Details for: BST2

Gene ID: 684

Symbol: BST2

Ensembl ID: ENSG00000130303

Description: bone marrow stromal cell antigen 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 297.9841
    Cell Significance Index: -46.3500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 129.3611
    Cell Significance Index: -53.2900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 119.6533
    Cell Significance Index: -48.6100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 105.8411
    Cell Significance Index: -49.9700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 102.8995
    Cell Significance Index: -52.9300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 75.8395
    Cell Significance Index: -50.8900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 68.5608
    Cell Significance Index: -17.3900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 52.5063
    Cell Significance Index: -50.1300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 37.9332
    Cell Significance Index: -46.7700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 31.5744
    Cell Significance Index: 185.5000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 16.0487
    Cell Significance Index: 205.5300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.1957
    Cell Significance Index: -40.5300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.1501
    Cell Significance Index: -47.9500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 8.4604
    Cell Significance Index: 72.7000
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 8.2292
    Cell Significance Index: 30.6700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 7.9118
    Cell Significance Index: 63.1700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 7.4397
    Cell Significance Index: -19.9300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 7.0861
    Cell Significance Index: 125.2200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 5.6756
    Cell Significance Index: 149.2400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 5.6219
    Cell Significance Index: 195.3600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.9359
    Cell Significance Index: 72.7500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.8381
    Cell Significance Index: 112.7200
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 3.1829
    Cell Significance Index: 15.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.8825
    Cell Significance Index: 185.9700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.6111
    Cell Significance Index: 136.0100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.5879
    Cell Significance Index: 59.7900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 2.2569
    Cell Significance Index: 60.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.1602
    Cell Significance Index: 265.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.9347
    Cell Significance Index: 51.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.6238
    Cell Significance Index: 121.0200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.5985
    Cell Significance Index: 11.4800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.3254
    Cell Significance Index: 156.3000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.2763
    Cell Significance Index: 230.0700
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 0.9594
    Cell Significance Index: 2.5700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7879
    Cell Significance Index: 711.4100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7719
    Cell Significance Index: 40.1000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.5727
    Cell Significance Index: 3.4600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5527
    Cell Significance Index: 70.8500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4476
    Cell Significance Index: 72.8000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4447
    Cell Significance Index: 242.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3276
    Cell Significance Index: 35.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2594
    Cell Significance Index: 7.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1696
    Cell Significance Index: 5.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1379
    Cell Significance Index: 13.6400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1106
    Cell Significance Index: 21.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0937
    Cell Significance Index: 18.6100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0773
    Cell Significance Index: 10.6200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0721
    Cell Significance Index: 3.3900
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.0463
    Cell Significance Index: 0.2900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0198
    Cell Significance Index: 0.2300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0142
    Cell Significance Index: 0.8500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0070
    Cell Significance Index: 5.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0238
    Cell Significance Index: -44.8000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0304
    Cell Significance Index: -56.0500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0324
    Cell Significance Index: -2.2400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0363
    Cell Significance Index: -55.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0412
    Cell Significance Index: -56.0500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0444
    Cell Significance Index: -4.5400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0446
    Cell Significance Index: -33.7800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0507
    Cell Significance Index: -6.5600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0574
    Cell Significance Index: -25.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0761
    Cell Significance Index: -56.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0787
    Cell Significance Index: -50.0100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0942
    Cell Significance Index: -58.8100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0953
    Cell Significance Index: -53.7500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1054
    Cell Significance Index: -2.2500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1088
    Cell Significance Index: -2.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1120
    Cell Significance Index: -50.8500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1275
    Cell Significance Index: -6.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1396
    Cell Significance Index: -40.1800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1450
    Cell Significance Index: -52.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1505
    Cell Significance Index: -6.8200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1586
    Cell Significance Index: -2.6600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1642
    Cell Significance Index: -2.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2416
    Cell Significance Index: -28.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2517
    Cell Significance Index: -50.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2657
    Cell Significance Index: -55.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2670
    Cell Significance Index: -30.5900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2987
    Cell Significance Index: -43.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.3070
    Cell Significance Index: -52.4200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3238
    Cell Significance Index: -10.3700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3289
    Cell Significance Index: -7.1300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3555
    Cell Significance Index: -14.5700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4458
    Cell Significance Index: -11.1500
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4476
    Cell Significance Index: -3.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4648
    Cell Significance Index: -48.4000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4929
    Cell Significance Index: -34.8600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5904
    Cell Significance Index: -46.7600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6056
    Cell Significance Index: -46.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6087
    Cell Significance Index: -37.3200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7296
    Cell Significance Index: -21.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7927
    Cell Significance Index: -53.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.8039
    Cell Significance Index: -49.4100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.8058
    Cell Significance Index: -22.5200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.8411
    Cell Significance Index: -14.5000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8463
    Cell Significance Index: -53.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.8857
    Cell Significance Index: -25.3900
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.9600
    Cell Significance Index: -6.0100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.9684
    Cell Significance Index: -5.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9967
    Cell Significance Index: -55.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BST2 is a 34-kDa protein that belongs to the BST2/Tetherin family of proteins. It is characterized by its ability to bind to viral particles, particularly enveloped viruses like SARS-CoV-1, and prevent their entry into host cells. BST2 also exhibits antiviral activity by inhibiting the replication of viral genomes and modulating the immune response. Its expression is restricted to specific cell types, including endothelial cells, immune cells, and placental cells, which highlights its role in immune surveillance and tissue homeostasis. **Pathways and Functions:** BST2 is involved in several key pathways that regulate antiviral immunity and immune responses. These include: 1. **Viral entry inhibition:** BST2 binds to viral particles, preventing their entry into host cells and limiting viral replication. 2. **Interferon signaling:** BST2 modulates the interferon-alpha/beta signaling pathway, which is crucial for inducing antiviral responses and promoting immune cell activation. 3. **Cytokine production:** BST2 regulates the production of cytokines, such as IFN-alpha, which are essential for coordinating the immune response against viral infections. 4. **Antiviral activity:** BST2 directly inhibits viral genome replication and modulates the immune response to prevent viral clearance. **Clinical Significance:** BST2 has significant implications in the diagnosis and treatment of infectious diseases, particularly those caused by enveloped viruses like SARS-CoV-1. Its expression on the surface of endothelial cells and immune cells makes it an attractive target for therapeutic interventions. BST2 has been implicated in various diseases, including: 1. **SARS-CoV-1 infection:** BST2 has been shown to inhibit SARS-CoV-1 entry into host cells, making it a potential therapeutic target for the treatment of SARS-CoV-1 infections. 2. **Other viral infections:** BST2 has been implicated in the regulation of antiviral responses against other enveloped viruses, such as HIV and influenza. 3. **Allergic diseases:** BST2 has been linked to the regulation of immune responses in allergic diseases, such as asthma and atopic dermatitis. In conclusion, BST2 is a critical regulator of antiviral immunity and immune responses. Its expression on the surface of various cell types makes it an attractive target for therapeutic interventions, particularly in the treatment of infectious diseases caused by enveloped viruses. Further research is needed to fully elucidate the mechanisms of BST2 and its implications in human disease.

