Details for: BRS3

Gene ID: 680

Symbol: BRS3

Ensembl ID: ENSG00000102239

Description: bombesin receptor subtype 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.4079
    Cell Significance Index: 4.2200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1583
    Cell Significance Index: 2.1600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.1521
    Cell Significance Index: 2.4400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.1493
    Cell Significance Index: 3.7300
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.1254
    Cell Significance Index: 1.1600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0440
    Cell Significance Index: 0.6300
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0124
    Cell Significance Index: 0.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0078
    Cell Significance Index: 0.8000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.0024
    Cell Significance Index: 0.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0009
    Cell Significance Index: 0.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0003
    Cell Significance Index: -0.2300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0003
    Cell Significance Index: -0.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0009
    Cell Significance Index: -0.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0012
    Cell Significance Index: -0.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0021
    Cell Significance Index: -0.2900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0029
    Cell Significance Index: -0.6100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0031
    Cell Significance Index: -0.5500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0031
    Cell Significance Index: -0.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0035
    Cell Significance Index: -0.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0046
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0052
    Cell Significance Index: -0.6000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0057
    Cell Significance Index: -0.3800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0094
    Cell Significance Index: -0.3300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.0112
    Cell Significance Index: -0.1200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0113
    Cell Significance Index: -0.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0113
    Cell Significance Index: -0.3700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0114
    Cell Significance Index: -0.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0116
    Cell Significance Index: -0.6500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0122
    Cell Significance Index: -0.1600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0129
    Cell Significance Index: -0.5700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0132
    Cell Significance Index: -0.3300
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0133
    Cell Significance Index: -0.1700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0137
    Cell Significance Index: -0.3000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0152
    Cell Significance Index: -0.3000
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0152
    Cell Significance Index: -0.2000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0153
    Cell Significance Index: -0.5800
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.0155
    Cell Significance Index: -0.1600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0155
    Cell Significance Index: -0.4900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0160
    Cell Significance Index: -0.4000
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0164
    Cell Significance Index: -0.2000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0168
    Cell Significance Index: -0.4800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0171
    Cell Significance Index: -0.3400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0203
    Cell Significance Index: -0.4300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0217
    Cell Significance Index: -0.6400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0221
    Cell Significance Index: -0.5800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0228
    Cell Significance Index: -0.5800
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0231
    Cell Significance Index: -0.2800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0232
    Cell Significance Index: -0.6700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0233
    Cell Significance Index: -0.6700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0234
    Cell Significance Index: -0.5100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0236
    Cell Significance Index: -0.6300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0240
    Cell Significance Index: -0.4700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0243
    Cell Significance Index: -0.4000
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0244
    Cell Significance Index: -0.4800
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0250
    Cell Significance Index: -0.2600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0253
    Cell Significance Index: -0.2500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0259
    Cell Significance Index: -0.5200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0262
    Cell Significance Index: -0.3300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0264
    Cell Significance Index: -0.5500
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0269
    Cell Significance Index: -0.3100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0279
    Cell Significance Index: -0.6700
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: -0.0289
    Cell Significance Index: -0.2200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0289
    Cell Significance Index: -0.6000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0290
    Cell Significance Index: -0.6700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0291
    Cell Significance Index: -0.3400
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0293
    Cell Significance Index: -0.3900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0294
    Cell Significance Index: -0.3200
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0298
    Cell Significance Index: -0.3600
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.0305
    Cell Significance Index: -0.3600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0309
    Cell Significance Index: -0.3200
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: -0.0313
    Cell Significance Index: -0.2000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.0314
    Cell Significance Index: -0.4300
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0324
    Cell Significance Index: -0.5600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0329
    Cell Significance Index: -0.5500
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: -0.0330
    Cell Significance Index: -0.3800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0332
    Cell Significance Index: -0.5600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0368
    Cell Significance Index: -0.5600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0379
    Cell Significance Index: -0.5600
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.0381
    Cell Significance Index: -0.4600
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0383
    Cell Significance Index: -0.6500
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.0387
    Cell Significance Index: -0.4600
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.0389
    Cell Significance Index: -0.4600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.0391
    Cell Significance Index: -0.4000
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0406
    Cell Significance Index: -0.4400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0410
    Cell Significance Index: -0.5200
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.0414
    Cell Significance Index: -0.4700
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0414
    Cell Significance Index: -0.6200
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0422
    Cell Significance Index: -0.4000
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: -0.0422
    Cell Significance Index: -0.4900
  • Cell Name: pulmonary alveolar type 1 cell (CL0002062)
    Fold Change: -0.0428
    Cell Significance Index: -0.4700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0429
    Cell Significance Index: -0.5600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0430
    Cell Significance Index: -0.5900
  • Cell Name: granulocyte (CL0000094)
    Fold Change: -0.0431
    Cell Significance Index: -0.5200
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.0434
    Cell Significance Index: -0.5700
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.0437
    Cell Significance Index: -0.5700
  • Cell Name: melanocyte (CL0000148)
    Fold Change: -0.0438
    Cell Significance Index: -0.4100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.0442
    Cell Significance Index: -0.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **G Protein-Coupled Receptor (GPCR)**: BRS3 belongs to the GPCR family, which are transmembrane receptors that respond to ligand binding by activating G proteins, leading to various signaling cascades. 2. **Neuropeptide Receptor**: BRS3 is a neuropeptide receptor, specifically binding to bombesin, a peptide hormone involved in regulating various physiological processes. 3. **Signaling Pathways**: BRS3 activates Gαq signaling events, which are involved in various cellular processes, including regulation of blood pressure, glucose metabolism, and cell proliferation. 4. **Cell Type-Specific Expression**: BRS3 is expressed in a wide range of cell types, including progenitor cells, blood vessel endothelial cells, and immune cells, highlighting its involvement in various physiological and pathological processes. **Pathways and Functions:** 1. **Gαq Signaling Events**: BRS3 activates Gαq signaling events, which are involved in the regulation of blood pressure, glucose metabolism, and cell proliferation. 2. **Regulation of Blood Pressure**: BRS3 is involved in the regulation of blood pressure, possibly through the activation of Gαq signaling events. 3. **Glucose Metabolic Process**: BRS3 is also involved in the regulation of glucose metabolism, possibly through the activation of Gαq signaling events. 4. **Neuroimmunological Interactions**: BRS3 expression in the central nervous system highlights its involvement in neuroimmunological interactions, possibly influencing the regulation of immune responses and inflammation. **Clinical Significance:** 1. **Regulation of Blood Pressure**: Dysregulation of BRS3 signaling may contribute to the development of hypertension and other cardiovascular diseases. 2. **Neuroimmunological Disorders**: BRS3 expression in the central nervous system suggests its involvement in neuroimmunological disorders, such as multiple sclerosis and Alzheimer's disease. 3. **Cancer and Inflammation**: BRS3 signaling may be involved in the regulation of cell proliferation and inflammation in cancer and inflammatory diseases. 4. **Therapeutic Targeting**: BRS3 may serve as a therapeutic target for the treatment of various diseases, including hypertension, cancer, and neuroimmunological disorders. In conclusion, BRS3 is a multifunctional receptor involved in various physiological and pathological processes, including regulation of blood pressure, glucose metabolism, and neuroimmunological interactions. Further research is needed to elucidate the mechanisms underlying BRS3 signaling and to explore its therapeutic potential in various diseases.

