Details for: BST1

Gene ID: 683

Symbol: BST1

Ensembl ID: ENSG00000109743

Description: bone marrow stromal cell antigen 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 47.7675
    Cell Significance Index: -7.4300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 17.6243
    Cell Significance Index: -7.1600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 15.7372
    Cell Significance Index: -8.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 13.0104
    Cell Significance Index: -3.3000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.0181
    Cell Significance Index: -7.4200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.0087
    Cell Significance Index: -8.0600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.5045
    Cell Significance Index: 46.2900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.3408
    Cell Significance Index: 161.8800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.2825
    Cell Significance Index: 36.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.1240
    Cell Significance Index: 404.2000
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 2.0364
    Cell Significance Index: 13.5100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.9285
    Cell Significance Index: -7.6100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4570
    Cell Significance Index: 87.4700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.1686
    Cell Significance Index: 31.2600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9450
    Cell Significance Index: 153.6900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9245
    Cell Significance Index: 100.5600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8568
    Cell Significance Index: 11.6900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7941
    Cell Significance Index: 717.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.5902
    Cell Significance Index: 20.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5829
    Cell Significance Index: 30.3600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5237
    Cell Significance Index: 51.8100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.4620
    Cell Significance Index: 7.3300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.3530
    Cell Significance Index: 8.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3416
    Cell Significance Index: 7.4000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3325
    Cell Significance Index: 6.4900
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.2882
    Cell Significance Index: 1.8400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2693
    Cell Significance Index: 7.7600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2449
    Cell Significance Index: 33.6400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1531
    Cell Significance Index: 3.2600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1343
    Cell Significance Index: 2.8700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1008
    Cell Significance Index: 2.5200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0947
    Cell Significance Index: 11.0400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0721
    Cell Significance Index: 3.6400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0659
    Cell Significance Index: 2.1100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0652
    Cell Significance Index: 4.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0552
    Cell Significance Index: 7.0700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0505
    Cell Significance Index: 0.4700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.0460
    Cell Significance Index: 0.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0376
    Cell Significance Index: 7.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0348
    Cell Significance Index: 15.3800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0278
    Cell Significance Index: 15.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0264
    Cell Significance Index: 1.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0127
    Cell Significance Index: 2.5400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0068
    Cell Significance Index: 0.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0064
    Cell Significance Index: 0.2900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0049
    Cell Significance Index: 0.1300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0038
    Cell Significance Index: 0.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0016
    Cell Significance Index: 2.4700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0007
    Cell Significance Index: 1.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0004
    Cell Significance Index: -0.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0013
    Cell Significance Index: -2.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0027
    Cell Significance Index: -3.7000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0031
    Cell Significance Index: -0.5600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0054
    Cell Significance Index: -0.2500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0087
    Cell Significance Index: -5.5400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0087
    Cell Significance Index: -6.6100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0092
    Cell Significance Index: -6.7800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0096
    Cell Significance Index: -7.0300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0101
    Cell Significance Index: -0.1700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0117
    Cell Significance Index: -6.5900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0128
    Cell Significance Index: -5.7900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0134
    Cell Significance Index: -1.3700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0151
    Cell Significance Index: -1.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0227
    Cell Significance Index: -6.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0294
    Cell Significance Index: -4.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0327
    Cell Significance Index: -0.8800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0346
    Cell Significance Index: -0.5000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0364
    Cell Significance Index: -7.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0373
    Cell Significance Index: -4.8200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0397
    Cell Significance Index: -6.7800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0406
    Cell Significance Index: -4.6500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0411
    Cell Significance Index: -1.0500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0481
    Cell Significance Index: -1.5200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0520
    Cell Significance Index: -3.1900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0534
    Cell Significance Index: -1.5300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0562
    Cell Significance Index: -0.9400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0601
    Cell Significance Index: -1.5800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0663
    Cell Significance Index: -7.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0670
    Cell Significance Index: -6.9800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0747
    Cell Significance Index: -1.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0841
    Cell Significance Index: -6.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0855
    Cell Significance Index: -6.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0868
    Cell Significance Index: -4.0800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0943
    Cell Significance Index: -7.4700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1019
    Cell Significance Index: -1.2600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1040
    Cell Significance Index: -6.9900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1140
    Cell Significance Index: -7.0100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1194
    Cell Significance Index: -2.1100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1199
    Cell Significance Index: -7.5600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1205
    Cell Significance Index: -6.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1206
    Cell Significance Index: -3.3700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1371
    Cell Significance Index: -2.6800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1421
    Cell Significance Index: -7.4600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.1435
    Cell Significance Index: -1.1700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.1439
    Cell Significance Index: -2.0200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1521
    Cell Significance Index: -4.4800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1543
    Cell Significance Index: -6.7100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1634
    Cell Significance Index: -3.4200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1643
    Cell Significance Index: -1.3800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1684
    Cell Significance Index: -7.4500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** BST1 is a non-coding gene that does not encode a protein sequence. Instead, it regulates the expression of other genes through post-transcriptional modifications, such as the synthesis of GPI-anchored proteins and the regulation of protein modification. BST1 is also involved in the regulation of various cellular processes, including: * Cell proliferation and differentiation * Immune response and inflammation * Cell signaling and adhesion * Metabolism and energy production **Pathways and Functions** BST1 is involved in several key biological pathways, including: * Humoral immune response: BST1 regulates the expression of immune-related genes, such as those involved in antibody production and B-cell activation. * Innate immune response: BST1 is involved in the regulation of innate immune responses, including neutrophil degranulation and chemotaxis. * Cell signaling: BST1 regulates the activity of various signaling molecules, including cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). * Metabolism: BST1 is involved in the regulation of metabolic pathways, including nicotinate metabolism and phosphorus-oxygen lyase activity. **Clinical Significance** Dysregulation of BST1 has been implicated in various diseases, including: * Autoimmune disorders, such as rheumatoid arthritis and lupus * Cancer, including leukemia and lymphoma * Neurological disorders, such as Alzheimer's disease and Parkinson's disease * Metabolic disorders, such as diabetes and metabolic syndrome Furthermore, BST1 has been identified as a potential therapeutic target for various diseases, including cancer and autoimmune disorders. Research into the role of BST1 in disease pathogenesis and the development of therapeutic strategies is ongoing. **Significantly Expressed Cells** BST1 is expressed in various cell types, including: * CD14-positive monocytes * CD14-positive, CD16-negative classical monocytes * Extravillous trophoblasts * Cerebral cortex GABAergic interneurons * Forebrain radial glial cells * Absorptive cells * Tuft cells of the colon * BEST4+ intestinal epithelial cells * Human, intestinal crypt stem cells of the colon In conclusion, BST1 is a multifaceted gene that plays a crucial role in various cellular processes, including immune regulation, cell signaling, and metabolism. Its dysregulation has been implicated in various diseases, and research into its role in disease pathogenesis and therapeutic strategies is ongoing.

