BRAF | ENSG00000157764 | NCBI 673

Details for: BRAF

Gene ID: 673

Symbol: BRAF

Ensembl ID: ENSG00000157764

Description: B-Raf proto-oncogene, serine/threonine kinase

Associated with

Arms-mediated activation
(R-HSA-170984)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Frs2-mediated activation
(R-HSA-170968)
Gain-of-function mras complexes activate raf signaling
(R-HSA-9726842)
Map2k and mapk activation
(R-HSA-5674135)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Negative feedback regulation of mapk pathway
(R-HSA-5674499)
Negative regulation of fgfr1 signaling
(R-HSA-5654726)
Negative regulation of fgfr2 signaling
(R-HSA-5654727)
Negative regulation of fgfr3 signaling
(R-HSA-5654732)
Negative regulation of fgfr4 signaling
(R-HSA-5654733)
Negative regulation of mapk pathway
(R-HSA-5675221)
Oncogenic mapk signaling
(R-HSA-6802957)
Paradoxical activation of raf signaling by kinase inactive braf
(R-HSA-6802955)
Prolonged erk activation events
(R-HSA-169893)
Raf/map kinase cascade
(R-HSA-5673001)
Raf activation
(R-HSA-5673000)
Shoc2 m1731 mutant abolishes mras complex function
(R-HSA-9726840)
Signaling by braf and raf1 fusions
(R-HSA-6802952)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by high-kinase activity braf mutants
(R-HSA-6802948)
Signaling by moderate kinase activity braf mutants
(R-HSA-6802946)
Signaling by mras-complex mutants
(R-HSA-9660537)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by raf1 mutants
(R-HSA-9656223)
Signaling by ras mutants
(R-HSA-6802949)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling downstream of ras mutants
(R-HSA-9649948)
Signalling to erks
(R-HSA-187687)
Signalling to p38 via rit and rin
(R-HSA-187706)
Signal transduction
(R-HSA-162582)
Spry regulation of fgf signaling
(R-HSA-1295596)
Animal organ morphogenesis
(GO:0009887)
Atp binding
(GO:0005524)
Calcium ion binding
(GO:0005509)
Cd4-positive, alpha-beta t cell differentiation
(GO:0043367)
Cd4-positive or cd8-positive, alpha-beta t cell lineage commitment
(GO:0043369)
Cellular response to calcium ion
(GO:0071277)
Cellular response to nerve growth factor stimulus
(GO:1990090)
Cellular response to xenobiotic stimulus
(GO:0071466)
Cytosol
(GO:0005829)
Endothelial cell apoptotic process
(GO:0072577)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Erk1 and erk2 cascade
(GO:0070371)
Establishment of protein localization to membrane
(GO:0090150)
Face development
(GO:0060324)
Head morphogenesis
(GO:0060323)
Identical protein binding
(GO:0042802)
Long-term synaptic potentiation
(GO:0060291)
Mapk cascade
(GO:0000165)
Map kinase kinase activity
(GO:0004708)
Map kinase kinase kinase activity
(GO:0004709)
Mitochondrion
(GO:0005739)
Mitogen-activated protein kinase kinase binding
(GO:0031434)
Myeloid progenitor cell differentiation
(GO:0002318)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of endothelial cell apoptotic process
(GO:2000352)
Negative regulation of fibroblast migration
(GO:0010764)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of synaptic vesicle exocytosis
(GO:2000301)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of axonogenesis
(GO:0050772)
Positive regulation of axon regeneration
(GO:0048680)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of glucose transmembrane transport
(GO:0010828)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of stress fiber assembly
(GO:0051496)
Positive regulation of substrate adhesion-dependent cell spreading
(GO:1900026)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of cell population proliferation
(GO:0042127)
Regulation of t cell differentiation
(GO:0045580)
Response to camp
(GO:0051591)
Response to peptide hormone
(GO:0043434)
Scaffold protein binding
(GO:0097110)
Small gtpase binding
(GO:0031267)
Somatic stem cell population maintenance
(GO:0035019)
Stress fiber assembly
(GO:0043149)
Substrate adhesion-dependent cell spreading
(GO:0034446)
Synaptic vesicle exocytosis
(GO:0016079)
T cell differentiation in thymus
(GO:0033077)
T cell receptor signaling pathway
(GO:0050852)
Thymus development
(GO:0048538)
Thyroid gland development
(GO:0030878)
Trehalose metabolism in response to stress
(GO:0070413)
Visual learning
(GO:0008542)

Other Information

Proteins

Proto-oncogene B-Raf

Genular Protein ID: 1605451111

Symbol: BRAF_HUMAN

Name: Proto-oncogene B-Raf

UniProtKB Accession Codes:

P15056 A4D1T4 B6HY61 B6HY62 B6HY63 B6HY64 B6HY65 B6HY66 Q13878 Q3MIN6 Q9UDP8 Q9Y6T3

Database IDs:

Citations:

PubMed ID: 1508179

Title: 95-kilodalton B-Raf serine/threonine kinase: identification of the protein and its major autophosphorylation site.

