Details for: ZFP36L1

Gene ID: 677

Symbol: ZFP36L1

Ensembl ID: ENSG00000185650

Description: ZFP36 ring finger protein like 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 770.8369
    Cell Significance Index: -119.9000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 482.7250
    Cell Significance Index: -122.4400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 294.0665
    Cell Significance Index: -121.1400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 270.1245
    Cell Significance Index: -109.7400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 265.4395
    Cell Significance Index: -125.3200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 240.4910
    Cell Significance Index: -123.7100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 187.8478
    Cell Significance Index: -126.0500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 116.5654
    Cell Significance Index: -111.2900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 101.0174
    Cell Significance Index: -124.5500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 38.5485
    Cell Significance Index: -118.4000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 33.7793
    Cell Significance Index: -90.4900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 31.6215
    Cell Significance Index: -124.7800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 26.0076
    Cell Significance Index: -56.9200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 12.9755
    Cell Significance Index: 166.1700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 9.4870
    Cell Significance Index: 58.3900
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 6.8808
    Cell Significance Index: 42.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 6.7122
    Cell Significance Index: 182.7000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 6.1558
    Cell Significance Index: 176.4600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 5.4969
    Cell Significance Index: 115.0600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 4.8833
    Cell Significance Index: 670.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 4.7399
    Cell Significance Index: 607.6300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 4.4470
    Cell Significance Index: 50.5200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 4.3253
    Cell Significance Index: 531.8400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 4.2217
    Cell Significance Index: 1866.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 4.0359
    Cell Significance Index: 210.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.6103
    Cell Significance Index: 650.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.4165
    Cell Significance Index: 160.5700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.3880
    Cell Significance Index: 59.8700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.3274
    Cell Significance Index: 61.5000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.2298
    Cell Significance Index: 74.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.1556
    Cell Significance Index: 84.2600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.9601
    Cell Significance Index: 32.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.5700
    Cell Significance Index: 191.5400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.5376
    Cell Significance Index: 88.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.4611
    Cell Significance Index: 290.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.2915
    Cell Significance Index: 106.8400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.2034
    Cell Significance Index: 1203.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.1975
    Cell Significance Index: 1984.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.1366
    Cell Significance Index: 59.7100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.9425
    Cell Significance Index: 137.3800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4370
    Cell Significance Index: 92.7100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.3682
    Cell Significance Index: 233.6300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.1818
    Cell Significance Index: 152.6800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0967
    Cell Significance Index: 119.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.0699
    Cell Significance Index: 60.0400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.0314
    Cell Significance Index: 20.1300
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.9335
    Cell Significance Index: 4.3100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8852
    Cell Significance Index: 175.6800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6499
    Cell Significance Index: 33.7600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6475
    Cell Significance Index: 38.8700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.6053
    Cell Significance Index: 15.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3882
    Cell Significance Index: 11.1900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2737
    Cell Significance Index: 12.4100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2020
    Cell Significance Index: 3.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1223
    Cell Significance Index: 92.5600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1104
    Cell Significance Index: 80.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0554
    Cell Significance Index: 10.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0317
    Cell Significance Index: 3.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0107
    Cell Significance Index: 20.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0268
    Cell Significance Index: -49.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0448
    Cell Significance Index: -68.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0463
    Cell Significance Index: -29.3800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0831
    Cell Significance Index: -61.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0948
    Cell Significance Index: -128.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1134
    Cell Significance Index: -51.4900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1283
    Cell Significance Index: -80.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1796
    Cell Significance Index: -101.2600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.1814
    Cell Significance Index: -125.4500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.2424
    Cell Significance Index: -23.9800
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.2639
    Cell Significance Index: -0.6000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3001
    Cell Significance Index: -34.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.3447
    Cell Significance Index: -123.6300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.3447
    Cell Significance Index: -17.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4015
    Cell Significance Index: -115.5100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4240
    Cell Significance Index: -11.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4312
    Cell Significance Index: -62.6800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4390
    Cell Significance Index: -5.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.4937
    Cell Significance Index: -99.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5692
    Cell Significance Index: -119.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5915
    Cell Significance Index: -68.9300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.5945
    Cell Significance Index: -41.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.6064
    Cell Significance Index: -98.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6839
    Cell Significance Index: -78.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.7465
    Cell Significance Index: -26.2300
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: -0.7731
    Cell Significance Index: -4.7700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.9181
    Cell Significance Index: -15.4700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -1.0633
    Cell Significance Index: -8.4900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.1033
    Cell Significance Index: -84.6700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.1595
    Cell Significance Index: -25.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.1639
    Cell Significance Index: -121.1900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.2140
    Cell Significance Index: -7.3400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.2564
    Cell Significance Index: -99.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.5190
    Cell Significance Index: -32.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.5210
    Cell Significance Index: -93.2500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.6178
    Cell Significance Index: -51.8200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.7344
    Cell Significance Index: -71.0700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.7991
    Cell Significance Index: -25.6100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.8886
    Cell Significance Index: -27.8800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.9558
    Cell Significance Index: -57.4400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.9651
    Cell Significance Index: -132.1400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ZFP36L1 is a member of the ZFP36 family of RNA-binding proteins, which are known for their ability to regulate mRNA stability and translation. The protein is characterized by its ability to bind to AU-rich elements (AREs) in the 3'-untranslated region (UTR) of target mRNAs, leading to mRNA degradation. This mechanism is crucial for the regulation of gene expression in response to various cellular stresses, including hypoxia, glucocorticoid stimulation, and insulin signaling. **Pathways and Functions:** ZFP36L1 is involved in multiple cellular pathways, including: 1. **mRNA destabilization:** ZFP36L1 binds to AREs in target mRNAs, leading to mRNA degradation and the regulation of gene expression. 2. **Apoptosis:** ZFP36L1 has been shown to regulate apoptosis by binding to pro-apoptotic mRNAs, such as BCL-2 and PUMA, and preventing their translation. 3. **Cell proliferation:** ZFP36L1 regulates cell proliferation by binding to mRNAs involved in the cell cycle, such as CDK4 and cyclin D1. 4. **Differentiation:** ZFP36L1 regulates differentiation by binding to mRNAs involved in the process, such as myogenic mRNAs. 5. **Stress response:** ZFP36L1 is involved in the regulation of gene expression in response to various cellular stresses, including hypoxia, glucocorticoid stimulation, and insulin signaling. **Clinical Significance:** ZFP36L1 has been implicated in various diseases, including: 1. **Cancer:** ZFP36L1 has been shown to be overexpressed in several types of cancer, including breast, lung, and colon cancer. 2. **Inflammatory diseases:** ZFP36L1 has been implicated in the regulation of inflammation and immune responses, making it a potential target for the treatment of inflammatory diseases. 3. **Neurological disorders:** ZFP36L1 has been shown to be involved in the regulation of gene expression in the nervous system, making it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, ZFP36L1 is a complex gene that plays a critical role in various cellular processes, including mRNA destabilization, apoptosis, cell proliferation, and differentiation. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms of ZFP36L1 and its potential therapeutic applications. **Significantly Expressed Cells:** ZFP36L1 is significantly expressed in various cell types, including: 1. **Uterine smooth muscle cells** 2. **CD38-negative naive B cells** 3. **Taste receptor cells** 4. **Epithelial cells of lower respiratory tract** 5. **Epithelial cells of prostate** 6. **Skeletal muscle satellite stem cells** 7. **Fibroblasts of mammary gland** 8. **Mesodermal cells** 9. **Endocardial cells** 10. **Basal cells of epithelium of trachea** **Proteins:** ZFP36L1 interacts with several proteins, including: 1. **TISB_HUMAN** 2. **B3KNA8_HUMAN** These interactions are critical for the regulation of gene expression and the maintenance of cellular homeostasis. In summary, ZFP36L1 is a complex gene that plays a critical role in various cellular processes, including mRNA destabilization, apoptosis, cell proliferation, and differentiation. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms of ZFP36L1 and its potential therapeutic applications.

