Mfn1 | ENSMUSG00000027668 | NCBI 67414

Details for: Mfn1

Gene ID: 67414

Symbol: Mfn1

Ensembl ID: ENSMUSG00000027668

Description: mitofusin 1

Associated with

Autophagy
(R-MMU-9612973)
Factors involved in megakaryocyte development and platelet production
(R-MMU-983231)
Hemostasis
(R-MMU-109582)
Macroautophagy
(R-MMU-1632852)
Miro gtpase cycle
(R-MMU-9715370)
Mitophagy
(R-MMU-5205647)
Pink1-prkn mediated mitophagy
(R-MMU-5205685)
Rhot2 gtpase cycle
(R-MMU-9013419)
Selective autophagy
(R-MMU-9663891)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Gtp metabolic process
(GO:0046039)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Intracellular distribution of mitochondria
(GO:0048312)
Membrane
(GO:0016020)
Mitochondrial fusion
(GO:0008053)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrion
(GO:0005739)
Mitochondrion localization
(GO:0051646)
Multicellular organism development
(GO:0007275)
Negative regulation of mitochondrial fission
(GO:0090258)
Nucleotide binding
(GO:0000166)
Outer mitochondrial membrane protein complex
(GO:0098799)
Positive regulation of dendritic spine morphogenesis
(GO:0061003)
Positive regulation of mitochondrial fusion
(GO:0010636)
Positive regulation of mitochondrial membrane potential
(GO:0010918)
Protein binding
(GO:0005515)

Other Information

Proteins

Mitofusin-1

Genular Protein ID: 2975295170

Symbol: MFN1_MOUSE

Name: Mitofusin-1

UniProtKB Accession Codes:

Q811U4 Q3URC4 Q811D5 Q8CEY6 Q99M10 Q9D395

Database IDs:

Citations:

PubMed ID: 12527753

Title: Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development.

PubMed ID: 12527753

DOI: 10.1083/jcb.200211046

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11950885

Title: Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo.

PubMed ID: 11950885

DOI: 10.1242/jcs.115.8.1663

PubMed ID: 12759376

Title: Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells.

PubMed ID: 12759376

DOI: 10.1242/jcs.00479

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23921378

Title: MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission.

PubMed ID: 23921378

DOI: 10.1074/jbc.m113.479873

PubMed ID: 23620051

Title: PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria.

PubMed ID: 23620051

DOI: 10.1126/science.1231031

PubMed ID: 24513856

Title: A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30.

PubMed ID: 24513856

DOI: 10.1038/cr.2014.20

PubMed ID: 15297672

Title: Structural basis of mitochondrial tethering by mitofusin complexes.

PubMed ID: 15297672

DOI: 10.1126/science.1099793

Sequence Information:

Length: 741
Mass: 83726
Checksum: 36E5E90DB0C0D5A1
Sequence:

MAETVSPLKH FVLAKKAITA IFGQLLEFVT EGSHFVEATY RNPELDRIAS EDDLVEIQGY 
RNKLAVIGEV LSRRHMKVAF FGRTSSGKSS VINAMLWDKV LPSGIGHTTN CFLSVEGTDG 
DKAYLMTEGS DEKKSVKTVN QLAHALHMDK DLKAGCLVHV FWPKAKCALL RDDLVLVDSP 
GTDVTTELDI WIDKFCLDAD VFVLVANSES TLMNTEKHFF HKVNERLSKP NIFILNNRWD 
ASASEPEYME DVRRQHMERC LHFLVEELKV VSPSEARNRI FFVSAKEVLN SRKHKAQGMP 
EGGGALAEGF QARLQEFQNF EQTFEECISQ SAVKTKFEQH TIRAKQILDT VKNILDSVNV 
AAAEKRVYSM EEREDQIDRL DFIRNQMNLL TLDVKKKIKE VTEEVANKVS CAMTDEICRL 
SVLVDEFCSE FHPTPSVLKV YKSELNKHIE DGMGRNLADR CTNEVNASIL QSQQEIIENL 
KPLLPAGIQN KLHTLIPCKK FDLSYDLNCH KLCSDFQEDI VFRFSLGWSS LVHRFLGSTN 
AQRVLLGLSE PIFQVPRSLA STPTAPSNPA APDNAAQEEL MITLITGLAS LTSRTSMGII 
VVGGVIWKTV GWKLISVTLS MYGALYLYER LTWTTRAKER AFKQQFVNYA TEKLQMIVSF 
TSANCSHQVQ QEMATTFARL CQQVDVTQKH LEEEIARLSK EIDQLEKIQN NSKLLRNKAV 
QLESELENFS KQFLHPSSGE S

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Mfn1

Associated with

Other Information

Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. PubMed ID: 12527753

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Membrane topology and mitochondrial targeting of mitofusins, ubiquitous mammalian homologs of the transmembrane GTPase Fzo. PubMed ID: 11950885

Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells. PubMed ID: 12759376

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission. PubMed ID: 23921378

PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria. PubMed ID: 23620051

A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30. PubMed ID: 24513856

Structural basis of mitochondrial tethering by mitofusin complexes. PubMed ID: 15297672