Genular Protein ID: 1351465413

Symbol: BST2_HUMAN

Name: Bone marrow stromal antigen 2

UniProtKB Accession Codes:

Q10589 A8K4Y4 Q53G07

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 15 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7607676

Title: Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth.

PubMed ID: 7607676

DOI: 10.1016/0888-7543(95)80171-h

PubMed ID: 10329429

Title: Molecular cloning and characterization of a surface antigen preferentially overexpressed on multiple myeloma cells.

PubMed ID: 10329429

DOI: 10.1006/bbrc.1999.0683

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16157322

Title: Characterization of antibodies submitted to the B cell section of the 8th Human Leukocyte Differentiation Antigens Workshop by flow cytometry and immunohistochemistry.

PubMed ID: 16157322

DOI: 10.1016/j.cellimm.2005.08.002

PubMed ID: 16602701

Title: Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment.

PubMed ID: 16602701

DOI: 10.1021/pr050419u

PubMed ID: 17566972

Title: Computational approach for identification and characterization of GPI-anchored peptides in proteomics experiments.

PubMed ID: 17566972

DOI: 10.1002/pmic.200700068

PubMed ID: 18342597

Title: The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein.

PubMed ID: 18342597

DOI: 10.1016/j.chom.2008.03.001

PubMed ID: 18200009

Title: Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu.

PubMed ID: 18200009

DOI: 10.1038/nature06553

PubMed ID: 20019814

Title: BCA2/Rabring7 promotes tetherin-dependent HIV-1 restriction.

PubMed ID: 20019814

DOI: 10.1371/journal.ppat.1000700

PubMed ID: 19879838

Title: Tetherin inhibits HIV-1 release by directly tethering virions to cells.

PubMed ID: 19879838

DOI: 10.1016/j.cell.2009.08.039

PubMed ID: 19917491

Title: A tail of Tetherin: how pandemic HIV-1 conquered the world.

PubMed ID: 19917491

DOI: 10.1016/j.chom.2009.11.002

PubMed ID: 19837671

Title: HIV-1 accessory protein Vpu internalizes cell-surface BST-2/tetherin through transmembrane interactions leading to lysosomes.

PubMed ID: 19837671

DOI: 10.1074/jbc.m109.058305

PubMed ID: 19564354

Title: Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction.

PubMed ID: 19564354

DOI: 10.1084/jem.20090547

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19036818

Title: Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin.

PubMed ID: 19036818

DOI: 10.1128/jvi.02211-08

PubMed ID: 19740980

Title: Antagonism to and intracellular sequestration of human tetherin by the human immunodeficiency virus type 2 envelope glycoprotein.

PubMed ID: 19740980

DOI: 10.1128/jvi.01515-09

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 19179289

Title: Tetherin-mediated restriction of filovirus budding is antagonized by the Ebola glycoprotein.

