Details for: KLF9

Gene ID: 687

Symbol: KLF9

Ensembl ID: ENSG00000119138

Description: KLF transcription factor 9

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.71
    Marker Score: 126324
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.08
    Marker Score: 3290
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.41
    Marker Score: 2768
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.35
    Marker Score: 2002
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.15
    Marker Score: 5461
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 2.15
    Marker Score: 499
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 2.14
    Marker Score: 1455.5
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.13
    Marker Score: 2654
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.09
    Marker Score: 482
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.06
    Marker Score: 2979
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.96
    Marker Score: 1865
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.95
    Marker Score: 1115
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.93
    Marker Score: 1665
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.92
    Marker Score: 2191.5
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.89
    Marker Score: 785
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.83
    Marker Score: 2663
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.83
    Marker Score: 4795
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.8
    Marker Score: 4090
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.79
    Marker Score: 3921.5
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.77
    Marker Score: 1162
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.73
    Marker Score: 3521
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.73
    Marker Score: 3328
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.68
    Marker Score: 831
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.64
    Marker Score: 2042
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.62
    Marker Score: 949
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 1.56
    Marker Score: 1511
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.55
    Marker Score: 484
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.54
    Marker Score: 393
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.54
    Marker Score: 858
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.52
    Marker Score: 3043
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.52
    Marker Score: 2855
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.52
    Marker Score: 17079
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.51
    Marker Score: 570
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.5
    Marker Score: 360
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.48
    Marker Score: 3632
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 1.44
    Marker Score: 1873
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.43
    Marker Score: 2533
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.43
    Marker Score: 1413
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.42
    Marker Score: 709
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.4
    Marker Score: 923.5
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.38
    Marker Score: 294
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.38
    Marker Score: 6755
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.37
    Marker Score: 2326.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.37
    Marker Score: 3228
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.37
    Marker Score: 400
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.36
    Marker Score: 1223
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.36
    Marker Score: 633.5
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.34
    Marker Score: 331
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 1.33
    Marker Score: 338
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.33
    Marker Score: 412
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.33
    Marker Score: 797
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.32
    Marker Score: 20729
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.31
    Marker Score: 1621
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.3
    Marker Score: 12389
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.3
    Marker Score: 410
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.3
    Marker Score: 11144
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.3
    Marker Score: 336
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.29
    Marker Score: 5418.5
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.29
    Marker Score: 1991
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.29
    Marker Score: 814
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.28
    Marker Score: 317
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.27
    Marker Score: 903
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.24
    Marker Score: 399
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.23
    Marker Score: 736
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.22
    Marker Score: 711
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.22
    Marker Score: 526
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.21
    Marker Score: 5227
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.21
    Marker Score: 5224
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2
    Marker Score: 1261
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.19
    Marker Score: 3200.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.19
    Marker Score: 73023
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.18
    Marker Score: 294
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.18
    Marker Score: 7557
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.17
    Marker Score: 25060
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.17
    Marker Score: 2919
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.17
    Marker Score: 294
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.16
    Marker Score: 651
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.16
    Marker Score: 2633
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.13
    Marker Score: 327
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.13
    Marker Score: 1747
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.13
    Marker Score: 1461
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.12
    Marker Score: 1015
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.12
    Marker Score: 435
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.12
    Marker Score: 1196
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.11
    Marker Score: 4289
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.1
    Marker Score: 215
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 1.08
    Marker Score: 286
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 1.07
    Marker Score: 580
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.07
    Marker Score: 838
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.06
    Marker Score: 397
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.06
    Marker Score: 455
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.06
    Marker Score: 5672
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 1.05
    Marker Score: 6283
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.03
    Marker Score: 1946
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.02
    Marker Score: 935.5
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.02
    Marker Score: 677
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.01
    Marker Score: 374
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.01
    Marker Score: 1383
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 1
    Marker Score: 476
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71634

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Other Information

**Key characteristics:** - KLF9 is a member of the Krüppel-like transcription factor family, which are a group of proteins that are involved in the regulation of cell proliferation, differentiation, and apoptosis. - KLF9 is a nuclear protein that is expressed in a variety of cell types, including fibroblasts, keratinocytes, and immune cells. - It is a key regulator of keratinocyte proliferation, differentiation, and survival. - In keratinocytes, KLF9 is essential for the maintenance of the skin barrier and the production of skin proteins. - It is also involved in the regulation of inflammation and wound healing. **Pathways and functions:** - KLF9 is a key regulator of keratinization. It is expressed in the basal layer of skin cells, which are responsible for producing the proteins that make up the skin barrier. - KLF9 binds to DNA sequences in the promoter region of keratin genes and activates their expression. - This allows keratinocytes to produce the proteins that are necessary for the formation of the skin barrier. - In addition to its role in keratinization, KLF9 is also involved in the regulation of cell proliferation, differentiation, and apoptosis. - In keratinocytes, KLF9 is essential for the maintenance of the skin barrier and the production of skin proteins. - It is also involved in the regulation of inflammation and wound healing. **Clinical significance:** - Mutations in the KLF9 gene have been linked to a number of skin diseases, including psoriasis, acne, and eczema. - These mutations can lead to the loss of function of KLF9, which can result in the disruption of the skin barrier and the development of skin diseases. - As a result, KLF9 is a promising target for the treatment of skin diseases. **Conclusion:** KLF9 is a key regulator of keratinization, cell proliferation, and differentiation. It is essential for the maintenance of the skin barrier and the production of skin proteins. Mutations in the KLF9 gene have been linked to a number of skin diseases, which highlights its importance in skin health.

Genular Protein ID: 3084599731

Symbol: KLF9_HUMAN

Name: Krueppel-like factor 9

UniProtKB Accession Codes:

Q13886 B2R943 Q16196

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 8 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8291025

Title: Chromosomal localization and cDNA sequence of human BTEB, a GC box binding protein.

PubMed ID: 8291025

DOI: 10.1007/bf01233255

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8051167

Title: Cell-specific translational control of transcription factor BTEB expression. The role of an upstream AUG in the 5'-untranslated region.

PubMed ID: 8051167

DOI: 10.1016/s0021-9258(17)32045-8

PubMed ID: 22711835

Title: Kruppel-like factor 9 is a circadian transcription factor in human epidermis that controls proliferation of keratinocytes.

PubMed ID: 22711835

DOI: 10.1073/pnas.1118641109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 33227311

Title: ZZEF1 is a Histone Reader and Transcriptional Coregulator of Krueppel-Like Factors.

PubMed ID: 33227311

DOI: 10.1016/j.jmb.2020.11.021

Sequence Information:

  • Length: 244
  • Mass: 27235
  • Checksum: 2D1B5A5BB9D42221
  • Sequence:
    • MSAAAYMDFV AAQCLVSISN RAAVPEHGVA PDAERLRLPE REVTKEHGDP GDTWKDYCTL 
VTIAKSLLDL NKYRPIQTPS VCSDSLESPD EDMGSDSDVT TESGSSPSHS PEERQDPGSA 
PSPLSLLHPG VAAKGKHASE KRHKCPYSGC GKVYGKSSHL KAHYRVHTGE RPFPCTWPDC 
LKKFSRSDEL TRHYRTHTGE KQFRCPLCEK RFMRSDHLTK HARRHTEFHP SMIKRSKKAL 
ANAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.