Details for: KLF9

Gene ID: 687

Symbol: KLF9

Ensembl ID: ENSG00000119138

Description: KLF transcription factor 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 305.4739
    Cell Significance Index: -47.5200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 179.9771
    Cell Significance Index: -45.6500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 100.9060
    Cell Significance Index: -47.6400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 88.4162
    Cell Significance Index: -45.4800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 71.3985
    Cell Significance Index: -47.9100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 38.7930
    Cell Significance Index: -47.8300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.5000
    Cell Significance Index: -46.8800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 13.6252
    Cell Significance Index: -29.8200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.1343
    Cell Significance Index: -37.2700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.1159
    Cell Significance Index: -47.8100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 6.4473
    Cell Significance Index: 184.8200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.4586
    Cell Significance Index: 25.7800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.3062
    Cell Significance Index: 31.8700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2857
    Cell Significance Index: 176.5600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.2014
    Cell Significance Index: 8.1400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.0798
    Cell Significance Index: 18.1900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9532
    Cell Significance Index: 20.6500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9178
    Cell Significance Index: 184.1000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8685
    Cell Significance Index: 23.6400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8393
    Cell Significance Index: 91.2900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.7327
    Cell Significance Index: 14.3000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6410
    Cell Significance Index: 41.3600
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 0.5724
    Cell Significance Index: 9.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5662
    Cell Significance Index: 203.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4326
    Cell Significance Index: 42.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.4101
    Cell Significance Index: 19.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4072
    Cell Significance Index: 28.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3906
    Cell Significance Index: 11.2600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3900
    Cell Significance Index: 20.4800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3827
    Cell Significance Index: 169.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3675
    Cell Significance Index: 28.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3224
    Cell Significance Index: 8.0600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3197
    Cell Significance Index: 52.0000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3193
    Cell Significance Index: 40.9300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2963
    Cell Significance Index: 19.9200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2465
    Cell Significance Index: 3.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1976
    Cell Significance Index: 24.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1758
    Cell Significance Index: 331.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1753
    Cell Significance Index: 7.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1480
    Cell Significance Index: 94.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1341
    Cell Significance Index: 26.6200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1298
    Cell Significance Index: 22.1600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1029
    Cell Significance Index: 5.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0968
    Cell Significance Index: 43.9200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0896
    Cell Significance Index: 4.2100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0674
    Cell Significance Index: 12.8200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0660
    Cell Significance Index: 48.4200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0173
    Cell Significance Index: 1.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0148
    Cell Significance Index: 1.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0012
    Cell Significance Index: 0.1600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0093
    Cell Significance Index: -0.2400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0098
    Cell Significance Index: -5.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0113
    Cell Significance Index: -15.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0173
    Cell Significance Index: -15.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0209
    Cell Significance Index: -32.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0229
    Cell Significance Index: -42.1800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0235
    Cell Significance Index: -13.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0237
    Cell Significance Index: -4.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0283
    Cell Significance Index: -20.9600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0310
    Cell Significance Index: -1.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0310
    Cell Significance Index: -19.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0343
    Cell Significance Index: -3.5000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0480
    Cell Significance Index: -33.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0505
    Cell Significance Index: -38.2000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0954
    Cell Significance Index: -4.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1218
    Cell Significance Index: -25.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1278
    Cell Significance Index: -36.7800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1391
    Cell Significance Index: -2.0000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1489
    Cell Significance Index: -21.6400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1782
    Cell Significance Index: -2.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2016
    Cell Significance Index: -23.5000
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.2040
    Cell Significance Index: -2.1300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2042
    Cell Significance Index: -23.3900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2724
    Cell Significance Index: -10.3200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3030
    Cell Significance Index: -24.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3061
    Cell Significance Index: -31.8700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3516
    Cell Significance Index: -41.4600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.3548
    Cell Significance Index: -2.9800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3621
    Cell Significance Index: -22.2000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3763
    Cell Significance Index: -42.9500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4120
    Cell Significance Index: -4.6800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.4191
    Cell Significance Index: -3.2300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4289
    Cell Significance Index: -7.3500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4789
    Cell Significance Index: -10.2000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5197
    Cell Significance Index: -10.7800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.5271
    Cell Significance Index: -5.6000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5379
    Cell Significance Index: -27.9400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6816
    Cell Significance Index: -19.4500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7090
    Cell Significance Index: -43.5800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7155
    Cell Significance Index: -16.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7754
    Cell Significance Index: -48.8700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.7875
    Cell Significance Index: -11.8000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7948
    Cell Significance Index: -16.9900
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.7975
    Cell Significance Index: -10.9200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8378
    Cell Significance Index: -11.4300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.8455
    Cell Significance Index: -23.6300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8677
    Cell Significance Index: -27.7900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9002
    Cell Significance Index: -50.5200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.9005
    Cell Significance Index: -28.6800
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.9640
    Cell Significance Index: -9.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KLF9 is a transcription factor that belongs to the KLF family, which consists of 12 members. It is characterized by its ability to bind to specific DNA sequences and regulate gene expression in response to various stimuli. KLF9 is known to interact with other transcription factors, such as NF-κB and AP-1, to modulate the expression of target genes. Its expression is tightly regulated by post-translational modifications, including phosphorylation and sumoylation, which can affect its activity and subcellular localization. **Pathways and Functions:** KLF9 is involved in several signaling pathways, including the cellular response to cortisol stimulus, chromatin regulation, and circadian rhythm. It plays a crucial role in the regulation of transcription by RNA polymerase II, which is essential for the expression of many genes involved in immune response and cell proliferation. KLF9 also modulates the activity of other transcription factors, such as NF-κB and AP-1, which are key regulators of immune responses. Its expression has been linked to the regulation of cell proliferation, differentiation, and survival in various cell types, including immune cells and epithelial cells. **Clinical Significance:** KLF9 has been implicated in several immune-related disorders, including autoimmune diseases and cancer. Its dysregulation has been linked to the development of various cancers, including breast cancer, prostate cancer, and leukemia. In autoimmune diseases, KLF9 has been shown to play a role in the regulation of immune responses and the development of autoimmunity. Its expression has also been observed in other diseases, including cardiovascular disease and metabolic disorders. Understanding the role of KLF9 in these diseases will provide valuable insights into the development of novel therapeutic strategies. **Significantly Expressed Cells:** KLF9 is expressed in a wide range of cell types, including: * Fibroblasts of mammary gland and connective tissue of nonglandular part of prostate * Skeletal muscle satellite stem cells * Vascular leptomeningeal cells * Fibroblasts of connective tissue of nonglandular part of prostate * Alveolar capillary type 1 and type 2 endothelial cells * Common lymphoid progenitor * Cardiac neurons * Keratocytes **Proteins:** The protein KLF9_HUMAN (Krueppel-like factor 9) is the human homolog of the KLF9 gene. In conclusion, KLF9 is a multifunctional transcription factor that plays a crucial role in various cellular processes, including immune response and cell proliferation. Its dysregulation has been linked to several immune-related disorders and cancers, highlighting its potential as a therapeutic target. Further research is needed to fully understand the role of KLF9 in these diseases and to develop novel therapeutic strategies.

