BTC | ENSG00000174808 | NCBI 685

Details for: BTC

Gene ID: 685

Symbol: BTC

Ensembl ID: ENSG00000174808

Description: betacellulin

Associated with

Cargo recognition for clathrin-mediated endocytosis
(R-HSA-8856825)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downregulation of erbb2 signaling
(R-HSA-8863795)
Egfr downregulation
(R-HSA-182971)
Egfr interacts with phospholipase c-gamma
(R-HSA-212718)
Erbb2 activates ptk6 signaling
(R-HSA-8847993)
Erbb2 regulates cell motility
(R-HSA-6785631)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-HSA-9634638)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Gab1 signalosome
(R-HSA-180292)
Grb2 events in egfr signaling
(R-HSA-179812)
Grb2 events in erbb2 signaling
(R-HSA-1963640)
Inhibition of signaling by overexpressed egfr
(R-HSA-5638303)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Membrane trafficking
(R-HSA-199991)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nuclear signaling by erbb4
(R-HSA-1251985)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k events in erbb2 signaling
(R-HSA-1963642)
Pi3k events in erbb4 signaling
(R-HSA-1250342)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Raf/map kinase cascade
(R-HSA-5673001)
Shc1 events in egfr signaling
(R-HSA-180336)
Shc1 events in erbb2 signaling
(R-HSA-1250196)
Shc1 events in erbb4 signaling
(R-HSA-1250347)
Signaling by egfr
(R-HSA-177929)
Signaling by egfr in cancer
(R-HSA-1643713)
Signaling by erbb2
(R-HSA-1227986)
Signaling by erbb2 in cancer
(R-HSA-1227990)
Signaling by erbb2 kd mutants
(R-HSA-9664565)
Signaling by erbb2 tmd/jmd mutants
(R-HSA-9665686)
Signaling by erbb4
(R-HSA-1236394)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by overexpressed wild-type egfr in cancer
(R-HSA-5638302)
Signaling by ptk6
(R-HSA-8848021)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Vesicle-mediated transport
(R-HSA-5653656)
Cell population proliferation
(GO:0008283)
Clathrin-coated endocytic vesicle membrane
(GO:0030669)
Epidermal growth factor receptor binding
(GO:0005154)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Epithelial cell apoptotic process
(GO:1904019)
Erbb2-egfr signaling pathway
(GO:0038134)
Erbb4-erbb4 signaling pathway
(GO:0038138)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Growth factor activity
(GO:0008083)
Negative regulation of epithelial cell apoptotic process
(GO:1904036)
Plasma membrane
(GO:0005886)
Positive regulation of cell differentiation
(GO:0045597)
Positive regulation of cell division
(GO:0051781)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of mitotic nuclear division
(GO:0045840)
Positive regulation of urine volume
(GO:0035810)
Protein binding
(GO:0005515)
Receptor ligand activity
(GO:0048018)
Transmembrane receptor protein tyrosine kinase activator activity
(GO:0030297)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 44.1171
Cell Significance Index: -11.1900
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 22.8754
Cell Significance Index: -10.8000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.4044
Cell Significance Index: 72.9600
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.0184
Cell Significance Index: 6.7600
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.9074
Cell Significance Index: 89.7600
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.7450
Cell Significance Index: 33.7700
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.7138
Cell Significance Index: 44.9900
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6854
Cell Significance Index: 618.9000
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6523
Cell Significance Index: 70.9600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4994
Cell Significance Index: 14.3900
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4933
Cell Significance Index: 80.2300
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.4637
Cell Significance Index: 2.4400
Cell Name: peg cell (CL4033014)
Fold Change: 0.4359
Cell Significance Index: 10.0700
Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.4305
Cell Significance Index: 6.4500
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.4237
Cell Significance Index: 9.1800
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 0.3702
Cell Significance Index: 5.2000
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3363
Cell Significance Index: 23.2600
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.3345
Cell Significance Index: 67.1000
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: 0.3272
Cell Significance Index: 4.5400
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2340
Cell Significance Index: 10.9100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1998
Cell Significance Index: 7.0200
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.1861
Cell Significance Index: 27.0500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1144
Cell Significance Index: 21.7700
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.1061
Cell Significance Index: 2.2600
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.0989
Cell Significance Index: 1.0200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0853
Cell Significance Index: 30.5900
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0833
Cell Significance Index: 15.0100
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0743
Cell Significance Index: 9.1400
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0493
Cell Significance Index: 31.3100
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0488
Cell Significance Index: 1.2200
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.0453
Cell Significance Index: 0.5400
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.0444
Cell Significance Index: 0.9200
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0359
Cell Significance Index: 15.8800
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0332
Cell Significance Index: 62.5700
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0318
Cell Significance Index: 17.3500
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.0315
Cell Significance Index: 0.2900
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.0291
Cell Significance Index: 0.4500
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0094
Cell Significance Index: 6.8800
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.0081
Cell Significance Index: 0.2300
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0064
Cell Significance Index: 4.4200
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0049
Cell Significance Index: 0.1400
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0025
Cell Significance Index: -4.6500
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0034
Cell Significance Index: -5.2200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0076
Cell Significance Index: -5.7800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0087
Cell Significance Index: -11.8400
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0088
Cell Significance Index: -0.2400
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0098
Cell Significance Index: -4.4500
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0136
Cell Significance Index: -10.0800
Cell Name: myometrial cell (CL0002366)
Fold Change: -0.0139
Cell Significance Index: -0.1600
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0195
Cell Significance Index: -11.0000
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0203
Cell Significance Index: -3.4600
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0217
Cell Significance Index: -13.5800
Cell Name: neoplastic cell (CL0001063)
Fold Change: -0.0277
