Gene BST2 - ENSG00000130303 | NCBI Gene ID: 684

Details for: BST2

Gene ID: 684

Symbol: BST2

Ensembl ID: ENSG00000130303

Description: bone marrow stromal cell antigen 2

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interferon alpha/beta signaling
(R-HSA-909733)
Interferon signaling
(R-HSA-913531)
Neutrophil degranulation
(R-HSA-6798695)
Sars-cov-1 activates/modulates innate immune responses
(R-HSA-9692916)
Sars-cov-1 infection
(R-HSA-9678108)
Sars-cov-1-host interactions
(R-HSA-9692914)
Sars-cov infections
(R-HSA-9679506)
Viral infection pathways
(R-HSA-9824446)
Apical plasma membrane
(GO:0016324)
Azurophil granule membrane
(GO:0035577)
B cell activation
(GO:0042113)
Cell surface
(GO:0009986)
Cytoplasm
(GO:0005737)
Defense response to virus
(GO:0051607)
Extracellular exosome
(GO:0070062)
Golgi apparatus
(GO:0005794)
Identical protein binding
(GO:0042802)
Innate immune response
(GO:0045087)
Intracellular membrane-bounded organelle
(GO:0043231)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Metalloendopeptidase inhibitor activity
(GO:0008191)
Multivesicular body
(GO:0005771)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of intracellular transport of viral material
(GO:1901253)
Negative regulation of plasmacytoid dendritic cell cytokine production
(GO:0002737)
Negative regulation of viral genome replication
(GO:0045071)
Plasma membrane
(GO:0005886)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of leukocyte proliferation
(GO:0070665)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Regulation of actin cytoskeleton organization
(GO:0032956)
Response to interferon-alpha
(GO:0035455)
Response to interferon-beta
(GO:0035456)
Response to type ii interferon
(GO:0034341)
Response to virus
(GO:0009615)
Rna binding
(GO:0003723)
Side of membrane
(GO:0098552)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 4.51
Marker Score: 11473
Cell Name: theca cell (CL0000503)
Fold Change: 4.28
Marker Score: 3066
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 3.94
Marker Score: 5704.5
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 3.6
Marker Score: 3102
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 3.58
Marker Score: 23310
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 3.5
Marker Score: 9658.5
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 3.16
Marker Score: 5177
Cell Name: blood cell (CL0000081)
Fold Change: 2.93
Marker Score: 34007
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 2.91
Marker Score: 162723.5
Cell Name: mature T cell (CL0002419)
Fold Change: 2.79
Marker Score: 27649
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 2.77
Marker Score: 2363
Cell Name: mesodermal cell (CL0000222)
Fold Change: 2.72
Marker Score: 35828
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 2.71
Marker Score: 5287
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 2.69
Marker Score: 1949
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.6
Marker Score: 5193.5
Cell Name: pro-T cell (CL0000827)
Fold Change: 2.51
Marker Score: 10268
Cell Name: Kupffer cell (CL0000091)
Fold Change: 2.51
Marker Score: 2509
Cell Name: granulosa cell (CL0000501)
Fold Change: 2.47
Marker Score: 24859
Cell Name: Unknown (CL0002371)
Fold Change: 2.45
Marker Score: 2606
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 2.41
Marker Score: 1711
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2.37
Marker Score: 4014
Cell Name: basophil (CL0000767)
Fold Change: 2.36
Marker Score: 1121
Cell Name: lung macrophage (CL1001603)
Fold Change: 2.36
Marker Score: 2699
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 2.36
Marker Score: 2617.5
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.35
Marker Score: 15047
Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 2.35
Marker Score: 547
Cell Name: endothelial cell (CL0000115)
Fold Change: 2.33
Marker Score: 2093
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 2.32
Marker Score: 521
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.27
Marker Score: 23053.5
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 2.26
Marker Score: 6596.5
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 2.22
Marker Score: 3780
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 2.2
Marker Score: 1211
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.18
Marker Score: 4546
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.17
Marker Score: 55654
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 2.15
Marker Score: 5861
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 2.13
Marker Score: 1811
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 2.1
Marker Score: 874
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 2.09
Marker Score: 6600
Cell Name: endothelial cell of sinusoid (CL0002262)
Fold Change: 2.07
Marker Score: 501