Genular Protein ID: 3084599731

Symbol: KLF9_HUMAN

Name: Krueppel-like factor 9

UniProtKB Accession Codes:

Q13886 B2R943 Q16196

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8291025

Title: Chromosomal localization and cDNA sequence of human BTEB, a GC box binding protein.

PubMed ID: 8291025

DOI: 10.1007/bf01233255

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8051167

Title: Cell-specific translational control of transcription factor BTEB expression. The role of an upstream AUG in the 5'-untranslated region.

PubMed ID: 8051167

DOI: 10.1016/s0021-9258(17)32045-8

PubMed ID: 22711835

Title: Kruppel-like factor 9 is a circadian transcription factor in human epidermis that controls proliferation of keratinocytes.

PubMed ID: 22711835

DOI: 10.1073/pnas.1118641109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 33227311

Title: ZZEF1 is a Histone Reader and Transcriptional Coregulator of Krueppel-Like Factors.

PubMed ID: 33227311

DOI: 10.1016/j.jmb.2020.11.021

Sequence Information:

  • Length: 244
  • Mass: 27235
  • Checksum: 2D1B5A5BB9D42221
  • Sequence:
    • MSAAAYMDFV AAQCLVSISN RAAVPEHGVA PDAERLRLPE REVTKEHGDP GDTWKDYCTL 
VTIAKSLLDL NKYRPIQTPS VCSDSLESPD EDMGSDSDVT TESGSSPSHS PEERQDPGSA 
PSPLSLLHPG VAAKGKHASE KRHKCPYSGC GKVYGKSSHL KAHYRVHTGE RPFPCTWPDC 
LKKFSRSDEL TRHYRTHTGE KQFRCPLCEK RFMRSDHLTK HARRHTEFHP SMIKRSKKAL 
ANAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.