Plpp3 | ENSMUSG00000028517 | NCBI 67916

Details for: Plpp3

Gene ID: 67916

Symbol: Plpp3

Ensembl ID: ENSMUSG00000028517

Description: phospholipid phosphatase 3

Associated with

Metabolism
(R-MMU-1430728)
Metabolism of lipids
(R-MMU-556833)
Sphingolipid catabolism
(R-MMU-9845614)
Sphingolipid metabolism
(R-MMU-428157)
Basolateral plasma membrane
(GO:0016323)
Bergmann glial cell differentiation
(GO:0060020)
Blood vessel development
(GO:0001568)
Cell-cell adhesion
(GO:0098609)
Cell-cell adhesion mediated by integrin
(GO:0033631)
Cell adhesion
(GO:0007155)
Ceramide-1-phosphate phosphatase activity
(GO:0106235)
Ceramide metabolic process
(GO:0006672)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum-golgi intermediate compartment membrane
(GO:0033116)
Endoplasmic reticulum exit site
(GO:0070971)
Endoplasmic reticulum membrane
(GO:0005789)
Gastrulation with mouth forming second
(GO:0001702)
Golgi apparatus
(GO:0005794)
Homotypic cell-cell adhesion
(GO:0034109)
Hydrolase activity
(GO:0016787)
Integrin-mediated signaling pathway
(GO:0007229)
Integrin binding
(GO:0005178)
Lipid metabolic process
(GO:0006629)
Lipid phosphatase activity
(GO:0042577)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Multicellular organism development
(GO:0007275)
Negative regulation of protein phosphorylation
(GO:0001933)
Phosphatidate phosphatase activity
(GO:0008195)
Phospholipid dephosphorylation
(GO:0046839)
Phospholipid metabolic process
(GO:0006644)
Plasma membrane
(GO:0005886)
Positive regulation of cell-cell adhesion
(GO:0022409)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of endothelial cell migration
(GO:0010595)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Protein stabilization
(GO:0050821)
Regulation of sphingolipid mediated signaling pathway
(GO:1902068)
Regulation of wnt signaling pathway
(GO:0030111)
Retrograde vesicle-mediated transport, golgi to endoplasmic reticulum
(GO:0006890)
Signal transduction
(GO:0007165)
Sphingosine-1-phosphate phosphatase activity
(GO:0042392)
Sphingosine metabolic process
(GO:0006670)
Trans-golgi network
(GO:0005802)
Wound healing
(GO:0042060)

Other Information

Proteins

Lipid phosphate phosphohydrolase 3

Genular Protein ID: 644097448

Symbol: PLPP3_MOUSE

Name: Lipid phosphate phosphohydrolase 3

UniProtKB Accession Codes:

Q99JY8 Q3TVM4 Q3TXR7 Q8BTB7

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12925589

Title: The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis and axis patterning.

PubMed ID: 12925589

DOI: 10.1242/dev.00635

PubMed ID: 16099422

Title: Murine lipid phosphate phosphohydrolase-3 acts as a cell-associated integrin ligand.

PubMed ID: 16099422

DOI: 10.1016/j.bbrc.2005.07.157

PubMed ID: 17610274

Title: Generation of a conditional Ppap2b/Lpp3 null allele.

PubMed ID: 17610274

DOI: 10.1002/dvg.20314

PubMed ID: 19123136

Title: Generation of a reporter-null allele of Ppap2b/Lpp3and its expression during embryogenesis.

PubMed ID: 19123136

DOI: 10.1387/ijdb.082745de

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21319224

Title: Expression of LPP3 in Bergmann glia is required for proper cerebellar sphingosine-1-phosphate metabolism/signaling and development.

PubMed ID: 21319224

DOI: 10.1002/glia.21126

PubMed ID: 27125875

Title: Endothelial lipid phosphate phosphatase-3 deficiency that disrupts the endothelial barrier function is a modifier of cardiovascular development.

PubMed ID: 27125875

DOI: 10.1093/cvr/cvw090

PubMed ID: 29889835

Title: Lipid phosphate phosphatase 3 regulates adipocyte sphingolipid synthesis, but not developmental adipogenesis or diet-induced obesity in mice.

PubMed ID: 29889835

DOI: 10.1371/journal.pone.0198063

Sequence Information:

Length: 312
Mass: 35216
Checksum: D782986E04B57D7D
Sequence:

MQSYKYDKAI VPESKNGGSP ALNNNPRKGG SKRVLLICLD LFCLFMAALP FLIIETSTIK 
PYRRGFYCND ESIKYPLKVS ETINDAVLCA VGIVIAILAI ITGEFYRIYY LKEKSRSTTQ 
NPYVAALYKQ VGCFLFGCAI SQSFTDIAKV SIGRLRPHFL SVCDPDFSQI NCSEGYIQNY 
RCRGEDSKVQ EARKSFFSGH ASFSMFTMLY LVLYLQARFT WRGARLLRPL LQFTLLMMAF 
YTGLSRVSDY KHHPSDVLAG FAQGALVACC IVFFVSDLFK TKTSLSLPAP AIRREILSPV 
DIIDRNNHHN MV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Plpp3

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The lipid phosphatase LPP3 regulates extra-embryonic vasculogenesis and axis patterning. PubMed ID: 12925589

Murine lipid phosphate phosphohydrolase-3 acts as a cell-associated integrin ligand. PubMed ID: 16099422

Generation of a conditional Ppap2b/Lpp3 null allele. PubMed ID: 17610274

Generation of a reporter-null allele of Ppap2b/Lpp3and its expression during embryogenesis. PubMed ID: 19123136

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Expression of LPP3 in Bergmann glia is required for proper cerebellar sphingosine-1-phosphate metabolism/signaling and development. PubMed ID: 21319224

Endothelial lipid phosphate phosphatase-3 deficiency that disrupts the endothelial barrier function is a modifier of cardiovascular development. PubMed ID: 27125875

Lipid phosphate phosphatase 3 regulates adipocyte sphingolipid synthesis, but not developmental adipogenesis or diet-induced obesity in mice. PubMed ID: 29889835