Gene BTC - ENSG00000174808 | NCBI Gene ID: 685

Details for: BTC

Gene ID: 685

Symbol: BTC

Ensembl ID: ENSG00000174808

Description: betacellulin

Associated with

Cargo recognition for clathrin-mediated endocytosis
(R-HSA-8856825)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downregulation of erbb2 signaling
(R-HSA-8863795)
Egfr downregulation
(R-HSA-182971)
Egfr interacts with phospholipase c-gamma
(R-HSA-212718)
Erbb2 activates ptk6 signaling
(R-HSA-8847993)
Erbb2 regulates cell motility
(R-HSA-6785631)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-HSA-9634638)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Gab1 signalosome
(R-HSA-180292)
Grb2 events in egfr signaling
(R-HSA-179812)
Grb2 events in erbb2 signaling
(R-HSA-1963640)
Inhibition of signaling by overexpressed egfr
(R-HSA-5638303)
Intracellular signaling by second messengers
(R-HSA-9006925)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Membrane trafficking
(R-HSA-199991)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Nuclear signaling by erbb4
(R-HSA-1251985)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k events in erbb2 signaling
(R-HSA-1963642)
Pi3k events in erbb4 signaling
(R-HSA-1250342)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Raf/map kinase cascade
(R-HSA-5673001)
Shc1 events in egfr signaling
(R-HSA-180336)
Shc1 events in erbb2 signaling
(R-HSA-1250196)
Shc1 events in erbb4 signaling
(R-HSA-1250347)
Signaling by egfr
(R-HSA-177929)
Signaling by egfr in cancer
(R-HSA-1643713)
Signaling by erbb2
(R-HSA-1227986)
Signaling by erbb2 in cancer
(R-HSA-1227990)
Signaling by erbb2 kd mutants
(R-HSA-9664565)
Signaling by erbb2 tmd/jmd mutants
(R-HSA-9665686)
Signaling by erbb4
(R-HSA-1236394)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by overexpressed wild-type egfr in cancer
(R-HSA-5638302)
Signaling by ptk6
(R-HSA-8848021)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Vesicle-mediated transport
(R-HSA-5653656)
Cell population proliferation
(GO:0008283)
Clathrin-coated endocytic vesicle membrane
(GO:0030669)
Epidermal growth factor receptor binding
(GO:0005154)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Epithelial cell apoptotic process
(GO:1904019)
Erbb2-egfr signaling pathway
(GO:0038134)
Erbb4-erbb4 signaling pathway
(GO:0038138)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Growth factor activity
(GO:0008083)
Negative regulation of epithelial cell apoptotic process
(GO:1904036)
Plasma membrane
(GO:0005886)
Positive regulation of cell differentiation
(GO:0045597)
Positive regulation of cell division
(GO:0051781)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of mitotic nuclear division
(GO:0045840)
Positive regulation of urine volume
(GO:0035810)
Protein binding
(GO:0005515)
Receptor ligand activity
(GO:0048018)
Transmembrane receptor protein tyrosine kinase activator activity
(GO:0030297)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: conventional dendritic cell (CL0000990)
Fold Change: 2.17
Marker Score: 1496
Cell Name: retina horizontal cell (CL0000745)
Fold Change: 1.55
Marker Score: 1490.5
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.46
Marker Score: 2770
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.35
Marker Score: 859
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 1.18
Marker Score: 447
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 1.04
Marker Score: 251786
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.03
Marker Score: 785
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1
Marker Score: 2038
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30407
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.97
Marker Score: 499
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.96
Marker Score: 453
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2410
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.91
Marker Score: 5209
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2731
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.89
Marker Score: 319
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5277
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.84
Marker Score: 51847
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.84
Marker Score: 13113
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.81
Marker Score: 7062
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.79
Marker Score: 472
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.77
Marker Score: 310
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.77
Marker Score: 1248
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 0.77
Marker Score: 7292
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.74
Marker Score: 491
Cell Name: brush cell (CL0002204)
Fold Change: 0.74
Marker Score: 675
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.73
Marker Score: 1393
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 175
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.67
Marker Score: 2825.5
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.62
Marker Score: 960
Cell Name: dendritic cell (CL0000451)
Fold Change: 0.61
Marker Score: 421
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.61
