Alkbh8 | ENSMUSG00000025899 | NCBI 67667

Details for: Alkbh8

Gene ID: 67667

Symbol: Alkbh8

Ensembl ID: ENSMUSG00000025899

Description: alkB homolog 8, tRNA methyltransferase

Associated with

2-oxoglutarate-dependent dioxygenase activity
(GO:0016706)
Catalytic activity
(GO:0003824)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna damage response
(GO:0006974)
Iron ion binding
(GO:0005506)
Metabolic process
(GO:0008152)
Metal ion binding
(GO:0046872)
Methylation
(GO:0032259)
Methyltransferase activity
(GO:0008168)
Nucleic acid binding
(GO:0003676)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Rna binding
(GO:0003723)
S-adenosylmethionine-dependent methyltransferase activity
(GO:0008757)
Transferase activity
(GO:0016740)
Trna (5-carboxymethyluridine(34)-5-o)-methyltransferase activity
(GO:0106335)
Trna (uridine) methyltransferase activity
(GO:0016300)
Trna binding
(GO:0000049)
Trna methylation
(GO:0030488)
Trna wobble uridine modification
(GO:0002098)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Alkylated DNA repair protein alkB homolog 8

Genular Protein ID: 2330103978

Symbol: ALKB8_MOUSE

Name: Alkylated DNA repair protein alkB homolog 8

UniProtKB Accession Codes:

Q80Y20 Q3TUG4 Q8BV08 Q9CX44

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20583019

Title: The AlkB domain of mammalian ABH8 catalyzes hydroxylation of 5-methoxycarbonylmethyluridine at the wobble position of tRNA.

PubMed ID: 20583019

DOI: 10.1002/anie.201001242

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20123966

Title: Mammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decoding.

PubMed ID: 20123966

DOI: 10.1128/mcb.01602-09

Sequence Information:

Length: 664
Mass: 74768
Checksum: 624A9F48768A903E
Sequence:

MNINHKGVLK LTKMEKKFLR KQSKARHVLL KHEGIQAVSY PTQSLVIANG GLGNGVSRKQ 
LLLTLEKCGP VEALLMPPNK PYAFVIFQTI EESKKAYFTL NGKEIIDDLG QKIFLYLNFV 
EKAQWKNMGL EALPPGLLVV EEIISSEEEK KLLESVNWTE DTGNQNFQRS LKHRRVKHFG 
YEFHYESNTV DKDKPLPGGL PEVCSSILEK LLKEGYIKHK PDQLTINQYE PGHGIPAHID 
THSAFEDEII SLSLGSAIVM DFKHPEGVTV QVMLPRRSLL VMTGESRYLW THGITPRKFD 
TVQASEQFKG GIITSDIGDL TLSKRGMRTS FTFRKVRRMP CNCSYSSVCD RQRKATPPSL 
TESSKEALEL EQKHVHQVYN EIASHFSSTR HSPWPRIVEF LKALPSGSIV ADIGCGNGKY 
LGINKDLYMI GCDRSQNLVD ICRERQFQAL VCDALAVPVR SGSCDACISI AVIHHFATAE 
RRVEALQELA RLLRPGGQAL IYVWAMEQEY KNQKSKYLRG KRISQGDKDE LNSATSTEEF 
LVNQTPEGVN EDPALSVNSS SITKEEEYKS RKVPNSELPI HINRTCFHSQ DVLVPWHLKR 
NPGKDKAIEP SGVAGCPDPS PVFHRYYHVF CDGELEASCQ AVGDVSILQS YYDQGNWCVV 
LQKV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Alkbh8

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The AlkB domain of mammalian ABH8 catalyzes hydroxylation of 5-methoxycarbonylmethyluridine at the wobble position of tRNA. PubMed ID: 20583019