Details for: BTK
Associated with
Other Information
Genular Protein ID: 1614508635
Symbol: BTK_HUMAN
Name: Tyrosine-protein kinase BTK
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8380905
Title: The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases.
PubMed ID: 8380905
DOI: 10.1038/361226a0
PubMed ID: 8090769
Title: Genomic organization and structure of Bruton agammaglobulinemia tyrosine kinase: localization of mutations associated with varied clinical presentations and course in X chromosome-linked agammaglobulinemia.
PubMed ID: 8090769
PubMed ID: 7927535
Title: The genomic structure of human BTK, the defective gene in X-linked agammaglobulinemia.
PubMed ID: 7927535
DOI: 10.1007/bf01246672
PubMed ID: 7880320
Title: Genomic organization of the Btk gene and exon scanning for mutations in patients with X-linked agammaglobulinemia.
PubMed ID: 7880320
PubMed ID: 7626884
Title: Sixty-nine kilobases of contiguous human genomic sequence containing the alpha-galactosidase A and Bruton's tyrosine kinase loci.
PubMed ID: 7626884
DOI: 10.1007/bf00364796
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15772651
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 8425221
Title: Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia.
PubMed ID: 8425221
PubMed ID: 12573241
Title: Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases.
PubMed ID: 12573241
PubMed ID: 8013627
Title: An exon-skipping mutation in the btk gene of a patient with X-linked agammaglobulinemia and isolated growth hormone deficiency.
PubMed ID: 8013627
PubMed ID: 8070576
Title: Tec homology (TH) adjacent to the PH domain.
PubMed ID: 8070576
PubMed ID: 8630736
Title: Regulation of Btk function by a major autophosphorylation site within the SH3 domain.
PubMed ID: 8630736
PubMed ID: 9012831
Title: BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement.
PubMed ID: 9012831
PubMed ID: 9571151
Title: Identification and characterization of a novel SH3-domain binding protein, Sab, which preferentially associates with Bruton's tyrosine kinase (Btk).
PubMed ID: 9571151
PubMed ID: 10196179
Title: Phosphatidylinositol 3-kinase-dependent membrane association of the Bruton's tyrosine kinase pleckstrin homology domain visualized in single living cells.
PubMed ID: 10196179
PubMed ID: 10339589
Title: Bruton's tyrosine kinase activity is negatively regulated by Sab, the Btk-SH3 domain-binding protein.
PubMed ID: 10339589
PubMed ID: 10602036
Title: Redistribution of Bruton's tyrosine kinase by activation of phosphatidylinositol 3-kinase and Rho-family GTPases.
PubMed ID: 10602036
DOI: 10.1002/1521-4141(200001)30:1<145::aid-immu145>3.0.co;2-0
PubMed ID: 11016936
Title: Nucleocytoplasmic shuttling of Bruton's tyrosine kinase.
PubMed ID: 11016936
PubMed ID: 11598012
Title: PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization.
PubMed ID: 11598012
PubMed ID: 11606584
Title: Tyrosine residues in phospholipase Cgamma 2 essential for the enzyme function in B-cell signaling.
PubMed ID: 11606584
PubMed ID: 11577348
Title: Direct inhibition of Bruton's tyrosine kinase by IBtk, a Btk-binding protein.
PubMed ID: 11577348
DOI: 10.1038/ni1001-939
PubMed ID: 11751885
Title: Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx.
PubMed ID: 11751885
PubMed ID: 15375214
Title: A phosphorylation site in Bruton's tyrosine kinase selectively regulates B cell calcium signaling efficiency by altering phospholipase C-gamma activation.
PubMed ID: 15375214
PubMed ID: 16644721
Title: Regulation of Bruton tyrosine kinase by the peptidylprolyl isomerase Pin1.
PubMed ID: 16644721
PubMed ID: 16517732
Title: Bruton's tyrosine kinase is required for TLR2 and TLR4-induced TNF, but not IL-6, production.
PubMed ID: 16517732
PubMed ID: 16738337
Title: Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I.
PubMed ID: 16738337
DOI: 10.1128/mcb.02009-05
PubMed ID: 16415872
Title: Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation.
PubMed ID: 16415872
DOI: 10.1038/ni1299
PubMed ID: 17932028
Title: Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase.
PubMed ID: 17932028
PubMed ID: 19807924
Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.
PubMed ID: 19807924
PubMed ID: 9751072
Title: Bruton's tyrosine kinase (BTK) as a dual-function regulator of apoptosis.
PubMed ID: 9751072
PubMed ID: 19290921
Title: Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain.
PubMed ID: 19290921
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23913792
Title: A novel isoform of the B cell tyrosine kinase BTK protects breast cancer cells from apoptosis.
PubMed ID: 23913792
DOI: 10.1002/gcc.22091
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 34554188
Title: BTK operates a phospho-tyrosine switch to regulate NLRP3 inflammasome activity.
PubMed ID: 34554188
DOI: 10.1084/jem.20201656
PubMed ID: 9218782
Title: Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia.
