Cdt1 | ENSMUSG00000006585 | NCBI 67177

Details for: Cdt1

Gene ID: 67177

Symbol: Cdt1

Ensembl ID: ENSMUSG00000006585

Description: chromatin licensing and DNA replication factor 1

Associated with

Activation of the pre-replicative complex
(R-MMU-68962)
Assembly of the pre-replicative complex
(R-MMU-68867)
Cell cycle, mitotic
(R-MMU-69278)
Dna replication pre-initiation
(R-MMU-69002)
G1/s transition
(R-MMU-69206)
Mitotic g1 phase and g1/s transition
(R-MMU-453279)
Orc1 removal from chromatin
(R-MMU-68949)
S phase
(R-MMU-69242)
Switching of origins to a post-replicative state
(R-MMU-69052)
Synthesis of dna
(R-MMU-69239)
Attachment of mitotic spindle microtubules to kinetochore
(GO:0051315)
Cell cycle
(GO:0007049)
Chromatin binding
(GO:0003682)
Chromosome
(GO:0005694)
Chromosome, centromeric region
(GO:0000775)
Dna binding
(GO:0003677)
Dna polymerase binding
(GO:0070182)
Dna replication
(GO:0006260)
Dna replication checkpoint signaling
(GO:0000076)
Dna replication preinitiation complex assembly
(GO:0071163)
Kinetochore
(GO:0000776)
Mitotic cell cycle
(GO:0000278)
Negative regulation of cell cycle
(GO:0045786)
Negative regulation of dna-templated dna replication
(GO:2000104)
Nuclear body
(GO:0016604)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of chromatin binding
(GO:0035563)
Positive regulation of dna-templated dna replication
(GO:2000105)
Positive regulation of dna replication
(GO:0045740)
Protein binding
(GO:0005515)
Regulation of dna-templated dna replication initiation
(GO:0030174)
Regulation of dna replication origin binding
(GO:1902595)
Regulation of nuclear cell cycle dna replication
(GO:0033262)
Response to sorbitol
(GO:0072708)

Other Information

Proteins

DNA replication factor Cdt1

Genular Protein ID: 3249230019

Symbol: CDT1_MOUSE

Name: DNA replication factor Cdt1

UniProtKB Accession Codes:

Q8R4E9 Q8BUQ1 Q8BX29 Q8R3V0 Q8R4E8

Database IDs:

Citations:

PubMed ID: 11850834

Title: Oncogenic potential of the DNA replication licensing protein CDT1.

PubMed ID: 11850834

DOI: 10.1038/sj.onc.1205175

PubMed ID: 12192004

Title: Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity.

PubMed ID: 12192004

DOI: 10.1074/jbc.m206202200

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14993212

Title: Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding.

PubMed ID: 14993212

DOI: 10.1074/jbc.m313175200

PubMed ID: 15811859

Title: Caenorhabditis elegans geminin homologue participates in cell cycle regulation and germ line development.

PubMed ID: 15811859

DOI: 10.1074/jbc.c500070200

PubMed ID: 15286659

Title: Structural basis for inhibition of the replication licensing factor Cdt1 by geminin.

PubMed ID: 15286659

DOI: 10.1038/nature02813

Sequence Information:

Length: 557
Mass: 61510
Checksum: BFBA4E6DB5ABC1E6
Sequence:

MAQSRVTDFY ACRRPGLTTP RAKSICLTPS PGGLVAPAFT RSSSRKRARP PAEPGSDQPA 
PLARRRLRLP GLDSCPSSLP EPSSPAEPSP PADPSPPADP GSPVCPSPVK RTKSTTVYVG 
QQPGKIPSED SVSELQSCLR RARKLGAQAR ALRARVQENA VEPSTPDAKV PTEQPCVEKA 
PAYQRFHALA QPGLPGLVLP YKYQVLVEMF RSMDTIVSML HNRSETVTFA KVKQGVQEMM 
RKRFEERNVG QIKTVYPTSY RFRQECNVPT FKDSIKRSDY QLTIEPLLGQ EAGGATQLTA 
TCLLQRRQVF RQNLVERVKE QHKVFLASLN PPMAVPDDQL TRWHPRFNVD EVPDIEPAEL 
PQPPVTEKLT TAQEVLARAR SLMTPKMEKA LSNLALRSAE PGSPGTSTPP LPATPPATPP 
AASPSALKGV SQALLERIRA KEVQKQLARM TRCPEQELRL QRLERLPELA RVLRNVFVSE 
RKPALTMEVV CARMVDSCQT ALSPGEMEKH LVLLAELLPD WLSLHRIRTD TYVKLDKAVD 
LAGLTARLAH HVHAEGL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cdt1

Associated with

Other Information

Oncogenic potential of the DNA replication licensing protein CDT1. PubMed ID: 11850834

Mouse geminin inhibits not only Cdt1-MCM6 interactions but also a novel intrinsic Cdt1 DNA binding activity. PubMed ID: 12192004

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding. PubMed ID: 14993212

Caenorhabditis elegans geminin homologue participates in cell cycle regulation and germ line development. PubMed ID: 15811859

Structural basis for inhibition of the replication licensing factor Cdt1 by geminin. PubMed ID: 15286659