Ufl1 | ENSMUSG00000040359 | NCBI 67490

Details for: Ufl1

Gene ID: 67490

Symbol: Ufl1

Ensembl ID: ENSMUSG00000040359

Description: UFM1 specific ligase 1

Associated with

Adaptive immune system
(R-MMU-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-MMU-983168)
Class i mhc mediated antigen processing & presentation
(R-MMU-983169)
Immune system
(R-MMU-168256)
Chromosome
(GO:0005694)
Cytoplasm
(GO:0005737)
Dna damage checkpoint signaling
(GO:0000077)
Dna damage response
(GO:0006974)
Dna repair
(GO:0006281)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Erythrocyte differentiation
(GO:0030218)
Hematopoietic stem cell differentiation
(GO:0060218)
Membrane
(GO:0016020)
Mitochondrial outer membrane
(GO:0005741)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of ire1-mediated unfolded protein response
(GO:1903895)
Negative regulation of nf-kappab transcription factor activity
(GO:0032088)
Negative regulation of protein ubiquitination
(GO:0031397)
Neuron projection
(GO:0043005)
Nucleus
(GO:0005634)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of glial cell proliferation
(GO:0060252)
Positive regulation of protein binding
(GO:0032092)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein k69-linked ufmylation
(GO:1990592)
Protein kinase binding
(GO:0019901)
Protein ufmylation
(GO:0071569)
Regulation of gene expression
(GO:0010468)
Regulation of intracellular estrogen receptor signaling pathway
(GO:0033146)
Regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032434)
Regulation of protein localization
(GO:0032880)
Response to endoplasmic reticulum stress
(GO:0034976)
Response to l-glutamate
(GO:1902065)
Reticulophagy
(GO:0061709)
Site of double-strand break
(GO:0035861)
Transferase activity
(GO:0016740)
Ufm1 ligase activity
(GO:0061666)
Ufm1 transferase activity
(GO:0071568)

Other Information

Proteins

UFL1_MOUSE

Genular Protein ID: 1303125651

Symbol: UFL1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8CCJ3 A2RSP7 B1AXU5 B1AXU6 Q3V145 Q6ZQ50 Q8BT70 Q8C484 Q9D8I8

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 14621295

Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PubMed ID: 14621295

DOI: 10.1093/dnares/10.4.167

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17208939

Title: Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS.

PubMed ID: 17208939

DOI: 10.1074/mcp.m600218-mcp200

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20531390

Title: Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity.

PubMed ID: 20531390

DOI: 10.1038/emboj.2010.116

PubMed ID: 20228063

Title: A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling.

PubMed ID: 20228063

DOI: 10.1074/jbc.m110.110619

PubMed ID: 21494687

Title: Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis.

PubMed ID: 21494687

DOI: 10.1371/journal.pone.0018517

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25952549

Title: RCAD/Ufl1, a Ufm1 E3 ligase, is essential for hematopoietic stem cell function and murine hematopoiesis.

PubMed ID: 25952549

DOI: 10.1038/cdd.2015.51

PubMed ID: 28575669

Title: The mammalian ribo-interactome reveals ribosome functional diversity and heterogeneity.

PubMed ID: 28575669

DOI: 10.1016/j.cell.2017.05.022

PubMed ID: 30354401

Title: Ufm1-specific ligase Ufl1 regulates endoplasmic reticulum homeostasis and protects against heart failure.

PubMed ID: 30354401

DOI: 10.1161/circheartfailure.118.004917

PubMed ID: 29461087

Title: Ufmylation is activated in vascular remodeling and lipopolysaccharide-induced endothelial cell injury.

PubMed ID: 29461087

DOI: 10.1089/dna.2017.4073

PubMed ID: 30701081

Title: Indispensable role of the ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation.

PubMed ID: 30701081

DOI: 10.1038/s41421-018-0070-x

PubMed ID: 30635284

Title: CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development.

PubMed ID: 30635284

DOI: 10.1242/dev.169235

Sequence Information:

Length: 793
Mass: 89520
Checksum: 182930A83D1F7155
Sequence:

MADAWEEIRR LAADFQRAQF AESTQRLSER NCIEIVNKLI SQKQLEVVHT LDGKEYITPA 
QISKEMRDEL HVRGGRVNIV DLQQVINVDL THIESRVSDI IKSEKHVQMV LGQLIDENYL 
DQLSEEVNDK LQESGQVTVS ELCKAYDLPG DFLTQALTQR LGRIINGHLD LDNRGVIFTE 
AFVARHKARI RGLFSAITRP TPVNSLVSKY GFQEQLLYSV LEDLVSTGRL RGTVVGGRQD 
KAVFVPDIYS RTQSTWVDSF FRQNGYLEFD ALSRLGIPDA VNYIKKRYKN TQLLFLKATC 
VGQGLVDQVE ASVEEAISSG TWVDISPLLP SSLSVEDAAM LLQQVMRPFG KLASAIVFSD 
TVVVSEKFIT DCTGLFSERM HQKAEKEMKN NPVHLITEED LKQISILESV NTSKKDKKDE 
RRKKATEGSG SVRGGGGGNA REYKIKKTKK KGRKDEDSDD ESQSSHGGKK KPDITFMFQD 
EIEDCLRKHI QDAPEEFISE LAEYLIKPLN KMYLEVVRSV FMSSTSASGT GRKRTIKDLQ 
EEVSNLYNNI RLFEKGMKYF ADDTQTALTK HLLKTVCTDI TNLMFNFLAS DFLMAVEEPA 
AITSDIRKKI LSKLTEETKV ALTKLHNSLN EKSIEDFLSC LDSATEACDI MVKKGDKKRE 
RQILFQHRQA LCEQLKVTED PALILHLTAV LLFQLSTHSM LHAPGRCVPQ IIAFLHSKIP 
EDQHTLLVKY QGLVVKQLVS QNKKTGQGED PSSDELDKEQ HDVTNATRKE LQELSLSIKD 
LVLKSRKSSV TEE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ufl1

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. PubMed ID: 14621295

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS. PubMed ID: 17208939

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity. PubMed ID: 20531390

A novel C53/LZAP-interacting protein regulates stability of C53/LZAP and DDRGK domain-containing Protein 1 (DDRGK1) and modulates NF-kappaB signaling. PubMed ID: 20228063

Ubiquitin fold modifier 1 (UFM1) and its target UFBP1 protect pancreatic beta cells from ER stress-induced apoptosis. PubMed ID: 21494687

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

RCAD/Ufl1, a Ufm1 E3 ligase, is essential for hematopoietic stem cell function and murine hematopoiesis. PubMed ID: 25952549

The mammalian ribo-interactome reveals ribosome functional diversity and heterogeneity. PubMed ID: 28575669

Ufm1-specific ligase Ufl1 regulates endoplasmic reticulum homeostasis and protects against heart failure. PubMed ID: 30354401

Ufmylation is activated in vascular remodeling and lipopolysaccharide-induced endothelial cell injury. PubMed ID: 29461087

Indispensable role of the ubiquitin-fold modifier 1-specific E3 ligase in maintaining intestinal homeostasis and controlling gut inflammation. PubMed ID: 30701081

CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development. PubMed ID: 30635284