Details for: BTF3

Gene ID: 689

Symbol: BTF3

Ensembl ID: ENSG00000145741

Description: basic transcription factor 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 1022.6608
    Cell Significance Index: -159.0700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 531.6520
    Cell Significance Index: -134.8500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 502.1755
    Cell Significance Index: -206.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 446.7860
    Cell Significance Index: -181.5100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 427.4843
    Cell Significance Index: -201.8300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 393.4988
    Cell Significance Index: -202.4100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 301.8082
    Cell Significance Index: -202.5200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 193.5495
    Cell Significance Index: -184.7900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 146.9801
    Cell Significance Index: -181.2200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 52.2624
    Cell Significance Index: -206.2300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 43.8164
    Cell Significance Index: -134.5800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 36.3476
    Cell Significance Index: -97.3700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 25.2492
    Cell Significance Index: -55.2600
  • Cell Name: theca cell (CL0000503)
    Fold Change: 13.0229
    Cell Significance Index: 76.5100
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 12.6741
    Cell Significance Index: 134.6600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 9.6193
    Cell Significance Index: 252.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 8.8464
    Cell Significance Index: 415.7700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 8.2731
    Cell Significance Index: 89.9400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 8.2644
    Cell Significance Index: 105.8400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 8.1434
    Cell Significance Index: 282.9800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 8.0583
    Cell Significance Index: 142.4000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 7.6955
    Cell Significance Index: 161.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 7.1778
    Cell Significance Index: 927.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 6.8931
    Cell Significance Index: 946.6100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 6.8134
    Cell Significance Index: 507.8000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 6.4115
    Cell Significance Index: 183.7900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 6.2956
    Cell Significance Index: 774.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 6.1710
    Cell Significance Index: 436.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 5.9099
    Cell Significance Index: 1065.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.8620
    Cell Significance Index: 273.3200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 5.8316
    Cell Significance Index: 66.2500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.8136
    Cell Significance Index: 170.7400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 5.6587
    Cell Significance Index: 34.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 5.6024
    Cell Significance Index: 660.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 5.5847
    Cell Significance Index: 152.0100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 5.5572
    Cell Significance Index: 358.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 5.3582
    Cell Significance Index: 2368.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.9168
    Cell Significance Index: 2685.1800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 4.4575
    Cell Significance Index: 35.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.7004
    Cell Significance Index: 474.3700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.4869
    Cell Significance Index: 32.1100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.3534
    Cell Significance Index: 77.4800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.8059
    Cell Significance Index: 51.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.4563
    Cell Significance Index: 127.6000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.4180
    Cell Significance Index: 125.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.3018
    Cell Significance Index: 393.0400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.6762
    Cell Significance Index: 88.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5567
    Cell Significance Index: 70.5600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1588
    Cell Significance Index: 229.9700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0984
    Cell Significance Index: 29.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9562
    Cell Significance Index: 20.7200
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.8803
    Cell Significance Index: 13.3700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.7042
    Cell Significance Index: 533.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5624
    Cell Significance Index: 107.0300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4612
    Cell Significance Index: 416.4600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2941
    Cell Significance Index: 29.1000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2133
    Cell Significance Index: 156.4200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2065
    Cell Significance Index: 59.4200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1733
    Cell Significance Index: 2.9000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0237
    Cell Significance Index: -2.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0260
    Cell Significance Index: -5.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0368
    Cell Significance Index: -69.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0735
    Cell Significance Index: -54.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.1122
    Cell Significance Index: -206.9100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.1361
    Cell Significance Index: -209.5200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1782
    Cell Significance Index: -242.3300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1976
    Cell Significance Index: -123.3700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2320
    Cell Significance Index: -130.8400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.2467
    Cell Significance Index: -88.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.2552
    Cell Significance Index: -162.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.4153
    Cell Significance Index: -188.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.4583
    Cell Significance Index: -74.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4795
    Cell Significance Index: -100.9900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5891
    Cell Significance Index: -15.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.7128
    Cell Significance Index: -19.9200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.9230
    Cell Significance Index: -105.7500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.9532
    Cell Significance Index: -108.8100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -1.1228
    Cell Significance Index: -130.8500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.1493
    Cell Significance Index: -72.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -1.2210
    Cell Significance Index: -177.4900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2358
    Cell Significance Index: -39.5800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.2413
    Cell Significance Index: -98.3100
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.2965
    Cell Significance Index: -22.3500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.5045
    Cell Significance Index: -9.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.5884
    Cell Significance Index: -97.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.7520
    Cell Significance Index: -46.8700
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -1.7837
    Cell Significance Index: -12.8100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.8964
    Cell Significance Index: -131.1500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.9357
    Cell Significance Index: -201.5500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.9565
    Cell Significance Index: -109.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -2.0515
    Cell Significance Index: -27.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -2.5431
    Cell Significance Index: -195.1600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -2.5898
    Cell Significance Index: -155.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -2.7995
    Cell Significance Index: -188.2400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.8290
    Cell Significance Index: -42.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -3.1963
    Cell Significance Index: -112.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -3.2897
    Cell Significance Index: -201.6900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.6742
    Cell Significance Index: -108.2200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -3.6972
    Cell Significance Index: -92.4200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -3.7670
    Cell Significance Index: -44.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** BTF3 acts as a transcriptional regulator by binding to specific DNA sequences, modulating the expression of target genes. 2. **Cellular Expression:** BTF3 is expressed in various cell types, including cord blood hematopoietic stem cells, mesenchymal stem cells, mature T cells, and thyroid follicular cells. 3. **Protein Localization:** BTF3 influences protein localization to the endoplasmic reticulum (ER) and regulates the trafficking of proteins to the nucleus. 4. **DNA Binding:** BTF3 exhibits a high degree of specificity in binding to DNA sequences, allowing for precise regulation of gene expression. **Pathways and Functions:** 1. **In Utero Embryonic Development:** BTF3 is involved in the regulation of embryonic development, particularly in the specification of neural and hematopoietic lineages. 2. **Nascent Polypeptide-Associated Complex (NAC):** BTF3 interacts with NAC, a complex involved in the regulation of protein synthesis and folding. 3. **Negative Regulation of Protein Localization to Endoplasmic Reticulum:** BTF3 inhibits the localization of proteins to the ER, thereby regulating protein trafficking and fate. 4. **Protein Binding:** BTF3 interacts with various proteins, including transcription factors, RNA-binding proteins, and chaperones, to modulate cellular processes. **Clinical Significance:** 1. **Cancer Association:** BTF3 has been implicated in various cancers, including leukemia, lymphoma, and breast cancer, suggesting its potential role as a tumor suppressor or oncogene. 2. **Immunological Disorders:** BTF3 is expressed in T cells and B cells, highlighting its involvement in immune function and disease, such as autoimmune disorders and immunodeficiency states. 3. **Thyroid Function:** BTF3 is expressed in thyroid follicular cells, suggesting its potential role in thyroid function and disease, including thyroid cancer and autoimmune thyroiditis. 4. **Regulation of Gene Expression:** BTF3's ability to regulate gene expression makes it a potential therapeutic target for various diseases, including cancer and immunological disorders. In conclusion, BTF3 is a multifunctional transcriptional regulator that plays a critical role in various cellular processes, including embryonic development, cell differentiation, and protein localization. Its clinical significance lies in its association with various diseases, including cancer, immunological disorders, and thyroid function. Further research is necessary to fully elucidate the mechanisms by which BTF3 regulates gene expression and to explore its potential as a therapeutic target.