Cell Significance Index: -5.5100
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0284
Cell Significance Index: -0.9100
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0408
Cell Significance Index: -11.7300
Cell Name: odontoblast (CL0000060)
Fold Change: -0.0438
Cell Significance Index: -5.6100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0460
Cell Significance Index: -5.2700
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0464
Cell Significance Index: -3.2800
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0511
Cell Significance Index: -5.9500
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0523
Cell Significance Index: -5.3400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0580
Cell Significance Index: -12.2100
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0619
Cell Significance Index: -8.0000
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0732
Cell Significance Index: -10.0500
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0923
Cell Significance Index: -9.6100
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0943
Cell Significance Index: -6.3400
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0982
Cell Significance Index: -1.3400
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.1019
Cell Significance Index: -1.0600
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1054
Cell Significance Index: -5.3300
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1071
Cell Significance Index: -7.9800
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1194
Cell Significance Index: -7.3200
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1239
Cell Significance Index: -9.5100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1337
Cell Significance Index: -10.5900
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1541
Cell Significance Index: -8.6500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1542
Cell Significance Index: -7.2500
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1580
Cell Significance Index: -6.4700
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1815
Cell Significance Index: -11.1600
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1821
Cell Significance Index: -5.8000
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.1855
Cell Significance Index: -2.8000
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.2073
Cell Significance Index: -5.4500
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.2087
Cell Significance Index: -7.3100
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2315
Cell Significance Index: -5.9500
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2381
Cell Significance Index: -12.5000
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2427
Cell Significance Index: -8.9100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2534
Cell Significance Index: -11.2100
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.2758
Cell Significance Index: -3.9500
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2781
Cell Significance Index: -9.1100
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: -0.2808
Cell Significance Index: -5.4900
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2984
Cell Significance Index: -11.3000
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: -0.3113
Cell Significance Index: -3.2500
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.3123
Cell Significance Index: -3.5500
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.3128
Cell Significance Index: -6.2800
Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
Fold Change: -0.3170
Cell Significance Index: -1.6600
Cell Name: keratocyte (CL0002363)
Fold Change: -0.3218
Cell Significance Index: -5.1100
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.3264
Cell Significance Index: -6.3700
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.3297
Cell Significance Index: -7.9900
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.3311
Cell Significance Index: -6.9300
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3315
Cell Significance Index: -11.5200
Cell Name: keratinocyte (CL0000312)
Fold Change: -0.3319
Cell Significance Index: -8.2900
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.3329
Cell Significance Index: -14.4800
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.3456
Cell Significance Index: -10.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** Betacellulin is a 25-kDa protein that belongs to the EGF family, which consists of seven members. It is produced by the pancreas and is also found in other tissues, including the retina, cardiac endothelial cells, and smooth muscle cells. Betacellulin is highly expressed in cells that require rapid proliferation and differentiation, such as granulocyte monocyte progenitor cells and absorptive cells. Its expression is downregulated in cancer cells, where it is often associated with a poor prognosis. **Pathways and Functions** Betacellulin's primary function is to regulate cell proliferation and differentiation through its interaction with EGFR. The binding of betacellulin to EGFR activates a signaling cascade that involves the activation of various downstream kinases, including MAPK1/3, PI3K, and AKT. This cascade regulates cell growth, migration, and survival by modulating the expression of target genes involved in these processes. Betacellulin's signaling pathway is also involved in negative regulation of apoptosis, particularly in epithelial cells. The activation of PI3K/AKT signaling by betacellulin inhibits the expression of pro-apoptotic genes and promotes the expression of anti-apoptotic genes. **Clinical Significance** Betacellulin has been implicated in various diseases, including cancer, diabetes, and cardiovascular disease. In cancer, betacellulin's downregulation is often associated with a poor prognosis, as it can inhibit the growth and survival of cancer cells. In diabetes, betacellulin's expression is reduced in pancreatic islets, leading to impaired insulin secretion and glucose metabolism. In cardiovascular disease, betacellulin's expression is increased in smooth muscle cells, leading to the proliferation and migration of these cells, which can contribute to the development of atherosclerosis. Betacellulin's signaling pathway has also been implicated in the regulation of fibroblast proliferation and mitotic nuclear division, which are critical processes in wound healing and tissue repair. **Implications for Therapeutic Interventions** Given its role in regulating cell proliferation and differentiation, betacellulin has potential therapeutic applications in cancer, diabetes, and cardiovascular disease. In cancer, betacellulin's downregulation could be targeted to inhibit the growth and survival of cancer cells. In diabetes, betacellulin's expression could be enhanced to improve insulin secretion and glucose metabolism. In cardiovascular disease, betacellulin's signaling pathway could be targeted to regulate fibroblast proliferation and mitotic nuclear division, which could contribute to the development of atherosclerosis. In conclusion, betacellulin is a growth factor that plays a crucial role in regulating cell proliferation, differentiation, and survival. Its signaling pathway is involved in various physiological and pathological processes, including cancer, diabetes, and cardiovascular disease. Further research is needed to fully understand the implications of betacellulin's role in these diseases and to explore its potential therapeutic applications.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Probetacellulin
A0A0S2Z3I5_HUMAN