PubMed ID: 9218782
PubMed ID: 9485443
Title: Solution structure of the SH3 domain from Bruton's tyrosine kinase.
PubMed ID: 9485443
DOI: 10.1021/bi972409f
PubMed ID: 10196129
Title: Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate.
PubMed ID: 10196129
PubMed ID: 10826882
Title: Solution structure of the human BTK SH3 domain complexed with a proline-rich peptide from p120cbl.
PubMed ID: 10826882
PubMed ID: 11527964
Title: Crystal structure of Bruton's tyrosine kinase domain suggests a novel pathway for activation and provides insights into the molecular basis of X-linked agammaglobulinemia.
PubMed ID: 11527964
PubMed ID: 16969585
Title: Solution structure and phosphopeptide binding of the SH2 domain from the human Bruton's tyrosine kinase.
PubMed ID: 16969585
PubMed ID: 20052711
Title: Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases.
PubMed ID: 20052711
DOI: 10.1002/pro.321
PubMed ID: 21280133
Title: Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures.
PubMed ID: 21280133
DOI: 10.1002/pro.575
PubMed ID: 8594569
Title: BTKbase, mutation database for X-linked agammaglobulinemia (XLA).
PubMed ID: 8594569
DOI: 10.1093/nar/24.1.160
PubMed ID: 9016530
Title: BTKbase, mutation database for X-linked agammaglobulinemia (XLA).
PubMed ID: 9016530
DOI: 10.1093/nar/25.1.166
PubMed ID: 8162056
Title: Mutation detection in the X-linked agammaglobulinemia gene, BTK, using single strand conformation polymorphism analysis.
PubMed ID: 8162056
DOI: 10.1093/hmg/3.1.79
PubMed ID: 8162018
Title: Mutation analysis of the Bruton's tyrosine kinase gene in X-linked agammaglobulinemia: identification of a mutation which affects the same codon as is altered in immunodeficient xid mice.
PubMed ID: 8162018
DOI: 10.1093/hmg/3.1.161
PubMed ID: 7849697
Title: Screening of genomic DNA to identify mutations in the gene for Bruton's tyrosine kinase.
PubMed ID: 7849697
PubMed ID: 7849721
Title: Unique mutations of Bruton's tyrosine kinase in fourteen unrelated X-linked agammaglobulinemia families.
PubMed ID: 7849721
PubMed ID: 7809124
Title: Structural basis for chromosome X-linked agammaglobulinemia: a tyrosine kinase disease.
PubMed ID: 7809124
PubMed ID: 7849006
Title: Structural basis for pleckstrin homology domain mutations in X-linked agammaglobulinemia.
PubMed ID: 7849006
DOI: 10.1021/bi00005a002
PubMed ID: 7711734
Title: DNA-based mutation analysis of Bruton's tyrosine kinase gene in patients with X-linked agammaglobulinaemia.
PubMed ID: 7711734
DOI: 10.1093/hmg/4.1.51
PubMed ID: 7633420
Title: Identification of Btk mutations in 20 unrelated patients with X-linked agammaglobulinaemia (XLA).
PubMed ID: 7633420
DOI: 10.1093/hmg/4.4.693
PubMed ID: 7633429
Title: Mutation analysis in Bruton's tyrosine kinase, the X-linked agammaglobulinaemia gene, including identification of an insertional hotspot.
PubMed ID: 7633429
DOI: 10.1093/hmg/4.4.755
PubMed ID: 8634718
Title: Improved oligonucleotide primer set for molecular diagnosis of X-linked agammaglobulinaemia: predominance of amino acid substitutions in the catalytic domain of Bruton's tyrosine kinase.
PubMed ID: 8634718
PubMed ID: 7627183
Title: Characterization of germline mutations of the gene encoding Bruton's tyrosine kinase in families with X-linked agammaglobulinemia.
PubMed ID: 7627183
PubMed ID: 7897635
Title: A new point mutation involving a highly conserved leucine in the Btk SH2 domain in a family with X linked agammaglobulinaemia.
PubMed ID: 7897635
DOI: 10.1136/jmg.32.1.77
PubMed ID: 8723128
Title: Detection of a novel mutation in the SRC homology domain 2 (SH2) of Bruton's tyrosine kinase and direct female carrier evaluation in a family with X-linked agammaglobulinemia.
PubMed ID: 8723128
DOI: 10.1002/(sici)1096-8628(19960503)63:1<318::aid-ajmg53>3.0.co;2-n
PubMed ID: 8695804
Title: Identification of Bruton's tyrosine kinase (Btk) gene mutations and characterization of the derived proteins in 35 X-linked agammaglobulinemia families: a nationwide study of Btk deficiency in Japan.
PubMed ID: 8695804
PubMed ID: 8834236
Title: Mutations of the Btk gene in 12 unrelated families with X-linked agammaglobulinemia in Japan.
PubMed ID: 8834236
PubMed ID: 9280283
Title: Missense mutations affecting a conserved cysteine pair in the TH domain of Btk.
