Details for: BSG

Gene ID: 682

Symbol: BSG

Ensembl ID: ENSG00000172270

Description: basigin (Ok blood group)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 386.1256
    Cell Significance Index: -60.0600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 372.5999
    Cell Significance Index: -94.5100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 269.7673
    Cell Significance Index: -111.1300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 238.4550
    Cell Significance Index: -112.5800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 233.2636
    Cell Significance Index: -94.7700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 211.3202
    Cell Significance Index: -108.7000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 169.2344
    Cell Significance Index: -113.5600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 100.3385
    Cell Significance Index: -95.8000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 61.5107
    Cell Significance Index: -75.8400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 28.5425
    Cell Significance Index: -112.6300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 28.2023
    Cell Significance Index: -75.5500
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 25.6507
    Cell Significance Index: -78.7900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 20.8902
    Cell Significance Index: -45.7200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 7.5630
    Cell Significance Index: 60.3900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 5.4299
    Cell Significance Index: 45.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.5490
    Cell Significance Index: 487.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.5203
    Cell Significance Index: 184.8300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.1336
    Cell Significance Index: 108.8900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.9435
    Cell Significance Index: 77.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.8950
    Cell Significance Index: 1581.0100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.5393
    Cell Significance Index: 132.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.4358
    Cell Significance Index: 181.5400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.1862
    Cell Significance Index: 58.3800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.8522
    Cell Significance Index: 87.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.8248
    Cell Significance Index: 85.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.8129
    Cell Significance Index: 234.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.8010
    Cell Significance Index: 324.6600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.5360
    Cell Significance Index: 108.6300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4604
    Cell Significance Index: 179.5700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.4092
    Cell Significance Index: 15.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.3501
    Cell Significance Index: 173.0800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.3325
    Cell Significance Index: 589.1400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3120
    Cell Significance Index: 263.1900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.2521
    Cell Significance Index: 16.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1223
    Cell Significance Index: 222.7200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.1041
    Cell Significance Index: 23.9200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.0793
    Cell Significance Index: 22.5900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.8516
    Cell Significance Index: 12.7600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8495
    Cell Significance Index: 767.0700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.8466
    Cell Significance Index: 14.9600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6885
    Cell Significance Index: 6.3400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6538
    Cell Significance Index: 41.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5882
    Cell Significance Index: 37.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5713
    Cell Significance Index: 43.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5639
    Cell Significance Index: 202.2500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3536
    Cell Significance Index: 41.7000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3414
    Cell Significance Index: 19.1600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3398
    Cell Significance Index: 7.8500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3016
    Cell Significance Index: 29.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2818
    Cell Significance Index: 7.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2499
    Cell Significance Index: 47.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2437
    Cell Significance Index: 178.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2278
    Cell Significance Index: 37.0600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2272
    Cell Significance Index: 157.1400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2114
    Cell Significance Index: 6.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2032
    Cell Significance Index: 9.2100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1727
    Cell Significance Index: 4.9500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1563
    Cell Significance Index: 2.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1311
    Cell Significance Index: 6.8100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1250
    Cell Significance Index: 94.6100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0961
    Cell Significance Index: 180.9800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0213
    Cell Significance Index: 0.6100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0297
    Cell Significance Index: -1.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0354
    Cell Significance Index: -65.3500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0490
    Cell Significance Index: -5.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0562
    Cell Significance Index: -86.5000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0571
    Cell Significance Index: -77.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0765
    Cell Significance Index: -13.0700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1063
    Cell Significance Index: -78.7400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1065
    Cell Significance Index: -67.6100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1732
    Cell Significance Index: -78.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1763
    Cell Significance Index: -99.4000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2097
    Cell Significance Index: -130.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2316
    Cell Significance Index: -16.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2832
    Cell Significance Index: -33.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3238
    Cell Significance Index: -93.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4035
    Cell Significance Index: -12.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.5501
    Cell Significance Index: -79.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5645
    Cell Significance Index: -64.6800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5807
    Cell Significance Index: -122.3200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.6399
    Cell Significance Index: -7.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7104
    Cell Significance Index: -47.7700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7620
    Cell Significance Index: -11.2500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.7936
    Cell Significance Index: -9.4600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.8150
    Cell Significance Index: -20.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.0222
    Cell Significance Index: -106.4400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.0244
    Cell Significance Index: -62.9700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.1000
    Cell Significance Index: -26.8400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.1245
    Cell Significance Index: -30.1300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -1.1636
    Cell Significance Index: -7.2300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.1920
    Cell Significance Index: -94.4100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.2717
    Cell Significance Index: -31.7900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -1.2902
    Cell Significance Index: -7.9400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.3030
    Cell Significance Index: -38.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.4134
    Cell Significance Index: -39.5000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.4505
    Cell Significance Index: -11.1800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.4825
    Cell Significance Index: -27.4000
  • Cell Name: germ cell (CL0000586)
    Fold Change: -1.5820
    Cell Significance Index: -11.9500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.6361
    Cell Significance Index: -100.3100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.8428
    Cell Significance Index: -31.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** Basigin is a type II transmembrane protein, consisting of a single extracellular domain and a single transmembrane domain. The extracellular domain is characterized by a C-terminal globular domain that contains a carbohydrate-binding site. Basigin has been shown to interact with various ligands, including proteoglycans, heparan sulfate, and sialic acid. It also exhibits ligand-induced conformational changes, which are essential for its function. Basigin has been implicated in several biological processes, including cell adhesion, migration, and signaling. It has been shown to interact with various cell surface receptors, including integrins, cadherins, and cadherin-associated proteins. Basigin also regulates the activity of proteases, such as matrix metalloproteinases (MMPs) and cathepsins, which are involved in tissue remodeling and immune responses. **Pathways and Functions** Basigin plays a crucial role in various signaling pathways, including: 1. **Cell adhesion**: Basigin interacts with integrins, cadherins, and cadherin-associated proteins, which are essential for cell adhesion and migration. 2. **Cell signaling**: Basigin has been shown to regulate the activity of proteases, such as MMPs and cathepsins, which are involved in tissue remodeling and immune responses. 3. **Transport**: Basigin regulates the transport of small molecules, including amino acids, sugars, and nucleotides, across cell membranes. 4. **Immune responses**: Basigin has been implicated in the regulation of immune responses, including neutrophil chemotaxis and phagocytosis. 5. **Tissue remodeling**: Basigin regulates the activity of proteases involved in tissue remodeling, including MMPs and cathepsins. **Clinical Significance** Basigin has been implicated in several diseases, including: 1. **Cancer**: Basigin has been shown to be overexpressed in various types of cancer, including breast, lung, and colon cancer. 2. **Inflammatory disorders**: Basigin has been implicated in the regulation of inflammatory responses, including rheumatoid arthritis and atherosclerosis. 3. **Neurological disorders**: Basigin has been shown to be involved in the regulation of synaptic plasticity and neuronal function in neurological disorders, including Alzheimer's disease and Parkinson's disease. 4. **Endocrine disorders**: Basigin has been implicated in the regulation of hormone signaling, including insulin and growth hormone. In conclusion, basigin is a multifunctional protein that plays a crucial role in various biological processes, including cell adhesion, signaling, and transport. Its dysregulation has been implicated in several diseases, highlighting the importance of further research into the functions and clinical implications of basigin.

