Details for: C1qtnf12

Gene ID: 67389

Symbol: C1qtnf12

Ensembl ID: ENSMUSG00000023571

Description: C1q and tumor necrosis factor related 12

Associated with

  • Establishment of localization in cell
    (GO:0051649)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Gluconeogenesis
    (GO:0006094)
  • Glucose import
    (GO:0046323)
  • Hormone activity
    (GO:0005179)
  • Negative regulation of gluconeogenesis
    (GO:0045721)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0043491)
  • Positive regulation of glucose import
    (GO:0046326)
  • Positive regulation of insulin receptor signaling pathway
    (GO:0046628)
  • Positive regulation of insulin secretion involved in cellular response to glucose stimulus
    (GO:0035774)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Regulation of glucose import
    (GO:0046324)
  • Regulation of glucose metabolic process
    (GO:0010906)

Other Information

Genular Protein ID: 3195135405

Symbol: ADIPL_MOUSE

Name: Complement C1q tumor necrosis factor-related protein 12

UniProtKB Accession Codes:

Q8R2Z0 Q9CQI8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CPTAC 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 5 Ensembl 1 GO 15 Gene3D 2 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 InterPro 2 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 21849507

Title: Adipolin/C1qdc2/CTRP12 protein functions as an adipokine that improves glucose metabolism.

PubMed ID: 21849507

DOI: 10.1074/jbc.m111.277319

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22275362

Title: C1q/TNF-related protein-12 (CTRP12), a novel adipokine that improves insulin sensitivity and glycemic control in mouse models of obesity and diabetes.

PubMed ID: 22275362

DOI: 10.1074/jbc.m111.303651

PubMed ID: 23068097

Title: Regulation of adipolin/CTRP12 cleavage by obesity.

PubMed ID: 23068097

DOI: 10.1016/j.bbrc.2012.10.031

PubMed ID: 22351773

Title: Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis.

PubMed ID: 22351773

DOI: 10.1074/jbc.m111.336834

PubMed ID: 22942287

Title: Endopeptidase cleavage generates a functionally distinct isoform of C1q/tumor necrosis factor-related protein-12 (CTRP12) with an altered oligomeric state and signaling specificity.

PubMed ID: 22942287

DOI: 10.1074/jbc.m112.365965

PubMed ID: 23633521

Title: Loss of Kruppel-like factor 3 (KLF3/BKLF) leads to upregulation of the insulin-sensitizing factor adipolin (FAM132A/CTRP12/C1qdc2).

PubMed ID: 23633521

DOI: 10.2337/db12-1745

PubMed ID: 24358263

Title: Transcriptional regulation of an insulin-sensitizing adipokine adipolin/CTRP12 in adipocytes by Krueppel-like factor 15.

PubMed ID: 24358263

DOI: 10.1371/journal.pone.0083183

Sequence Information:

  • Length: 308
  • Mass: 33267
  • Checksum: 888681DBDCDD5835
  • Sequence:
    • MWAWGWAAAA LLWLQTAGAG ARQELKKSRQ LFARVDSPNI TTSNREGFPG SVKPPEASGP 
ELSDAHMTWL NFVRRPDDGS SRKRCRGRDK KSRGLSGLPG PPGPPGPPGP PGSPGVGVTP 
EALLQEFQEI LKEATELRFS GLPDTLLPQE PSQRLVVEAF YCRLKGPVLV DKKTLVELQG 
FQAPTTQGAF LRGSGLSLSL GRFTAPVSAI FQFSASLHVD HSELQGRGRL RTRDMVRVLI 
CIESLCHRHT SLEAVSGLES NSRVFTVQVQ GLLHLQSGQY VSVFVDNSSG AVLTIQNTSS 
FSGMLLGT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.