Marker Score: 1428
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.61
Marker Score: 177
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.55
Marker Score: 353.5
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 438
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.52
Marker Score: 1229
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.52
Marker Score: 245
Cell Name: B cell (CL0000236)
Fold Change: 0.51
Marker Score: 484
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 0.5
Marker Score: 331
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.5
Marker Score: 415
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.49
Marker Score: 2047
Cell Name: mast cell (CL0000097)
Fold Change: 0.49
Marker Score: 283
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.49
Marker Score: 716
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.48
Marker Score: 466
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.48
Marker Score: 201
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 0.48
Marker Score: 3579
Cell Name: podocyte (CL0000653)
Fold Change: 0.48
Marker Score: 177
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 0.48
Marker Score: 140
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.47
Marker Score: 225
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.46
Marker Score: 1058
Cell Name: smooth muscle cell of small intestine (CL1000275)
Fold Change: 0.46
Marker Score: 120
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.43
Marker Score: 115
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.4
Marker Score: 1006
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.4
Marker Score: 404
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.39
Marker Score: 417
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.38
Marker Score: 1021
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.37
Marker Score: 252
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.36
Marker Score: 364
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: 0.35
Marker Score: 350
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.35
Marker Score: 321
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.35
Marker Score: 2650
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.34
Marker Score: 98
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.34
Marker Score: 191
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.33
Marker Score: 318
Cell Name: malignant cell (CL0001064)
Fold Change: 0.33
Marker Score: 4463
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.33
Marker Score: 149
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.33
Marker Score: 218
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.33
Marker Score: 103
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.33
Marker Score: 152
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.32
Marker Score: 247
Cell Name: mesothelial cell (CL0000077)
Fold Change: 0.32
Marker Score: 127
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.31
Marker Score: 444
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 0.31
Marker Score: 11658
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.31
Marker Score: 151
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.3
Marker Score: 133
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 0.29
Marker Score: 314
Cell Name: bronchial smooth muscle cell (CL0002598)
Fold Change: 0.29
Marker Score: 83
Cell Name: muscle cell (CL0000187)
Fold Change: 0.29
Marker Score: 81.5
Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.28
Marker Score: 122
Cell Name: endothelial cell of artery (CL1000413)
Fold Change: 0.28
Marker Score: 116
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.27
Marker Score: 2361
Cell Name: mucous neck cell (CL0000651)
Fold Change: 0.27
Marker Score: 615
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.27
Marker Score: 1759
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.26
Marker Score: 637
Cell Name: pericyte (CL0000669)
Fold Change: 0.26
Marker Score: 151
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.26
Marker Score: 182
Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.25
Marker Score: 1323
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.25
Marker Score: 703
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 0.25
Marker Score: 236
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.24
Marker Score: 85
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.24
Marker Score: 164
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.24
Marker Score: 381
Cell Name: neural cell (CL0002319)
Fold Change: 0.24
Marker Score: 115
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.24
Marker Score: 246
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.24
Marker Score: 909
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.23
Marker Score: 247
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.23
Marker Score: 60
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.23
Marker Score: 1974
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 65
Cell Name: fibrocyte (CL0000135)
Fold Change: 0.23
Marker Score: 70
Cell Name: stem cell (CL0000034)
Fold Change: 0.23
Marker Score: 535