Genular Protein ID: 4127376403

Symbol: TISB_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q07352 Q13851

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 59 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8346037

Title: Coding sequence of ERF-1, the human homologue of Tis11b/cMG1, members of the Tis11 family of early response genes.

PubMed ID: 8346037

DOI: 10.1093/nar/21.15.3580

PubMed ID: 8024689

Title: Cloning and characterization of ERF-1, a human member of the Tis11 family of early-response genes.

PubMed ID: 8024689

DOI: 10.1089/dna.1994.13.449

PubMed ID: 8898945

Title: Distinct mechanisms for rescue from apoptosis in Ramos human B cells by signaling through CD40 and interleukin-4 receptor: role for inhibition of an early response gene, Berg36.

PubMed ID: 8898945

DOI: 10.1002/eji.1830261013

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10367403

Title: Differential effects of sodium butyrate on the transcription of the human TIS11 family of early-response genes in colorectal cancer cells.

PubMed ID: 10367403

PubMed ID: 12198173

Title: Functional cloning of BRF1, a regulator of ARE-dependent mRNA turnover.

PubMed ID: 12198173

DOI: 10.1093/emboj/cdf444

PubMed ID: 15465005

Title: Butyrate response factor 1 is regulated by parathyroid hormone and bone morphogenetic protein-2 in osteoblastic cells.

PubMed ID: 15465005

DOI: 10.1016/j.bbrc.2004.09.030

PubMed ID: 15538381

Title: The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B.

PubMed ID: 15538381

DOI: 10.1038/sj.emboj.7600477

PubMed ID: 15467755

Title: Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b.

PubMed ID: 15467755

DOI: 10.1038/sj.onc.1207939

PubMed ID: 15687258

Title: Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1.

