Details for: Sirt5

Gene ID: 68346

Symbol: Sirt5

Ensembl ID: ENSMUSG00000054021

Description: sirtuin 5

Associated with

Other Information

Genular Protein ID: 1313850682

Symbol: SIR5_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8K2C6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChEBI 28 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 22 Gene3D 2 GeneTree 1 Genevisible 1 HAMAP 1 HAMAP-Rule 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MGI 1 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 9 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19410549

Title: SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle.

PubMed ID: 19410549

DOI: 10.1016/j.cell.2009.02.026

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21908771

Title: The first identification of lysine malonylation substrates and its regulatory enzyme.

PubMed ID: 21908771

DOI: 10.1074/mcp.m111.012658

PubMed ID: 22076378

Title: Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.

PubMed ID: 22076378

DOI: 10.1126/science.1207861

PubMed ID: 23085393

Title: SIRT5 deacetylates and activates urate oxidase in liver mitochondria of mice.

PubMed ID: 23085393

DOI: 10.1016/j.febslet.2012.10.009

PubMed ID: 24315375

Title: SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks.

PubMed ID: 24315375

DOI: 10.1016/j.cmet.2013.11.013

PubMed ID: 23438705

Title: Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases.

PubMed ID: 23438705

DOI: 10.1016/j.mito.2013.02.002

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 24076663

Title: Metabolic characterization of a Sirt5 deficient mouse model.

PubMed ID: 24076663

DOI: 10.1038/srep02806

PubMed ID: 24703693

Title: Lysine glutarylation is a protein posttranslational modification regulated by SIRT5.

PubMed ID: 24703693

DOI: 10.1016/j.cmet.2014.03.014

Sequence Information:

  • Length: 310
  • Mass: 34134
  • Checksum: A0C4962D5E6F8729
  • Sequence:
    • MRPLLIAPGR FISQLCCRRK PPASPQSKIC LTMARPSSNM ADFRKCFANA KHIAIISGAG 
VSAESGVPTF RGAGGYWRKW QAQDLATPQA FARNPSQVWE FYHYRREVMR SKEPNPGHLA 
IAQCEARLRD QGRRVVVITQ NIDELHRKAG TKNLLEIHGT LFKTRCTSCG TVAENYRSPI 
CPALAGKGAP EPETQDARIP VDKLPRCEEA GCGGLLRPHV VWFGENLDPA ILEEVDRELA 
LCDLCLVVGT SSVVYPAAMF APQVASRGVP VAEFNMETTP ATDRFRFHFP GPCGKTLPEA 
LAPHETERTS

Genular Protein ID: 3941110195

Symbol: A0A1Y7VM56_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A1Y7VM56

Database IDs:

AGR 1 ARBA 2 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 CDD 1 CTD 1 ChEBI 28 ChiTaRS 1 DNASU 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 12 Gene3D 2 GeneTree 1 HAMAP 1 HAMAP-Rule 1 InterPro 5 MGI 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 5 Rhea 9 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 350
  • Mass: 38230
  • Checksum: B2048CF9D70044F4
  • Sequence:
    • MRPLLIAPGR FISQLCCRRK PPASPQSKIC LTMARPSSNM ADFRKCFANA KHIAIISGAG 
VSAESGVPTF RGAGGYWRKW QAQDLATPQA FARNPSQVWE FYHYRREVMR SKEPNPGHLA 
IAQCEARLRD QGRRVVVITQ NIDELHRKAG TKNLLEIHGT LFKTRCTSCG TVAENYRSPI 
CPALAGKGAP EPETQDARIP VDKLPRCEEA GCGGLLRPHV VWFGENLDPA ILEEVDRELA 
LCDLCLVVGT SSVVYPAAMF APQVASRGVP VAEFNMETTP ATDRFRVSLC SPGCPGTHFV 
DQAGLELRNL PASASQVLGL KACTTTPGDC TVLISVEDQR GECGQKRESW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.