Details for: KLF5

Gene ID: 688

Symbol: KLF5

Ensembl ID: ENSG00000102554

Description: KLF transcription factor 5

Associated with

  • Developmental biology
    (R-HSA-1266738)
  • Transcriptional regulation of granulopoiesis
    (R-HSA-9616222)
  • Transcriptional regulation of white adipocyte differentiation
    (R-HSA-381340)
  • Angiogenesis
    (GO:0001525)
  • Cell-cell signaling via exosome
    (GO:0099156)
  • Cellular response to leukemia inhibitory factor
    (GO:1990830)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Golgi apparatus
    (GO:0005794)
  • Intestinal epithelial cell development
    (GO:0060576)
  • Intracellular membrane-bounded organelle
    (GO:0043231)
  • Metal ion binding
    (GO:0046872)
  • Microvillus assembly
    (GO:0030033)
  • Mrf binding
    (GO:0043426)
  • Myotube differentiation involved in skeletal muscle regeneration
    (GO:0014908)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Positive regulation of fat cell differentiation
    (GO:0045600)
  • Positive regulation of mirna transcription
    (GO:1902895)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of transcription by transcription factor localization
    (GO:0061586)
  • Protein binding
    (GO:0005515)
  • Regulation of microvillus assembly
    (GO:0032534)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Satellite cell activation involved in skeletal muscle regeneration
    (GO:0014901)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Skeletal muscle satellite cell differentiation
    (GO:0014816)
  • Transcription regulator complex
    (GO:0005667)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.5
    Marker Score: 8,551
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.45
    Marker Score: 2,716
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.23
    Marker Score: 3,395
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.12
    Marker Score: 9,805
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.12
    Marker Score: 23,209
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.85
    Marker Score: 1,904
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.68
    Marker Score: 17,122
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.68
    Marker Score: 23,119
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.59
    Marker Score: 3,822
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.58
    Marker Score: 6,132
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.54
    Marker Score: 5,759
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.5
    Marker Score: 847
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.49
    Marker Score: 11,972
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.47
    Marker Score: 1,679
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.43
    Marker Score: 18,965
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.42
    Marker Score: 1,681
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.37
    Marker Score: 3,062
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.33
    Marker Score: 4,260
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.32
    Marker Score: 2,222
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.28
    Marker Score: 1,784
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.18
    Marker Score: 2,469
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.17
    Marker Score: 2,399
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.16
    Marker Score: 3,439
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.13
    Marker Score: 614
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.11
    Marker Score: 1,039
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.07
    Marker Score: 4,380
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.01
    Marker Score: 485
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.92
    Marker Score: 897
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.9
    Marker Score: 603
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.88
    Marker Score: 706
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.87
    Marker Score: 1,619
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.87
    Marker Score: 1,862
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.87
    Marker Score: 6,912
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.86
    Marker Score: 64,481
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.86
    Marker Score: 1,081
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.82
    Marker Score: 15,837
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.77
    Marker Score: 1,583
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.77
    Marker Score: 511
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.74
    Marker Score: 2,859
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.74
    Marker Score: 2,095
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.71
    Marker Score: 11,124
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.64
    Marker Score: 1,916
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.63
    Marker Score: 5,594
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.55
    Marker Score: 2,945
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.53
    Marker Score: 2,363
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.49
    Marker Score: 370
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168,162
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.44
    Marker Score: 791
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.42
    Marker Score: 7,481
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.41
    Marker Score: 285
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.38
    Marker Score: 5,408
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.37
    Marker Score: 3,113
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.34
    Marker Score: 26,692
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.3
    Marker Score: 330
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.27
    Marker Score: 1,064
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.27
    Marker Score: 555
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.27
    Marker Score: 569
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.24
    Marker Score: 780
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.24
    Marker Score: 427
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.23
    Marker Score: 19,703
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.17
    Marker Score: 285
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.16
    Marker Score: 1,864
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.15
    Marker Score: 461
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.15
    Marker Score: 592
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.14
    Marker Score: 1,010
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.13
    Marker Score: 422
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.1
    Marker Score: 317
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.06
    Marker Score: 208
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,766
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.04
    Marker Score: 434
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 1.01
    Marker Score: 289
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,784
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,009
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,403
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.97
    Marker Score: 4,059
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 496
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,410
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.94
    Marker Score: 1,534
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.94
    Marker Score: 2,555
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.94
    Marker Score: 1,776
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.93
    Marker Score: 444
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,324
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.93
    Marker Score: 1,640
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,729
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.91
    Marker Score: 262
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.91
    Marker Score: 224
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.91
    Marker Score: 14,162
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.89
    Marker Score: 1,818
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.88
    Marker Score: 610
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.88
    Marker Score: 232
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,271
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.87
    Marker Score: 928
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.81
    Marker Score: 27,632
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 611
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.8
    Marker Score: 413
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.77
    Marker Score: 660
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.76
    Marker Score: 219
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 387

