Details for: KLF5

Gene ID: 688

Symbol: KLF5

Ensembl ID: ENSG00000102554

Description: KLF transcription factor 5

Associated with

  • Developmental biology
    (R-HSA-1266738)
  • Transcriptional regulation of granulopoiesis
    (R-HSA-9616222)
  • Transcriptional regulation of white adipocyte differentiation
    (R-HSA-381340)
  • Angiogenesis
    (GO:0001525)
  • Cell-cell signaling via exosome
    (GO:0099156)
  • Cellular response to leukemia inhibitory factor
    (GO:1990830)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Golgi apparatus
    (GO:0005794)
  • Intestinal epithelial cell development
    (GO:0060576)
  • Intracellular membrane-bounded organelle
    (GO:0043231)
  • Metal ion binding
    (GO:0046872)
  • Microvillus assembly
    (GO:0030033)
  • Mrf binding
    (GO:0043426)
  • Myotube differentiation involved in skeletal muscle regeneration
    (GO:0014908)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Positive regulation of fat cell differentiation
    (GO:0045600)
  • Positive regulation of mirna transcription
    (GO:1902895)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of transcription by transcription factor localization
    (GO:0061586)
  • Protein binding
    (GO:0005515)
  • Regulation of microvillus assembly
    (GO:0032534)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Satellite cell activation involved in skeletal muscle regeneration
    (GO:0014901)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Skeletal muscle satellite cell differentiation
    (GO:0014816)
  • Transcription regulator complex
    (GO:0005667)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.5
    Marker Score: 8551
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.45
    Marker Score: 2716
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.23
    Marker Score: 3395
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.12
    Marker Score: 9805
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.12
    Marker Score: 23209
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.85
    Marker Score: 1904
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.68
    Marker Score: 17122
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.68
    Marker Score: 23119
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.59
    Marker Score: 3822
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.58
    Marker Score: 6132
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.54
    Marker Score: 5759
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.5
    Marker Score: 847
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.49
    Marker Score: 11972
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.47
    Marker Score: 1679
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.43
    Marker Score: 18965
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.42
    Marker Score: 1681
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.37
    Marker Score: 3062
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.33
    Marker Score: 4260
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.32
    Marker Score: 2221.5
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.28
    Marker Score: 1784
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.18
    Marker Score: 2469
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.17
    Marker Score: 2399
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.16
    Marker Score: 3439
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.13
    Marker Score: 614
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.11
    Marker Score: 1039
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.07
    Marker Score: 4380
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.01
    Marker Score: 485
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.92
    Marker Score: 897
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.9
    Marker Score: 602.5
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.88
    Marker Score: 706
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.87
    Marker Score: 1619
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.87
    Marker Score: 1862
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.87
    Marker Score: 6911.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.86
    Marker Score: 64481
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.86
    Marker Score: 1081
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.82
    Marker Score: 15836.5
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.77
    Marker Score: 1583
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.77
    Marker Score: 511
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.74
    Marker Score: 2859
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.74
    Marker Score: 2095
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.71
    Marker Score: 11124
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.64
    Marker Score: 1916
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.63
    Marker Score: 5594
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.55
    Marker Score: 2945
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.53
    Marker Score: 2363
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.49
    Marker Score: 370
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168162
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.44
    Marker Score: 791
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.42
    Marker Score: 7481
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.41
    Marker Score: 284.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.38
    Marker Score: 5408
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.37
    Marker Score: 3113
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.34
    Marker Score: 26692
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.3
    Marker Score: 330
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.27
    Marker Score: 1064
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.27
    Marker Score: 555
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.27
    Marker Score: 569
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1.24
    Marker Score: 779.5
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.24
    Marker Score: 426.5
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.23
    Marker Score: 19703
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.17
    Marker Score: 285
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.16
    Marker Score: 1864
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.15
    Marker Score: 461
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.15
    Marker Score: 592
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.14
    Marker Score: 1010
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.13
    Marker Score: 422
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.1
    Marker Score: 316.5
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.06
    Marker Score: 208
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251766
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.04
    Marker Score: 434
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 1.01
    Marker Score: 289
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71784
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48009
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 0.97
    Marker Score: 4059
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 496
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.94
    Marker Score: 1534
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.94
    Marker Score: 2555
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.94
    Marker Score: 1776
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.93
    Marker Score: 443.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5324
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.93
    Marker Score: 1640
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2729
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.91
    Marker Score: 261.5
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.91
    Marker Score: 224
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.91
    Marker Score: 14162
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.89
    Marker Score: 1818
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.88
    Marker Score: 610
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.88
    Marker Score: 232
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5271
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.87
    Marker Score: 928
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.81
    Marker Score: 27632
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 610.5
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.8
    Marker Score: 413
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.77
    Marker Score: 660
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.76
    Marker Score: 219
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 387

