ZFP36L1 | ENSG00000185650 | NCBI 677

Details for: ZFP36L1

Gene ID: 677

Symbol: ZFP36L1

Ensembl ID: ENSG00000185650

Description: ZFP36 ring finger protein like 1

Associated with

Butyrate response factor 1 (brf1) binds and destabilizes mrna
(R-HSA-450385)
Metabolism of rna
(R-HSA-8953854)
Regulation of mrna stability by proteins that bind au-rich elements
(R-HSA-450531)
3'-utr-mediated mrna destabilization
(GO:0061158)
14-3-3 protein binding
(GO:0071889)
Apoptotic process
(GO:0006915)
Cell population proliferation
(GO:0008283)
Cellular response to camp
(GO:0071320)
Cellular response to epidermal growth factor stimulus
(GO:0071364)
Cellular response to fibroblast growth factor stimulus
(GO:0044344)
Cellular response to glucocorticoid stimulus
(GO:0071385)
Cellular response to hypoxia
(GO:0071456)
Cellular response to insulin stimulus
(GO:0032869)
Cellular response to peptide hormone stimulus
(GO:0071375)
Cellular response to raffinose
(GO:0097403)
Cellular response to salt stress
(GO:0071472)
Cellular response to transforming growth factor beta stimulus
(GO:0071560)
Cellular response to tumor necrosis factor
(GO:0071356)
Chorio-allantoic fusion
(GO:0060710)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna binding
(GO:0003677)
Erk1 and erk2 cascade
(GO:0070371)
Heart development
(GO:0007507)
Mapk cascade
(GO:0000165)
Mesendoderm development
(GO:0048382)
Metal ion binding
(GO:0046872)
Mrna 3'-utr au-rich region binding
(GO:0035925)
Mrna binding
(GO:0003729)
Mrna processing
(GO:0006397)
Mrna transport
(GO:0051028)
Multicellular organism growth
(GO:0035264)
Negative regulation of erythrocyte differentiation
(GO:0045647)
Negative regulation of mitotic cell cycle phase transition
(GO:1901991)
Neural tube development
(GO:0021915)
Nuclear-transcribed mrna catabolic process, deadenylation-dependent decay
(GO:0000288)
Nuclear-transcribed mrna catabolic process, deadenylation-independent decay
(GO:0031086)
Nucleus
(GO:0005634)
P-body
(GO:0000932)
P38mapk cascade
(GO:0038066)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Positive regulation of fat cell differentiation
(GO:0045600)
Positive regulation of intracellular mrna localization
(GO:1904582)
Positive regulation of monocyte differentiation
(GO:0045657)
Positive regulation of nuclear-transcribed mrna catabolic process, deadenylation-dependent decay
(GO:1900153)
Proepicardium development
(GO:0003342)
Protein binding
(GO:0005515)
Regulation of b cell differentiation
(GO:0045577)
Regulation of gene expression
(GO:0010468)
Regulation of keratinocyte apoptotic process
(GO:1902172)
Regulation of keratinocyte differentiation
(GO:0045616)
Regulation of keratinocyte proliferation
(GO:0010837)
Regulation of mrna 3'-end processing
(GO:0031440)
Regulation of mrna stability
(GO:0043488)
Regulation of myoblast differentiation
(GO:0045661)
Regulation of stem cell proliferation
(GO:0072091)
Regulation of translation
(GO:0006417)
Response to wounding
(GO:0009611)
Ribonucleoprotein complex
(GO:1990904)
Rna binding
(GO:0003723)
T cell differentiation in thymus
(GO:0033077)
Vasculogenesis
(GO:0001570)

Other Information

Proteins

TISB_HUMAN
B3KNA8_HUMAN

Genular Protein ID: 4127376403

Symbol: TISB_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q07352 Q13851

Database IDs:

Citations:

PubMed ID: 8346037

Title: Coding sequence of ERF-1, the human homologue of Tis11b/cMG1, members of the Tis11 family of early response genes.

PubMed ID: 8346037

DOI: 10.1093/nar/21.15.3580

PubMed ID: 8024689

Title: Cloning and characterization of ERF-1, a human member of the Tis11 family of early-response genes.

PubMed ID: 8024689

DOI: 10.1089/dna.1994.13.449

PubMed ID: 8898945

Title: Distinct mechanisms for rescue from apoptosis in Ramos human B cells by signaling through CD40 and interleukin-4 receptor: role for inhibition of an early response gene, Berg36.

