Details for: KLF5

Gene ID: 688

Symbol: KLF5

Ensembl ID: ENSG00000102554

Description: KLF transcription factor 5

Associated with

  • Adipogenesis
    (R-HSA-9843745)
  • Developmental biology
    (R-HSA-1266738)
  • Transcriptional regulation of granulopoiesis
    (R-HSA-9616222)
  • Transcriptional regulation of white adipocyte differentiation
    (R-HSA-381340)
  • Angiogenesis
    (GO:0001525)
  • Cellular response to leukemia inhibitory factor
    (GO:1990830)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Golgi apparatus
    (GO:0005794)
  • Intestinal epithelial cell development
    (GO:0060576)
  • Intracellular membrane-bounded organelle
    (GO:0043231)
  • Metal ion binding
    (GO:0046872)
  • Microvillus assembly
    (GO:0030033)
  • Mrf binding
    (GO:0043426)
  • Myotube differentiation involved in skeletal muscle regeneration
    (GO:0014908)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Positive regulation of fat cell differentiation
    (GO:0045600)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of transcription by transcription factor localization
    (GO:0061586)
  • Protein binding
    (GO:0005515)
  • Regulation of microvillus assembly
    (GO:0032534)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Satellite cell activation involved in skeletal muscle regeneration
    (GO:0014901)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Skeletal muscle satellite cell differentiation
    (GO:0014816)
  • Transcription regulator complex
    (GO:0005667)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 180.1405
    Cell Significance Index: -28.0200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 111.2586
    Cell Significance Index: -28.2200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 62.7386
    Cell Significance Index: -25.8500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 42.6513
    Cell Significance Index: -28.6200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 22.7340
    Cell Significance Index: -28.0300
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 17.5941
    Cell Significance Index: 52.3300
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 14.3536
    Cell Significance Index: 32.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.5702
    Cell Significance Index: -31.0000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 11.1957
    Cell Significance Index: 184.4900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.1641
    Cell Significance Index: -28.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 6.5981
    Cell Significance Index: 342.7500
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 5.8269
    Cell Significance Index: 35.9500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 5.4331
    Cell Significance Index: 82.5200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.0903
    Cell Significance Index: 138.5600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 4.1452
    Cell Significance Index: 674.1700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 3.7913
    Cell Significance Index: 412.3800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 3.6752
    Cell Significance Index: 102.7100
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.2470
    Cell Significance Index: 20.1000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.0303
    Cell Significance Index: 70.0100
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 2.9288
    Cell Significance Index: 29.5500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.9212
    Cell Significance Index: 84.1700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.9024
    Cell Significance Index: 131.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.8823
    Cell Significance Index: 519.5900
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.7365
    Cell Significance Index: 38.9600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.4940
    Cell Significance Index: 306.6600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.4053
    Cell Significance Index: 22.1500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.0424
    Cell Significance Index: -4.4700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.9554
    Cell Significance Index: 29.3000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.8093
    Cell Significance Index: 233.7500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5645
    Cell Significance Index: 154.7600
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 1.4139
    Cell Significance Index: 12.1500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3926
    Cell Significance Index: 760.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.3623
    Cell Significance Index: 64.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1322
    Cell Significance Index: 500.5700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 1.1317
    Cell Significance Index: 11.7200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.8848
    Cell Significance Index: 10.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8309
    Cell Significance Index: 38.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.7899
    Cell Significance Index: 25.3000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7893
    Cell Significance Index: 16.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7791
    Cell Significance Index: 148.2600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6992
    Cell Significance Index: 18.6700
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.6524
    Cell Significance Index: 6.7300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.5902
    Cell Significance Index: 20.7400
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.5423
    Cell Significance Index: 4.4900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5317
    Cell Significance Index: 480.0700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.5102
    Cell Significance Index: 146.7900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.4970
    Cell Significance Index: 7.6900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.4131
    Cell Significance Index: 4.2800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3824
    Cell Significance Index: 28.5000
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.2704
    Cell Significance Index: 2.4000
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.2403
    Cell Significance Index: 0.9200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2070
    Cell Significance Index: 7.8400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2057
    Cell Significance Index: 9.1000
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 0.1999
    Cell Significance Index: 2.0000
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.1690
    Cell Significance Index: 1.0500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1538
    Cell Significance Index: 4.4100
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.1110
    Cell Significance Index: 0.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0650
    Cell Significance Index: 1.6700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0498
    Cell Significance Index: 6.3900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0318
    Cell Significance Index: 24.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0202
    Cell Significance Index: 2.7800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0175
    Cell Significance Index: 12.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0079
    Cell Significance Index: 1.5600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0017
    Cell Significance Index: -3.2000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0073
    Cell Significance Index: -0.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0079
    Cell Significance Index: -1.5900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0167
    Cell Significance Index: -30.8700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0189
    Cell Significance Index: -13.8600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0205
    Cell Significance Index: -31.5900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0247
    Cell Significance Index: -33.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0322
    Cell Significance Index: -20.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0373
    Cell Significance Index: -27.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0428
    Cell Significance Index: -7.3000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0476
    Cell Significance Index: -1.1900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0484
    Cell Significance Index: -30.2300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0497
    Cell Significance Index: -28.0400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0569
    Cell Significance Index: -25.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0579
    Cell Significance Index: -20.7800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0715
    Cell Significance Index: -1.5500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0778
    Cell Significance Index: -5.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1083
    Cell Significance Index: -11.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1213
    Cell Significance Index: -14.1400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1402
    Cell Significance Index: -29.5400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1421
    Cell Significance Index: -20.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1425
    Cell Significance Index: -16.3300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2236
    Cell Significance Index: -26.3700
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.2282
    Cell Significance Index: -1.4100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2337
    Cell Significance Index: -11.8100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2534
    Cell Significance Index: -26.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2679
    Cell Significance Index: -20.5600
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: -0.2831
    Cell Significance Index: -2.3400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2966
    Cell Significance Index: -12.1500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3005
    Cell Significance Index: -23.8000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3282
    Cell Significance Index: -6.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3340
    Cell Significance Index: -20.4800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3398
    Cell Significance Index: -3.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3593
    Cell Significance Index: -7.5200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3630
    Cell Significance Index: -7.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3633
    Cell Significance Index: -22.3300
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.3723
    Cell Significance Index: -2.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** KLF5 is a member of the Kruppel-like factor (KLF) family of transcription factors, characterized by their zinc finger DNA-binding motif. KLF5 is specifically expressed in various cell types, including epithelial cells, stem cells, and immune cells. Its expression is tightly regulated by post-translational modifications, such as phosphorylation and acetylation, which influence its activity and subcellular localization. **Pathways and Functions:** KLF5 is involved in numerous signaling pathways, including: 1. **Cell-cell signaling via exosome**: KLF5 regulates the expression of genes involved in cell-cell communication, including those involved in the formation of the epithelial barrier. 2. **Angiogenesis**: KLF5 modulates the expression of angiogenic factors, influencing the formation of new blood vessels. 3. **Cellular response to leukemia inhibitory factor (LIF)**: KLF5 regulates the expression of genes involved in the LIF signaling pathway, which plays a crucial role in immune cell development and function. 4. **Chromatin remodeling**: KLF5 interacts with chromatin-modifying enzymes, influencing the regulation of gene expression. KLF5 functions as a transcriptional regulator, modulating the expression of genes involved in various biological processes, including: 1. **Intestinal epithelial cell development**: KLF5 regulates the expression of genes involved in the development and maintenance of the intestinal epithelium. 2. **Microvillus assembly**: KLF5 modulates the expression of genes involved in the formation of microvilli, which are essential for the function of intestinal epithelial cells. 3. **Myotube differentiation**: KLF5 regulates the expression of genes involved in the differentiation of skeletal muscle stem cells into myotubes. 4. **Granulopoiesis**: KLF5 modulates the expression of genes involved in the development and function of granulocytes, a type of white blood cell. **Clinical Significance:** KLF5 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases**: KLF5 has been shown to regulate the expression of genes involved in autoimmune disease pathogenesis, including rheumatoid arthritis and multiple sclerosis. 2. **Cancer**: KLF5 has been implicated in the development and progression of various cancers, including leukemia and colon cancer. 3. **Inflammatory disorders**: KLF5 regulates the expression of genes involved in the development and maintenance of inflammation, including those involved in conditions such as asthma and psoriasis. In conclusion, KLF5 is a multifaceted transcription factor that plays a critical role in immune regulation, cellular development, and tissue homeostasis. Its dysregulation has been implicated in various disease states, highlighting the importance of further research into the role of KLF5 in human health and disease.