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 2.03
Marker Score: 17854
Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 2.02
Marker Score: 1954.5
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 2.02
Marker Score: 699
Cell Name: ILC1, human (CL0001077)
Fold Change: 1.98
Marker Score: 503
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 1.96
Marker Score: 628
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 1.95
Marker Score: 1595
Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
Fold Change: 1.94
Marker Score: 640
Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 1.94
Marker Score: 2340.5
Cell Name: B-1 B cell (CL0000819)
Fold Change: 1.93
Marker Score: 3367
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 1.92
Marker Score: 1682
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 1.91
Marker Score: 2631
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 1.91
Marker Score: 2818
Cell Name: type I NK T cell (CL0000921)
Fold Change: 1.91
Marker Score: 1500
Cell Name: glomerular endothelial cell (CL0002188)
Fold Change: 1.91
Marker Score: 485
Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
Fold Change: 1.91
Marker Score: 3736
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 1.9
Marker Score: 1912
Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
Fold Change: 1.87
Marker Score: 609
Cell Name: hematopoietic precursor cell (CL0008001)
Fold Change: 1.86
Marker Score: 652
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 1.86
Marker Score: 1579
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 1.86
Marker Score: 407
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.85
Marker Score: 1766
Cell Name: plasmablast (CL0000980)
Fold Change: 1.83
Marker Score: 2433.5
Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 1.82
Marker Score: 4721
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.81
Marker Score: 6973
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 1.8
Marker Score: 459.5
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 1.8
Marker Score: 1359
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 1.79
Marker Score: 894
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 1.79
Marker Score: 3168
Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 1.78
Marker Score: 770
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 1.78
Marker Score: 741
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 1.77
Marker Score: 618
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 1.77
Marker Score: 1118.5
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.77
Marker Score: 4410
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 1.76
Marker Score: 1034
Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 1.76
Marker Score: 684
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 1.76
Marker Score: 4292
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.76
Marker Score: 1050
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 1.74
Marker Score: 371
Cell Name: Unknown (CL0000548)
Fold Change: 1.72
Marker Score: 1252
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 1.71
Marker Score: 12749.5
Cell Name: exhausted T cell (CL0011025)
Fold Change: 1.71
Marker Score: 985
Cell Name: memory B cell (CL0000787)
Fold Change: 1.71
Marker Score: 1295
Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
Fold Change: 1.71
Marker Score: 1236
Cell Name: dendritic cell, human (CL0001056)
Fold Change: 1.71
Marker Score: 1738
Cell Name: dendritic cell (CL0000451)
Fold Change: 1.7
Marker Score: 1163
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 1.7
Marker Score: 1824
Cell Name: secretory cell (CL0000151)
Fold Change: 1.69
Marker Score: 3087
Cell Name: naive B cell (CL0000788)
Fold Change: 1.67
Marker Score: 1495
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.66
Marker Score: 4925
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 1.66
Marker Score: 1103
Cell Name: DN1 thymic pro-T cell (CL0000894)
Fold Change: 1.66
Marker Score: 513.5
Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
Fold Change: 1.64
Marker Score: 373
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 1.64
Marker Score: 679
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.63
Marker Score: 2370
Cell Name: non-classical monocyte (CL0000875)
Fold Change: 1.63
Marker Score: 3930
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.63
Marker Score: 1469
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 1.62
Marker Score: 1089
Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
Fold Change: 1.61
Marker Score: 4526
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 1.61
Marker Score: 787
Cell Name: kidney cell (CL1000497)
Fold Change: 1.61
Marker Score: 1075
Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 1.61
Marker Score: 943