Genular Protein ID: 1700627151

Symbol: BRS3_HUMAN

Name: Bombesin receptor subtype-3

UniProtKB Accession Codes:

P32247

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8383682

Title: BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells.

PubMed ID: 8383682

DOI: 10.1016/s0021-9258(18)53415-3

PubMed ID: 8131855

Title: Organization and chromosomal localization of the gene for the human bombesin receptor subtype expressed in pregnant uterus.

PubMed ID: 8131855

DOI: 10.1016/0014-5793(94)80150-9

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 21857995

Title: Cloning of a novel protein interacting with BRS-3 and its effects in wound repair of bronchial epithelial cells.

PubMed ID: 21857995

DOI: 10.1371/journal.pone.0023072

Sequence Information:

  • Length: 399
  • Mass: 44411
  • Checksum: 979C93E962A3A28A
  • Sequence:
    • MAQRQPHSPN QTLISITNDT ESSSSVVSND NTNKGWSGDN SPGIEALCAI YITYAVIISV 
GILGNAILIK VFFKTKSMQT VPNIFITSLA FGDLLLLLTC VPVDATHYLA EGWLFGRIGC 
KVLSFIRLTS VGVSVFTLTI LSADRYKAVV KPLERQPSNA ILKTCVKAGC VWIVSMIFAL 
PEAIFSNVYT FRDPNKNMTF ESCTSYPVSK KLLQEIHSLL CFLVFYIIPL SIISVYYSLI 
ARTLYKSTLN IPTEEQSHAR KQIESRKRIA RTVLVLVALF ALCWLPNHLL YLYHSFTSQT 
YVDPSAMHFI FTIFSRVLAF SNSCVNPFAL YWLSKSFQKH FKAQLFCCKA ERPEPPVADT 
SLTTLAVMGT VPGTGSIQMS EISVTSFTGC SVKQAEDRF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.