Details for: Serpina12

Gene ID: 68054

Symbol: Serpina12

Ensembl ID: ENSMUSG00000041567

Description: serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12

Associated with

  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Gluconeogenesis
    (GO:0006094)
  • Lipid biosynthetic process
    (GO:0008610)
  • Molecular function inhibitor activity
    (GO:0140678)
  • Negative regulation of endopeptidase activity
    (GO:0010951)
  • Negative regulation of gluconeogenesis
    (GO:0045721)
  • Negative regulation of lipid biosynthetic process
    (GO:0051055)
  • Negative regulation of peptidase activity
    (GO:0010466)
  • Peptidase inhibitor activity
    (GO:0030414)
  • Phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0043491)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of insulin receptor signaling pathway
    (GO:0046628)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Protein binding
    (GO:0005515)
  • Regulation of cholesterol metabolic process
    (GO:0090181)
  • Regulation of triglyceride metabolic process
    (GO:0090207)
  • Serine-type endopeptidase inhibitor activity
    (GO:0004867)

Other Information

Genular Protein ID: 381645355

Symbol: SPA12_MOUSE

Name: Serpin A12

UniProtKB Accession Codes:

Q7TMF5 Q9CQ32

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 Ensembl 1 GO 13 Gene3D 2 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 InterPro 6 KEGG 1 MEROPS 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 16030142

Title: Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity.

PubMed ID: 16030142

DOI: 10.1073/pnas.0504703102

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 23370777

Title: Vaspin inhibits kallikrein 7 by serpin mechanism.

PubMed ID: 23370777

DOI: 10.1007/s00018-013-1258-8

Sequence Information:

  • Length: 413
  • Mass: 47634
  • Checksum: D0AE8E1EE24FD60A
  • Sequence:
    • MTRMLDLGLF LAGLLTVKGL LQDRDAPDMY DSPVRVQEWR GKKDARQLAR HNMEFGFKLL 
QRLASNSPQG NIFLSPLSIS TAFSMLSLGA QNSTLEEIRE GFNFKEMSNW DVHAAFHYLL 
HKLNQETEDT KMNLGNALFM DQKLRPQQRF LNLAKNVYDA DMVLTNFQDL ENTQKDINRY 
ISQKTHSRIK NMVKSIDPGT VMILTNYIYF RGRWQYEFDP KQTKEEEFFI EKGKTVKVPM 
MFQRGLYDMA YDSQLSCTIL EIPYRGNITA TFVLPDNGKL KLLEQGLQAD IFAKWKSLLS 
KRVVDVWVPK LRISSTYNMK KVLSRLGISK IFEENGDLTR ISSHRSLKVG EAVHKAELKM 
DEKGMEGAAG SGAQTLPMET PRHMKLDRPF LMMIYENFMP SMVFLARIYD PSG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.