Atg12 | ENSMUSG00000032905 | NCBI 67526

Details for: Atg12

Gene ID: 67526

Symbol: Atg12

Ensembl ID: ENSMUSG00000032905

Description: autophagy related 12

Associated with

Mitophagy
(R-MMU-5205647)
Pink1-prkn mediated mitophagy
(R-MMU-5205685)
Receptor mediated mitophagy
(R-MMU-8934903)
Selective autophagy
(R-MMU-9663891)
Atg8-family ligase activity
(GO:0019776)
Atg12-atg5-atg16 complex
(GO:0034274)
Autophagosome
(GO:0005776)
Autophagosome assembly
(GO:0000045)
Autophagosome maturation
(GO:0097352)
Autophagosome membrane
(GO:0000421)
Autophagy
(GO:0006914)
Autophagy of mitochondrion
(GO:0000422)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Glycophagy
(GO:0061723)
Intracellular membrane-bounded organelle
(GO:0043231)
Macroautophagy
(GO:0016236)
Membrane
(GO:0016020)
Negative regulation of defense response to virus
(GO:0050687)
Negative regulation of innate immune response
(GO:0045824)
Negative regulation of type i interferon production
(GO:0032480)
Nucleoplasm
(GO:0005654)
Phagophore assembly site membrane
(GO:0034045)
Piecemeal microautophagy of the nucleus
(GO:0034727)
Positive regulation of viral translation
(GO:1904973)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein lipidation involved in autophagosome assembly
(GO:0061739)
Regulation of autophagosome maturation
(GO:1901096)
Transferase complex
(GO:1990234)

Other Information

Proteins

Ubiquitin-like protein ATG12

Genular Protein ID: 622686691

Symbol: ATG12_MOUSE

Name: Ubiquitin-like protein ATG12

UniProtKB Accession Codes:

Q9CQY1 Q3TKE5 Q9D7Y5

Database IDs:

Citations:

PubMed ID: 11266458

Title: Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells.

PubMed ID: 11266458

DOI: 10.1083/jcb.152.4.657

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12482611

Title: Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid method.

PubMed ID: 12482611

DOI: 10.1016/s0014-5793(02)03739-0

PubMed ID: 12890687

Title: The mouse APG10 homologue, an E2-like enzyme for Apg12p conjugation, facilitates MAP-LC3 modification.

PubMed ID: 12890687

DOI: 10.1074/jbc.m300550200

PubMed ID: 12665549

Title: Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate.

PubMed ID: 12665549

DOI: 10.1242/jcs.00381

PubMed ID: 17709747

Title: The Atg5-Atg12 conjugate associates with innate antiviral immune responses.

PubMed ID: 17709747

DOI: 10.1073/pnas.0704014104

PubMed ID: 18704115

Title: The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. 'Protein modifications: beyond the usual suspects' review series.

PubMed ID: 18704115

DOI: 10.1038/embor.2008.163

PubMed ID: 18768753

Title: The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice.

PubMed ID: 18768753

DOI: 10.1091/mbc.e08-03-0309

PubMed ID: 19417210

Title: Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation.

PubMed ID: 19417210

DOI: 10.1182/blood-2008-04-151639

PubMed ID: 20723759

Title: ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death.

PubMed ID: 20723759

DOI: 10.1016/j.cell.2010.07.018

PubMed ID: 22082872

Title: Atg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12-5-16L2 complex.

PubMed ID: 22082872

DOI: 10.4161/auto.7.12.18025

Sequence Information:

Length: 141
Mass: 15207
Checksum: 440F9A625624A78B
Sequence:

MSEDSEVVLQ LPSAPVGAGG ESLPELSPET ATPEPPSSAA VSPGTEEPPG DTKKKIDILL 
KAVGDTPIMK TKKWAVERTR TIQGLIDFIK KFLKLVASEQ LFIYVNQSFA PSPDQEVGTL 
YECFGSDGKL VLHYCKSQAW G

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Atg12

Associated with

Other Information

Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. PubMed ID: 11266458

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mouse Apg10 as an Apg12-conjugating enzyme: analysis by the conjugation-mediated yeast two-hybrid method. PubMed ID: 12482611

The mouse APG10 homologue, an E2-like enzyme for Apg12p conjugation, facilitates MAP-LC3 modification. PubMed ID: 12890687

Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate. PubMed ID: 12665549

The Atg5-Atg12 conjugate associates with innate antiviral immune responses. PubMed ID: 17709747

The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. 'Protein modifications: beyond the usual suspects' review series. PubMed ID: 18704115

The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. PubMed ID: 18768753

Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation. PubMed ID: 19417210

ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death. PubMed ID: 20723759

Atg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12-5-16L2 complex. PubMed ID: 22082872