Details for: Abcg8

Gene ID: 67470

Symbol: Abcg8

Ensembl ID: ENSMUSG00000024254

Description: ATP binding cassette subfamily G member 8

Associated with

Other Information

Genular Protein ID: 1428657413

Symbol: ABCG8_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11452359

Title: Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively.

PubMed ID: 11452359

DOI: 10.1086/321294

PubMed ID: 11907139

Title: Molecular cloning, genomic organization, genetic variations, and characterization of murine sterolin genes Abcg5 and Abcg8.

PubMed ID: 11907139

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 11099417

Title: Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters.

PubMed ID: 11099417

DOI: 10.1126/science.290.5497.1771

PubMed ID: 12208867

Title: Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface.

PubMed ID: 12208867

DOI: 10.1172/jci16000

PubMed ID: 12444248

Title: Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion.

PubMed ID: 12444248

DOI: 10.1073/pnas.252582399

PubMed ID: 14504269

Title: ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion.

PubMed ID: 14504269

DOI: 10.1074/jbc.m310223200

PubMed ID: 12777468

Title: Endotoxin down-regulates ABCG5 and ABCG8 in mouse liver and ABCA1 and ABCG1 in J774 murine macrophages: differential role of LXR.

PubMed ID: 12777468

DOI: 10.1194/jlr.m300100-jlr200

PubMed ID: 15040800

Title: A mouse model of sitosterolemia: absence of Abcg8/sterolin-2 results in failure to secrete biliary cholesterol.

PubMed ID: 15040800

DOI: 10.1186/1741-7015-2-5

PubMed ID: 15054092

Title: Missense mutations in ABCG5 and ABCG8 disrupt heterodimerization and trafficking.

PubMed ID: 15054092

DOI: 10.1074/jbc.m402634200

PubMed ID: 14657202

Title: Selective sterol accumulation in ABCG5/ABCG8-deficient mice.

PubMed ID: 14657202

DOI: 10.1194/jlr.m300377-jlr200

PubMed ID: 16352607

Title: Functional asymmetry of nucleotide-binding domains in ABCG5 and ABCG8.

PubMed ID: 16352607

DOI: 10.1074/jbc.m512277200

PubMed ID: 16867993

Title: Sterol transfer by ABCG5 and ABCG8: in vitro assay and reconstitution.

PubMed ID: 16867993

DOI: 10.1074/jbc.m605603200

PubMed ID: 18402465

Title: Purification and reconstitution of sterol transfer by native mouse ABCG5 and ABCG8.

PubMed ID: 18402465

DOI: 10.1021/bi800292v

PubMed ID: 25378657

Title: Relative roles of ABCG5/ABCG8 in liver and intestine.

PubMed ID: 25378657

DOI: 10.1194/jlr.m054544

Sequence Information:

  • Length: 673
  • Mass: 75996
  • Checksum: 78012611A5DF2589
  • Sequence:
  • MAEKTKEETQ LWNGTVLQDA SQGLQDSLFS SESDNSLYFT YSGQSNTLEV RDLTYQVDIA 
    SQVPWFEQLA QFKIPWRSHS SQDSCELGIR NLSFKVRSGQ MLAIIGSSGC GRASLLDVIT 
    GRGHGGKMKS GQIWINGQPS TPQLVRKCVA HVRQHDQLLP NLTVRETLAF IAQMRLPRTF 
    SQAQRDKRVE DVIAELRLRQ CANTRVGNTY VRGVSGGERR RVSIGVQLLW NPGILILDEP 
    TSGLDSFTAH NLVTTLSRLA KGNRLVLISL HQPRSDIFRL FDLVLLMTSG TPIYLGAAQQ 
    MVQYFTSIGH PCPRYSNPAD FYVDLTSIDR RSKEREVATV EKAQSLAALF LEKVQGFDDF 
    LWKAEAKELN TSTHTVSLTL TQDTDCGTAV ELPGMIEQFS TLIRRQISND FRDLPTLLIH 
    GSEACLMSLI IGFLYYGHGA KQLSFMDTAA LLFMIGALIP FNVILDVVSK CHSERSMLYY 
    ELEDGLYTAG PYFFAKILGE LPEHCAYVII YAMPIYWLTN LRPVPELFLL HFLLVWLVVF 
    CCRTMALAAS AMLPTFHMSS FFCNALYNSF YLTAGFMINL DNLWIVPAWI SKLSFLRWCF 
    SGLMQIQFNG HLYTTQIGNF TFSILGDTMI SAMDLNSHPL YAIYLIVIGI SYGFLFLYYL 
    SLKLIKQKSI QDW