Hover over a box to see details here...

**Key characteristics:** * The protein is a member of the immunoglobulin superfamily. * It is expressed in high levels in immune cells, including macrophages, dendritic cells, and endothelial cells. * It is involved in the regulation of inflammation and immune responses to pathogens. **Pathways and functions:** * BST2 is a key regulator of innate immune responses. * It is involved in the regulation of inflammation and the development of autoimmune diseases. * It is also involved in the regulation of tissue repair and regeneration. **Clinical significance:** * Mutations in the BST2 gene have been linked to the development of several autoimmune diseases, including rheumatoid arthritis, psoriasis, and lupus. * Targeting BST2 has been investigated as a therapeutic strategy for these diseases. **Additional information:** * The gene is located on chromosome 15q21.1. * It is a highly conserved protein, with a similar gene found in mice and rats. * It is expressed in high levels in healthy humans, but its expression is increased in inflammatory diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Bone marrow stromal antigen 2

Genular Protein ID: 1351465413

Symbol: BST2_HUMAN

Name: Bone marrow stromal antigen 2

UniProtKB Accession Codes:

Q10589 A8K4Y4 Q53G07

Database IDs:

Citations:

PubMed ID: 7607676

Title: Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth.

PubMed ID: 7607676

DOI: 10.1016/0888-7543(95)80171-h

PubMed ID: 10329429

Title: Molecular cloning and characterization of a surface antigen preferentially overexpressed on multiple myeloma cells.

PubMed ID: 10329429

DOI: 10.1006/bbrc.1999.0683

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16157322

Title: Characterization of antibodies submitted to the B cell section of the 8th Human Leukocyte Differentiation Antigens Workshop by flow cytometry and immunohistochemistry.

PubMed ID: 16157322

DOI: 10.1016/j.cellimm.2005.08.002

PubMed ID: 16602701

Title: Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment.

PubMed ID: 16602701

DOI: 10.1021/pr050419u

PubMed ID: 17566972

Title: Computational approach for identification and characterization of GPI-anchored peptides in proteomics experiments.

PubMed ID: 17566972

DOI: 10.1002/pmic.200700068

PubMed ID: 18342597

Title: The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein.

PubMed ID: 18342597

DOI: 10.1016/j.chom.2008.03.001

PubMed ID: 18200009

Title: Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu.

PubMed ID: 18200009

DOI: 10.1038/nature06553

PubMed ID: 19879838

Title: Tetherin inhibits HIV-1 release by directly tethering virions to cells.

PubMed ID: 19879838

DOI: 10.1016/j.cell.2009.08.039

PubMed ID: 19917491

Title: A tail of Tetherin: how pandemic HIV-1 conquered the world.

PubMed ID: 19917491

DOI: 10.1016/j.chom.2009.11.002

PubMed ID: 19837671

Title: HIV-1 accessory protein Vpu internalizes cell-surface BST-2/tetherin through transmembrane interactions leading to lysosomes.

PubMed ID: 19837671

DOI: 10.1074/jbc.m109.058305

PubMed ID: 19564354

Title: Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction.

PubMed ID: 19564354

DOI: 10.1084/jem.20090547

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19036818

Title: Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin.

PubMed ID: 19036818

DOI: 10.1128/jvi.02211-08

PubMed ID: 19740980

Title: Antagonism to and intracellular sequestration of human tetherin by the human immunodeficiency virus type 2 envelope glycoprotein.

PubMed ID: 19740980

DOI: 10.1128/jvi.01515-09

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 19179289

Title: Tetherin-mediated restriction of filovirus budding is antagonized by the Ebola glycoprotein.

PubMed ID: 19179289

DOI: 10.1073/pnas.0811014106

PubMed ID: 19737401

Title: The formation of cysteine-linked dimers of BST-2/tetherin is important for inhibition of HIV-1 virus release but not for sensitivity to Vpu.

PubMed ID: 19737401

DOI: 10.1186/1742-4690-6-80

PubMed ID: 20686043

Title: Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin.

PubMed ID: 20686043

DOI: 10.1128/jvi.00103-10

PubMed ID: 20943977

Title: Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms.

PubMed ID: 20943977

DOI: 10.1128/jvi.01328-10

PubMed ID: 20419159

Title: The RING-CH ligase K5 antagonizes restriction of KSHV and HIV-1 particle release by mediating ubiquitin-dependent endosomal degradation of tetherin.

PubMed ID: 20419159

DOI: 10.1371/journal.ppat.1000843

PubMed ID: 20688520

Title: BST-2/tetherin: a new component of the innate immune response to enveloped viruses.

PubMed ID: 20688520

DOI: 10.1016/j.tim.2010.06.010

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22180752

Title: structural basis for the antiviral activity of Bst-2/tetherin and its viral antagonism.