Genular Protein ID: 240671694

Symbol: KLF5_HUMAN

Name: Krueppel-like factor 5

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10572182

Title: Isolation and characterization of a gene encoding human Kruppel-like factor 5 (IKLF): binding to the CAAT/GT box of the mouse lactoferrin gene promoter.

PubMed ID: 10572182

DOI: 10.1093/nar/27.24.4807

PubMed ID: 23134681

Title: Shaking the family tree: Identification of novel and biologically active alternatively spliced isoforms across the KLF family of transcription factors.

PubMed ID: 23134681

DOI: 10.1096/fj.12-220319

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8479902

Title: cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2.

PubMed ID: 8479902

DOI: 10.1093/nar/21.7.1527

PubMed ID: 15735697

Title: Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells.

PubMed ID: 15735697

DOI: 10.1038/sj.onc.1208497

PubMed ID: 18039846

Title: Promoter region-specific histone incorporation by the novel histone chaperone ANP32B and DNA-binding factor KLF5.

PubMed ID: 18039846

DOI: 10.1128/mcb.01396-07

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31375868

Title: The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs.

PubMed ID: 31375868

DOI: 10.1007/s00018-019-03251-w

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 26079537

Title: Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Krueppel-like factor 5 (KLF5).

PubMed ID: 26079537

DOI: 10.18632/oncotarget.4128

Sequence Information:

  • Length: 457
  • Mass: 50792
  • Checksum: 3BF12BE272716E57
  • Sequence:
  • MATRVLSMSA RLGPVPQPPA PQDEPVFAQL KPVLGAANPA RDAALFPGEE LKHAHHRPQA 
    QPAPAQAPQP AQPPATGPRL PPEDLVQTRC EMEKYLTPQL PPVPIIPEHK KYRRDSASVV 
    DQFFTDTEGL PYSINMNVFL PDITHLRTGL YKSQRPCVTH IKTEPVAIFS HQSETTAPPP 
    APTQALPEFT SIFSSHQTAA PEVNNIFIKQ ELPTPDLHLS VPTQQGHLYQ LLNTPDLDMP 
    SSTNQTAAMD TLNVSMSAAM AGLNTHTSAV PQTAVKQFQG MPPCTYTMPS QFLPQQATYF 
    PPSPPSSEPG SPDRQAEMLQ NLTPPPSYAA TIASKLAIHN PNLPTTLPVN SQNIQPVRYN 
    RRSNPDLEKR RIHYCDYPGC TKVYTKSSHL KAHLRTHTGE KPYKCTWEGC DWRFARSDEL 
    TRHYRKHTGA KPFQCGVCNR SFSRSDHLAL HMKRHQN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.