Peli1 | ENSMUSG00000020134 | NCBI 67245

Details for: Peli1

Gene ID: 67245

Symbol: Peli1

Ensembl ID: ENSMUSG00000020134

Description: pellino 1

Associated with

Cytokine signaling in immune system
(R-MMU-1280215)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interleukin-1 family signaling
(R-MMU-446652)
Interleukin-1 signaling
(R-MMU-9020702)
Irak1 recruits ikk complex
(R-MMU-937039)
Irak1 recruits ikk complex upon tlr7/8 or 9 stimulation
(R-MMU-975144)
Myd88 cascade initiated on plasma membrane
(R-MMU-975871)
Myd88 dependent cascade initiated on endosome
(R-MMU-975155)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-MMU-166058)
Programmed cell death
(R-MMU-5357801)
Regulated necrosis
(R-MMU-5218859)
Regulation of necroptotic cell death
(R-MMU-5675482)
Ripk1-mediated regulated necrosis
(R-MMU-5213460)
Signaling by interleukins
(R-MMU-449147)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 2 (tlr2) cascade
(R-MMU-181438)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Toll like receptor 5 (tlr5) cascade
(R-MMU-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-MMU-168181)
Toll like receptor 9 (tlr9) cascade
(R-MMU-168138)
Toll like receptor 10 (tlr10) cascade
(R-MMU-168142)
Toll like receptor tlr1:tlr2 cascade
(R-MMU-168179)
Toll like receptor tlr6:tlr2 cascade
(R-MMU-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-MMU-975138)
Negative regulation of necroptotic process
(GO:0060546)
Negative regulation of nf-kappab transcription factor activity
(GO:0032088)
Negative regulation of t cell activation
(GO:0050868)
Negative regulation of t cell proliferation
(GO:0042130)
Nucleus
(GO:0005634)
Positive regulation of b cell activation
(GO:0050871)
Positive regulation of b cell proliferation
(GO:0030890)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of protein ubiquitination
(GO:0031398)
Positive regulation of toll-like receptor 3 signaling pathway
(GO:0034141)
Positive regulation of toll-like receptor 4 signaling pathway
(GO:0034145)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein binding
(GO:0005515)
Protein k48-linked ubiquitination
(GO:0070936)
Protein k63-linked ubiquitination
(GO:0070534)
Protein polyubiquitination
(GO:0000209)
Regulation of toll signaling pathway
(GO:0008592)
Response to dsrna
(GO:0043331)
Response to lipopolysaccharide
(GO:0032496)
T cell activation
(GO:0042110)
T cell proliferation
(GO:0042098)
Transferase activity
(GO:0016740)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin protein ligase activity
(GO:0061630)

Other Information

Proteins

E3 ubiquitin-protein ligase pellino homolog 1

Genular Protein ID: 2307722491

Symbol: PELI1_MOUSE

Name: E3 ubiquitin-protein ligase pellino homolog 1

UniProtKB Accession Codes:

Q8C669 Q91YL9 Q9CV22 Q9ERJ8

Database IDs:

Citations:

PubMed ID: 11306823

Title: Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping.

PubMed ID: 11306823

DOI: 10.1159/000056895

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16951688

Title: Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adapter Pellino-1.

PubMed ID: 16951688

DOI: 10.1038/ni1383

PubMed ID: 29883609

Title: PELI1 selectively targets kinase-active RIP3 for ubiquitylation-dependent proteasomal degradation.

PubMed ID: 29883609

DOI: 10.1016/j.molcel.2018.05.016

Sequence Information:

Length: 418
Mass: 46259
Checksum: 26072654577EBBF7
Sequence:

MFSPDQENHP SKAPVKYGEL IVLGYNGSLP NGDRGRRKSR FALFKRPKAN GVKPSTVHIA 
CTPQAAKAIS NKDQHSISYT LSRAQTVVVE YTHDSNTDMF QIGRSTESPI DFVVTDTVPG 
SQSNSDTQSV QSTISRFACR IICERSPPFT ARIYAAGFDS SKNIFLGEKA AKWKTSDGQM 
DGLTTNGVLV MHPRNGFTED SKPGIWREIS VCGNVFSLRE TRSAQQRGKM VEIETNQLQD 
GSLIDLCGAT LLWRTAEGLS HTPTVKHLEA LRQEINAARP QCPVGFNTLA FPSMKRKDVV 
DEKQPWVYLN CGHVHGYHNW GNKEERDGKD RECPMCRSVG PYVPLWLGCE AGFYVDAGPP 
THAFSPCGHV CSEKTTAYWS QIPLPHGTHT FHAACPFCAH QLAGEQGYIR LIFQGPLD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Peli1

Associated with

Other Information

Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping. PubMed ID: 11306823

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334