PubMed ID: 22180752

DOI: 10.3389/fmicb.2011.00250

PubMed ID: 21166593

Title: The interferon-inducible host factor bone marrow stromal antigen 2/tetherin restricts virion release, but is it actually a viral restriction factor?

PubMed ID: 21166593

DOI: 10.1089/jir.2010.0108

PubMed ID: 21222046

Title: Tetherin and its viral antagonists.

PubMed ID: 21222046

DOI: 10.1007/s11481-010-9256-1

PubMed ID: 21529378

Title: Tetherin inhibits prototypic foamy virus release.

PubMed ID: 21529378

DOI: 10.1186/1743-422x-8-198

PubMed ID: 21621240

Title: Influenza virus is not restricted by tetherin whereas influenza VLP production is restricted by tetherin.

PubMed ID: 21621240

DOI: 10.1016/j.virol.2011.05.006

PubMed ID: 21994744

Title: Antiviral inhibition of enveloped virus release by tetherin/BST-2: action and counteraction.

PubMed ID: 21994744

DOI: 10.3390/v3050520

PubMed ID: 22509177

Title: Vpu and BST2: still not there yet?

PubMed ID: 22509177

DOI: 10.3389/fmicb.2012.00131

PubMed ID: 22065321

Title: BST-2 binding with cellular MT1-MMP blocks cell growth and migration via decreasing MMP2 activity.

PubMed ID: 22065321

DOI: 10.1002/jcb.23433

PubMed ID: 22811908

Title: Restriction of retroviral replication by tetherin/BST-2.

PubMed ID: 22811908

DOI: 10.1155/2012/424768

PubMed ID: 23028328

Title: Identification of alternatively translated Tetherin isoforms with differing antiviral and signaling activities.

PubMed ID: 23028328

DOI: 10.1371/journal.ppat.1002931

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 22520941

Title: Modulation of hepatitis C virus release by the interferon-induced protein BST-2/tetherin.

PubMed ID: 22520941

DOI: 10.1016/j.virol.2012.03.011

PubMed ID: 26172439

Title: Vpu exploits the cross-talk between BST2 and the ILT7 receptor to suppress anti-HIV-1 responses by plasmacytoid dendritic Cells.

PubMed ID: 26172439

DOI: 10.1371/journal.ppat.1005024

PubMed ID: 26378163

Title: Severe Acute Respiratory Syndrome Coronavirus ORF7a Inhibits Bone Marrow Stromal Antigen 2 Virion Tethering through a Novel Mechanism of Glycosylation Interference.

PubMed ID: 26378163

DOI: 10.1128/jvi.02274-15

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 31199522

Title: Severe acute respiratory syndrome coronavirus spike protein counteracts BST2-mediated restriction of virus-like particle release.

PubMed ID: 31199522

DOI: 10.1002/jmv.25518

PubMed ID: 20399176

Title: Structural basis of HIV-1 tethering to membranes by the BST-2/tetherin ectodomain.

PubMed ID: 20399176

DOI: 10.1016/j.chom.2010.03.005

PubMed ID: 20880831

Title: Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations.

PubMed ID: 20880831

DOI: 10.1073/pnas.1008206107

PubMed ID: 20940320

Title: Structural insight into the mechanisms of enveloped virus tethering by tetherin.

PubMed ID: 20940320

DOI: 10.1073/pnas.1011485107

Sequence Information:

Length: 180
Mass: 19769
Checksum: CAF52340D69061EE
Sequence:

MASTSYDYCR VPMEDGDKRC KLLLGIGILV LLIIVILGVP LIIFTIKANS EACRDGLRAV 
MECRNVTHLL QQELTEAQKG FQDVEAQAAT CNHTVMALMA SLDAEKAQGQ KKVEELEGEI 
TTLNHKLQDA SAEVERLRRE NQVLSVRIAD KKYYPSSQDS SSAAAPQLLI VLLGLSALLQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: BST2

Associated with

Cells (max top 100)

Other Information

Molecular cloning and chromosomal mapping of a bone marrow stromal cell surface gene, BST2, that may be involved in pre-B-cell growth. PubMed ID: 7607676

Molecular cloning and characterization of a surface antigen preferentially overexpressed on multiple myeloma cells. PubMed ID: 10329429