Genular Protein ID: 2222156240

Symbol: BTC_HUMAN

Name: Probetacellulin

UniProtKB Accession Codes:

P35070 Q96F48

Database IDs:

Citations:

PubMed ID: 8439318

Title: Cloning and expression of cDNA encoding human betacellulin, a new member of the EGF family.

PubMed ID: 8439318

DOI: 10.1006/bbrc.1993.1173

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8144591

Title: Recombinant human betacellulin. Molecular structure, biological activities, and receptor interaction.

PubMed ID: 8144591

DOI: 10.1016/s0021-9258(17)36977-6

PubMed ID: 8919026

Title: Human betacellulin, a member of the EGF family dominantly expressed in pancreas and small intestine, is fully active in a monomeric form.

PubMed ID: 8919026

DOI: 10.3109/08977199609003220

PubMed ID: 8570211

Title: Betacellulin activates the epidermal growth factor receptor and erbB-4, and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-beta.

PubMed ID: 8570211

PubMed ID: 10867024

Title: Ligand discrimination in signaling through an ErbB4 receptor homodimer.

PubMed ID: 10867024

DOI: 10.1074/jbc.c901015199

PubMed ID: 12074582

Title: Solution structure of betacellulin, a new member of EGF-family ligands.

PubMed ID: 12074582

DOI: 10.1016/s0006-291x(02)00585-5

Sequence Information:

Length: 178
Mass: 19746
Checksum: 27AC77BD92001F0F
Sequence:

MDRAARCSGA SSLPLLLALA LGLVILHCVV ADGNSTRSPE TNGLLCGDPE ENCAATTTQS 
KRKGHFSRCP KQYKHYCIKG RCRFVVAEQT PSCVCDEGYI GARCERVDLF YLRGDRGQIL 
VICLIAVMVV FIILVIGVCT CCHPLRKRRK RKKKEEEMET LGKDITPINE DIEETNIA

Genular Protein ID: 1030526547

Symbol: A0A0S2Z3I5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z3I5

Database IDs:

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

Length: 129
Mass: 14301
Checksum: F969472876D876BB
Sequence:

MDRAARCSGA SSLPLLLALA LGLVILHCVV ADGNSTRSPE TNGLLCGDPE ENCAATTTQS 
KRKGHFSRCP KQYKHYCIKG RCRFVVAEQT PSCVPLRKRR KRKKKEEEME TLGKDITPIN 
EDIEETNIA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: BTC

Associated with

Cells (max top 100)

Other Information

Cloning and expression of cDNA encoding human betacellulin, a new member of the EGF family. PubMed ID: 8439318

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Recombinant human betacellulin. Molecular structure, biological activities, and receptor interaction. PubMed ID: 8144591

Human betacellulin, a member of the EGF family dominantly expressed in pancreas and small intestine, is fully active in a monomeric form. PubMed ID: 8919026

Betacellulin activates the epidermal growth factor receptor and erbB-4, and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-beta. PubMed ID: 8570211

Ligand discrimination in signaling through an ErbB4 receptor homodimer. PubMed ID: 10867024

Solution structure of betacellulin, a new member of EGF-family ligands. PubMed ID: 12074582

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. PubMed ID: 26871637