Details for: ZFP36L1

Gene ID: 677

Symbol: ZFP36L1

Ensembl ID: ENSG00000185650

Description: ZFP36 ring finger protein like 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 4.64
    Marker Score: 6042
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 4.16
    Marker Score: 8714.5
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 4.07
    Marker Score: 3520
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 4.05
    Marker Score: 16876
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 4.05
    Marker Score: 2809
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 4.03
    Marker Score: 4299.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.03
    Marker Score: 136975
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.98
    Marker Score: 52469
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 3.83
    Marker Score: 2162
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.7
    Marker Score: 27539
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.67
    Marker Score: 23848
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.66
    Marker Score: 2862.5
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.63
    Marker Score: 6618
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 3.6
    Marker Score: 48327
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 3.6
    Marker Score: 4438
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.57
    Marker Score: 18753
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.42
    Marker Score: 2915
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 3.36
    Marker Score: 2370
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.29
    Marker Score: 5071
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 3.24
    Marker Score: 2891
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.2
    Marker Score: 5251.5
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.19
    Marker Score: 3040
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.16
    Marker Score: 3814
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.14
    Marker Score: 5904
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.13
    Marker Score: 4531.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.09
    Marker Score: 3255
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 3.08
    Marker Score: 1325
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.07
    Marker Score: 7795
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.04
    Marker Score: 3481
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.03
    Marker Score: 26636
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 3.03
    Marker Score: 1095
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3
    Marker Score: 167910
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 3
    Marker Score: 1491
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.97
    Marker Score: 3466
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 2.96
    Marker Score: 2862
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.94
    Marker Score: 1225
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.93
    Marker Score: 3782
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.93
    Marker Score: 7153
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.92
    Marker Score: 1066
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.92
    Marker Score: 2076
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.88
    Marker Score: 3474
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.87
    Marker Score: 18721
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.86
    Marker Score: 2167
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.86
    Marker Score: 7487
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.85
    Marker Score: 28643
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.84
    Marker Score: 5671
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.83
    Marker Score: 3045
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.8
    Marker Score: 4889
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.78
    Marker Score: 1586
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.78
    Marker Score: 31311
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.77
    Marker Score: 888
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.75
    Marker Score: 7493
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.72
    Marker Score: 921
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.71
    Marker Score: 2425
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.7
    Marker Score: 31440.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.7
    Marker Score: 3163
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.7
    Marker Score: 1794
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.7
    Marker Score: 1101.5
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.69
    Marker Score: 1639
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.69
    Marker Score: 2686
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.66
    Marker Score: 11462
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 2.66
    Marker Score: 1342
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.66
    Marker Score: 1748
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.65
    Marker Score: 2346
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.62
    Marker Score: 2917
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.62
    Marker Score: 4498
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.62
    Marker Score: 6606
  • Cell Name: theca cell (CL0000503)
    Fold Change: 2.62
    Marker Score: 1875
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.62
    Marker Score: 2796
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.61
    Marker Score: 624
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.61
    Marker Score: 1217
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.6
    Marker Score: 5064
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.58
    Marker Score: 3545
  • Cell Name: pericyte (CL0000669)
    Fold Change: 2.57
    Marker Score: 1504
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.57
    Marker Score: 2418
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.57
    Marker Score: 8407
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 2.56
    Marker Score: 1443.5
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.56
    Marker Score: 4330
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.56
    Marker Score: 15171
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.55
    Marker Score: 809
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.55
    Marker Score: 5322.5
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.54
    Marker Score: 962
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.54
    Marker Score: 5981
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.54
    Marker Score: 19820
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.53
    Marker Score: 25016
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.5
    Marker Score: 2120
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.49
    Marker Score: 131853
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 2.49
    Marker Score: 614
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.49
    Marker Score: 4225
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.46
    Marker Score: 2315
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 2.46
    Marker Score: 2042
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.45
    Marker Score: 6574
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 2.45
    Marker Score: 1493
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.44
    Marker Score: 4452
  • Cell Name: PP cell (CL0000696)
    Fold Change: 2.44
    Marker Score: 550
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.43
    Marker Score: 1918
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.43
    Marker Score: 2028
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.42
    Marker Score: 9342
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.42
    Marker Score: 584
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.42
    Marker Score: 2571

