Details for: BTN1A1

Gene ID: 696

Symbol: BTN1A1

Ensembl ID: ENSG00000124557

Description: butyrophilin subfamily 1 member A1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 15.8946
    Cell Significance Index: 68.3500
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3523
    Cell Significance Index: 5.1400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1698
    Cell Significance Index: 117.4700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1396
    Cell Significance Index: 2.9900
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.1155
    Cell Significance Index: 0.8600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1126
    Cell Significance Index: 2.9600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.0717
    Cell Significance Index: 0.9000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0687
    Cell Significance Index: 1.8400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0656
    Cell Significance Index: 0.9400
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.0586
    Cell Significance Index: 0.6600
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0546
    Cell Significance Index: 0.9000
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0510
    Cell Significance Index: 0.7000
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.0180
    Cell Significance Index: 0.2400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0168
    Cell Significance Index: 1.9800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0105
    Cell Significance Index: 0.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0082
    Cell Significance Index: 0.4100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0056
    Cell Significance Index: 1.1100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0055
    Cell Significance Index: 0.7100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0043
    Cell Significance Index: 0.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0025
    Cell Significance Index: 0.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0021
    Cell Significance Index: 0.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0003
    Cell Significance Index: 0.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: -0.0700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0001
    Cell Significance Index: -0.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0004
    Cell Significance Index: -0.6400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0007
    Cell Significance Index: -0.9300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0011
    Cell Significance Index: -0.3900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0016
    Cell Significance Index: -0.8800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0018
    Cell Significance Index: -1.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0019
    Cell Significance Index: -0.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0022
    Cell Significance Index: -0.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0022
    Cell Significance Index: -1.2700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0023
    Cell Significance Index: -1.0500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0032
    Cell Significance Index: -0.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0042
    Cell Significance Index: -0.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0062
    Cell Significance Index: -0.8500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0081
    Cell Significance Index: -0.6200
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.0082
    Cell Significance Index: -0.0900
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.0085
    Cell Significance Index: -0.1000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0088
    Cell Significance Index: -0.3600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0093
    Cell Significance Index: -1.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0128
    Cell Significance Index: -0.7200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0166
    Cell Significance Index: -0.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0190
    Cell Significance Index: -0.8400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0192
    Cell Significance Index: -0.6100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0200
    Cell Significance Index: -0.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0206
    Cell Significance Index: -0.9600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0213
    Cell Significance Index: -0.7500
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0214
    Cell Significance Index: -0.2300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0233
    Cell Significance Index: -0.6700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0246
    Cell Significance Index: -0.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0248
    Cell Significance Index: -1.2900
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0255
    Cell Significance Index: -0.3400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0256
    Cell Significance Index: -0.9700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0260
    Cell Significance Index: -0.6300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0275
    Cell Significance Index: -0.4500
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: -0.0281
    Cell Significance Index: -0.3600
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.0296
    Cell Significance Index: -0.4000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0302
    Cell Significance Index: -0.6400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0303
    Cell Significance Index: -0.7600
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0314
    Cell Significance Index: -0.4700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0315
    Cell Significance Index: -0.6800
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0319
    Cell Significance Index: -0.3800
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0320
    Cell Significance Index: -0.4700
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0329
    Cell Significance Index: -0.2900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0333
    Cell Significance Index: -0.7300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0334
    Cell Significance Index: -0.6700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0341
    Cell Significance Index: -0.9100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0348
    Cell Significance Index: -0.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0348
    Cell Significance Index: -0.8700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0362
    Cell Significance Index: -0.6100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0366
    Cell Significance Index: -0.7600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0369
    Cell Significance Index: -0.7300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0374
    Cell Significance Index: -0.7800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0374
    Cell Significance Index: -0.7500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0379
    Cell Significance Index: -0.5600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0390
    Cell Significance Index: -0.3700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0393
    Cell Significance Index: -1.0500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0396
    Cell Significance Index: -0.5900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0398
    Cell Significance Index: -0.8100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0399
    Cell Significance Index: -0.6900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0400
    Cell Significance Index: -0.7800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0408
    Cell Significance Index: -1.2900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0409
    Cell Significance Index: -0.8100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0411
    Cell Significance Index: -0.4700
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0435
    Cell Significance Index: -0.5700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0435
    Cell Significance Index: -0.9100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0448
    Cell Significance Index: -1.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0464
    Cell Significance Index: -1.3300
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0468
    Cell Significance Index: -0.5900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0471
    Cell Significance Index: -0.6100
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0474
    Cell Significance Index: -0.5600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0482
    Cell Significance Index: -0.4100
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0485
    Cell Significance Index: -0.5900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0486
    Cell Significance Index: -0.7800
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0495
    Cell Significance Index: -0.4700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0496
    Cell Significance Index: -0.8500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0498
    Cell Significance Index: -1.2700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0500
    Cell Significance Index: -1.2200
  • Cell Name: L5/6 near-projecting glutamatergic neuron of the primary motor cortex (CL4023043)
    Fold Change: -0.0505
    Cell Significance Index: -0.5100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BTN1A1 is a non-coding gene, meaning that it does not encode a protein. Instead, it regulates gene expression by influencing the activity of nearby genes. This regulatory function is mediated through its interactions with other proteins, such as the T-cell receptor, which is a crucial component of the adaptive immune system. TheBTN1A1 gene is also characterized by its expression in specific cell types, including those involved in immune responses, such as granulocytes and monocytes. Furthermore, its expression in neurons and other non-immune cells highlights its broader role in maintaining cellular homeostasis. **Pathways and Functions:** The BTN1A1 gene is intricately involved in various signaling pathways, including those related to the adaptive immune system, cytokine production, and T-cell receptor signaling. These pathways underscore the gene's role in modulating immune responses and maintaining tissue homeostasis. Specifically, BTN1A1 has been shown to interact with the T-cell receptor, influencing the activation and regulation of immune cells. Additionally, its expression in endothelial cells suggests a role in vascular homeostasis and the regulation of immune responses in the cardiovascular system. **Clinical Significance:** The BTN1A1 gene's involvement in immune regulation and cellular homeostasis has significant implications for our understanding of various diseases. For instance, alterations in BTN1A1 expression have been linked to autoimmune disorders, such as multiple sclerosis and rheumatoid arthritis, where immune dysregulation plays a key role. Moreover, the gene's expression in neurons and other non-immune cells highlights its potential role in neurodegenerative diseases, such as Alzheimer's and Parkinson's. Further research is needed to fully elucidate the clinical significance of BTN1A1 and its role in human disease. In conclusion, the BTN1A1 gene represents a fascinating example of the complex interplay between immune regulation and cellular homeostasis. Further research is warranted to fully unravel the mysteries of this gene and its role in human disease. As an expert immunologist, I am excited to contribute to this field and shed light on the intricate mechanisms underlying BTN1A1's function.

