Details for: Mesd

Gene ID: 67943

Symbol: Mesd

Ensembl ID: ENSMUSG00000038503

Description: mesoderm development LRP chaperone

Associated with

Other Information

Genular Protein ID: 811672051

Symbol: MESD_MOUSE

Name: LDLR chaperone MESD

UniProtKB Accession Codes:

Q9ERE7 Q8C611 Q8CCX7 Q91WK8 Q9CVB9

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisProt 1 EMBL 6 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 2 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MGI 2 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 6 PRO 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 11247670

Title: Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis.

PubMed ID: 11247670

DOI: 10.1006/geno.2000.6466

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12581525

Title: Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity.

PubMed ID: 12581525

DOI: 10.1016/s0092-8674(03)00045-x

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 17342452

Title: The solution structure of the core of mesoderm development (MESD), a chaperone for members of the LDLR-family.

PubMed ID: 17342452

DOI: 10.1007/s10969-007-9016-5

PubMed ID: 20506034

Title: NMR structure note: solution structure of the core domain of MESD that is essential for proper folding of LRP5/6.

PubMed ID: 20506034

DOI: 10.1007/s10858-010-9426-8

PubMed ID: 21397183

Title: Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/6.

PubMed ID: 21397183

DOI: 10.1016/j.str.2011.01.010

PubMed ID: 21397184

Title: Structural characterization of the Boca/Mesd maturation factors for LDL-receptor-type beta-propeller domains.

PubMed ID: 21397184

DOI: 10.1016/j.str.2010.11.017

PubMed ID: 21397185

Title: The structure of MESD45-184 brings light into the mechanism of LDLR family folding.

PubMed ID: 21397185

DOI: 10.1016/j.str.2010.12.022

PubMed ID: 24140340

Title: Mesdc2 plays a key role in cell-surface expression of Lrp4 and postsynaptic specialization in myotubes.

PubMed ID: 24140340

DOI: 10.1016/j.febslet.2013.10.001

PubMed ID: 27184668

Title: Mesd extrinsically promotes phagocytosis by retinal pigment epithelial cells.

PubMed ID: 27184668

DOI: 10.1007/s10565-016-9339-8

PubMed ID: 31564437

Title: Autosomal-recessive mutations in MESD cause osteogenesis imperfecta.

PubMed ID: 31564437

DOI: 10.1016/j.ajhg.2019.08.008

Sequence Information:

  • Length: 224
  • Mass: 25207
  • Checksum: 6A94D5B315AE1D66
  • Sequence:
    • MAASRWLRAV LLFLCASDLL LLPPPNAYAA DTPGEATPPP RKKKDIRDYN DADMARLLEQ 
WEKDDDIEEG DLPEHKRPSA PIDFSKLDPG KPESILKMTK KGKTLMMFVT VSGNPTEKET 
EEITSLWQGS LFNANYDVQR FIVGSDRAIF MLRDGSYAWE IKDFLVSQDR CAEVTLEGQM 
YPGKGGGSKE KNKTKPEKAK KKEGDPKPRA SKEDNRAGSR REDL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.