Details for: BUB1

Gene ID: 699

Symbol: BUB1

Ensembl ID: ENSG00000169679

Description: BUB1 mitotic checkpoint serine/threonine kinase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 18.2934
    Cell Significance Index: -4.6400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 14.5164
    Cell Significance Index: -5.9800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 11.4460
    Cell Significance Index: -4.6500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 4.8704
    Cell Significance Index: -4.6500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.6984
    Cell Significance Index: -4.5600
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 2.9205
    Cell Significance Index: 1.3300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.8665
    Cell Significance Index: -5.0000
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.4522
    Cell Significance Index: 10.9700
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.7635
    Cell Significance Index: 4.3400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6903
    Cell Significance Index: 112.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6760
    Cell Significance Index: 79.7200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6058
    Cell Significance Index: 115.3000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5502
    Cell Significance Index: 59.8400
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.5484
    Cell Significance Index: 6.8100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5137
    Cell Significance Index: 101.9400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.5123
    Cell Significance Index: 28.7500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.4212
    Cell Significance Index: -0.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3696
    Cell Significance Index: 10.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3667
    Cell Significance Index: 331.0700
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.3280
    Cell Significance Index: 0.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3117
    Cell Significance Index: 16.1900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3033
    Cell Significance Index: 20.9800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2913
    Cell Significance Index: 7.8100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2880
    Cell Significance Index: 5.9800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2826
    Cell Significance Index: 9.0500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.2636
    Cell Significance Index: 6.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2458
    Cell Significance Index: 28.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2236
    Cell Significance Index: 22.1200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.2070
    Cell Significance Index: 2.2500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2014
    Cell Significance Index: 5.3000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1425
    Cell Significance Index: 2.0400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1284
    Cell Significance Index: 70.1100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.1040
    Cell Significance Index: 1.7500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0892
    Cell Significance Index: 3.1000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.0663
    Cell Significance Index: 0.9300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0618
    Cell Significance Index: 1.5500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.0594
    Cell Significance Index: 0.5100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0572
    Cell Significance Index: 1.5300
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: 0.0429
    Cell Significance Index: 0.3900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0425
    Cell Significance Index: 0.9200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0342
    Cell Significance Index: 6.1700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.0182
    Cell Significance Index: 0.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0180
    Cell Significance Index: 0.5200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0153
    Cell Significance Index: 6.7600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0151
    Cell Significance Index: 0.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0120
    Cell Significance Index: 1.4700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0102
    Cell Significance Index: 0.1700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0094
    Cell Significance Index: 0.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0033
    Cell Significance Index: 0.2100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0028
    Cell Significance Index: 0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0023
    Cell Significance Index: -4.2900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0033
    Cell Significance Index: -6.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0037
    Cell Significance Index: -2.8000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0037
    Cell Significance Index: -5.7000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0042
    Cell Significance Index: -0.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0045
    Cell Significance Index: -6.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0067
    Cell Significance Index: -5.0000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0076
    Cell Significance Index: -4.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0085
    Cell Significance Index: -3.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0086
    Cell Significance Index: -1.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0095
    Cell Significance Index: -5.3700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0105
    Cell Significance Index: -4.7800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0134
    Cell Significance Index: -0.4000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0158
    Cell Significance Index: -4.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0185