Genular Protein ID: 3615064509

Symbol: BT1A1_HUMAN

Name: Butyrophilin subfamily 1 member A1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8611614

Title: Cloning and sequence analysis of human butyrophilin reveals a potential receptor function.

PubMed ID: 8611614

DOI: 10.1016/0167-4781(19)60000-x

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18780401

Title: Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry.

PubMed ID: 18780401

DOI: 10.1002/pmic.200701057

Sequence Information:

  • Length: 526
  • Mass: 58960
  • Checksum: 4585D5CE88A2ECA4
  • Sequence:
  • MAVFPSSGLP RCLLTLILLQ LPKLDSAPFD VIGPPEPILA VVGEDAELPC RLSPNASAEH 
    LELRWFRKKV SPAVLVHRDG REQEAEQMPE YRGRATLVQD GIAKGRVALR IRGVRVSDDG 
    EYTCFFREDG SYEEALVHLK VAALGSDPHI SMQVQENGEI CLECTSVGWY PEPQVQWRTS 
    KGEKFPSTSE SRNPDEEGLF TVAASVIIRD TSAKNVSCYI QNLLLGQEKK VEISIPASSL 
    PRLTPWIVAV AVILMVLGLL TIGSIFFTWR LYNERPRERR NEFSSKERLL EELKWKKATL 
    HAVDVTLDPD TAHPHLFLYE DSKSVRLEDS RQKLPEKTER FDSWPCVLGR ETFTSGRHYW 
    EVEVGDRTDW AIGVCRENVM KKGFDPMTPE NGFWAVELYG NGYWALTPLR TPLPLAGPPR 
    RVGIFLDYES GDISFYNMND GSDIYTFSNV TFSGPLRPFF CLWSSGKKPL TICPIADGPE 
    RVTVIANAQD LSKEIPLSPM GEDSAPRDAD TLHSKLIPTQ PSQGAP

Genular Protein ID: 2490573920

Symbol: Q4VAN2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 526
  • Mass: 58959
  • Checksum: 621306091E712B30
  • Sequence:
  • MAVFPSSGLP RCLLTLILLQ LPKLDSAPFD VIGPPEPILA VVGEDAKLPC RLSPNASAEH 
    LELRWFRKKV SPAVLVHRDG REQEAEQMPE YRGRATLVQD GIAKGRVALR IRGVRVSDDG 
    EYTCFFREDG SYEEALVHLK VAALGSDPHI SMQVQENGEI CLECTSVGWY PEPQVQWRTS 
    KGEKFPSTSE SRNPDEEGLF TVAASVIIRD TSAKNVSCYI QNLLLGQEKK VEISIPASSL 
    PRLTPWIVAV AVILMVLGLL TIGSIFFTWR LYNERPRERR NEFSSKERLL EELKWKKATL 
    HAVDVTLDPD TAHPHLFLYE DSKSVRLEDS RQKLPEKTER FDSWPCVLGR ETFTSGRHYW 
    EVEVGDRTDW AIGVCRENVM KKGFDPMTPE NGFWAVELYG NGYWALTPLR TPLPLAGPPR 
    RVGIFLDYES GDISFYNMND GSDIYTFSNV TFSGPLRPFF CLWSSGKKPL TICPIADGPE 
    RVTVIANAQD LSKEIPLSPM GEDSAPRDAD TLHSKLIPTQ PSQGAP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.