BRAF | ENSG00000157764 | NCBI 673

Details for: BRAF

Gene ID: 673

Symbol: BRAF

Ensembl ID: ENSG00000157764

Description: B-Raf proto-oncogene, serine/threonine kinase

Associated with

Arms-mediated activation
(R-HSA-170984)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Frs2-mediated activation
(R-HSA-170968)
Gain-of-function mras complexes activate raf signaling
(R-HSA-9726842)
Map2k and mapk activation
(R-HSA-5674135)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Negative feedback regulation of mapk pathway
(R-HSA-5674499)
Negative regulation of fgfr1 signaling
(R-HSA-5654726)
Negative regulation of fgfr2 signaling
(R-HSA-5654727)
Negative regulation of fgfr3 signaling
(R-HSA-5654732)
Negative regulation of fgfr4 signaling
(R-HSA-5654733)
Negative regulation of mapk pathway
(R-HSA-5675221)
Oncogenic mapk signaling
(R-HSA-6802957)
Paradoxical activation of raf signaling by kinase inactive braf
(R-HSA-6802955)
Prolonged erk activation events
(R-HSA-169893)
Raf/map kinase cascade
(R-HSA-5673001)
Raf activation
(R-HSA-5673000)
Shoc2 m1731 mutant abolishes mras complex function
(R-HSA-9726840)
Signaling by braf and raf1 fusions
(R-HSA-6802952)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by high-kinase activity braf mutants
(R-HSA-6802948)
Signaling by moderate kinase activity braf mutants
(R-HSA-6802946)
Signaling by mras-complex mutants
(R-HSA-9660537)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by raf1 mutants
(R-HSA-9656223)
Signaling by ras mutants
(R-HSA-6802949)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling downstream of ras mutants
(R-HSA-9649948)
Signalling to erks
(R-HSA-187687)
Signalling to p38 via rit and rin
(R-HSA-187706)
Signal transduction
(R-HSA-162582)
Spry regulation of fgf signaling
(R-HSA-1295596)
Animal organ morphogenesis
(GO:0009887)
Atp binding
(GO:0005524)
Calcium ion binding
(GO:0005509)
Cd4-positive, alpha-beta t cell differentiation
(GO:0043367)
Cd4-positive or cd8-positive, alpha-beta t cell lineage commitment
(GO:0043369)
Cellular response to calcium ion
(GO:0071277)
Cellular response to nerve growth factor stimulus
(GO:1990090)
Cellular response to xenobiotic stimulus
(GO:0071466)
Cytosol
(GO:0005829)
Endothelial cell apoptotic process
(GO:0072577)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Erk1 and erk2 cascade
(GO:0070371)
Establishment of protein localization to membrane
(GO:0090150)
Face development
(GO:0060324)
Head morphogenesis
(GO:0060323)
Identical protein binding
(GO:0042802)
Long-term synaptic potentiation
(GO:0060291)
Mapk cascade
(GO:0000165)
Map kinase kinase activity
(GO:0004708)
Map kinase kinase kinase activity
(GO:0004709)
Mitochondrion
(GO:0005739)
Mitogen-activated protein kinase kinase binding
(GO:0031434)
Myeloid progenitor cell differentiation
(GO:0002318)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of endothelial cell apoptotic process
(GO:2000352)
Negative regulation of fibroblast migration
(GO:0010764)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of synaptic vesicle exocytosis
(GO:2000301)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of axonogenesis
(GO:0050772)
Positive regulation of axon regeneration
(GO:0048680)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of glucose transmembrane transport
(GO:0010828)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of stress fiber assembly
(GO:0051496)
Positive regulation of substrate adhesion-dependent cell spreading
(GO:1900026)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of cell population proliferation
(GO:0042127)
Regulation of t cell differentiation
(GO:0045580)
Response to camp
(GO:0051591)
Response to peptide hormone
(GO:0043434)
Scaffold protein binding
(GO:0097110)
Small gtpase binding
(GO:0031267)
Somatic stem cell population maintenance
(GO:0035019)
Stress fiber assembly
(GO:0043149)
Substrate adhesion-dependent cell spreading
(GO:0034446)
Synaptic vesicle exocytosis
(GO:0016079)
T cell differentiation in thymus
(GO:0033077)
T cell receptor signaling pathway
(GO:0050852)
Thymus development
(GO:0048538)
Thyroid gland development
(GO:0030878)
Trehalose metabolism in response to stress
(GO:0070413)
Visual learning
(GO:0008542)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hepatoblast (CL0005026)
Fold Change: 3.82