Details for: BTG1

Gene ID: 694

Symbol: BTG1

Ensembl ID: ENSG00000133639

Description: BTG anti-proliferation factor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 5.36
    Marker Score: 11236.5
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 5.19
    Marker Score: 15135
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 5.04
    Marker Score: 3653
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 5.03
    Marker Score: 49832
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 4.81
    Marker Score: 2473
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 4.55
    Marker Score: 2931
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.5
    Marker Score: 5430
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.49
    Marker Score: 237479
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 4.29
    Marker Score: 7363
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 4.27
    Marker Score: 11971
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 4.25
    Marker Score: 3799
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 4.23
    Marker Score: 1374
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.17
    Marker Score: 13166
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 4.16
    Marker Score: 11478
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 4.13
    Marker Score: 1774
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 4.13
    Marker Score: 2510
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 4.09
    Marker Score: 3100
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 4.03
    Marker Score: 2844
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 4.02
    Marker Score: 17230
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 4.01
    Marker Score: 3950
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.99
    Marker Score: 3400
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.99
    Marker Score: 9723
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.98
    Marker Score: 3754
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 3.95
    Marker Score: 2316
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 3.82
    Marker Score: 9702.5
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 3.81
    Marker Score: 4966.5
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.8
    Marker Score: 5595
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.7
    Marker Score: 3112
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 3.67
    Marker Score: 49369
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.64
    Marker Score: 3882.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.62
    Marker Score: 123123.5
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.58
    Marker Score: 3367
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.48
    Marker Score: 3866.5
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 3.47
    Marker Score: 4789
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.45
    Marker Score: 1905
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 3.45
    Marker Score: 2119
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 3.44
    Marker Score: 2922
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 3.39
    Marker Score: 2776.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.39
    Marker Score: 189460.5
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 3.37
    Marker Score: 895
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.37
    Marker Score: 2959
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.36
    Marker Score: 803
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.36
    Marker Score: 2543
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.32
    Marker Score: 6238
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.32
    Marker Score: 8103
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 3.32
    Marker Score: 3668.5
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: 3.3
    Marker Score: 7424
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.28
    Marker Score: 1367
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 3.26
    Marker Score: 3055
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 3.25
    Marker Score: 1622
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 3.24
    Marker Score: 1976
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 3.23
    Marker Score: 2368
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.22
    Marker Score: 2130
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.21
    Marker Score: 42333
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 3.2
    Marker Score: 4625.5
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 3.19
    Marker Score: 1114
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.17
    Marker Score: 6339
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 3.16
    Marker Score: 1365
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.16
    Marker Score: 1416
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.15
    Marker Score: 20460
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 3.14
    Marker Score: 1063
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 3.13
    Marker Score: 5596
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 3.13
    Marker Score: 1800
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 3.12
    Marker Score: 1026
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.09
    Marker Score: 6285
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 3.08
    Marker Score: 5214
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.08
    Marker Score: 3519
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 3.07
    Marker Score: 1105
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.07
    Marker Score: 2197
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 3.06
    Marker Score: 1318
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 3.05
    Marker Score: 1788
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 3.05
    Marker Score: 1838
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.04
    Marker Score: 2394
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 3.04
    Marker Score: 1075
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 3.02
    Marker Score: 3536
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 3.01
    Marker Score: 932
  • Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
    Fold Change: 3
    Marker Score: 2647.5
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 2.99
    Marker Score: 908
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.99
    Marker Score: 2678
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 2.98
    Marker Score: 2477
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.97
    Marker Score: 1085
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.97
    Marker Score: 1338
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.97
    Marker Score: 786
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.96
    Marker Score: 29982
  • Cell Name: basophil (CL0000767)
    Fold Change: 2.94
    Marker Score: 1399
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.94
    Marker Score: 11334
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.94
    Marker Score: 18735
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.93
    Marker Score: 2084
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 2.92
    Marker Score: 1263
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 2.92
    Marker Score: 4754
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.9
    Marker Score: 12101.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.9
    Marker Score: 4753
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.89
    Marker Score: 3146
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 2.89
    Marker Score: 1338
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.89
    Marker Score: 1423
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.89
    Marker Score: 18811
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 2.88
    Marker Score: 758
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 2.85
    Marker Score: 653
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 2.84
    Marker Score: 721
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 2.82
    Marker Score: 1186

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - BTG1 is a secreted protein that is expressed in a variety of cell types. - It is a member of the BTG (brachyuryin-1) family of proteins. - BTG1 is a dimeric protein, meaning it consists of two identical subunits that come together to form a functional unit. - It is a highly conserved protein, with a similar sequence in humans, mice, and flies. **Pathways and functions:** - BTG1 is a key regulator of cell migration, proliferation, and survival. - It is involved in the regulation of epithelial-mesenchymal transition (EMT), a process that allows epithelial cells to lose their epithelial characteristics and acquire mesenchymal characteristics. - BTG1 binds to the FoxO transcription factor, which is a key regulator of cell growth, proliferation, and differentiation. - When BTG1 binds to FoxO, it inhibits FoxO-mediated transcription of cell cycle genes, leading to cell cycle arrest or apoptosis. - In addition to its role in cell migration, BTG1 also plays a role in the regulation of endothelial cell differentiation. - It is also involved in the response to oxidative stress and the response to peptide hormones. **Clinical significance:** - Mutations in the BTG1 gene have been linked to several human cancers, including lung cancer, breast cancer, and colon cancer. - Targeting BTG1 has emerged as a promising therapeutic strategy for cancer treatment. - Several clinical trials are currently evaluating the use of BTG1 inhibitors to treat cancer.

Genular Protein ID: 3476807470

Symbol: BTG1_HUMAN

Name: Protein BTG1

UniProtKB Accession Codes:

P62324 P31607

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1373383

Title: BTG1, a member of a new family of antiproliferative genes.

PubMed ID: 1373383

DOI: 10.1002/j.1460-2075.1992.tb05213.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9712883

Title: Interaction of BTG1 and p53-regulated BTG2 gene products with mCaf1, the murine homolog of a component of the yeast CCR4 transcriptional regulatory complex.

PubMed ID: 9712883

DOI: 10.1074/jbc.273.35.22563

PubMed ID: 11136725

Title: Relationships of the antiproliferative proteins BTG1 and BTG2 with CAF1, the human homolog of a component of the yeast CCR4 transcriptional complex: involvement in estrogen receptor alpha signaling pathway.

PubMed ID: 11136725

DOI: 10.1074/jbc.m008201200

PubMed ID: 2069907

Title: A chromosome 12 coding region is juxtaposed to the MYC protooncogene locus in a t(8;12)(q24;q22) translocation in a case of B-cell chronic lymphocytic leukemia.

PubMed ID: 2069907

DOI: 10.1002/gcc.2870030106

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 171
  • Mass: 19209
  • Checksum: EFED8BE09013BE60
  • Sequence:
    • MHPFYTRAAT MIGEIAAAVS FISKFLRTKG LTSERQLQTF SQSLQELLAE HYKHHWFPEK 
PCKGSGYRCI RINHKMDPLI GQAAQRIGLS SQELFRLLPS ELTLWVDPYE VSYRIGEDGS 
ICVLYEASPA GGSTQNSTNV QMVDSRISCK EELLLGRTSP SKNYNMMTVS G

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.