PubMed ID: 19179289

DOI: 10.1073/pnas.0811014106

PubMed ID: 19737401

Title: The formation of cysteine-linked dimers of BST-2/tetherin is important for inhibition of HIV-1 virus release but not for sensitivity to Vpu.

PubMed ID: 19737401

DOI: 10.1186/1742-4690-6-80

PubMed ID: 20686043

Title: Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin.

PubMed ID: 20686043

DOI: 10.1128/jvi.00103-10

PubMed ID: 20943977

Title: Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms.

PubMed ID: 20943977

DOI: 10.1128/jvi.01328-10

PubMed ID: 20419159

Title: The RING-CH ligase K5 antagonizes restriction of KSHV and HIV-1 particle release by mediating ubiquitin-dependent endosomal degradation of tetherin.

PubMed ID: 20419159

DOI: 10.1371/journal.ppat.1000843

PubMed ID: 20688520

Title: BST-2/tetherin: a new component of the innate immune response to enveloped viruses.

PubMed ID: 20688520

DOI: 10.1016/j.tim.2010.06.010

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22180752

Title: structural basis for the antiviral activity of Bst-2/tetherin and its viral antagonism.

PubMed ID: 22180752

DOI: 10.3389/fmicb.2011.00250

PubMed ID: 21166593

Title: The interferon-inducible host factor bone marrow stromal antigen 2/tetherin restricts virion release, but is it actually a viral restriction factor?

PubMed ID: 21166593

DOI: 10.1089/jir.2010.0108

PubMed ID: 21222046

Title: Tetherin and its viral antagonists.

PubMed ID: 21222046

DOI: 10.1007/s11481-010-9256-1

PubMed ID: 21529378

Title: Tetherin inhibits prototypic foamy virus release.

PubMed ID: 21529378

DOI: 10.1186/1743-422x-8-198

PubMed ID: 21621240

Title: Influenza virus is not restricted by tetherin whereas influenza VLP production is restricted by tetherin.

PubMed ID: 21621240

DOI: 10.1016/j.virol.2011.05.006

PubMed ID: 21994744

Title: Antiviral inhibition of enveloped virus release by tetherin/BST-2: action and counteraction.

PubMed ID: 21994744

DOI: 10.3390/v3050520

PubMed ID: 22509177

Title: Vpu and BST2: still not there yet?

PubMed ID: 22509177

DOI: 10.3389/fmicb.2012.00131

PubMed ID: 22065321

Title: BST-2 binding with cellular MT1-MMP blocks cell growth and migration via decreasing MMP2 activity.

PubMed ID: 22065321

DOI: 10.1002/jcb.23433

PubMed ID: 22811908

Title: Restriction of retroviral replication by tetherin/BST-2.

PubMed ID: 22811908

DOI: 10.1155/2012/424768

PubMed ID: 23028328

Title: Identification of alternatively translated Tetherin isoforms with differing antiviral and signaling activities.

PubMed ID: 23028328

DOI: 10.1371/journal.ppat.1002931

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 22520941

Title: Modulation of hepatitis C virus release by the interferon-induced protein BST-2/tetherin.

PubMed ID: 22520941

DOI: 10.1016/j.virol.2012.03.011

PubMed ID: 26172439

Title: Vpu exploits the cross-talk between BST2 and the ILT7 receptor to suppress anti-HIV-1 responses by plasmacytoid dendritic Cells.

PubMed ID: 26172439

DOI: 10.1371/journal.ppat.1005024

PubMed ID: 26378163

Title: Severe Acute Respiratory Syndrome Coronavirus ORF7a Inhibits Bone Marrow Stromal Antigen 2 Virion Tethering through a Novel Mechanism of Glycosylation Interference.

PubMed ID: 26378163

DOI: 10.1128/jvi.02274-15

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 31199522

Title: Severe acute respiratory syndrome coronavirus spike protein counteracts BST2-mediated restriction of virus-like particle release.

PubMed ID: 31199522

DOI: 10.1002/jmv.25518

PubMed ID: 20399176

Title: Structural basis of HIV-1 tethering to membranes by the BST-2/tetherin ectodomain.

PubMed ID: 20399176

DOI: 10.1016/j.chom.2010.03.005

PubMed ID: 20880831

Title: Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations.

PubMed ID: 20880831

DOI: 10.1073/pnas.1008206107

PubMed ID: 20940320

Title: Structural insight into the mechanisms of enveloped virus tethering by tetherin.

PubMed ID: 20940320

DOI: 10.1073/pnas.1011485107

Sequence Information:

  • Length: 180
  • Mass: 19769
  • Checksum: CAF52340D69061EE
  • Sequence:
    • MASTSYDYCR VPMEDGDKRC KLLLGIGILV LLIIVILGVP LIIFTIKANS EACRDGLRAV 
MECRNVTHLL QQELTEAQKG FQDVEAQAAT CNHTVMALMA SLDAEKAQGQ KKVEELEGEI 
TTLNHKLQDA SAEVERLRRE NQVLSVRIAD KKYYPSSQDS SSAAAPQLLI VLLGLSALLQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.