Gene ZFP36L2 - ENSG00000152518 | NCBI Gene ID: 678

Details for: ZFP36L2

Gene ID: 678

Symbol: ZFP36L2

Ensembl ID: ENSG00000152518

Description: ZFP36 ring finger protein like 2

Associated with

Developmental biology
(R-HSA-1266738)
M-decay: degradation of maternal mrnas by maternally stored factors
(R-HSA-9820841)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
3'-utr-mediated mrna destabilization
(GO:0061158)
Cellular response to epidermal growth factor stimulus
(GO:0071364)
Cellular response to fibroblast growth factor stimulus
(GO:0044344)
Cellular response to glucocorticoid stimulus
(GO:0071385)
Cellular response to granulocyte macrophage colony-stimulating factor stimulus
(GO:0097011)
Cellular response to transforming growth factor beta stimulus
(GO:0071560)
Cellular response to tumor necrosis factor
(GO:0071356)
Cytoplasm
(GO:0005737)
Definitive hemopoiesis
(GO:0060216)
Erk1 and erk2 cascade
(GO:0070371)
Hemopoiesis
(GO:0030097)
Metal ion binding
(GO:0046872)
Mrna 3'-utr au-rich region binding
(GO:0035925)
Mrna catabolic process
(GO:0006402)
Negative regulation of fat cell differentiation
(GO:0045599)
Negative regulation of mitotic cell cycle phase transition
(GO:1901991)
Negative regulation of stem cell differentiation
(GO:2000737)
Nuclear-transcribed mrna catabolic process, deadenylation-dependent decay
(GO:0000288)
Nucleus
(GO:0005634)
Positive regulation of nuclear-transcribed mrna catabolic process, deadenylation-dependent decay
(GO:1900153)
Protein binding
(GO:0005515)
Regulation of b cell differentiation
(GO:0045577)
Regulation of mrna stability
(GO:0043488)
Regulation of translation
(GO:0006417)
Response to wounding
(GO:0009611)
Ribonucleoprotein complex
(GO:1990904)
Rna binding
(GO:0003723)
Somatic stem cell division
(GO:0048103)
Somatic stem cell population maintenance
(GO:0035019)
T cell differentiation in thymus
(GO:0033077)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: early promyelocyte (CL0002154)
Fold Change: 5.13
Marker Score: 4109
Cell Name: mature T cell (CL0002419)
Fold Change: 4.58
Marker Score: 45351
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 4.49
Marker Score: 13119
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 4.23
Marker Score: 13359.5
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 4.19
Marker Score: 11747
Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
Fold Change: 4.18
Marker Score: 3036
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 4.16
Marker Score: 11484
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 3.98
Marker Score: 17051
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 3.95
Marker Score: 208698
Cell Name: natural T-regulatory cell (CL0000903)
Fold Change: 3.87
Marker Score: 1988
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 3.82
Marker Score: 2238.5
Cell Name: memory T cell (CL0000813)
Fold Change: 3.68
Marker Score: 1580
Cell Name: naive T cell (CL0000898)
Fold Change: 3.67
Marker Score: 2362
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 3.59
Marker Score: 2810
Cell Name: CD38-negative naive B cell (CL0002102)
Fold Change: 3.52
Marker Score: 7387
Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 3.52
Marker Score: 2964
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 3.49
Marker Score: 3434
Cell Name: double negative thymocyte (CL0002489)
Fold Change: 3.44
Marker Score: 4750
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 3.43
Marker Score: 5053
Cell Name: alpha-beta T cell (CL0000789)
Fold Change: 3.41
Marker Score: 2584
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 3.38
Marker Score: 1864
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 3.38
Marker Score: 5793
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.29
Marker Score: 184071
Cell Name: acinar cell (CL0000622)
Fold Change: 3.29
Marker Score: 2320.5
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.28
Marker Score: 111446
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.26
Marker Score: 7954
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 3.23
Marker Score: 1614
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.17
Marker Score: 3380
Cell Name: naive B cell (CL0000788)
Fold Change: 3.16
Marker Score: 2826
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 3.12
Marker Score: 1015
Cell Name: late promyelocyte (CL0002151)
Fold Change: 3.11
Marker Score: 780
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 3.09
Marker Score: 1899
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 3.08
Marker Score: 2887
Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 3.08
Marker Score: 1533
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 3.06
Marker Score: 1321
Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
Fold Change: 3.03
Marker Score: 2218
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 2.99
Marker Score: 1965
Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
Fold Change: 2.98
Marker Score: 6712.5
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 2.97
Marker Score: 1004
Cell Name: mesodermal cell (CL0000222)
Fold Change: 2.95
Marker Score: 38964
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 2.93
Marker Score: 907
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.86
Marker Score: 28936
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 2.85
Marker Score: 7456
Cell Name: myelocyte (CL0002193)
Fold Change: 2.84
Marker Score: 1227
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 2.81
Marker Score: 3126
Cell Name: reticular cell (CL0000432)
Fold Change: 2.8
Marker Score: 1022
Cell Name: inflammatory cell (CL0009002)
Fold Change: 2.79
Marker Score: 1199
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 2.78
Marker Score: 4563
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 2.76
Marker Score: 909
Cell Name: lung macrophage (CL1001603)
Fold Change: 2.75
Marker Score: 3151
Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 2.73
Marker Score: 953
Cell Name: ILC1, human (CL0001077)
Fold Change: 2.73
Marker Score: 692
Cell Name: microglial cell (CL0000129)
Fold Change: 2.71
Marker Score: 4933
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.69
Marker Score: 643
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 2.68
Marker Score: 2019
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 2.67
Marker Score: 1933
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 2.65
Marker Score: 5164
Cell Name: innate lymphoid cell (CL0001065)
Fold Change: 2.63
Marker Score: 946
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 2.63
Marker Score: 1282
Cell Name: memory B cell (CL0000787)
Fold Change: 2.62
Marker Score: 1985
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 2.62
Marker Score: 3229
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 2.61
Marker Score: 1575
Cell Name: pro-T cell (CL0000827)
Fold Change: 2.59
Marker Score: 10607
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.59
Marker Score: 5176
Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 2.57
Marker Score: 2772
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.56
Marker Score: 9877
Cell Name: exhausted T cell (CL0011025)
Fold Change: 2.53
Marker Score: 1454
Cell Name: Unknown (CL0000548)
Fold Change: 2.52
Marker Score: 1836
Cell Name: T follicular helper cell (CL0002038)
Fold Change: 2.5
Marker Score: 2074
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 2.49
Marker Score: 1460
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 2.48
Marker Score: 879
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 2.48
Marker Score: 2031.5
Cell Name: mucosal invariant T cell (CL0000940)
Fold Change: 2.47
Marker Score: 2199
Cell Name: stromal cell (CL0000499)
Fold Change: 2.46
Marker Score: 2878
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 2.45
Marker Score: 745
Cell Name: bronchial epithelial cell (CL0002328)
Fold Change: 2.44
Marker Score: 645
Cell Name: adventitial cell (CL0002503)
Fold Change: 2.42
Marker Score: 598
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2.42
Marker Score: 4091
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 2.41
Marker Score: 2141
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 2.4
Marker Score: 7526
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 2.39
Marker Score: 2246
Cell Name: PP cell (CL0000696)
Fold Change: 2.38
Marker Score: 535
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 2.37
Marker Score: 2093
Cell Name: regulatory T cell (CL0000815)
Fold Change: 2.37
Marker Score: 2619
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.36
Marker Score: 15346
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 2.32
Marker Score: 874
Cell Name: group 3 innate lymphoid cell (CL0001071)
Fold Change: 2.31
Marker Score: 968.5
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.3
Marker Score: 25940
Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
Fold Change: 2.3
Marker Score: 3747
Cell Name: CD4-positive helper T cell (CL0000492)
Fold Change: 2.3
Marker Score: 2504
Cell Name: erythroblast (CL0000765)
Fold Change: 2.3
Marker Score: 1437
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 2.29
Marker Score: 5707
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 2.28
Marker Score: 642
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 2.27
Marker Score: 794
Cell Name: lymphocyte (CL0000542)
Fold Change: 2.27
Marker Score: 1144
Cell Name: keratocyte (CL0002363)
Fold Change: 2.26
Marker Score: 521
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 2.26
Marker Score: 1927
Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 2.26
Marker Score: 496
Cell Name: endothelial cell (CL0000115)
Fold Change: 2.25
Marker Score: 2019
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 2.25
Marker Score: 918