PubMed ID: 15687258

DOI: 10.1101/gad.1282305

PubMed ID: 15967811

Title: Stress granules and processing bodies are dynamically linked sites of mRNP remodeling.

PubMed ID: 15967811

DOI: 10.1083/jcb.200502088

PubMed ID: 17030608

Title: BRF1 protein turnover and mRNA decay activity are regulated by protein kinase B at the same phosphorylation sites.

PubMed ID: 17030608

DOI: 10.1128/mcb.01099-06

PubMed ID: 17369404

Title: TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements.

PubMed ID: 17369404

DOI: 10.1101/gad.1494707

PubMed ID: 18326031

Title: The AU-rich element mRNA decay-promoting activity of BRF1 is regulated by mitogen-activated protein kinase-activated protein kinase 2.

PubMed ID: 18326031

DOI: 10.1261/rna.983708

PubMed ID: 19179481

Title: cAMP-dependent posttranscriptional regulation of steroidogenic acute regulatory (STAR) protein by the zinc finger protein ZFP36L1/TIS11b.

PubMed ID: 19179481

DOI: 10.1210/me.2008-0296

PubMed ID: 20166898

Title: ZFP36L1 is regulated by growth factors and cytokines in keratinocytes and influences their VEGF production.

PubMed ID: 20166898

DOI: 10.3109/08977190903578660

PubMed ID: 20702587

Title: ZFP36L1 negatively regulates erythroid differentiation of CD34+ hematopoietic stem cells by interfering with the Stat5b pathway.

PubMed ID: 20702587

DOI: 10.1091/mbc.e10-01-0040

PubMed ID: 21832157

Title: A novel function of Tis11b/BRF1 as a regulator of Dll4 mRNA 3'-end processing.

PubMed ID: 21832157

DOI: 10.1091/mbc.e11-02-0149

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24700863

Title: Hypertonicity compromises renal mineralocorticoid receptor signaling through Tis11b-mediated post-transcriptional control.

PubMed ID: 24700863

DOI: 10.1681/asn.2013091023

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25106868

Title: ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway.

PubMed ID: 25106868

DOI: 10.1093/nar/gku652

PubMed ID: 25014217

Title: Post-transcriptional regulation of BCL2 mRNA by the RNA-binding protein ZFP36L1 in malignant B cells.

PubMed ID: 25014217

DOI: 10.1371/journal.pone.0102625

PubMed ID: 26542173

Title: ZFP36L1 promotes monocyte/macrophage differentiation by repressing CDK6.

PubMed ID: 26542173

DOI: 10.1038/srep16229

PubMed ID: 27182009

Title: Functional analysis of ZFP36 proteins in keratinocytes.

PubMed ID: 27182009

DOI: 10.1016/j.ejcb.2016.04.007

PubMed ID: 15713487

Title: Thermodynamic and structural equivalence of two HLA-B27 subtypes complexed with a self-peptide.

PubMed ID: 15713487

DOI: 10.1016/j.jmb.2004.12.047

Sequence Information:

  • Length: 338
  • Mass: 36314
  • Checksum: 98236CD40C4531D2
  • Sequence:
    • MTTTLVSATI FDLSEVLCKG NKMLNYSAPS AGGCLLDRKA VGTPAGGGFP RRHSVTLPSS 
KFHQNQLLSS LKGEPAPALS SRDSRFRDRS FSEGGERLLP TQKQPGGGQV NSSRYKTELC 
RPFEENGACK YGDKCQFAHG IHELRSLTRH PKYKTELCRT FHTIGFCPYG PRCHFIHNAE 
ERRALAGARD LSADRPRLQH SFSFAGFPSA AATAAATGLL DSPTSITPPP ILSADDLLGS 
PTLPDGTNNP FAFSSQELAS LFAPSMGLPG GGSPTTFLFR PMSESPHMFD SPPSPQDSLS 
DQEGYLSSSS SSHSGSDSPT LDNSRRLPIF SRLSISDD

Genular Protein ID: 373451243

Symbol: B3KNA8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KNA8

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 7 Gene3D 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 2 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 338
  • Mass: 36342
  • Checksum: F04EDA0F6103D5BC
  • Sequence:
    • MTTTLVSATI FDLSEVLCKG NKMLNYSAPS AGGCLLDRKA VGTPAGGGFP RRHSVTLPSS 
KFHQNQLLSS LKGEPAPALS SRDSRFRDRS FSEGGERLLP TRKQPGGGQV NSSRYKTELC 
RPFEENGACK YGDKCQFAHG IHELRSLTRH PKYKTELCRT FHTIGFCPYG PRCHFIHNAE 
ERRALAGARD LSADRPRLQH SFSFAGFPSA AATAAATGLL DSPTSITPPP ILSADDLLGS 
PTLPDGTNNP FAFSSQELAS LFAPSMGLPG GGSPTTFLFR PMSESPHMFD SPPSPQDSLS 
DQEGYLSSSS SSHSGSDSPT LDNSRRLPIF SRLSISDD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.