PubMed ID: 9280283
PubMed ID: 9260159
Title: Molecular and structural characterization of five novel mutations in the Bruton's tyrosine kinase gene from patients with X-linked agammaglobulinemia.
PubMed ID: 9260159
DOI: 10.1007/bf03401694
PubMed ID: 9545398
Title: Mutations in btk in patients with presumed X-linked agammaglobulinemia.
PubMed ID: 9545398
DOI: 10.1086/301828
PubMed ID: 9445504
Title: Mutation screening of the BTK gene in 56 families with X-linked agammaglobulinemia (XLA): 47 unique mutations without correlation to clinical course.
PubMed ID: 9445504
PubMed ID: 10220140
Title: Mutations of the human BTK gene coding for Bruton tyrosine kinase in X-linked agammaglobulinemia.
PubMed ID: 10220140
DOI: 10.1002/(sici)1098-1004(1999)13:4<280::aid-humu3>3.0.co;2-l
PubMed ID: 10678660
Title: Twin carriers of X-linked agammaglobulinemia (XLA) due to germline mutation in the Btk gene.
PubMed ID: 10678660
DOI: 10.1002/(sici)1096-8628(20000131)90:3<229::aid-ajmg8>3.0.co;2-q
PubMed ID: 10612838
Title: Identification of nine novel mutations in the Bruton's tyrosine kinase gene in X-linked agammaglobulinaemia patients.
PubMed ID: 10612838
DOI: 10.1002/(sici)1098-1004(200001)15:1<117::aid-humu26>3.0.co;2-h
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
PubMed ID: 24869598
Title: Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib.
PubMed ID: 24869598
PubMed ID: 24869597
Title: Ibrutinib resistance in chronic lymphocytic leukemia.
PubMed ID: 24869597
DOI: 10.1056/nejmc1402716
PubMed ID: 25189416
Title: Functional characterization of BTK(C481S) mutation that confers ibrutinib resistance: exploration of alternative kinase inhibitors.
PubMed ID: 25189416
DOI: 10.1038/leu.2014.263
Sequence Information:
- Length: 659
- Mass: 76281
- Checksum: DF06B5D1FEC257CC
- Sequence:
MAAVILESIF LKRSQQKKKT SPLNFKKRLF LLTVHKLSYY EYDFERGRRG SKKGSIDVEK ITCVETVVPE KNPPPERQIP RRGEESSEME QISIIERFPY PFQVVYDEGP LYVFSPTEEL RKRWIHQLKN VIRYNSDLVQ KYHPCFWIDG QYLCCSQTAK NAMGCQILEN RNGSLKPGSS HRKTKKPLPP TPEEDQILKK PLPPEPAAAP VSTSELKKVV ALYDYMPMNA NDLQLRKGDE YFILEESNLP WWRARDKNGQ EGYIPSNYVT EAEDSIEMYE WYSKHMTRSQ AEQLLKQEGK EGGFIVRDSS KAGKYTVSVF AKSTGDPQGV IRHYVVCSTP QSQYYLAEKH LFSTIPELIN YHQHNSAGLI SRLKYPVSQQ NKNAPSTAGL GYGSWEIDPK DLTFLKELGT GQFGVVKYGK WRGQYDVAIK MIKEGSMSED EFIEEAKVMM NLSHEKLVQL YGVCTKQRPI FIITEYMANG CLLNYLREMR HRFQTQQLLE MCKDVCEAME YLESKQFLHR DLAARNCLVN DQGVVKVSDF GLSRYVLDDE YTSSVGSKFP VRWSPPEVLM YSKFSSKSDI WAFGVLMWEI YSLGKMPYER FTNSETAEHI AQGLRLYRPH LASEKVYTIM YSCWHEKADE RPTFKILLSN ILDVMDEES
Genular Protein ID: 794988476
Symbol: Q5JY90_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11181995
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15772651
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
Sequence Information:
- Length: 483
- Mass: 55881
- Checksum: EC1A5FB717810D71
- Sequence:
MAAVILESIF LKRSQQKKKT SPLNFKKRLF LLTVHKLSYY EYDFERGRRG SKKGSIDVEK ITCVETVVPE KNPPPERQIP RRGEESSEME QISIIERFPY PFQVVYDEGP LYVFSPTEEL RKRWIHQLKN VIRYNSDLVQ KYHPCFWIDG QYLCCSQTAK NAMGCQILEN RNGSLKPGSS HRKTKKPLPP TPEEDQILKK PLPPEPAAAP VSTSELKKVV ALYDYMPMNA NDLQLRKGDE YFILEESNLP WWRARDKNGQ EGYIPSNYVT EAEDSIEMYE WYSKHMTRSQ AEQLLKQEGK EGGFIVRDSS KAGKYTVSVF AKSTGDPQGV IRHYVVCSTP QSQYYLAARN CLVNDQGVVK VSDFGLSRYV LDDEYTSSVG SKFPVRWSPP EVLMYSKFSS KSDIWAFGVL MWEIYSLGKM PYERFTNSET AEHIAQGLRL YRPHLASEKV YTIMYSCWHE KADERPTFKI LLSNILDVMD EES
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.