PubMed ID: 1508179

DOI: 10.1128/mcb.12.9.3733-3742.1992

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1630826

Title: Chromosomal assignment of two human B-raf(Rmil) proto-oncogene loci: B-raf-1 encoding the p94Braf/Rmil and B-raf-2, a processed pseudogene.

PubMed ID: 1630826

PubMed ID: 2284096

Title: Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies.

PubMed ID: 2284096

PubMed ID: 18974108

Title: Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas.

PubMed ID: 18974108

DOI: 10.1158/0008-5472.can-08-2097

PubMed ID: 3043188

Title: B-raf, a new member of the raf family, is activated by DNA rearrangement.

PubMed ID: 3043188

DOI: 10.1128/mcb.8.6.2651-2654.1988

PubMed ID: 11410590

Title: Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf.

PubMed ID: 11410590

DOI: 10.1074/jbc.m102808200

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19710016

Title: Diacylglycerol kinase eta augments C-Raf activity and B-Raf/C-Raf heterodimerization.

PubMed ID: 19710016

DOI: 10.1074/jbc.m109.043604

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21102438

Title: AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade.

PubMed ID: 21102438

DOI: 10.1038/ncb2130

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21441910

Title: A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK.

PubMed ID: 21441910

DOI: 10.1038/nature09860

PubMed ID: 21917714

Title: Protein arginine methyltransferase 5 regulates ERK1/2 signal transduction amplitude and cell fate through CRAF.

PubMed ID: 21917714

DOI: 10.1126/scisignal.2001936

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22628551

Title: Ring finger protein 149 is an E3 ubiquitin ligase active on wild-type v-Raf murine sarcoma viral oncogene homolog B1 (BRAF).

PubMed ID: 22628551

DOI: 10.1074/jbc.m111.319822

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23907581

Title: Lys63-linked polyubiquitination of BRAF at lysine 578 is required for BRAF-mediated signaling.

PubMed ID: 23907581

DOI: 10.1038/srep02344

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27353360

Title: The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding.

PubMed ID: 27353360

DOI: 10.1038/ncomms12037

PubMed ID: 31024343

Title: A YWHAZ variant associated with cardiofaciocutaneous syndrome activates the RAF-ERK pathway.

PubMed ID: 31024343

DOI: 10.3389/fphys.2019.00388

PubMed ID: 36402789

Title: BRAF activation by metabolic stress promotes glycolysis sensitizing NRASQ61-mutated melanomas to targeted therapy.

PubMed ID: 36402789

DOI: 10.1038/s41467-022-34907-0

PubMed ID: 18287029

Title: Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity.

PubMed ID: 18287029

DOI: 10.1073/pnas.0711741105

PubMed ID: 29433126

Title: MEK drives BRAF activation through allosteric control of KSR proteins.

PubMed ID: 29433126

DOI: 10.1038/nature25478

PubMed ID: 12460919

Title: Missense mutations of the BRAF gene in human lung adenocarcinoma.

PubMed ID: 12460919

PubMed ID: 12068308

Title: Mutations of the BRAF gene in human cancer.

PubMed ID: 12068308

DOI: 10.1038/nature00766

PubMed ID: 12198537

Title: Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status.

PubMed ID: 12198537

DOI: 10.1038/418934a

PubMed ID: 14612909

Title: BRAF mutations in non-Hodgkin's lymphoma.

PubMed ID: 14612909

DOI: 10.1038/sj.bjc.6601371

PubMed ID: 14500344

Title: Suppression of BRAF(V599E) in human melanoma abrogates transformation.

PubMed ID: 14500344

PubMed ID: 16474404

Title: Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome.

PubMed ID: 16474404

DOI: 10.1038/ng1749

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 16439621

Title: Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome.

PubMed ID: 16439621

DOI: 10.1126/science.1124642

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

PubMed ID: 18042262

Title: Mutation and phenotypic spectrum in patients with cardio-facio-cutaneous and Costello syndrome.

PubMed ID: 18042262

DOI: 10.1111/j.1399-0004.2007.00931.x

PubMed ID: 19206169

Title: Germline BRAF mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: molecular diversity and associated phenotypic spectrum.

PubMed ID: 19206169

DOI: 10.1002/humu.20955

PubMed ID: 23263490

Title: Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas.

PubMed ID: 23263490

DOI: 10.1038/ng.2503

PubMed ID: 24455489

Title: Evidence that GRIN2A mutations in melanoma correlate with decreased survival.