    Cell Significance Index: -2.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0186
    Cell Significance Index: -1.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0274
    Cell Significance Index: -5.7800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0308
    Cell Significance Index: -4.4700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0324
    Cell Significance Index: -1.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0345
    Cell Significance Index: -5.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0369
    Cell Significance Index: -2.2600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0397
    Cell Significance Index: -5.1300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0425
    Cell Significance Index: -0.4400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0432
    Cell Significance Index: -1.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0448
    Cell Significance Index: -5.1300
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.0454
    Cell Significance Index: -0.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0456
    Cell Significance Index: -5.8400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0470
    Cell Significance Index: -2.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0471
    Cell Significance Index: -4.9000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0503
    Cell Significance Index: -3.0900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0641
    Cell Significance Index: -4.5400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0657
    Cell Significance Index: -5.0400
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0691
    Cell Significance Index: -0.4100
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.0701
    Cell Significance Index: -0.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0708
    Cell Significance Index: -3.1300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0720
    Cell Significance Index: -4.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0725
    Cell Significance Index: -5.4000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0800
    Cell Significance Index: -3.0300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0831
    Cell Significance Index: -1.0500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0835
    Cell Significance Index: -5.0100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0849
    Cell Significance Index: -5.3500
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0862
    Cell Significance Index: -2.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0864
    Cell Significance Index: -4.0600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0918
    Cell Significance Index: -1.4200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1078
    Cell Significance Index: -5.6600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1090
    Cell Significance Index: -5.0800
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1112
    Cell Significance Index: -1.1000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1276
    Cell Significance Index: -4.4700
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.1357
    Cell Significance Index: -0.6600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1393
    Cell Significance Index: -3.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BUB1 is a serine/threonine kinase that is specifically expressed in cells undergoing mitosis. It is a key player in the mitotic checkpoint, a complex system that ensures proper chromosome segregation. BUB1 is activated by the kinetochore, a protein structure that attaches to chromosomes, and it phosphorylates key targets to regulate mitotic progression. BUB1 is also involved in the regulation of sister chromatid cohesion, centromeric function, and chromosome segregation. **Pathways and Functions:** BUB1 is involved in several key pathways, including: 1. **Amplification of signal from the kinetochore**: BUB1 is activated by the kinetochore, which is a protein structure that attaches to chromosomes. This activation leads to the phosphorylation of key targets, such as MAD2, which is involved in the regulation of mitotic progression. 2. **Amplification of signal from unattached kinetochores**: BUB1 is also activated by unattached kinetochores, which are chromosomes that are not attached to the spindle apparatus. This activation leads to the phosphorylation of key targets, such as MAD2, which is involved in the regulation of mitotic progression. 3. **Apoptotic process**: BUB1 is involved in the regulation of apoptosis, a process that eliminates damaged or dysfunctional cells. 4. **ATP binding**: BUB1 is an ATP-binding protein, which is necessary for its kinase activity. 5. **Cell cycle**: BUB1 is involved in the regulation of the cell cycle, specifically during mitosis. **Clinical Significance:** Dysregulation of BUB1 has been implicated in various cancers, including breast, lung, and colon cancer. BUB1 mutations or amplifications have been found in tumor cells, suggesting that BUB1 may play a role in tumorigenesis. Additionally, BUB1 has been shown to be a target for cancer therapy, with several small molecule inhibitors targeting BUB1 currently in development. In conclusion, BUB1 is a critical gene that plays a key role in maintaining genome stability during mitosis. Its dysregulation has been implicated in various cancers, highlighting its importance in cancer biology. Further research is needed to fully understand the role of BUB1 in cancer and to develop effective therapeutic strategies targeting this gene. **Significantly Expressed Cells:** BUB1 is expressed in a variety of cell types, including: 1. Retinal bipolar neurons 2. Germ cells 3. Retina horizontal cells 4. Erythroblasts 5. Plasmablasts 6. Oogonial cells 7. Large pre-B-II cells 8. IgG plasmablasts 9. Enterocytes of the epithelium of small intestine 10. Cerebral cortex GABAergic interneurons **Proteins:** BUB1 is encoded by the BUB1_HUMAN gene, which is a serine/threonine kinase. The B4DYG2_HUMAN protein is also encoded by the BUB1_HUMAN gene, although its function is not well understood.