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Other Information

**Key characteristics:** * ZFP36L1 is a protein of the RING family of transcription factors. * It is found in the nucleus and cytoplasm of cells. * It is a key regulator of gene expression, and its expression is controlled by a variety of factors, including growth factors, cytokines, and microRNAs. * ZFP36L1 is involved in the regulation of apoptosis, cell proliferation, and metabolism. **Pathways and functions:** * ZFP36L1 is involved in the regulation of apoptosis. It is a key regulator of the expression of genes involved in apoptosis, including those encoding pro-apoptotic proteins and anti-apoptotic proteins. * It is also involved in the regulation of cell proliferation. It is a key regulator of the expression of genes involved in cell cycle progression, including those encoding cyclin-dependent kinase inhibitors and cell cycle checkpoints. * ZFP36L1 is also involved in the regulation of metabolism. It is a key regulator of the expression of genes involved in lipid metabolism, including those encoding fatty acids, cholesterol, and cholesterol derivatives. **Clinical significance:** ZFP36L1 is a potential therapeutic target for a variety of diseases. It is a target for cancer immunotherapy, and it is being investigated as a potential treatment for a variety of cancers, including breast cancer, lung cancer, and colon cancer.

Genular Protein ID: 4127376403

Symbol: TISB_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q07352 Q13851

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 58 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8346037

Title: Coding sequence of ERF-1, the human homologue of Tis11b/cMG1, members of the Tis11 family of early response genes.

PubMed ID: 8346037

DOI: 10.1093/nar/21.15.3580

PubMed ID: 8024689

Title: Cloning and characterization of ERF-1, a human member of the Tis11 family of early-response genes.

PubMed ID: 8024689

DOI: 10.1089/dna.1994.13.449

PubMed ID: 8898945

Title: Distinct mechanisms for rescue from apoptosis in Ramos human B cells by signaling through CD40 and interleukin-4 receptor: role for inhibition of an early response gene, Berg36.

PubMed ID: 8898945

DOI: 10.1002/eji.1830261013

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10367403

Title: Differential effects of sodium butyrate on the transcription of the human TIS11 family of early-response genes in colorectal cancer cells.

PubMed ID: 10367403

PubMed ID: 12198173

Title: Functional cloning of BRF1, a regulator of ARE-dependent mRNA turnover.

PubMed ID: 12198173

DOI: 10.1093/emboj/cdf444

PubMed ID: 15465005

Title: Butyrate response factor 1 is regulated by parathyroid hormone and bone morphogenetic protein-2 in osteoblastic cells.

PubMed ID: 15465005

DOI: 10.1016/j.bbrc.2004.09.030

PubMed ID: 15538381

Title: The ARE-dependent mRNA-destabilizing activity of BRF1 is regulated by protein kinase B.

PubMed ID: 15538381

DOI: 10.1038/sj.emboj.7600477

PubMed ID: 15467755

Title: Destabilization of vascular endothelial growth factor mRNA by the zinc-finger protein TIS11b.

PubMed ID: 15467755

DOI: 10.1038/sj.onc.1207939

PubMed ID: 15687258

Title: Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1.

PubMed ID: 15687258

DOI: 10.1101/gad.1282305

PubMed ID: 15967811

Title: Stress granules and processing bodies are dynamically linked sites of mRNP remodeling.

PubMed ID: 15967811

DOI: 10.1083/jcb.200502088

PubMed ID: 17030608

Title: BRF1 protein turnover and mRNA decay activity are regulated by protein kinase B at the same phosphorylation sites.

PubMed ID: 17030608

DOI: 10.1128/mcb.01099-06

PubMed ID: 17369404

Title: TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements.

PubMed ID: 17369404

DOI: 10.1101/gad.1494707

PubMed ID: 18326031

Title: The AU-rich element mRNA decay-promoting activity of BRF1 is regulated by mitogen-activated protein kinase-activated protein kinase 2.