Genular Protein ID: 2548920936

Symbol: BASI_HUMAN

Name: 5F7

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1634773

Title: Human leukocyte activation antigen M6, a member of the Ig superfamily, is the species homologue of rat OX-47, mouse basigin, and chicken HT7 molecule.

PubMed ID: 1634773

PubMed ID: 1783610

Title: The basigin group of the immunoglobulin superfamily: complete conservation of a segment in and around transmembrane domains of human and mouse basigin and chicken HT7 antigen.

PubMed ID: 1783610

DOI: 10.1093/oxfordjournals.jbchem.a123657

PubMed ID: 7812975

Title: The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily.

PubMed ID: 7812975

PubMed ID: 9767135

Title: Characterization of the gene for human EMMPRIN, a tumor cell surface inducer of matrix metalloproteinases.

PubMed ID: 9767135

DOI: 10.1016/s0378-1119(98)00400-4

PubMed ID: 12939332

Title: Retina-specific expression of 5A11/Basigin-2, a member of the immunoglobulin gene superfamily.

PubMed ID: 12939332

DOI: 10.1167/iovs.02-0995

PubMed ID: 21536654

Title: Characterization of basigin isoforms and the inhibitory function of basigin-3 in human hepatocellular carcinoma proliferation and invasion.

PubMed ID: 21536654

DOI: 10.1128/mcb.05160-11

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 1846736

Title: Partial sequencing and characterization of the tumor cell-derived collagenase stimulatory factor.

