Details for: BTN1A1

Gene ID: 696

Symbol: BTN1A1

Ensembl ID: ENSG00000124557

Description: butyrophilin subfamily 1 member A1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.21
    Marker Score: 2229
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.11
    Marker Score: 1199
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.38
    Marker Score: 874
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7690
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.15
    Marker Score: 606
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71832
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48057
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.99
    Marker Score: 2523
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5345
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.88
    Marker Score: 369
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.85
    Marker Score: 646
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.67
    Marker Score: 1372
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 489
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.56
    Marker Score: 340
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 280
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.44
    Marker Score: 828
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.43
    Marker Score: 410.5
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.41
    Marker Score: 239
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.33
    Marker Score: 332
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 0.33
    Marker Score: 1049
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.31
    Marker Score: 189
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.3
    Marker Score: 196
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.29
    Marker Score: 367
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.26
    Marker Score: 4062
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.26
    Marker Score: 481
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.22
    Marker Score: 122
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.21
    Marker Score: 334
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.2
    Marker Score: 79
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.19
    Marker Score: 90
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.18
    Marker Score: 99
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.18
    Marker Score: 367
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.13
    Marker Score: 123
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.12
    Marker Score: 159
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.11
    Marker Score: 127
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.11
    Marker Score: 100
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.1
    Marker Score: 32
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.1
    Marker Score: 128
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1
    Marker Score: 968
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.09
    Marker Score: 40
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.09
    Marker Score: 40
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.08
    Marker Score: 17
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.08
    Marker Score: 92
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.08
    Marker Score: 125
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.08
    Marker Score: 40
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.08
    Marker Score: 44
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.06
    Marker Score: 27
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.06
    Marker Score: 82
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.06
    Marker Score: 333
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.05
    Marker Score: 63
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.05
    Marker Score: 59
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.05
    Marker Score: 44
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.05
    Marker Score: 39
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.05
    Marker Score: 30
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.05
    Marker Score: 31
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.05
    Marker Score: 28
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.04
    Marker Score: 77
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.04
    Marker Score: 22
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.04
    Marker Score: 127
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.04
    Marker Score: 41
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.04
    Marker Score: 42
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.04
    Marker Score: 526
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.04
    Marker Score: 93
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.04
    Marker Score: 35
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.04
    Marker Score: 12
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.04
    Marker Score: 15
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.04
    Marker Score: 14.5
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.04
    Marker Score: 17
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.03
    Marker Score: 358
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.03
    Marker Score: 14
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.03
    Marker Score: 22.5
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.03
    Marker Score: 31
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.03
    Marker Score: 16

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Other Information

**Key characteristics:** * The protein encoded by this gene is a cell surface receptor. * It is a member of the butyrophilin subfamily 1, which is characterized by a single extracellular domain that is responsible for binding to specific ligands. * The protein is expressed on different cell types, suggesting that it has multiple functions. **Pathways and functions:** * The protein encoded by this gene is involved in the adaptive immune system. * It is expressed in blood vessel endothelial cells, which are key cells in the immune system. * In blood vessel endothelial cells, the protein is expressed on the surface of endothelial cells and is involved in the regulation of immune cell migration and adhesion. * It is also expressed on megakaryocytes, granulocyte monocyte progenitors, goblet cells, hematopoietic stem cells, and cerebral cortex GABAergic interneurons. * In these cell types, the protein is involved in the regulation of immune cell activation and migration. **Clinical significance:** * Mutations in the BTN1A1 gene have been linked to several autoimmune diseases, including systemic sclerosis, rheumatoid arthritis, and Crohn's disease. * The protein encoded by this gene is a potential target for therapeutic interventions in these diseases. * Studies have shown that blocking the expression of BTN1A1 in immune cells can ameliorate the symptoms of autoimmune diseases. **Additional information:** * The BTN1A1 gene is located on chromosome 19p13.2. * The protein encoded by this gene is a glycosylated protein. * It is a relatively new gene, with the first known transcript being identified in 2011.

Genular Protein ID: 3615064509

Symbol: BT1A1_HUMAN

Name: Butyrophilin subfamily 1 member A1

UniProtKB Accession Codes:

Q13410 Q4VAN3 Q4VAN4 Q9H458

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 4 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 4 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8611614

Title: Cloning and sequence analysis of human butyrophilin reveals a potential receptor function.

PubMed ID: 8611614

DOI: 10.1016/0167-4781(19)60000-x

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18780401

Title: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.

PubMed ID: 18780401

DOI: 10.1002/pmic.200701057

Sequence Information:

  • Length: 526
  • Mass: 58960
  • Checksum: 4585D5CE88A2ECA4
  • Sequence:
    • MAVFPSSGLP RCLLTLILLQ LPKLDSAPFD VIGPPEPILA VVGEDAELPC RLSPNASAEH 
LELRWFRKKV SPAVLVHRDG REQEAEQMPE YRGRATLVQD GIAKGRVALR IRGVRVSDDG 
EYTCFFREDG SYEEALVHLK VAALGSDPHI SMQVQENGEI CLECTSVGWY PEPQVQWRTS 
KGEKFPSTSE SRNPDEEGLF TVAASVIIRD TSAKNVSCYI QNLLLGQEKK VEISIPASSL 
PRLTPWIVAV AVILMVLGLL TIGSIFFTWR LYNERPRERR NEFSSKERLL EELKWKKATL 
HAVDVTLDPD TAHPHLFLYE DSKSVRLEDS RQKLPEKTER FDSWPCVLGR ETFTSGRHYW 
EVEVGDRTDW AIGVCRENVM KKGFDPMTPE NGFWAVELYG NGYWALTPLR TPLPLAGPPR 
RVGIFLDYES GDISFYNMND GSDIYTFSNV TFSGPLRPFF CLWSSGKKPL TICPIADGPE 
RVTVIANAQD LSKEIPLSPM GEDSAPRDAD TLHSKLIPTQ PSQGAP

Genular Protein ID: 2490573920

Symbol: Q4VAN2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q4VAN2

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 DNASU 1 EMBL 2 GO 1 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 13 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1 SAM 3 SMART 4 SUPFAM 2

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 526
  • Mass: 58959
  • Checksum: 621306091E712B30
  • Sequence:
    • MAVFPSSGLP RCLLTLILLQ LPKLDSAPFD VIGPPEPILA VVGEDAKLPC RLSPNASAEH 
LELRWFRKKV SPAVLVHRDG REQEAEQMPE YRGRATLVQD GIAKGRVALR IRGVRVSDDG 
EYTCFFREDG SYEEALVHLK VAALGSDPHI SMQVQENGEI CLECTSVGWY PEPQVQWRTS 
KGEKFPSTSE SRNPDEEGLF TVAASVIIRD TSAKNVSCYI QNLLLGQEKK VEISIPASSL 
PRLTPWIVAV AVILMVLGLL TIGSIFFTWR LYNERPRERR NEFSSKERLL EELKWKKATL 
HAVDVTLDPD TAHPHLFLYE DSKSVRLEDS RQKLPEKTER FDSWPCVLGR ETFTSGRHYW 
EVEVGDRTDW AIGVCRENVM KKGFDPMTPE NGFWAVELYG NGYWALTPLR TPLPLAGPPR 
RVGIFLDYES GDISFYNMND GSDIYTFSNV TFSGPLRPFF CLWSSGKKPL TICPIADGPE 
RVTVIANAQD LSKEIPLSPM GEDSAPRDAD TLHSKLIPTQ PSQGAP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.