PubMed ID: 24455489

DOI: 10.3389/fonc.2013.00333

Sequence Information:

Length: 766
Mass: 84437
Checksum: 0798C2AAB487E813
Sequence:

MAALSGGGGG GAEPGQALFN GDMEPEAGAG AGAAASSAAD PAIPEEVWNI KQMIKLTQEH 
IEALLDKFGG EHNPPSIYLE AYEEYTSKLD ALQQREQQLL ESLGNGTDFS VSSSASMDTV 
TSSSSSSLSV LPSSLSVFQN PTDVARSNPK SPQKPIVRVF LPNKQRTVVP ARCGVTVRDS 
LKKALMMRGL IPECCAVYRI QDGEKKPIGW DTDISWLTGE ELHVEVLENV PLTTHNFVRK 
TFFTLAFCDF CRKLLFQGFR CQTCGYKFHQ RCSTEVPLMC VNYDQLDLLF VSKFFEHHPI 
PQEEASLAET ALTSGSSPSA PASDSIGPQI LTSPSPSKSI PIPQPFRPAD EDHRNQFGQR 
DRSSSAPNVH INTIEPVNID DLIRDQGFRG DGGSTTGLSA TPPASLPGSL TNVKALQKSP 
GPQRERKSSS SSEDRNRMKT LGRRDSSDDW EIPDGQITVG QRIGSGSFGT VYKGKWHGDV 
AVKMLNVTAP TPQQLQAFKN EVGVLRKTRH VNILLFMGYS TKPQLAIVTQ WCEGSSLYHH 
LHIIETKFEM IKLIDIARQT AQGMDYLHAK SIIHRDLKSN NIFLHEDLTV KIGDFGLATV 
KSRWSGSHQF EQLSGSILWM APEVIRMQDK NPYSFQSDVY AFGIVLYELM TGQLPYSNIN 
NRDQIIFMVG RGYLSPDLSK VRSNCPKAMK RLMAECLKKK RDERPLFPQI LASIELLARS 
LPKIHRSASE PSLNRAGFQT EDFSLYACAS PKTPIQAGGY GAFPVH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: BRAF

Associated with

Other Information

95-kilodalton B-Raf serine/threonine kinase: identification of the protein and its major autophosphorylation site. PubMed ID: 1508179

Human chromosome 7: DNA sequence and biology. PubMed ID: 12690205

The DNA sequence of human chromosome 7. PubMed ID: 12853948

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Chromosomal assignment of two human B-raf(Rmil) proto-oncogene loci: B-raf-1 encoding the p94Braf/Rmil and B-raf-2, a processed pseudogene. PubMed ID: 1630826

Complete coding sequence of a human B-raf cDNA and detection of B-raf protein kinase with isozyme specific antibodies. PubMed ID: 2284096

Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas. PubMed ID: 18974108

B-raf, a new member of the raf family, is activated by DNA rearrangement. PubMed ID: 3043188

Serum- and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf. PubMed ID: 11410590

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Diacylglycerol kinase eta augments C-Raf activity and B-Raf/C-Raf heterodimerization. PubMed ID: 19710016

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade. PubMed ID: 21102438

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK. PubMed ID: 21441910

Protein arginine methyltransferase 5 regulates ERK1/2 signal transduction amplitude and cell fate through CRAF. PubMed ID: 21917714

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Ring finger protein 149 is an E3 ubiquitin ligase active on wild-type v-Raf murine sarcoma viral oncogene homolog B1 (BRAF). PubMed ID: 22628551

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Lys63-linked polyubiquitination of BRAF at lysine 578 is required for BRAF-mediated signaling. PubMed ID: 23907581

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. PubMed ID: 27353360

A YWHAZ variant associated with cardiofaciocutaneous syndrome activates the RAF-ERK pathway. PubMed ID: 31024343

BRAF activation by metabolic stress promotes glycolysis sensitizing NRASQ61-mutated melanomas to targeted therapy. PubMed ID: 36402789

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. PubMed ID: 18287029

MEK drives BRAF activation through allosteric control of KSR proteins. PubMed ID: 29433126

Missense mutations of the BRAF gene in human lung adenocarcinoma. PubMed ID: 12460919

Mutations of the BRAF gene in human cancer. PubMed ID: 12068308

Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. PubMed ID: 12198537

BRAF mutations in non-Hodgkin's lymphoma. PubMed ID: 14612909

Suppression of BRAF(V599E) in human melanoma abrogates transformation. PubMed ID: 14500344

Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome. PubMed ID: 16474404

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974

Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome. PubMed ID: 16439621

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846

Mutation and phenotypic spectrum in patients with cardio-facio-cutaneous and Costello syndrome. PubMed ID: 18042262

Germline BRAF mutations in Noonan, LEOPARD, and cardiofaciocutaneous syndromes: molecular diversity and associated phenotypic spectrum. PubMed ID: 19206169

Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas. PubMed ID: 23263490

Evidence that GRIN2A mutations in melanoma correlate with decreased survival. PubMed ID: 24455489