Details for: BTG1

Gene ID: 694

Symbol: BTG1

Ensembl ID: ENSG00000133639

Description: BTG anti-proliferation factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 946.9915
    Cell Significance Index: -147.3000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 564.0202
    Cell Significance Index: -143.0600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 390.8385
    Cell Significance Index: -161.0100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 328.8023
    Cell Significance Index: -155.2400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 316.6498
    Cell Significance Index: -162.8800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 232.5855
    Cell Significance Index: -156.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 120.3125
    Cell Significance Index: -148.3400
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 45.8288
    Cell Significance Index: 122.7700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 43.5934
    Cell Significance Index: -133.9000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 39.1784
    Cell Significance Index: -154.6000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 26.4783
    Cell Significance Index: -57.9500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.1960
    Cell Significance Index: -59.4600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 12.7678
    Cell Significance Index: 670.3600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 8.5574
    Cell Significance Index: 151.2200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 5.6006
    Cell Significance Index: 717.9700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 5.4970
    Cell Significance Index: 42.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 5.1527
    Cell Significance Index: 242.1700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 4.7992
    Cell Significance Index: 29.5400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 4.6986
    Cell Significance Index: 324.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 4.5726
    Cell Significance Index: 340.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.3650
    Cell Significance Index: 281.6100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 4.1953
    Cell Significance Index: 47.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 4.1629
    Cell Significance Index: 490.9300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.5741
    Cell Significance Index: 124.2000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.5463
    Cell Significance Index: 639.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.4522
    Cell Significance Index: 72.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.2294
    Cell Significance Index: 397.0800
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 3.1910
    Cell Significance Index: 9.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.9717
    Cell Significance Index: 1313.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.9692
    Cell Significance Index: 407.7500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.7765
    Cell Significance Index: 79.5900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.2318
    Cell Significance Index: 41.2500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.1920
    Cell Significance Index: 283.1900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.1609
    Cell Significance Index: 56.8200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.9329
    Cell Significance Index: 1055.5800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.8785
    Cell Significance Index: 25.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.8486
    Cell Significance Index: 130.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4155
    Cell Significance Index: 38.5300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.1369
    Cell Significance Index: 14.5600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.0736
    Cell Significance Index: 65.9900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0591
    Cell Significance Index: 28.2800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.8538
    Cell Significance Index: 19.7300
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.8426
    Cell Significance Index: 4.9500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.7409
    Cell Significance Index: 21.7600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.6407
    Cell Significance Index: 73.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5232
    Cell Significance Index: 103.8400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4442
    Cell Significance Index: 84.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4316
    Cell Significance Index: 73.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3127
    Cell Significance Index: 282.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2735
    Cell Significance Index: 98.1200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2556
    Cell Significance Index: 4.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1417
    Cell Significance Index: 7.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1351
    Cell Significance Index: 102.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1130
    Cell Significance Index: 82.8800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1020
    Cell Significance Index: 10.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0911
    Cell Significance Index: 140.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0151
    Cell Significance Index: -1.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0266
    Cell Significance Index: -5.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0336
    Cell Significance Index: -63.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0443
    Cell Significance Index: -81.7900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0562
    Cell Significance Index: -0.9400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0614
    Cell Significance Index: -83.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0695
    Cell Significance Index: -51.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0700
    Cell Significance Index: -2.4600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0735
    Cell Significance Index: -3.8200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0781
    Cell Significance Index: -8.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1567
    Cell Significance Index: -97.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1827
    Cell Significance Index: -116.0200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2061
    Cell Significance Index: -116.2200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2570
    Cell Significance Index: -116.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4244
    Cell Significance Index: -89.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4807
    Cell Significance Index: -138.3200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.5024
    Cell Significance Index: -8.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.6610
    Cell Significance Index: -19.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.7252
    Cell Significance Index: -105.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.7359
    Cell Significance Index: -34.3100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.8907
    Cell Significance Index: -102.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.9603
    Cell Significance Index: -111.9100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.9963
    Cell Significance Index: -9.1800
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -1.0457
    Cell Significance Index: -7.5100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.0606
    Cell Significance Index: -11.5300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.1783
    Cell Significance Index: -32.9300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.1909
    Cell Significance Index: -75.0600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.2436
    Cell Significance Index: -95.4400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.3383
    Cell Significance Index: -35.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.4310
    Cell Significance Index: -149.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.4723
    Cell Significance Index: -99.0000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.4976
    Cell Significance Index: -118.6100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.6206
    Cell Significance Index: -41.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.7160
    Cell Significance Index: -45.9800
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -1.8577
    Cell Significance Index: -10.1300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.9195
    Cell Significance Index: -61.4800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.9479
    Cell Significance Index: -88.2900
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -2.1252
    Cell Significance Index: -36.5100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -2.3447
    Cell Significance Index: -27.9500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.5563
    Cell Significance Index: -156.7300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -2.9797
    Cell Significance Index: -155.2100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -3.1389
    Cell Significance Index: -75.2800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -3.1980
    Cell Significance Index: -131.0400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -3.2588
    Cell Significance Index: -48.8300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transcriptional regulation**: BTG1 functions as a transcription factor, influencing gene expression through binding to specific DNA sequences and interacting with other transcriptional regulators. 2. **Anti-proliferative properties**: BTG1 exhibits anti-proliferative effects, negatively regulating cell population proliferation and the mitotic cell cycle. 3. **Cell type specificity**: BTG1 is significantly expressed in immune cells, such as T cells, natural T-regulatory cells, and innate lymphoid cells, as well as in glycinergic neurons. 4. **Regulation of cellular processes**: BTG1 influences various cellular processes, including angiogenesis, endothelial cell differentiation, and myoblast differentiation. **Pathways and Functions** 1. **Foxo-mediated transcription**: BTG1 interacts with the Forkhead box O (Foxo) transcription factor family, influencing the expression of cell cycle genes and regulating cellular proliferation. 2. **Gene expression (transcription)**: BTG1 regulates the expression of target genes through binding to specific DNA sequences and interacting with other transcriptional regulators. 3. **Cell migration and population proliferation**: BTG1 negatively regulates cell population proliferation and the mitotic cell cycle, influencing cellular migration and proliferation. 4. **Response to oxidative stress**: BTG1 responds to oxidative stress, highlighting its importance in maintaining cellular homeostasis. **Clinical Significance** 1. **Cancer research**: BTG1's anti-proliferative properties make it a potential target for cancer therapy, particularly in the treatment of proliferative diseases. 2. **Immune system disorders**: BTG1's involvement in immune cell regulation suggests its potential role in the pathogenesis of immune system disorders, such as autoimmune diseases and immunodeficiency syndromes. 3. **Neurological disorders**: BTG1's expression in glycinergic neurons highlights its potential role in neurological disorders, such as epilepsy and neurodegenerative diseases. 4. **Spermatogenesis**: BTG1's involvement in spermatogenesis suggests its importance in male fertility and its potential role in infertility disorders. In conclusion, the BTG1 gene plays a crucial role in regulating cellular processes, including cell growth, proliferation, and differentiation. Its anti-proliferative properties and involvement in immune cell regulation make it a potential target for cancer therapy and immune system disorders. Further research is necessary to fully elucidate the clinical significance of BTG1 and its potential applications in human disease.

