Details for: BTF3

Gene ID: 689

Symbol: BTF3

Ensembl ID: ENSG00000145741

Description: basic transcription factor 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 8.69
    Marker Score: 6556
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 5.05
    Marker Score: 7779
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 4.89
    Marker Score: 48433
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.78
    Marker Score: 3740.5
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 4.71
    Marker Score: 63287.5
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 4.71
    Marker Score: 1736
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 4.65
    Marker Score: 9742.5
  • Cell Name: theca cell (CL0000503)
    Fold Change: 4.59
    Marker Score: 3292
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 4.59
    Marker Score: 156083.5
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.51
    Marker Score: 14233
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.51
    Marker Score: 238333
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 4.45
    Marker Score: 8120
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.28
    Marker Score: 56445
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 4.28
    Marker Score: 7340
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 4.26
    Marker Score: 3808
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 4.22
    Marker Score: 12327
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 4.16
    Marker Score: 1874
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.11
    Marker Score: 10050
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 4.11
    Marker Score: 5348
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.09
    Marker Score: 47565.5
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 4.06
    Marker Score: 2470
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 4.05
    Marker Score: 2611
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4
    Marker Score: 223584.5
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.97
    Marker Score: 29583
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.96
    Marker Score: 16986
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.96
    Marker Score: 3375
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.93
    Marker Score: 4192
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.91
    Marker Score: 3849.5
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.87
    Marker Score: 9844
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.85
    Marker Score: 5573.5
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.84
    Marker Score: 3714
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.83
    Marker Score: 10752.5
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.83
    Marker Score: 10581
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.83
    Marker Score: 1716
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 3.79
    Marker Score: 2378
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.78
    Marker Score: 9217
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.77
    Marker Score: 2958
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.75
    Marker Score: 2001
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 3.74
    Marker Score: 1922
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 3.73
    Marker Score: 2189
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 3.73
    Marker Score: 6660
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.72
    Marker Score: 6998
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.71
    Marker Score: 3490
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.7
    Marker Score: 5449
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.7
    Marker Score: 3111
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.68
    Marker Score: 23956.5
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.67
    Marker Score: 3825
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 3.64
    Marker Score: 2642
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.64
    Marker Score: 868.5
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 3.63
    Marker Score: 1160
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.61
    Marker Score: 19000
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.58
    Marker Score: 4327
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.58
    Marker Score: 3144
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 3.57
    Marker Score: 2011.5
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.53
    Marker Score: 3140
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.52
    Marker Score: 5772.5
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 3.51
    Marker Score: 4139
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.48
    Marker Score: 2634
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.48
    Marker Score: 3864.5
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 3.45
    Marker Score: 2824
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 3.44
    Marker Score: 2621
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 3.42
    Marker Score: 2288
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 3.41
    Marker Score: 1761
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.41
    Marker Score: 2260
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.41
    Marker Score: 26633
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.39
    Marker Score: 3020
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.37
    Marker Score: 1405
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 3.37
    Marker Score: 1977
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.36
    Marker Score: 1106
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 3.36
    Marker Score: 2427
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 3.36
    Marker Score: 1526
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.35
    Marker Score: 7629
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.35
    Marker Score: 2381
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.34
    Marker Score: 21797
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.34
    Marker Score: 12884.5
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 3.34
    Marker Score: 3589
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 3.3
    Marker Score: 16234
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 3.29
    Marker Score: 2797
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.29
    Marker Score: 2736
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 3.29
    Marker Score: 3582
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.29
    Marker Score: 2593.5
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 3.28
    Marker Score: 3072
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 3.28
    Marker Score: 3844.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.28
    Marker Score: 113475
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 3.27
    Marker Score: 4633
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.27
    Marker Score: 1633
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.27
    Marker Score: 6527.5
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.27
    Marker Score: 5526.5
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 3.26
    Marker Score: 2148
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.26
    Marker Score: 3733
  • Cell Name: basophil (CL0000767)
    Fold Change: 3.26
    Marker Score: 1550
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 3.26
    Marker Score: 862.5
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 3.25
    Marker Score: 1056.5
  • Cell Name: centroblast (CL0009112)
    Fold Change: 3.25
    Marker Score: 1600.5
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.25
    Marker Score: 3248.5
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.24
    Marker Score: 7358
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 3.24
    Marker Score: 4002
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 3.23
    Marker Score: 851
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 3.23
    Marker Score: 19133
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 3.21
    Marker Score: 2880

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Other Information

**Key characteristics:** * BTF3 is a transcription factor belonging to the basic transcription factor family. * It is a highly conserved protein with a conserved domain structure. * BTF3 has been shown to regulate the expression of numerous genes involved in cell cycle regulation, proliferation, differentiation, and apoptosis. * It is a key regulator of embryonic stem cell differentiation and maintenance. **Pathways and functions:** * BTF3 is involved in the cytoplasm, cytosol, and in utero embryonic development. * It is a key regulator of the Nascent polypeptide-associated complex (NPC), a complex that is essential for the initiation of protein translation. * BTF3 negatively regulates the expression of genes involved in the formation of the NPC. * It is also involved in the regulation of the transcription of genes involved in negative regulation of protein localization to the endoplasmic reticulum, the nucleus, and protein binding. * BTF3 is critical for the development and maintenance of the immune system. * It is expressed in high levels in hematopoietic stem cells, where it plays a crucial role in the development and maintenance of these cells. * It is also expressed in various immune cells, where it regulates the development and function of these cells. **Clinical significance:** * BTF3 mutations have been linked to a number of human diseases, including leukemia, lymphoma, and solid tumors. * Targeting BTF3 has emerged as a promising therapeutic strategy for these diseases. * BTF3 inhibitors are being investigated as potential treatments for cancer and autoimmune diseases.

Genular Protein ID: 1576148175

Symbol: BTF3_HUMAN

Name: Transcription factor BTF3

UniProtKB Accession Codes:

P20290 A8K510 Q13893 Q76M56

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 2 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2320128

Title: Sequencing and expression of complementary DNA for the general transcription factor BTF3.

PubMed ID: 2320128

DOI: 10.1038/344556a0

PubMed ID: 1386332

Title: Genomic structure of the putative BTF3 transcription factor.

PubMed ID: 1386332

DOI: 10.1016/0378-1119(92)90732-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10982809

Title: The alpha and beta subunit of the nascent polypeptide-associated complex have distinct functions.

PubMed ID: 10982809

DOI: 10.1074/jbc.m006368200

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 21203952

Title: Crystal structures of NAC domains of human nascent polypeptide-associated complex (NAC) and its alphaNAC subunit.

PubMed ID: 21203952

DOI: 10.1007/s13238-010-0049-3

Sequence Information:

  • Length: 206
  • Mass: 22168
  • Checksum: 9653AC480EAF64C6
  • Sequence:
    • MRRTGAPAQA DSRGRGRARG GCPGGEATLS QPPPRGGTRG QEPQMKETIM NQEKLAKLQA 
QVRIGGKGTA RRKKKVVHRT ATADDKKLQF SLKKLGVNNI SGIEEVNMFT NQGTVIHFNN 
PKVQASLAAN TFTITGHAET KQLTEMLPSI LNQLGADSLT SLRRLAEALP KQSVDGKAPL 
ATGEDDDDEV PDLVENFDEA SKNEAN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.