Slc39a8 | ENSMUSG00000053897 | NCBI 67547

Details for: Slc39a8

Gene ID: 67547

Symbol: Slc39a8

Ensembl ID: ENSMUSG00000053897

Description: solute carrier family 39 (metal ion transporter), member 8

Associated with

Metal ion slc transporters
(R-MMU-425410)
Slc-mediated transmembrane transport
(R-MMU-425407)
Transport of bile salts and organic acids, metal ions and amine compounds
(R-MMU-425366)
Transport of small molecules
(R-MMU-382551)
Zinc influx into cells by the slc39 gene family
(R-MMU-442380)
Zinc transporters
(R-MMU-435354)
Apical plasma membrane
(GO:0016324)
Arginine metabolic process
(GO:0006525)
Basolateral plasma membrane
(GO:0016323)
Bicarbonate transport
(GO:0015701)
Cadmium ion transmembrane transport
(GO:0070574)
Cartilage homeostasis
(GO:1990079)
Cellular detoxification of cadmium ion
(GO:0098849)
Cobalt ion transport
(GO:0006824)
Dna-templated transcription
(GO:0006351)
Extracellular matrix organization
(GO:0030198)
Intracellular manganese ion homeostasis
(GO:0030026)
Intracellular zinc ion homeostasis
(GO:0006882)
Iron ion import across plasma membrane
(GO:0098711)
Leukocyte adhesion to arterial endothelial cell
(GO:0061757)
Lysosomal membrane
(GO:0005765)
Lysosome
(GO:0005764)
Manganese ion transmembrane transport
(GO:0071421)
Membrane
(GO:0016020)
Mercury ion transport
(GO:0015694)
Metal ion transmembrane transporter activity
(GO:0046873)
Metal ion transport
(GO:0030001)
Mitochondrial manganese ion transmembrane transport
(GO:1990540)
Monoatomic cation:bicarbonate symporter activity
(GO:0140410)
Monoatomic ion transport
(GO:0006811)
Negative regulation of canonical nf-kappab signal transduction
(GO:0043124)
Negative regulation of inflammatory response
(GO:0050728)
Organelle membrane
(GO:0031090)
Plasma membrane
(GO:0005886)
Plasma membrane selenite transport
(GO:0097080)
Protein n-linked glycosylation
(GO:0006487)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of membrane potential
(GO:0042391)
Symporter activity
(GO:0015293)
Transmembrane transport
(GO:0055085)
Zinc:bicarbonate symporter activity
(GO:0140412)
Zinc ion import across plasma membrane
(GO:0071578)
Zinc ion transmembrane transport
(GO:0071577)
Zinc ion transmembrane transporter activity
(GO:0005385)
Zinc ion transport
(GO:0006829)

Other Information

Proteins

S39A8_MOUSE

Genular Protein ID: 54399408

Symbol: S39A8_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q91W10 Q8BTQ3 Q8BUD6 Q9D426 Q9D5V4

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15722412

Title: Identification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testis.

PubMed ID: 15722412

DOI: 10.1073/pnas.0406085102

PubMed ID: 16638970

Title: ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter family: characterization of transporter properties.

PubMed ID: 16638970

DOI: 10.1124/mol.106.024521

PubMed ID: 17108009

Title: Enhanced cadmium-induced testicular necrosis and renal proximal tubule damage caused by gene-dose increase in a Slc39a8-transgenic mouse line.

PubMed ID: 17108009

DOI: 10.1152/ajpcell.00409.2006

PubMed ID: 18037372

Title: Cd2+ versus Zn2+ uptake by the ZIP8 HCO3--dependent symporter: kinetics, electrogenicity and trafficking.

PubMed ID: 18037372

DOI: 10.1016/j.bbrc.2007.11.067

PubMed ID: 22898811

Title: ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading.

PubMed ID: 22898811

DOI: 10.1074/jbc.m112.367284

PubMed ID: 22563477

Title: ZIP8 zinc transporter: indispensable role for both multiple-organ organogenesis and hematopoiesis in utero.

PubMed ID: 22563477

DOI: 10.1371/journal.pone.0036055

PubMed ID: 23403290

Title: ZIP8 regulates host defense through zinc-mediated inhibition of NF-kappaB.