Genular Protein ID: 3476807470

Symbol: BTG1_HUMAN

Name: Protein BTG1

UniProtKB Accession Codes:

P62324 P31607

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1373383

Title: BTG1, a member of a new family of antiproliferative genes.

PubMed ID: 1373383

DOI: 10.1002/j.1460-2075.1992.tb05213.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9712883

Title: Interaction of BTG1 and p53-regulated BTG2 gene products with mCaf1, the murine homolog of a component of the yeast CCR4 transcriptional regulatory complex.

PubMed ID: 9712883

DOI: 10.1074/jbc.273.35.22563

PubMed ID: 11136725

Title: Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway.

PubMed ID: 11136725

DOI: 10.1074/jbc.m008201200

PubMed ID: 2069907

Title: A chromosome 12 coding region is juxtaposed to the MYC protooncogene locus in a t(8;12)(q24;q22) translocation in a case of B-cell chronic lymphocytic leukemia.

PubMed ID: 2069907

DOI: 10.1002/gcc.2870030106

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 171
  • Mass: 19209
  • Checksum: EFED8BE09013BE60
  • Sequence:
    • MHPFYTRAAT MIGEIAAAVS FISKFLRTKG LTSERQLQTF SQSLQELLAE HYKHHWFPEK 
PCKGSGYRCI RINHKMDPLI GQAAQRIGLS SQELFRLLPS ELTLWVDPYE VSYRIGEDGS 
ICVLYEASPA GGSTQNSTNV QMVDSRISCK EELLLGRTSP SKNYNMMTVS G

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.