Genular Protein ID: 4239127474

Symbol: BST1_HUMAN

Name: ADP-ribosyl cyclase 2

UniProtKB Accession Codes:

Q10588 B2R6A2 Q1XII0 Q5U0K0 Q96EN3

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 ChEBI 16 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EC 1 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 23 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 2 Rhea 6 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8202488

Title: BST-1, a surface molecule of bone marrow stromal cell lines that facilitates pre-B-cell growth.

PubMed ID: 8202488

DOI: 10.1073/pnas.91.12.5325

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7805847

Title: ADP ribosyl cyclase activity of a novel bone marrow stromal cell surface molecule, BST-1.

PubMed ID: 7805847

DOI: 10.1016/0014-5793(94)01279-2

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 11866528

Title: Crystallographic studies on human BST-1/CD157 with ADP-ribosyl cyclase and NAD glycohydrolase activities.

PubMed ID: 11866528

DOI: 10.1006/jmbi.2001.5386

Sequence Information:

  • Length: 318
  • Mass: 35724
  • Checksum: E0DD04C89A8F4215
  • Sequence:
    • MAAQGCAASR LLQLLLQLLL LLLLLAAGGA RARWRGEGTS AHLRDIFLGR CAEYRALLSP 
EQRNKNCTAI WEAFKVALDK DPCSVLPSDY DLFINLSRHS IPRDKSLFWE NSHLLVNSFA 
DNTRRFMPLS DVLYGRVADF LSWCRQKNDS GLDYQSCPTS EDCENNPVDS FWKRASIQYS 
KDSSGVIHVM LNGSEPTGAY PIKGFFADYE IPNLQKEKIT RIEIWVMHEI GGPNVESCGE 
GSMKVLEKRL KDMGFQYSCI NDYRPVKLLQ CVDHSTHPDC ALKSAAAATQ RKAPSLYTEQ 
RAGLIIPLFL VLASRTQL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.