Genular Protein ID: 1283239159

Symbol: E9Q0P2_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 546
  • Mass: 61990
  • Checksum: 47D2725D9DFAC363
  • Sequence:
  • MKSGQIWING QPSTPQLVRK CVAHVRQHDQ LLPNLTVRET LAFIAQMRLP RTFSQAQRDK 
    RVEDVIAELR LRQCANTRVG NTYVRGVSGG ERRRVSIGVQ LLWNPGILIL DEPTSGLDSF 
    TAHNLVTTLS RLAKGNRLVL ISLHQPRSDI FRLFDLVLLM TSGTPIYLGA AQQMVQYFTS 
    IGHPCPRYSN PADFYVDLTS IDRRSKEREV ATVEKAQSLA ALFLEKVQGF DDFLWKAEAK 
    ELNTSTHTVS LTLTQDTDCG TAVELPGMIE QFSTLIRRQI SNDFRDLPTL LIHGSEACLM 
    SLIIGFLYYG HGAKQLSFMD TAALLFMIGA LIPFNVILDV VSKCHSERSM LYYELEDGLY 
    TAGPYFFAKI LGELPEHCAY VIIYAMPIYW LTNLRPVPEL FLLHFLLVWL VVFCCRTMAL 
    AASAMLPTFH MSSFFCNALY NSFYLTAGFM INLDNLWIVP AWISKLSFLR WCFSGLMQIQ 
    FNGHLYTTQI GNFTFSILGD TMISAMDLNS HPLYAIYLIV IGISYGFLFL YYLSLKLIKQ 
    KSIQDW

Genular Protein ID: 1177614203

Symbol: Q7TSR6_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

  • Length: 672
  • Mass: 75868
  • Checksum: CAB720502EA8FE21
  • Sequence:
  • MAEKTKEETQ LWNGTVLQDA SGLQDSLFSS ESDNSLYFTY SGQSNTLEVR DLTYQVDIAS 
    QVPWFEQLAQ FKIPWRSHSS QDSCELGIRN LSFKVRSGQM LAIIGSSGCG RASLLDVITG 
    RGHGGKMKSG QIWINGQPST PQLVRKCVAH VRQHDQLLPN LTVRETLAFI AQMRLPRTFS 
    QAQRDKRVED VIAELRLRQC ANTRVGNTYV RGVSGGERRR VSIGVQLLWN PGILILDEPT 
    SGLDSFTAHN LVTTLSRLAK GNRLVLISLH QPRSDIFRLF DLVLLMTSGT PIYLGAAQQM 
    VQYFTSIGHP CPRYSNPADF YVDLTSIDRR SKEREVATVE KAQSLAALFL EKVQGFDDFL 
    WKAEAKELNT STHTVSLTLT QDTDCGTAVE LPGMIEQFST LIRRQISNDF RDLPTLLIHG 
    SEACLMSLII GFLYYGHGAK QLSFMDTAAL LFMIGALIPF NVILDVVSKC HSERSMLYYE 
    LEDGLYTAGP YFFAKILGEL PEHCAYVIIY AMPIYWLTNL RPVPELFLLH FLLVWLVVFC 
    CRTMALAASA MLPTFHMSSF FCNALYNSFY LTAGFMINLD NLWIVPAWIS KLSFLRWCFS 
    GLMQIQFNGH LYTTQIGNFT FSILGDTMIS AMDLNSHPLY AIYLIVIGIS YGFLFLYYLS 
    LKLIKQKSIQ DW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.