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of antibodies submitted to the B cell section of the 8th Human Leukocyte Differentiation Antigens Workshop by flow cytometry and immunohistochemistry. PubMed ID: 16157322

Modification-specific proteomics of plasma membrane proteins: identification and characterization of glycosylphosphatidylinositol-anchored proteins released upon phospholipase D treatment. PubMed ID: 16602701

Computational approach for identification and characterization of GPI-anchored peptides in proteomics experiments. PubMed ID: 17566972

The interferon-induced protein BST-2 restricts HIV-1 release and is downregulated from the cell surface by the viral Vpu protein. PubMed ID: 18342597

Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu. PubMed ID: 18200009

Tetherin inhibits HIV-1 release by directly tethering virions to cells. PubMed ID: 19879838

A tail of Tetherin: how pandemic HIV-1 conquered the world. PubMed ID: 19917491

HIV-1 accessory protein Vpu internalizes cell-surface BST-2/tetherin through transmembrane interactions leading to lysosomes. PubMed ID: 19837671

Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction. PubMed ID: 19564354

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

Broad-spectrum inhibition of retroviral and filoviral particle release by tetherin. PubMed ID: 19036818

Antagonism to and intracellular sequestration of human tetherin by the human immunodeficiency virus type 2 envelope glycoprotein. PubMed ID: 19740980

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. PubMed ID: 19349973

Tetherin-mediated restriction of filovirus budding is antagonized by the Ebola glycoprotein. PubMed ID: 19179289

The formation of cysteine-linked dimers of BST-2/tetherin is important for inhibition of HIV-1 virus release but not for sensitivity to Vpu. PubMed ID: 19737401

Infectious Lassa virus, but not filoviruses, is restricted by BST-2/tetherin. PubMed ID: 20686043

Interferon-induced cell membrane proteins, IFITM3 and tetherin, inhibit vesicular stomatitis virus infection via distinct mechanisms. PubMed ID: 20943977

The RING-CH ligase K5 antagonizes restriction of KSHV and HIV-1 particle release by mediating ubiquitin-dependent endosomal degradation of tetherin. PubMed ID: 20419159

BST-2/tetherin: a new component of the innate immune response to enveloped viruses. PubMed ID: 20688520

Initial characterization of the human central proteome. PubMed ID: 21269460

structural basis for the antiviral activity of Bst-2/tetherin and its viral antagonism. PubMed ID: 22180752

The interferon-inducible host factor bone marrow stromal antigen 2/tetherin restricts virion release, but is it actually a viral restriction factor? PubMed ID: 21166593

Tetherin and its viral antagonists. PubMed ID: 21222046

Tetherin inhibits prototypic foamy virus release. PubMed ID: 21529378

Influenza virus is not restricted by tetherin whereas influenza VLP production is restricted by tetherin. PubMed ID: 21621240

Antiviral inhibition of enveloped virus release by tetherin/BST-2: action and counteraction. PubMed ID: 21994744

Vpu and BST2: still not there yet? PubMed ID: 22509177

BST-2 binding with cellular MT1-MMP blocks cell growth and migration via decreasing MMP2 activity. PubMed ID: 22065321

Restriction of retroviral replication by tetherin/BST-2. PubMed ID: 22811908

Identification of alternatively translated Tetherin isoforms with differing antiviral and signaling activities. PubMed ID: 23028328

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Modulation of hepatitis C virus release by the interferon-induced protein BST-2/tetherin. PubMed ID: 22520941

Vpu exploits the cross-talk between BST2 and the ILT7 receptor to suppress anti-HIV-1 responses by plasmacytoid dendritic Cells. PubMed ID: 26172439

Severe Acute Respiratory Syndrome Coronavirus ORF7a Inhibits Bone Marrow Stromal Antigen 2 Virion Tethering through a Novel Mechanism of Glycosylation Interference. PubMed ID: 26378163

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Severe acute respiratory syndrome coronavirus spike protein counteracts BST2-mediated restriction of virus-like particle release. PubMed ID: 31199522

Structural basis of HIV-1 tethering to membranes by the BST-2/tetherin ectodomain. PubMed ID: 20399176

Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations. PubMed ID: 20880831

Structural insight into the mechanisms of enveloped virus tethering by tetherin. PubMed ID: 20940320