVS AESNRLVGEL KLDRLLLELK 
HSNIGPFPVE LLQDIMNYIV PILVLPRVNE KLQKGFPLPT PARVQLYNVV LQPHQNFLLF 
GADVVYK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.