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**Key characteristics:** * ZFP36L2 is a protein of the ZF protein family. * It is expressed in a variety of cell types. * It is a key regulator of b cell differentiation. * It plays a role in the regulation of mrna stability and translation. * It is involved in the negative regulation of fat cell differentiation. **Pathways and functions:** * ZFP36L2 is involved in the cellular response to fibroblast growth factor stimulus. * It is a key regulator of developmental biology. * It plays a role in the hematopoiesis process, as it is expressed in a variety of hematopoietic cell types. * It is involved in the M-decay: degradation of maternal mrnas by maternally stored factors. * It is involved in the Maternal to zygotic transition (mzt). * It is involved in the regulation of the negative regulation of fat cell differentiation. * It is involved in the regulation of protein binding. * It plays a role in the regulation of mrna stability and translation. * It is involved in the response to wounding. * It is involved in the regulation of T cell differentiation in the thymus. **Clinical significance:** * Mutations in ZFP36L2 have been linked to a number of human diseases, including cancer, autoimmune disorders, and metabolic disorders. * Targeting ZFP36L2 has been investigated as a potential treatment for these diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

TISD_HUMAN

Genular Protein ID: 2812763884

Symbol: TISD_HUMAN

Name: N/A

UniProtKB Accession Codes:

P47974 Q53TB4 Q9BSJ3

Database IDs:

Citations:

PubMed ID: 8545129

Title: Identification of a member of the TIS11 early response gene family at the insertion point of a DNA fragment containing a gene for the T-cell receptor beta chain in an acute T-cell leukemia.