Genular Protein ID: 4060076248

Symbol: BUB1_HUMAN

Name: Mitotic checkpoint serine/threonine-protein kinase BUB1

UniProtKB Accession Codes:

O43683 E9PC26 F5GXI5 O43430 O43643 O60626 Q53QE4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 3 ELM 1 EMBL 24 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 6 RefSeq 2 Rhea 6 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9521327

Title: Mutations of mitotic checkpoint genes in human cancers.

PubMed ID: 9521327

DOI: 10.1038/32688

PubMed ID: 9790499

Title: Human Bub1: a putative spindle checkpoint kinase closely linked to cell proliferation.

PubMed ID: 9790499

PubMed ID: 9660858

Title: The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase.

PubMed ID: 9660858

DOI: 10.1083/jcb.142.1.1

PubMed ID: 10198256

Title: Phosphorylation of human MAD1 by the BUB1 kinase in vitro.

PubMed ID: 10198256

DOI: 10.1006/bbrc.1999.0514

PubMed ID: 10366450

Title: Characterization of MAD2B and other mitotic spindle checkpoint genes.

PubMed ID: 10366450

DOI: 10.1006/geno.1999.5831

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9441741

Title: Mammalian BUB1 protein kinases: map positions and in vivo expression.

PubMed ID: 9441741

DOI: 10.1006/geno.1997.5068

PubMed ID: 15020684

Title: Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression.

PubMed ID: 15020684

DOI: 10.1242/jcs.01006

PubMed ID: 15525512

Title: Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint.

PubMed ID: 15525512

DOI: 10.1016/j.molcel.2004.09.031

PubMed ID: 15723797

Title: Human Bub1 defines the persistent cohesion site along the mitotic chromosome by affecting Shugoshin localization.

PubMed ID: 15723797

DOI: 10.1016/j.cub.2004.12.044

PubMed ID: 16760428

Title: Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1.

PubMed ID: 16760428

DOI: 10.1091/mbc.e06-03-0240

PubMed ID: 17981135

Title: Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1.

PubMed ID: 17981135

DOI: 10.1016/j.devcel.2007.09.005

PubMed ID: 17158872

Title: KEN-box-dependent degradation of the Bub1 spindle checkpoint kinase by the anaphase-promoting complex/cyclosome.

PubMed ID: 17158872

DOI: 10.1074/jbc.m609376200

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 18922873

Title: Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding.

PubMed ID: 18922873

DOI: 10.1128/jvi.01515-08

PubMed ID: 19487456

Title: Bub1 regulates chromosome segregation in a kinetochore-independent manner.

PubMed ID: 19487456

DOI: 10.1083/jcb.200902128

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20739936

Title: Phosphorylation of the CPC by Cdk1 promotes chromosome bi-orientation.

PubMed ID: 20739936

DOI: 10.1038/nature09390

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26223641

Title: Bub1 in Complex with LANA Recruits PCNA To Regulate Kaposi's Sarcoma-Associated Herpesvirus Latent Replication and DNA Translesion Synthesis.

PubMed ID: 26223641

DOI: 10.1128/jvi.01524-15

PubMed ID: 35044816

Title: Biallelic BUB1 mutations cause microcephaly, developmental delay, and variable effects on cohesion and chromosome segregation.

PubMed ID: 35044816

DOI: 10.1126/sciadv.abk0114

PubMed ID: 12655561

Title: A double missense variation of the BUB1 gene and a defective mitotic spindle checkpoint in the pancreatic cancer cell line Hs766T.