PubMed ID: 1846736

DOI: 10.1016/0003-9861(91)90332-d

PubMed ID: 11688976

Title: CD147 is a signaling receptor for cyclophilin B.

PubMed ID: 11688976

DOI: 10.1006/bbrc.2001.5847

PubMed ID: 11353871

Title: CD147 facilitates HIV-1 infection by interacting with virus-associated cyclophilin A.

PubMed ID: 11353871

DOI: 10.1073/pnas.111583198

PubMed ID: 12553375

Title: EMMPRIN-mediated MMP regulation in tumor and endothelial cells.

PubMed ID: 12553375

DOI: 10.1023/a:1021350718226

PubMed ID: 11992541

Title: Basigin (CD147) is expressed on melanoma cells and induces tumor cell invasion by stimulating production of matrix metalloproteinases by fibroblasts.

PubMed ID: 11992541

DOI: 10.1002/ijc.10390

PubMed ID: 11943775

Title: Active site residues of cyclophilin A are crucial for its signaling activity via CD147.

PubMed ID: 11943775

DOI: 10.1074/jbc.m201593200

PubMed ID: 12792908

Title: Basigin (CD147): a multifunctional transmembrane protein involved in reproduction, neural function, inflammation and tumor invasion.

PubMed ID: 12792908

DOI: 10.14670/hh-18.981

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 15833850

Title: Extracellular matrix metalloproteinase inducer stimulates tumor angiogenesis by elevating vascular endothelial cell growth factor and matrix metalloproteinases.

PubMed ID: 15833850

DOI: 10.1158/0008-5472.can-04-3605

PubMed ID: 15688292

Title: Function of HAb18G/CD147 in invasion of host cells by severe acute respiratory syndrome coronavirus.

PubMed ID: 15688292

DOI: 10.1086/427811

PubMed ID: 15946952

Title: Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60.

PubMed ID: 15946952

DOI: 10.1074/jbc.m503770200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 17127621

Title: The role of charged residues in the transmembrane helices of monocarboxylate transporter 1 and its ancillary protein basigin in determining plasma membrane expression and catalytic activity.

PubMed ID: 17127621

DOI: 10.1080/09687860600841967

PubMed ID: 17267690

Title: junction protein shrew-1 influences cell invasion and interacts with invasion-promoting protein CD147.

PubMed ID: 17267690

DOI: 10.1091/mbc.e06-07-0637

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19837976

Title: EMMPRIN promotes angiogenesis through hypoxia-inducible factor-2alpha-mediated regulation of soluble VEGF isoforms and their receptor VEGFR-2.

PubMed ID: 19837976

DOI: 10.1182/blood-2009-04-217380

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 20147391

Title: CD147/EMMPRIN acts as a functional entry receptor for measles virus on epithelial cells.

PubMed ID: 20147391

DOI: 10.1128/jvi.02168-09

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21778275

Title: Juvenile cataract-associated mutation of solute carrier SLC16A12 impairs trafficking of the protein to the plasma membrane.

PubMed ID: 21778275

DOI: 10.1167/iovs.10-6579

PubMed ID: 21245143

Title: Cyclophilin A (CyPA) induces chemotaxis independent of its peptidylprolyl cis-trans isomerase activity: direct binding between CyPA and the ectodomain of CD147.

PubMed ID: 21245143

DOI: 10.1074/jbc.c110.181347

PubMed ID: 22080952

Title: Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum.

PubMed ID: 22080952

DOI: 10.1038/nature10606

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24297912

Title: RH5-Basigin interaction plays a major role in the host tropism of Plasmodium falciparum.

PubMed ID: 24297912

DOI: 10.1073/pnas.1320771110

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25957687

Title: Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis.

PubMed ID: 25957687

DOI: 10.1016/j.cell.2015.03.023

PubMed ID: 26195724

Title: Basigin is a druggable target for host-oriented antimalarial interventions.

PubMed ID: 26195724

DOI: 10.1084/jem.20150032

PubMed ID: 25825981

Title: EMMPRIN/CD147 is a novel coreceptor of VEGFR-2 mediating its activation by VEGF.

PubMed ID: 25825981

DOI: 10.18632/oncotarget.2870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27503893

Title: Xkr8 phospholipid scrambling complex in apoptotic phosphatidylserine exposure.

PubMed ID: 27503893

DOI: 10.1073/pnas.1610403113

PubMed ID: 28666119

Title: Type 2 diabetes variants disrupt function of SLC16A11 through two distinct mechanisms.

