Details for: KLF5
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 180.1405
Cell Significance Index: -28.0200 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 111.2586
Cell Significance Index: -28.2200 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 62.7386
Cell Significance Index: -25.8500 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 42.6513
Cell Significance Index: -28.6200 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 22.7340
Cell Significance Index: -28.0300 - Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 17.5941
Cell Significance Index: 52.3300 - Cell Name: epidermal cell (CL0000362)
Fold Change: 14.3536
Cell Significance Index: 32.3600 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 11.5702
Cell Significance Index: -31.0000 - Cell Name: epithelial cell of pancreas (CL0000083)
Fold Change: 11.1957
Cell Significance Index: 184.4900 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 7.1641
Cell Significance Index: -28.2700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 6.5981
Cell Significance Index: 342.7500 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 5.8269
Cell Significance Index: 35.9500 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 5.4331
Cell Significance Index: 82.5200 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 5.0903
Cell Significance Index: 138.5600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 4.1452
Cell Significance Index: 674.1700 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 3.7913
Cell Significance Index: 412.3800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 3.6752
Cell Significance Index: 102.7100 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 3.2470
Cell Significance Index: 20.1000 - Cell Name: peg cell (CL4033014)
Fold Change: 3.0303
Cell Significance Index: 70.0100 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 2.9288
Cell Significance Index: 29.5500 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 2.9212
Cell Significance Index: 84.1700 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 2.9024
Cell Significance Index: 131.5600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 2.8823
Cell Significance Index: 519.5900 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 2.7365
Cell Significance Index: 38.9600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 2.4940
Cell Significance Index: 306.6600 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 2.4053
Cell Significance Index: 22.1500 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 2.0424
Cell Significance Index: -4.4700 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 1.9554
Cell Significance Index: 29.3000 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.8093
Cell Significance Index: 233.7500 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.5645
Cell Significance Index: 154.7600 - Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 1.4139
Cell Significance Index: 12.1500 - Cell Name: cell in vitro (CL0001034)
Fold Change: 1.3926
Cell Significance Index: 760.5400 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 1.3623
Cell Significance Index: 64.0300 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 1.1322
Cell Significance Index: 500.5700 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 1.1317
Cell Significance Index: 11.7200 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 0.8848
Cell Significance Index: 10.2900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.8309
Cell Significance Index: 38.7400 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.7899
Cell Significance Index: 25.3000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.7893
Cell Significance Index: 16.8100 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.7791
Cell Significance Index: 148.2600 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.6992
Cell Significance Index: 18.6700 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.6524
Cell Significance Index: 6.7300 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.5902
Cell Significance Index: 20.7400 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.5423
Cell Significance Index: 4.4900 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5317
Cell Significance Index: 480.0700 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.5102
Cell Significance Index: 146.7900 - Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: 0.4970
Cell Significance Index: 7.6900 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.4131
Cell Significance Index: 4.2800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.3824
Cell Significance Index: 28.5000 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 0.2704
Cell Significance Index: 2.4000 - Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 0.2403
Cell Significance Index: 0.9200 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.2070
Cell Significance Index: 7.8400 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.2057
Cell Significance Index: 9.1000 - Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
Fold Change: 0.1999
Cell Significance Index: 2.0000 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.1690
Cell Significance Index: 1.0500 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.1538
Cell Significance Index: 4.4100 - Cell Name: secretory cell (CL0000151)
Fold Change: 0.1110
Cell Significance Index: 0.7700 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.0650
Cell Significance Index: 1.6700 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0498
Cell Significance Index: 6.3900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.0318
Cell Significance Index: 24.0500 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.0202
