Details for: BRS3

Gene ID: 680

Symbol: BRS3

Ensembl ID: ENSG00000102239

Description: bombesin receptor subtype 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.23
    Marker Score: 53057
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3176
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.3
    Marker Score: 3971
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.99
    Marker Score: 2224
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.27
    Marker Score: 1210
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71823
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48048
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.97
    Marker Score: 1203
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5354
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 500
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 714
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 405
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1202
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.68
    Marker Score: 540
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.63
    Marker Score: 1140
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.53
    Marker Score: 310
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.5
    Marker Score: 488
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 284
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 386
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.43
    Marker Score: 1779.5
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.39
    Marker Score: 375
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.31
    Marker Score: 581
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.29
    Marker Score: 583
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.27
    Marker Score: 281.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.25
    Marker Score: 3957
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.25
    Marker Score: 151
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.11
    Marker Score: 53
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.11
    Marker Score: 25
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.11
    Marker Score: 666
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.11
    Marker Score: 108
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.11
    Marker Score: 224
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.11
    Marker Score: 27
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.11
    Marker Score: 26
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1
    Marker Score: 26.5
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.09
    Marker Score: 69
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.09
    Marker Score: 27
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.08
    Marker Score: 33
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.08
    Marker Score: 24
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.07
    Marker Score: 26
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.06
    Marker Score: 171
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.05
    Marker Score: 19.5
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.05
    Marker Score: 29
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.05
    Marker Score: 130
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.05
    Marker Score: 32
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.05
    Marker Score: 130
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.04
    Marker Score: 27
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.03
    Marker Score: 40
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.03
    Marker Score: 61
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.03
    Marker Score: 27
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.03
    Marker Score: 27
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.03
    Marker Score: 33.5
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.03
    Marker Score: 21
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.03
    Marker Score: 114
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.03
    Marker Score: 25
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.02
    Marker Score: 56
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.02
    Marker Score: 20
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.02
    Marker Score: 32
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.02
    Marker Score: 23
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.02
    Marker Score: 26
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.02
    Marker Score: 25
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.02
    Marker Score: 195
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.02
    Marker Score: 58
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.02
    Marker Score: 19
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.02
    Marker Score: 27
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.02
    Marker Score: 62
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.02
    Marker Score: 24
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.01
    Marker Score: 24
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.01
    Marker Score: 23
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.01
    Marker Score: 26
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.01
    Marker Score: 27
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.01
    Marker Score: 21
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.01
    Marker Score: 26
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.01
    Marker Score: 27
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.01
    Marker Score: 27
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.01
    Marker Score: 37
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.01
    Marker Score: 108
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.01
    Marker Score: 25
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.01
    Marker Score: 26

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - BRS3 is a transmembrane protein with a molecular weight of approximately 140 kDa. - It is a member of the GPCR class a/1. - It is expressed in a variety of cell types, including progenitor cell, blood vessel endothelial cell, T cell, plasma cell, B cell, goblet cell, cerebral cortex GABAergic interneuron, forebrain radial glial cell, absorptive cell, and oligodendrocyte precursor cell. - It is a ligand-gated channel that is sensitive to bombesin, a peptide hormone. **Pathways and functions:** - BRS3 is a key regulator of blood pressure. It is expressed in the blood vessels of the kidneys and is activated by bombesin, a peptide hormone that is produced by the kidneys in response to high blood pressure. - BRS3 signaling is involved in a variety of cellular processes, including inflammation, cell migration, and cell growth. - It is also involved in the regulation of blood pressure. **Clinical significance:** - Mutations in the BRS3 gene have been linked to a number of human diseases, including hypertension, heart failure, and chronic pain. - BRS3 is a potential target for the treatment of these diseases. - Inhibition of BRS3 has been shown to reduce blood pressure and improve symptoms of hypertension. **Additional information:** - BRS3 is a relatively new receptor, and there is still much that is unknown about its function. - It is a promising target for the treatment of a variety of human diseases.

Genular Protein ID: 1700627151

Symbol: BRS3_HUMAN

Name: Bombesin receptor subtype-3

UniProtKB Accession Codes:

P32247

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8383682

Title: BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells.

PubMed ID: 8383682

DOI: 10.1016/s0021-9258(18)53415-3

PubMed ID: 8131855

Title: Organization and chromosomal localization of the gene for the human bombesin receptor subtype expressed in pregnant uterus.

PubMed ID: 8131855

DOI: 10.1016/0014-5793(94)80150-9

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 21857995

Title: Cloning of a novel protein interacting with BRS-3 and its effects in wound repair of bronchial epithelial cells.

PubMed ID: 21857995

DOI: 10.1371/journal.pone.0023072

Sequence Information:

  • Length: 399
  • Mass: 44411
  • Checksum: 979C93E962A3A28A
  • Sequence:
    • MAQRQPHSPN QTLISITNDT ESSSSVVSND NTNKGWSGDN SPGIEALCAI YITYAVIISV 
GILGNAILIK VFFKTKSMQT VPNIFITSLA FGDLLLLLTC VPVDATHYLA EGWLFGRIGC 
KVLSFIRLTS VGVSVFTLTI LSADRYKAVV KPLERQPSNA ILKTCVKAGC VWIVSMIFAL 
PEAIFSNVYT FRDPNKNMTF ESCTSYPVSK KLLQEIHSLL CFLVFYIIPL SIISVYYSLI 
ARTLYKSTLN IPTEEQSHAR KQIESRKRIA RTVLVLVALF ALCWLPNHLL YLYHSFTSQT 
YVDPSAMHFI FTIFSRVLAF SNSCVNPFAL YWLSKSFQKH FKAQLFCCKA ERPEPPVADT 
SLTTLAVMGT VPGTGSIQMS EISVTSFTGC SVKQAEDRF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.