PubMed ID: 8545129

PubMed ID: 7835719

Title: ERF-2, the human homologue of the murine Tis11d early response gene.

PubMed ID: 7835719

DOI: 10.1016/0378-1119(94)00696-p

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10367403

Title: Differential effects of sodium butyrate on the transcription of the human TIS11 family of early-response genes in colorectal cancer cells.

PubMed ID: 10367403

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20166898

Title: ZFP36L1 is regulated by growth factors and cytokines in keratinocytes and influences their VEGF production.

PubMed ID: 20166898

DOI: 10.3109/08977190903578660

PubMed ID: 20506496

Title: A computational study of RNA binding and specificity in the tandem zinc finger domain of TIS11d.

PubMed ID: 20506496

DOI: 10.1002/pro.401

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21109922

Title: Mutation in the RNA binding protein TIS11D/ZFP36L2 is associated with the pathogenesis of acute leukemia.

PubMed ID: 21109922

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25106868

Title: ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway.

PubMed ID: 25106868

DOI: 10.1093/nar/gku652

PubMed ID: 27182009

Title: Functional analysis of ZFP36 proteins in keratinocytes.

PubMed ID: 27182009

DOI: 10.1016/j.ejcb.2016.04.007

PubMed ID: 34611029

Title: Biallelic variants in ZFP36L2 cause female infertility characterised by recurrent preimplantation embryo arrest.

PubMed ID: 34611029

DOI: 10.1136/jmedgenet-2021-107933

PubMed ID: 14981510

Title: Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d.

PubMed ID: 14981510

DOI: 10.1038/nsmb738

Sequence Information:

Length: 494
Mass: 51063
Checksum: 10E23FA9E2DDABD4
Sequence:

MSTTLLSAFY DVDFLCKTEK SLANLNLNNM LDKKAVGTPV AAAPSSGFAP GFLRRHSASN 
LHALAHPAPS PGSCSPKFPG AANGSSCGSA AAGGPTSYGT LKEPSGGGGT ALLNKENKFR 
DRSFSENGDR SQHLLHLQQQ QKGGGGSQIN STRYKTELCR PFEESGTCKY GEKCQFAHGF 
HELRSLTRHP KYKTELCRTF HTIGFCPYGP RCHFIHNADE RRPAPSGGAS GDLRAFGTRD 
ALHLGFPREP RPKLHHSLSF SGFPSGHHQP PGGLESPLLL DSPTSRTPPP PSCSSASSCS 
SSASSCSSAS AASTPSGAPT CCASAAAAAA AALLYGTGGA EDLLAPGAPC AACSSASCAN 
NAFAFGPELS SLITPLAIQT HNFAAVAAAA YYRSQQQQQQ QGLAPPAQPP APPSATLPAG 
AAAPPSPPFS FQLPRRLSDS PVFDAPPSPP DSLSDRDSYL SGSLSSGSLS GSESPSLDPG 
RRLPIFSRLS ISDD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: ZFP36L2

Associated with

Cells (max top 100)

Other Information

Identification of a member of the TIS11 early response gene family at the insertion point of a DNA fragment containing a gene for the T-cell receptor beta chain in an acute T-cell leukemia. PubMed ID: 8545129

ERF-2, the human homologue of the murine Tis11d early response gene. PubMed ID: 7835719

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Differential effects of sodium butyrate on the transcription of the human TIS11 family of early-response genes in colorectal cancer cells. PubMed ID: 10367403

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

ZFP36L1 is regulated by growth factors and cytokines in keratinocytes and influences their VEGF production. PubMed ID: 20166898

A computational study of RNA binding and specificity in the tandem zinc finger domain of TIS11d. PubMed ID: 20506496

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Mutation in the RNA binding protein TIS11D/ZFP36L2 is associated with the pathogenesis of acute leukemia. PubMed ID: 21109922

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway. PubMed ID: 25106868

Functional analysis of ZFP36 proteins in keratinocytes. PubMed ID: 27182009

Biallelic variants in ZFP36L2 cause female infertility characterised by recurrent preimplantation embryo arrest. PubMed ID: 34611029

Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d. PubMed ID: 14981510