PubMed ID: 8898945

DOI: 10.1002/eji.1830261013

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10367403

Title: Differential effects of sodium butyrate on the transcription of the human TIS11 family of early-response genes in colorectal cancer cells.

PubMed ID: 10367403

PubMed ID: 12198173

Title: Functional cloning of BRF1, a regulator of ARE-dependent mRNA turnover.

PubMed ID: 12198173

DOI: 10.1093/emboj/cdf444

PubMed ID: 15465005

Title: Butyrate response factor 1 is regulated by parathyroid hormone and bone morphogenetic protein-2 in osteoblastic cells.

PubMed ID: 15465005

DOI: 10.1016/j.bbrc.2004.09.030

PubMed ID: 15538381

Title: The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B.

PubMed ID: 15538381

DOI: 10.1038/sj.emboj.7600477

PubMed ID: 15467755

Title: Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b.

PubMed ID: 15467755

DOI: 10.1038/sj.onc.1207939

PubMed ID: 15687258

Title: Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1.

PubMed ID: 15687258

DOI: 10.1101/gad.1282305

PubMed ID: 15967811

Title: Stress granules and processing bodies are dynamically linked sites of mRNP remodeling.

PubMed ID: 15967811

DOI: 10.1083/jcb.200502088

PubMed ID: 17030608

Title: BRF1 protein turnover and mRNA decay activity are regulated by protein kinase B at the same phosphorylation sites.

PubMed ID: 17030608

DOI: 10.1128/mcb.01099-06

PubMed ID: 17369404

Title: TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements.

PubMed ID: 17369404

DOI: 10.1101/gad.1494707

PubMed ID: 18326031

Title: The AU-rich element mRNA decay-promoting activity of BRF1 is regulated by mitogen-activated protein kinase-activated protein kinase 2.

PubMed ID: 18326031

DOI: 10.1261/rna.983708

PubMed ID: 19179481

Title: cAMP-dependent posttranscriptional regulation of steroidogenic acute regulatory (STAR) protein by the zinc finger protein ZFP36L1/TIS11b.

PubMed ID: 19179481

DOI: 10.1210/me.2008-0296

PubMed ID: 20166898

Title: ZFP36L1 is regulated by growth factors and cytokines in keratinocytes and influences their VEGF production.

PubMed ID: 20166898

DOI: 10.3109/08977190903578660

PubMed ID: 20702587

Title: ZFP36L1 negatively regulates erythroid differentiation of CD34+ hematopoietic stem cells by interfering with the Stat5b pathway.

PubMed ID: 20702587

DOI: 10.1091/mbc.e10-01-0040

PubMed ID: 21832157

Title: A novel function of Tis11b/BRF1 as a regulator of Dll4 mRNA 3'-end processing.

PubMed ID: 21832157

DOI: 10.1091/mbc.e11-02-0149

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24700863

Title: Hypertonicity compromises renal mineralocorticoid receptor signaling through Tis11b-mediated post-transcriptional control.

PubMed ID: 24700863

DOI: 10.1681/asn.2013091023

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25106868

Title: ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway.

PubMed ID: 25106868

DOI: 10.1093/nar/gku652

PubMed ID: 25014217

Title: Post-transcriptional regulation of BCL2 mRNA by the RNA-binding protein ZFP36L1 in malignant B cells.

PubMed ID: 25014217

DOI: 10.1371/journal.pone.0102625

PubMed ID: 26542173

Title: ZFP36L1 promotes monocyte/macrophage differentiation by repressing CDK6.

PubMed ID: 26542173

DOI: 10.1038/srep16229

PubMed ID: 27182009

Title: Functional analysis of ZFP36 proteins in keratinocytes.

PubMed ID: 27182009

DOI: 10.1016/j.ejcb.2016.04.007

PubMed ID: 15713487

Title: Thermodynamic and structural equivalence of two HLA-B27 subtypes complexed with a self-peptide.

