ZFP36L2 | ENSG00000152518 | NCBI 678

Details for: ZFP36L2

Gene ID: 678

Symbol: ZFP36L2

Ensembl ID: ENSG00000152518

Description: ZFP36 ring finger protein like 2

Associated with

Developmental biology
(R-HSA-1266738)
M-decay: degradation of maternal mrnas by maternally stored factors
(R-HSA-9820841)
Maternal to zygotic transition (mzt)
(R-HSA-9816359)
3'-utr-mediated mrna destabilization
(GO:0061158)
Cellular response to epidermal growth factor stimulus
(GO:0071364)
Cellular response to fibroblast growth factor stimulus
(GO:0044344)
Cellular response to glucocorticoid stimulus
(GO:0071385)
Cellular response to granulocyte macrophage colony-stimulating factor stimulus
(GO:0097011)
Cellular response to transforming growth factor beta stimulus
(GO:0071560)
Cellular response to tumor necrosis factor
(GO:0071356)
Cytoplasm
(GO:0005737)
Definitive hemopoiesis
(GO:0060216)
Erk1 and erk2 cascade
(GO:0070371)
Hemopoiesis
(GO:0030097)
Metal ion binding
(GO:0046872)
Mrna 3'-utr au-rich region binding
(GO:0035925)
Mrna catabolic process
(GO:0006402)
Negative regulation of fat cell differentiation
(GO:0045599)
Negative regulation of mitotic cell cycle phase transition
(GO:1901991)
Negative regulation of stem cell differentiation
(GO:2000737)
Nuclear-transcribed mrna catabolic process, deadenylation-dependent decay
(GO:0000288)
Nucleus
(GO:0005634)
Positive regulation of nuclear-transcribed mrna catabolic process, deadenylation-dependent decay
(GO:1900153)
Protein binding
(GO:0005515)
Regulation of b cell differentiation
(GO:0045577)
Regulation of mrna stability
(GO:0043488)
Regulation of translation
(GO:0006417)
Response to wounding
(GO:0009611)
Ribonucleoprotein complex
(GO:1990904)
Rna binding
(GO:0003723)
Somatic stem cell division
(GO:0048103)
Somatic stem cell population maintenance
(GO:0035019)
T cell differentiation in thymus
(GO:0033077)

Other Information

Proteins

TISD_HUMAN

Genular Protein ID: 2812763884

Symbol: TISD_HUMAN

Name: N/A

UniProtKB Accession Codes:

P47974 Q53TB4 Q9BSJ3

Database IDs:

Citations:

PubMed ID: 8545129

Title: Identification of a member of the TIS11 early response gene family at the insertion point of a DNA fragment containing a gene for the T-cell receptor beta chain in an acute T-cell leukemia.

PubMed ID: 8545129

PubMed ID: 7835719

Title: ERF-2, the human homologue of the murine Tis11d early response gene.

PubMed ID: 7835719

DOI: 10.1016/0378-1119(94)00696-p

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10367403

Title: Differential effects of sodium butyrate on the transcription of the human TIS11 family of early-response genes in colorectal cancer cells.

PubMed ID: 10367403

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20166898

Title: ZFP36L1 is regulated by growth factors and cytokines in keratinocytes and influences their VEGF production.

PubMed ID: 20166898

DOI: 10.3109/08977190903578660

PubMed ID: 20506496

Title: A computational study of RNA binding and specificity in the tandem zinc finger domain of TIS11d.

PubMed ID: 20506496

DOI: 10.1002/pro.401

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21109922

Title: Mutation in the RNA binding protein TIS11D/ZFP36L2 is associated with the pathogenesis of acute leukemia.

PubMed ID: 21109922

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25106868

Title: ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway.

PubMed ID: 25106868

DOI: 10.1093/nar/gku652

PubMed ID: 27182009

Title: Functional analysis of ZFP36 proteins in keratinocytes.

PubMed ID: 27182009

DOI: 10.1016/j.ejcb.2016.04.007

PubMed ID: 34611029

Title: Biallelic variants in ZFP36L2 cause female infertility characterised by recurrent preimplantation embryo arrest.

PubMed ID: 34611029

DOI: 10.1136/jmedgenet-2021-107933

PubMed ID: 14981510

Title: Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d.

PubMed ID: 14981510

DOI: 10.1038/nsmb738

Sequence Information:

Length: 494
Mass: 51063
Checksum: 10E23FA9E2DDABD4
Sequence:

MSTTLLSAFY DVDFLCKTEK SLANLNLNNM LDKKAVGTPV AAAPSSGFAP GFLRRHSASN 
LHALAHPAPS PGSCSPKFPG AANGSSCGSA AAGGPTSYGT LKEPSGGGGT ALLNKENKFR 
DRSFSENGDR SQHLLHLQQQ QKGGGGSQIN STRYKTELCR PFEESGTCKY GEKCQFAHGF 
HELRSLTRHP KYKTELCRTF HTIGFCPYGP RCHFIHNADE RRPAPSGGAS GDLRAFGTRD 
ALHLGFPREP RPKLHHSLSF SGFPSGHHQP PGGLESPLLL DSPTSRTPPP PSCSSASSCS 
SSASSCSSAS AASTPSGAPT CCASAAAAAA AALLYGTGGA EDLLAPGAPC AACSSASCAN 
NAFAFGPELS SLITPLAIQT HNFAAVAAAA YYRSQQQQQQ QGLAPPAQPP APPSATLPAG 
AAAPPSPPFS FQLPRRLSDS PVFDAPPSPP DSLSDRDSYL SGSLSSGSLS GSESPSLDPG 
RRLPIFSRLS ISDD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ZFP36L2

Associated with

Other Information

Identification of a member of the TIS11 early response gene family at the insertion point of a DNA fragment containing a gene for the T-cell receptor beta chain in an acute T-cell leukemia. PubMed ID: 8545129

ERF-2, the human homologue of the murine Tis11d early response gene. PubMed ID: 7835719

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Differential effects of sodium butyrate on the transcription of the human TIS11 family of early-response genes in colorectal cancer cells. PubMed ID: 10367403

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

ZFP36L1 is regulated by growth factors and cytokines in keratinocytes and influences their VEGF production. PubMed ID: 20166898

A computational study of RNA binding and specificity in the tandem zinc finger domain of TIS11d. PubMed ID: 20506496

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Mutation in the RNA binding protein TIS11D/ZFP36L2 is associated with the pathogenesis of acute leukemia. PubMed ID: 21109922

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway. PubMed ID: 25106868

Functional analysis of ZFP36 proteins in keratinocytes. PubMed ID: 27182009

Biallelic variants in ZFP36L2 cause female infertility characterised by recurrent preimplantation embryo arrest. PubMed ID: 34611029

Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d. PubMed ID: 14981510