PubMed ID: 28666119

DOI: 10.1016/j.cell.2017.06.011

PubMed ID: 28409866

Title: P. falciparum RH5-Basigin interaction induces changes in the cytoskeleton of the host RBC.

PubMed ID: 28409866

DOI: 10.1111/cmi.12747

PubMed ID: 29739904

Title: CD147 Promotes Entry of Pentamer-Expressing Human Cytomegalovirus into Epithelial and Endothelial Cells.

PubMed ID: 29739904

DOI: 10.1128/mbio.00781-18

PubMed ID: 32307653

Title: CD147 as a Target for COVID-19 Treatment: Suggested Effects of Azithromycin and Stem Cell Engagement.

PubMed ID: 32307653

DOI: 10.1007/s12015-020-09976-7

PubMed ID: 33432067

Title: No evidence for basigin/CD147 as a direct SARS-CoV-2 spike binding receptor.

PubMed ID: 33432067

DOI: 10.1038/s41598-020-80464-1

PubMed ID: 18430721

Title: Crystal structure of HAb18G/CD147: implications for immunoglobulin superfamily homophilic adhesion.

PubMed ID: 18430721

DOI: 10.1074/jbc.m802694200

PubMed ID: 19768682

Title: Structure of the EMMPRIN N-terminal domain 1: dimerization via beta-strand swapping.

PubMed ID: 19768682

DOI: 10.1002/prot.22577

PubMed ID: 21620857

Title: The retinal specific CD147 Ig0 domain: from molecular structure to biological activity.

PubMed ID: 21620857

DOI: 10.1016/j.jmb.2011.04.060

PubMed ID: 25132548

Title: Structure of malaria invasion protein RH5 with erythrocyte basigin and blocking antibodies.

PubMed ID: 25132548

DOI: 10.1038/nature13715

PubMed ID: 33333023

Title: Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates.

PubMed ID: 33333023

DOI: 10.1016/j.cell.2020.11.043

PubMed ID: 9130641

Title: The Ok(a) blood group antigen is a marker for the M6 leukocyte activation antigen, the human homolog of OX-47 antigen, basigin and neurothelin, an immunoglobulin superfamily molecule that is widely expressed in human cells and tissues.

PubMed ID: 9130641

DOI: 10.1002/eji.1830270414

PubMed ID: 32867305

Title: COVID-19 and Genetic Variants of Protein Involved in the SARS-CoV-2 Entry into the Host Cells.

PubMed ID: 32867305

DOI: 10.3390/genes11091010

Sequence Information:

  • Length: 385
  • Mass: 42200
  • Checksum: D74C37455BF26685
  • Sequence:
  • MAAALFVLLG FALLGTHGAS GAAGFVQAPL SQQRWVGGSV ELHCEAVGSP VPEIQWWFEG 
    QGPNDTCSQL WDGARLDRVH IHATYHQHAA STISIDTLVE EDTGTYECRA SNDPDRNHLT 
    RAPRVKWVRA QAVVLVLEPG TVFTTVEDLG SKILLTCSLN DSATEVTGHR WLKGGVVLKE 
    DALPGQKTEF KVDSDDQWGE YSCVFLPEPM GTANIQLHGP PRVKAVKSSE HINEGETAML 
    VCKSESVPPV TDWAWYKITD SEDKALMNGS ESRFFVSSSQ GRSELHIENL NMEADPGQYR 
    CNGTSSKGSD QAIITLRVRS HLAALWPFLG IVAEVLVLVT IIFIYEKRRK PEDVLDDDDA 
    GSAPLKSSGQ HQNDKGKNVR QRNSS

Genular Protein ID: 2335838124

Symbol: Q54A51_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 269
  • Mass: 29221
  • Checksum: 0C9D6BEB966AC258
  • Sequence:
  • MAAALFVLLG FALLGTHGAS GAAGTVFTTV EDLGSKILLT CSLNDSATEV TGHRWLKGGV 
    VLKEDALPGQ KTEFKVDSDD QWGEYSCVFL PEPMGTANIQ LHGPPRVKAV KSSEHINEGE 
    TAMLVCKSES VPPVTDWAWY KITDSEDKAL MNGSESRFFV SSSQGRSELH IENLNMEADP 
    GQYRCNGTSS KGSDQAIITL RVRSHLAALW PFLGIVAEVL VLVTIIFIYE KRRKPEDVLD 
    DDDAGSAPLK SSGQHQNDKG KNVRQRNSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.