Genular Protein ID: 1576148175

Symbol: BTF3_HUMAN

Name: Transcription factor BTF3

UniProtKB Accession Codes:

P20290 A8K510 Q13893 Q76M56

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 2 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2320128

Title: Sequencing and expression of complementary DNA for the general transcription factor BTF3.

PubMed ID: 2320128

DOI: 10.1038/344556a0

PubMed ID: 1386332

Title: Genomic structure of the putative BTF3 transcription factor.

PubMed ID: 1386332

DOI: 10.1016/0378-1119(92)90732-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10982809

Title: The alpha and beta subunit of the nascent polypeptide-associated complex have distinct functions.

PubMed ID: 10982809

DOI: 10.1074/jbc.m006368200

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 21203952

Title: Crystal structures of NAC domains of human nascent polypeptide-associated complex (NAC) and its alphaNAC subunit.

PubMed ID: 21203952

DOI: 10.1007/s13238-010-0049-3

Sequence Information:

  • Length: 206
  • Mass: 22168
  • Checksum: 9653AC480EAF64C6
  • Sequence:
    • MRRTGAPAQA DSRGRGRARG GCPGGEATLS QPPPRGGTRG QEPQMKETIM NQEKLAKLQA 
QVRIGGKGTA RRKKKVVHRT ATADDKKLQF SLKKLGVNNI SGIEEVNMFT NQGTVIHFNN 
PKVQASLAAN TFTITGHAET KQLTEMLPSI LNQLGADSLT SLRRLAEALP KQSVDGKAPL 
ATGEDDDDEV PDLVENFDEA SKNEAN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.