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics**: - KLF5 is a member of the Krüppel-like transcription factor family, which are characterized by their ability to bind to specific DNA sequences and regulate gene expression. - It is a key regulator of skeletal muscle differentiation and regeneration, as it is highly expressed in the basal cells of skeletal muscle tissues. - It plays a crucial role in the specification of skeletal muscle satellite cells, which are responsible for the development and maintenance of skeletal muscle tissue. - It also regulates the differentiation of other cell types, including endothelial cells, fibroblasts, and immune cells. **Pathways and functions**: - KLF5 is involved in the regulation of angiogenesis, as it promotes the migration and proliferation of endothelial cells. - It is also involved in the regulation of tissue development, as it is essential for the specification and differentiation of skeletal muscle cells. - It plays a role in the regulation of inflammation, as it can promote the production of inflammatory cytokines. - It also regulates the metabolism of the body, as it is involved in the regulation of lipid metabolism and glucose uptake. **Clinical significance**: - Mutations in the KLF5 gene have been linked to a number of human diseases, including prostate cancer, breast cancer, and heart disease. - Targeting KLF5 has been investigated as a potential therapy for these diseases, as it has been shown to be a potent anti-tumor agent. - However, there are also potential side effects associated with KLF5 inhibition, including liver damage and kidney failure. Overall, KLF5 is a critical transcription factor that plays a crucial role in skeletal muscle development, differentiation, and regeneration. Its dysregulation has been linked to a number of human diseases, and targeting KLF5 has been investigated as a potential therapy for these diseases.

Genular Protein ID: 240671694

Symbol: KLF5_HUMAN

Name: Krueppel-like factor 5

UniProtKB Accession Codes:

Q13887 A2TJX0 L0R3U5 L0R4T9 Q9UHP8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10572182

Title: Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter.

PubMed ID: 10572182

DOI: 10.1093/nar/27.24.4807

PubMed ID: 23134681

Title: Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors.

PubMed ID: 23134681

DOI: 10.1096/fj.12-220319

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8479902

Title: cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2.

PubMed ID: 8479902

DOI: 10.1093/nar/21.7.1527

PubMed ID: 15735697

Title: Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells.

PubMed ID: 15735697

DOI: 10.1038/sj.onc.1208497

PubMed ID: 18039846

Title: Promoter region-specific histone incorporation by the novel histone chaperone ANP32B and DNA-binding factor KLF5.

PubMed ID: 18039846

DOI: 10.1128/mcb.01396-07

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31375868

Title: The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs.

PubMed ID: 31375868

DOI: 10.1007/s00018-019-03251-w

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 26079537

Title: Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Krueppel-like factor 5 (KLF5).

PubMed ID: 26079537

DOI: 10.18632/oncotarget.4128

Sequence Information:

  • Length: 457
  • Mass: 50792
  • Checksum: 3BF12BE272716E57
  • Sequence:
    • MATRVLSMSA RLGPVPQPPA PQDEPVFAQL KPVLGAANPA RDAALFPGEE LKHAHHRPQA 
QPAPAQAPQP AQPPATGPRL PPEDLVQTRC EMEKYLTPQL PPVPIIPEHK KYRRDSASVV 
DQFFTDTEGL PYSINMNVFL PDITHLRTGL YKSQRPCVTH IKTEPVAIFS HQSETTAPPP 
APTQALPEFT SIFSSHQTAA PEVNNIFIKQ ELPTPDLHLS VPTQQGHLYQ LLNTPDLDMP 
SSTNQTAAMD TLNVSMSAAM AGLNTHTSAV PQTAVKQFQG MPPCTYTMPS QFLPQQATYF 
PPSPPSSEPG SPDRQAEMLQ NLTPPPSYAA TIASKLAIHN PNLPTTLPVN SQNIQPVRYN 
RRSNPDLEKR RIHYCDYPGC TKVYTKSSHL KAHLRTHTGE KPYKCTWEGC DWRFARSDEL 
TRHYRKHTGA KPFQCGVCNR SFSRSDHLAL HMKRHQN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.