PubMed ID: 23403290

DOI: 10.1016/j.celrep.2013.01.009

PubMed ID: 24529376

Title: Regulation of the catabolic cascade in osteoarthritis by the zinc-ZIP8-MTF1 axis.

PubMed ID: 24529376

DOI: 10.1016/j.cell.2014.01.007

PubMed ID: 27166256

Title: Zinc- and bicarbonate-dependent ZIP8 transporter mediates selenite uptake.

PubMed ID: 27166256

DOI: 10.18632/oncotarget.9205

PubMed ID: 28481222

Title: Hepatic metal ion transporter ZIP8 regulates manganese homeostasis and manganese-dependent enzyme activity.

PubMed ID: 28481222

DOI: 10.1172/jci90896

PubMed ID: 30015240

Title: ZIP8 induces monocyte adhesion to the aortas ex-vivo by regulating zinc influx.

PubMed ID: 30015240

DOI: 10.1016/j.intimp.2018.06.018

PubMed ID: 29337306

Title: Zinc transporter Slc39a8 is essential for cardiac ventricular compaction.

PubMed ID: 29337306

DOI: 10.1172/jci96993

PubMed ID: 29927450

Title: Role of ZIP8 in regulating cell morphology and NF-kappaB/Snail2 signaling.

PubMed ID: 29927450

DOI: 10.1039/c8mt00079d

Sequence Information:

Length: 462
Mass: 50082
Checksum: 52EBA157C295411C
Sequence:

MAPGRAVAGL LLLAATSLGH PSEGPELAFS EDVLSVFGAN RSLSAAQLGR LLERLGAASQ 
QGALDLGQLH FNQCLSAEDI FSLHGFSNVT QITSSNFSAI CPAILQQLNF HPCEDLRKHN 
AKPSLSEVWG YGFLSVTIIN LASLLGLILT PLIKKSYFPK ILTYFVGLAI GTLFSNAIFQ 
LIPEAFGFNP KIDNYVEKAV AVFGGFYMLF FVERTLKMLL KTYGQNDHTH FRNDDFGSKE 
KTHQPKTLPL PAVNGVTCYA NPAVTEPNGH IHFDTVSVVS LQDGKTEPSS CTCLKGPKLS 
EIGTIAWMIT LCDALHNFID GLAIGASCTL SLLQGLSTSI AILCEEFPHE LGDFVILLNA 
GMSTRQALLF NFLSACSCYV GLAFGILVGN NFAPNIIFAL AGGMFLYISL ADMFPEMNDM 
LREKVTGRQT DFTFFMIQNA GMLTGFTAIL LITLYAGDIE LQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Slc39a8

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of mouse SLC39A8 as the transporter responsible for cadmium-induced toxicity in the testis. PubMed ID: 15722412

ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter family: characterization of transporter properties. PubMed ID: 16638970

Enhanced cadmium-induced testicular necrosis and renal proximal tubule damage caused by gene-dose increase in a Slc39a8-transgenic mouse line. PubMed ID: 17108009

Cd2+ versus Zn2+ uptake by the ZIP8 HCO3--dependent symporter: kinetics, electrogenicity and trafficking. PubMed ID: 18037372

ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading. PubMed ID: 22898811

ZIP8 zinc transporter: indispensable role for both multiple-organ organogenesis and hematopoiesis in utero. PubMed ID: 22563477

ZIP8 regulates host defense through zinc-mediated inhibition of NF-kappaB. PubMed ID: 23403290

Regulation of the catabolic cascade in osteoarthritis by the zinc-ZIP8-MTF1 axis. PubMed ID: 24529376

Zinc- and bicarbonate-dependent ZIP8 transporter mediates selenite uptake. PubMed ID: 27166256

Hepatic metal ion transporter ZIP8 regulates manganese homeostasis and manganese-dependent enzyme activity. PubMed ID: 28481222

ZIP8 induces monocyte adhesion to the aortas ex-vivo by regulating zinc influx. PubMed ID: 30015240

Zinc transporter Slc39a8 is essential for cardiac ventricular compaction. PubMed ID: 29337306

Role of ZIP8 in regulating cell morphology and NF-kappaB/Snail2 signaling. PubMed ID: 29927450