PubMed ID: 15713487

DOI: 10.1016/j.jmb.2004.12.047

Sequence Information:

Length: 338
Mass: 36314
Checksum: 98236CD40C4531D2
Sequence:

MTTTLVSATI FDLSEVLCKG NKMLNYSAPS AGGCLLDRKA VGTPAGGGFP RRHSVTLPSS 
KFHQNQLLSS LKGEPAPALS SRDSRFRDRS FSEGGERLLP TQKQPGGGQV NSSRYKTELC 
RPFEENGACK YGDKCQFAHG IHELRSLTRH PKYKTELCRT FHTIGFCPYG PRCHFIHNAE 
ERRALAGARD LSADRPRLQH SFSFAGFPSA AATAAATGLL DSPTSITPPP ILSADDLLGS 
PTLPDGTNNP FAFSSQELAS LFAPSMGLPG GGSPTTFLFR PMSESPHMFD SPPSPQDSLS 
DQEGYLSSSS SSHSGSDSPT LDNSRRLPIF SRLSISDD

Genular Protein ID: 373451243

Symbol: B3KNA8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KNA8

Database IDs:

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

Length: 338
Mass: 36342
Checksum: F04EDA0F6103D5BC
Sequence:

MTTTLVSATI FDLSEVLCKG NKMLNYSAPS AGGCLLDRKA VGTPAGGGFP RRHSVTLPSS 
KFHQNQLLSS LKGEPAPALS SRDSRFRDRS FSEGGERLLP TRKQPGGGQV NSSRYKTELC 
RPFEENGACK YGDKCQFAHG IHELRSLTRH PKYKTELCRT FHTIGFCPYG PRCHFIHNAE 
ERRALAGARD LSADRPRLQH SFSFAGFPSA AATAAATGLL DSPTSITPPP ILSADDLLGS 
PTLPDGTNNP FAFSSQELAS LFAPSMGLPG GGSPTTFLFR PMSESPHMFD SPPSPQDSLS 
DQEGYLSSSS SSHSGSDSPT LDNSRRLPIF SRLSISDD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ZFP36L1

Associated with

Other Information

Coding sequence of ERF-1, the human homologue of Tis11b/cMG1, members of the Tis11 family of early response genes. PubMed ID: 8346037

Cloning and characterization of ERF-1, a human member of the Tis11 family of early-response genes. PubMed ID: 8024689

Distinct mechanisms for rescue from apoptosis in Ramos human B cells by signaling through CD40 and interleukin-4 receptor: role for inhibition of an early response gene, Berg36. PubMed ID: 8898945

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Differential effects of sodium butyrate on the transcription of the human TIS11 family of early-response genes in colorectal cancer cells. PubMed ID: 10367403

Functional cloning of BRF1, a regulator of ARE-dependent mRNA turnover. PubMed ID: 12198173

Butyrate response factor 1 is regulated by parathyroid hormone and bone morphogenetic protein-2 in osteoblastic cells. PubMed ID: 15465005

The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B. PubMed ID: 15538381

Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b. PubMed ID: 15467755

Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1. PubMed ID: 15687258

Stress granules and processing bodies are dynamically linked sites of mRNP remodeling. PubMed ID: 15967811

BRF1 protein turnover and mRNA decay activity are regulated by protein kinase B at the same phosphorylation sites. PubMed ID: 17030608

TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements. PubMed ID: 17369404

The AU-rich element mRNA decay-promoting activity of BRF1 is regulated by mitogen-activated protein kinase-activated protein kinase 2. PubMed ID: 18326031

cAMP-dependent posttranscriptional regulation of steroidogenic acute regulatory (STAR) protein by the zinc finger protein ZFP36L1/TIS11b. PubMed ID: 19179481

ZFP36L1 is regulated by growth factors and cytokines in keratinocytes and influences their VEGF production. PubMed ID: 20166898

ZFP36L1 negatively regulates erythroid differentiation of CD34+ hematopoietic stem cells by interfering with the Stat5b pathway. PubMed ID: 20702587

A novel function of Tis11b/BRF1 as a regulator of Dll4 mRNA 3'-end processing. PubMed ID: 21832157

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Hypertonicity compromises renal mineralocorticoid receptor signaling through Tis11b-mediated post-transcriptional control. PubMed ID: 24700863

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway. PubMed ID: 25106868

Post-transcriptional regulation of BCL2 mRNA by the RNA-binding protein ZFP36L1 in malignant B cells. PubMed ID: 25014217

ZFP36L1 promotes monocyte/macrophage differentiation by repressing CDK6. PubMed ID: 26542173

Functional analysis of ZFP36 proteins in keratinocytes. PubMed ID: 27182009

Thermodynamic and structural equivalence of two HLA-B27 subtypes complexed with a self-peptide. PubMed ID: 15713487

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039