Hover over a box to see details here...

**Key characteristics:** - Beta-catenin is a type III transmembrane protein with a molecular weight of approximately 120 kDa. - It is a key component of the Wnt signaling pathway, which is involved in cell fate determination, tissue development, and cancer development. - It is also involved in the regulation of the epithelial-mesenchymal transition (EMT), a process by which epithelial cells lose their epithelial characteristics and acquire mesenchymal characteristics. **Pathways and functions:** - Beta-catenin is a key regulator of the Wnt signaling pathway. - It is a downstream target of the Wnt proteins, which are secreted by various cell types. - When beta-catenin binds to Wnt proteins, it recruits them to the plasma membrane, where they form a complex that activates the transcription of target genes. - This pathway is essential for various developmental processes, including tissue formation, organogenesis, and cancer development. **Clinical significance:** - Mutations in the beta-catenin gene are associated with several human cancers, including breast cancer, colon cancer, and lung cancer. - Targeting the Wnt signaling pathway with small molecule inhibitors is a promising therapeutic strategy for these cancers. - Inhibition of beta-catenin has been shown to inhibit cancer cell growth and metastasis. **Additional notes:** - Beta-catenin is a highly conserved protein, with similar sequences found in organisms from yeast to humans. - It is a key regulator of the development and maintenance of epithelial tissues. - Mutations in the beta-catenin gene have been linked to a number of human diseases, including cancer and developmental disorders.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Probetacellulin
A0A0S2Z3I5_HUMAN

Genular Protein ID: 2222156240

Symbol: BTC_HUMAN

Name: Probetacellulin

UniProtKB Accession Codes:

P35070 Q96F48

Database IDs:

Citations:

PubMed ID: 8439318

Title: Cloning and expression of cDNA encoding human betacellulin, a new member of the EGF family.

PubMed ID: 8439318

DOI: 10.1006/bbrc.1993.1173

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8144591

Title: Recombinant human betacellulin. Molecular structure, biological activities, and receptor interaction.

PubMed ID: 8144591

DOI: 10.1016/s0021-9258(17)36977-6

PubMed ID: 8919026

Title: Human betacellulin, a member of the EGF family dominantly expressed in pancreas and small intestine, is fully active in a monomeric form.

PubMed ID: 8919026

DOI: 10.3109/08977199609003220

PubMed ID: 8570211

Title: Betacellulin activates the epidermal growth factor receptor and erbB-4, and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-beta.

PubMed ID: 8570211

PubMed ID: 10867024

Title: Ligand discrimination in signaling through an ErbB4 receptor homodimer.

PubMed ID: 10867024

DOI: 10.1074/jbc.c901015199

PubMed ID: 12074582

Title: Solution structure of betacellulin, a new member of EGF-family ligands.

PubMed ID: 12074582

DOI: 10.1016/s0006-291x(02)00585-5

Sequence Information:

Length: 178
Mass: 19746
Checksum: 27AC77BD92001F0F
Sequence:

MDRAARCSGA SSLPLLLALA LGLVILHCVV ADGNSTRSPE TNGLLCGDPE ENCAATTTQS 
KRKGHFSRCP KQYKHYCIKG RCRFVVAEQT PSCVCDEGYI GARCERVDLF YLRGDRGQIL 
VICLIAVMVV FIILVIGVCT CCHPLRKRRK RKKKEEEMET LGKDITPINE DIEETNIA

Genular Protein ID: 1030526547

Symbol: A0A0S2Z3I5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z3I5

Database IDs:

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

Length: 129
Mass: 14301
Checksum: F969472876D876BB
Sequence:

MDRAARCSGA SSLPLLLALA LGLVILHCVV ADGNSTRSPE TNGLLCGDPE ENCAATTTQS 
KRKGHFSRCP KQYKHYCIKG RCRFVVAEQT PSCVPLRKRR KRKKKEEEME TLGKDITPIN 
EDIEETNIA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: BTC

Associated with

Cells (max top 100)

Other Information

Cloning and expression of cDNA encoding human betacellulin, a new member of the EGF family. PubMed ID: 8439318

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Recombinant human betacellulin. Molecular structure, biological activities, and receptor interaction. PubMed ID: 8144591

Human betacellulin, a member of the EGF family dominantly expressed in pancreas and small intestine, is fully active in a monomeric form. PubMed ID: 8919026

Betacellulin activates the epidermal growth factor receptor and erbB-4, and induces cellular response patterns distinct from those stimulated by epidermal growth factor or neuregulin-beta. PubMed ID: 8570211

Ligand discrimination in signaling through an ErbB4 receptor homodimer. PubMed ID: 10867024

Solution structure of betacellulin, a new member of EGF-family ligands. PubMed ID: 12074582

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. PubMed ID: 26871637