PubMed ID: 18326031

DOI: 10.1261/rna.983708

PubMed ID: 19179481

Title: cAMP-dependent posttranscriptional regulation of steroidogenic acute regulatory (STAR) protein by the zinc finger protein ZFP36L1/TIS11b.

PubMed ID: 19179481

DOI: 10.1210/me.2008-0296

PubMed ID: 20166898

Title: ZFP36L1 is regulated by growth factors and cytokines in keratinocytes and influences their VEGF production.

PubMed ID: 20166898

DOI: 10.3109/08977190903578660

PubMed ID: 20702587

Title: ZFP36L1 negatively regulates erythroid differentiation of CD34+ hematopoietic stem cells by interfering with the Stat5b pathway.

PubMed ID: 20702587

DOI: 10.1091/mbc.e10-01-0040

PubMed ID: 21832157

Title: A novel function of Tis11b/BRF1 as a regulator of Dll4 mRNA 3'-end processing.

PubMed ID: 21832157

DOI: 10.1091/mbc.e11-02-0149

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24700863

Title: Hypertonicity compromises renal mineralocorticoid receptor signaling through Tis11b-mediated post-transcriptional control.

PubMed ID: 24700863

DOI: 10.1681/asn.2013091023

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25106868

Title: ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway.

PubMed ID: 25106868

DOI: 10.1093/nar/gku652

PubMed ID: 25014217

Title: Post-transcriptional regulation of BCL2 mRNA by the RNA-binding protein ZFP36L1 in malignant B cells.

PubMed ID: 25014217

DOI: 10.1371/journal.pone.0102625

PubMed ID: 26542173

Title: ZFP36L1 promotes monocyte/macrophage differentiation by repressing CDK6.

PubMed ID: 26542173

DOI: 10.1038/srep16229

PubMed ID: 27182009

Title: Functional analysis of ZFP36 proteins in keratinocytes.

PubMed ID: 27182009

DOI: 10.1016/j.ejcb.2016.04.007

PubMed ID: 15713487

Title: Thermodynamic and structural equivalence of two HLA-B27 subtypes complexed with a self-peptide.

PubMed ID: 15713487

DOI: 10.1016/j.jmb.2004.12.047

Sequence Information:

  • Length: 338
  • Mass: 36314
  • Checksum: 98236CD40C4531D2
  • Sequence:
    • MTTTLVSATI FDLSEVLCKG NKMLNYSAPS AGGCLLDRKA VGTPAGGGFP RRHSVTLPSS 
KFHQNQLLSS LKGEPAPALS SRDSRFRDRS FSEGGERLLP TQKQPGGGQV NSSRYKTELC 
RPFEENGACK YGDKCQFAHG IHELRSLTRH PKYKTELCRT FHTIGFCPYG PRCHFIHNAE 
ERRALAGARD LSADRPRLQH SFSFAGFPSA AATAAATGLL DSPTSITPPP ILSADDLLGS 
PTLPDGTNNP FAFSSQELAS LFAPSMGLPG GGSPTTFLFR PMSESPHMFD SPPSPQDSLS 
DQEGYLSSSS SSHSGSDSPT LDNSRRLPIF SRLSISDD

Genular Protein ID: 373451243

Symbol: B3KNA8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KNA8

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 7 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 2 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 338
  • Mass: 36342
  • Checksum: F04EDA0F6103D5BC
  • Sequence:
    • MTTTLVSATI FDLSEVLCKG NKMLNYSAPS AGGCLLDRKA VGTPAGGGFP RRHSVTLPSS 
KFHQNQLLSS LKGEPAPALS SRDSRFRDRS FSEGGERLLP TRKQPGGGQV NSSRYKTELC 
RPFEENGACK YGDKCQFAHG IHELRSLTRH PKYKTELCRT FHTIGFCPYG PRCHFIHNAE 
ERRALAGARD LSADRPRLQH SFSFAGFPSA AATAAATGLL DSPTSITPPP ILSADDLLGS 
PTLPDGTNNP FAFSSQELAS LFAPSMGLPG GGSPTTFLFR PMSESPHMFD SPPSPQDSLS 
DQEGYLSSSS SSHSGSDSPT LDNSRRLPIF SRLSISDD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.