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KLF5 is a member of the Kruppel-like factor (KLF) family of transcription factors, characterized by their zinc finger DNA-binding motif. KLF5 is specifically expressed in various cell types, including epithelial cells, stem cells, and immune cells. Its expression is tightly regulated by post-translational modifications, such as phosphorylation and acetylation, which influence its activity and subcellular localization. **Pathways and Functions:** KLF5 is involved in numerous signaling pathways, including: 1. **Cell-cell signaling via exosome**: KLF5 regulates the expression of genes involved in cell-cell communication, including those involved in the formation of the epithelial barrier. 2. **Angiogenesis**: KLF5 modulates the expression of angiogenic factors, influencing the formation of new blood vessels. 3. **Cellular response to leukemia inhibitory factor (LIF)**: KLF5 regulates the expression of genes involved in the LIF signaling pathway, which plays a crucial role in immune cell development and function. 4. **Chromatin remodeling**: KLF5 interacts with chromatin-modifying enzymes, influencing the regulation of gene expression. KLF5 functions as a transcriptional regulator, modulating the expression of genes involved in various biological processes, including: 1. **Intestinal epithelial cell development**: KLF5 regulates the expression of genes involved in the development and maintenance of the intestinal epithelium. 2. **Microvillus assembly**: KLF5 modulates the expression of genes involved in the formation of microvilli, which are essential for the function of intestinal epithelial cells. 3. **Myotube differentiation**: KLF5 regulates the expression of genes involved in the differentiation of skeletal muscle stem cells into myotubes. 4. **Granulopoiesis**: KLF5 modulates the expression of genes involved in the development and function of granulocytes, a type of white blood cell. **Clinical Significance:** KLF5 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases**: KLF5 has been shown to regulate the expression of genes involved in autoimmune disease pathogenesis, including rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: KLF5 has been implicated in the development and progression of various cancers, including leukemia and colon cancer. 3. **Inflammatory disorders**: KLF5 regulates the expression of genes involved in the development and maintenance of inflammation, including those involved in conditions such as asthma and psoriasis. In conclusion, KLF5 is a multifaceted transcription factor that plays a critical role in immune regulation, cellular development, and tissue homeostasis. Its dysregulation has been implicated in various disease states, highlighting the importance of further research into the role of KLF5 in human health and disease.

Genular Protein ID: 240671694

Symbol: KLF5_HUMAN

Name: Krueppel-like factor 5

UniProtKB Accession Codes:

Q13887 A2TJX0 L0R3U5 L0R4T9 Q9UHP8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10572182

Title: Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter.

PubMed ID: 10572182

DOI: 10.1093/nar/27.24.4807

PubMed ID: 23134681

Title: Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors.

PubMed ID: 23134681

DOI: 10.1096/fj.12-220319

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8479902

Title: cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2.

PubMed ID: 8479902

DOI: 10.1093/nar/21.7.1527

PubMed ID: 15735697

Title: Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells.

PubMed ID: 15735697

DOI: 10.1038/sj.onc.1208497

PubMed ID: 18039846

Title: Promoter region-specific histone incorporation by the novel histone chaperone ANP32B and DNA-binding factor KLF5.

PubMed ID: 18039846

DOI: 10.1128/mcb.01396-07

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31375868

Title: The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs.

PubMed ID: 31375868

DOI: 10.1007/s00018-019-03251-w

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 26079537

Title: Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Krueppel-like factor 5 (KLF5).

PubMed ID: 26079537

DOI: 10.18632/oncotarget.4128

Sequence Information:

  • Length: 457
  • Mass: 50792
  • Checksum: 3BF12BE272716E57
  • Sequence:
    • MATRVLSMSA RLGPVPQPPA PQDEPVFAQL KPVLGAANPA RDAALFPGEE LKHAHHRPQA 
QPAPAQAPQP AQPPATGPRL PPEDLVQTRC EMEKYLTPQL PPVPIIPEHK KYRRDSASVV 
DQFFTDTEGL PYSINMNVFL PDITHLRTGL YKSQRPCVTH IKTEPVAIFS HQSETTAPPP 
APTQALPEFT SIFSSHQTAA PEVNNIFIKQ ELPTPDLHLS VPTQQGHLYQ LLNTPDLDMP 
SSTNQTAAMD TLNVSMSAAM AGLNTHTSAV PQTAVKQFQG MPPCTYTMPS QFLPQQATYF 
PPSPPSSEPG SPDRQAEMLQ NLTPPPSYAA TIASKLAIHN PNLPTTLPVN SQNIQPVRYN 
RRSNPDLEKR RIHYCDYPGC TKVYTKSSHL KAHLRTHTGE KPYKCTWEGC DWRFARSDEL 
TRHYRKHTGA KPFQCGVCNR SFSRSDHLAL HMKRHQN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.