Pnpla8 | ENSMUSG00000036257 | NCBI 67452

Details for: Pnpla8

Gene ID: 67452

Symbol: Pnpla8

Ensembl ID: ENSMUSG00000036257

Description: patatin-like phospholipase domain containing 8

Associated with

Acyl chain remodelling of pc
(R-MMU-1482788)
Acyl chain remodelling of pe
(R-MMU-1482839)
Glycerophospholipid biosynthesis
(R-MMU-1483206)
Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Phospholipid metabolism
(R-MMU-1483257)
Arachidonic acid metabolic process
(GO:0019369)
Arachidonic acid secretion
(GO:0050482)
Calcium-independent phospholipase a2 activity
(GO:0047499)
Cardiolipin metabolic process
(GO:0032048)
Endoplasmic reticulum
(GO:0005783)
Fatty acid metabolic process
(GO:0006631)
Hydrolase activity
(GO:0016787)
Intracellular signal transduction
(GO:0035556)
Linoleic acid metabolic process
(GO:0043651)
Lipid catabolic process
(GO:0016042)
Lipid homeostasis
(GO:0055088)
Lipid metabolic process
(GO:0006629)
Lysophospholipase activity
(GO:0004622)
Membrane
(GO:0016020)
Mitochondrion
(GO:0005739)
Peroxisomal membrane
(GO:0005778)
Peroxisome
(GO:0005777)
Phosphatidylcholine catabolic process
(GO:0034638)
Phosphatidylethanolamine catabolic process
(GO:0046338)
Phosphatidyl phospholipase b activity
(GO:0102545)
Phospholipase activity
(GO:0004620)
Prostaglandin biosynthetic process
(GO:0001516)
Regulation of cellular response to oxidative stress
(GO:1900407)
Triglyceride homeostasis
(GO:0070328)

Other Information

Proteins

Intracellular membrane-associated calcium-independent phospholipase A2 gamma

Genular Protein ID: 2653868401

Symbol: PLPL8_MOUSE

Name: Intracellular membrane-associated calcium-independent phospholipase A2 gamma

UniProtKB Accession Codes:

Q8K1N1 Q3TH33 Q8VEC0 Q9DC20

Database IDs:

Citations:

PubMed ID: 10833412

Title: A novel intracellular membrane-bound calcium-independent phospholipase A(2).

PubMed ID: 10833412

DOI: 10.1006/bbrc.2000.2776

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17213206

Title: Dramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing human calcium-independent phospholipase A2gamma.

PubMed ID: 17213206

DOI: 10.1074/jbc.m607307200

PubMed ID: 17923475

Title: Genetic ablation of calcium-independent phospholipase A2gamma leads to alterations in mitochondrial lipid metabolism and function resulting in a deficient mitochondrial bioenergetic phenotype.

PubMed ID: 17923475

DOI: 10.1074/jbc.m707795200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 28442572

Title: The phospholipase iPLA2gamma is a major mediator releasing oxidized aliphatic chains from cardiolipin, integrating mitochondrial bioenergetics and signaling.

PubMed ID: 28442572

DOI: 10.1074/jbc.m117.783068

Sequence Information:

Length: 776
Mass: 87381
Checksum: 1140CC8358B1E119
Sequence:

MSINLTLDIY IYFLNNARSL CGKQRSKQLH FVCSKQYWRM NHVNVHREFH TSKKSCKWNR 
SEAHCSKHWH SPSNHGLHFG IVRLSTSAPK GLTKVSIHMS RIKSTLNSVS KAIFGSQNEM 
VTRLAQFKPS SRILRKVSDK GWLKQKNVKQ AVESLKNYSD KSAGKNSLAE QKSYFADKEE 
DSGKHSLFHY TYGITTRFGE SFSVLANHIN SYFKSKGKMS QTKEDKQLQD KPDLEERKSS 
SPGPDTVADR PDSESPLEVK DKLSSPTQMP EAHPVSAKQS IANFLSRPTE GVQALVGGYI 
GGLVPKLKSD PKSPPEEQEV SAKTEQAVNK DKKAEEKKRV LLQQEKIIAR VSIDNRTRAL 
VQALRRTADP KLCITRVEEL TFHLLEFPEG KGVAIKEKII PYLLRLRQVK DETLQAAVRE 
ILALIGYVDP VKGRGIRILT IDGGGTRGVV ALQTLRKLVE LTQKPIHQLF DYICGVSTGA 
ILAFMLGLFH MPLDECEELY RKLGSDVFTQ NVIVGTVKMS WSHAFYDSNT WEKILKDRIG 
SALMIETARN PACPKVAAIS TIVNRGQTPK AFVFRNYGHF PGTNSHYLGG CQYKMWQAIR 
ASSAAPGYFA EYALGSDLHQ DGGLLLNNPS ALALHECKCI WPDTPLECIV SLGTGRYESD 
VRNTSTYTSL KTKLSNVISS ATDTEEVHIM LDGLLPSDTY FRFNPVICEN IPLDESRDEK 
LDQLQLEGMK YIERNDQKMK KVAKILSQEK TTLQKINDWI KLKSDMYEGL PFFSKL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pnpla8

Associated with

Other Information

A novel intracellular membrane-bound calcium-independent phospholipase A(2). PubMed ID: 10833412

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Dramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing human calcium-independent phospholipase A2gamma. PubMed ID: 17213206

Genetic ablation of calcium-independent phospholipase A2gamma leads to alterations in mitochondrial lipid metabolism and function resulting in a deficient mitochondrial bioenergetic phenotype. PubMed ID: 17923475

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

The phospholipase iPLA2gamma is a major mediator releasing oxidized aliphatic chains from cardiolipin, integrating mitochondrial bioenergetics and signaling. PubMed ID: 28442572