Cell Significance Index: 2.7800 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0175
Cell Significance Index: 12.1000 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0079
Cell Significance Index: 1.5600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0017
Cell Significance Index: -3.2000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0073
Cell Significance Index: -0.1000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0079
Cell Significance Index: -1.5900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0167
Cell Significance Index: -30.8700 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0189
Cell Significance Index: -13.8600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0205
Cell Significance Index: -31.5900 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0247
Cell Significance Index: -33.5300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0322
Cell Significance Index: -20.4400 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0373
Cell Significance Index: -27.6500 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0428
Cell Significance Index: -7.3000 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.0476
Cell Significance Index: -1.1900 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0484
Cell Significance Index: -30.2300 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0497
Cell Significance Index: -28.0400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0569
Cell Significance Index: -25.8400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0579
Cell Significance Index: -20.7800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.0715
Cell Significance Index: -1.5500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0778
Cell Significance Index: -5.5000 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1083
Cell Significance Index: -11.0600 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1213
Cell Significance Index: -14.1400 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1402
Cell Significance Index: -29.5400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1421
Cell Significance Index: -20.6500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1425
Cell Significance Index: -16.3300 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2236
Cell Significance Index: -26.3700 - Cell Name: colonocyte (CL1000347)
Fold Change: -0.2282
Cell Significance Index: -1.4100 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.2337
Cell Significance Index: -11.8100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2534
Cell Significance Index: -26.3800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.2679
Cell Significance Index: -20.5600 - Cell Name: tracheal goblet cell (CL1000329)
Fold Change: -0.2831
Cell Significance Index: -2.3400 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.2966
Cell Significance Index: -12.1500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3005
Cell Significance Index: -23.8000 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.3282
Cell Significance Index: -6.4900 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3340
Cell Significance Index: -20.4800 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.3398
Cell Significance Index: -3.8600 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.3593
Cell Significance Index: -7.5200 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.3630
Cell Significance Index: -7.7600 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.3633
Cell Significance Index: -22.3300 - Cell Name: enterocyte (CL0000584)
Fold Change: -0.3723
Cell Significance Index: -2.3100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 240671694
Symbol: KLF5_HUMAN
Name: Krueppel-like factor 5
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10572182
Title: Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter.
PubMed ID: 10572182
PubMed ID: 23134681
Title: Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors.
PubMed ID: 23134681
DOI: 10.1096/fj.12-220319
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15057823
Title: The DNA sequence and analysis of human chromosome 13.
PubMed ID: 15057823
DOI: 10.1038/nature02379
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8479902
Title: cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2.
PubMed ID: 8479902
PubMed ID: 15735697
Title: Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells.
PubMed ID: 15735697
PubMed ID: 18039846
Title: Promoter region-specific histone incorporation by the novel histone chaperone ANP32B and DNA-binding factor KLF5.
PubMed ID: 18039846
DOI: 10.1128/mcb.01396-07
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 31375868
Title: The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs.
PubMed ID: 31375868
PubMed ID: 16959974
Title: The consensus coding sequences of human breast and colorectal cancers.
PubMed ID: 16959974
PubMed ID: 26079537
Title: Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Krueppel-like factor 5 (KLF5).
PubMed ID: 26079537
Sequence Information:
- Length: 457
- Mass: 50792
- Checksum: 3BF12BE272716E57
- Sequence:
MATRVLSMSA RLGPVPQPPA PQDEPVFAQL KPVLGAANPA RDAALFPGEE LKHAHHRPQA QPAPAQAPQP AQPPATGPRL PPEDLVQTRC EMEKYLTPQL PPVPIIPEHK KYRRDSASVV DQFFTDTEGL PYSINMNVFL PDITHLRTGL YKSQRPCVTH IKTEPVAIFS HQSETTAPPP APTQALPEFT SIFSSHQTAA PEVNNIFIKQ ELPTPDLHLS VPTQQGHLYQ LLNTPDLDMP SSTNQTAAMD TLNVSMSAAM AGLNTHTSAV PQTAVKQFQG MPPCTYTMPS QFLPQQATYF PPSPPSSEPG SPDRQAEMLQ NLTPPPSYAA TIASKLAIHN PNLPTTLPVN SQNIQPVRYN RRSNPDLEKR RIHYCDYPGC TKVYTKSSHL KAHLRTHTGE KPYKCTWEGC DWRFARSDEL TRHYRKHTGA KPFQCGVCNR SFSRSDHLAL HMKRHQN
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.