PubMed ID: 12655561

DOI: 10.1002/humu.9120

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 1085
  • Mass: 122375
  • Checksum: 38AE5E1F88C53BDC
  • Sequence:
    • MDTPENVLQM LEAHMQSYKG NDPLGEWERY IQWVEENFPE NKEYLITLLE HLMKEFLDKK 
KYHNDPRFIS YCLKFAEYNS DLHQFFEFLY NHGIGTLSSP LYIAWAGHLE AQGELQHASA 
VLQRGIQNQA EPREFLQQQY RLFQTRLTET HLPAQARTSE PLHNVQVLNQ MITSKSNPGN 
NMACISKNQG SELSGVISSA CDKESNMERR VITISKSEYS VHSSLASKVD VEQVVMYCKE 
KLIRGESEFS FEELRAQKYN QRRKHEQWVN EDRHYMKRKE ANAFEEQLLK QKMDELHKKL 
HQVVETSHED LPASQERSEV NPARMGPSVG SQQELRAPCL PVTYQQTPVN MEKNPREAPP 
VVPPLANAIS AALVSPATSQ SIAPPVPLKA QTVTDSMFAV ASKDAGCVNK STHEFKPQSG 
AEIKEGCETH KVANTSSFHT TPNTSLGMVQ ATPSKVQPSP TVHTKEALGF IMNMFQAPTL 
PDISDDKDEW QSLDQNEDAF EAQFQKNVRS SGAWGVNKII SSLSSAFHVF EDGNKENYGL 
PQPKNKPTGA RTFGERSVSR LPSKPKEEVP HAEEFLDDST VWGIRCNKTL APSPKSPGDF 
TSAAQLASTP FHKLPVESVH ILEDKENVVA KQCTQATLDS CEENMVVPSR DGKFSPIQEK 
SPKQALSSHM YSASLLRLSQ PAAGGVLTCE AELGVEACRL TDTDAAIAED PPDAIAGLQA 
EWMQMSSLGT VDAPNFIVGN PWDDKLIFKL LSGLSKPVSS YPNTFEWQCK LPAIKPKTEF 
QLGSKLVYVH HLLGEGAFAQ VYEATQGDLN DAKNKQKFVL KVQKPANPWE FYIGTQLMER 
LKPSMQHMFM KFYSAHLFQN GSVLVGELYS YGTLLNAINL YKNTPEKVMP QGLVISFAMR 
MLYMIEQVHD CEIIHGDIKP DNFILGNGFL EQDDEDDLSA GLALIDLGQS IDMKLFPKGT 
IFTAKCETSG FQCVEMLSNK PWNYQIDYFG VAATVYCMLF GTYMKVKNEG GECKPEGLFR 
RLPHLDMWNE FFHVMLNIPD CHHLPSLDLL RQKLKKVFQQ HYTNKIRALR NRLIVLLLEC 
KRSRK

Genular Protein ID: 1532600584

Symbol: B4DYG2_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DYG2

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 3 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 1065
  • Mass: 119960
  • Checksum: 8228D2098FE544E6
  • Sequence:
    • MDTPENVLQY IQWVEENFPE NKEYLITLLE HLMKEFLDKK KYHNDPRFIS YCLKFAEYNS 
DLHQFFEFLY NHGIGTLSSP LYIAWAGHLE AQGELQHASA VLQRGIQNQA EPREFLQQQY 
RLFQTRLTET HLPAQARTSE PLHNVQVLNQ MITSKSNPGN NMACISKNQG SELSGVISSA 
CDKESNMERR VITISRSEYS VHSSLASKVD VEQVVMYCKE KLIRGESEFS FEELRAQKYN 
QRRKHEQWVN EDRHYMKRKE ANAFEEQLLK QKMDELHKKL HQVVETSHED LPASQERSEV 
NPARMGPSVG SQQELRAPCL PVTYQQTPVN MEKNPREAPP VVPPLANAIS AALVSPATSQ 
SIAPPVPLKA QTVTDSMFAV ASKDAGCVNK GTHEFKPQSG AEIKEGCETH KVANTSSFHT 
TPNTSLGMVQ ATPSKVQPSP TVHTKEALGF IMNMFQAPTL PDISDDKDEW QSLDQNEDAF 
EAQFQKNVRS SGAWGVNKII SSLSSAFHVF EDGNKENYGL PQPKNKPTGA RTFGERSVSR 
LPSKPKEEVP HAEEFLDDST VWGIRCNKTL APSPKSPGDF TSAAQLASTP FPKLPVESVH 
ILEDKENVVA KQCTQATLDS CEENMVVPSR DGKFSPIQEK SPKQALSSHM YSASLLRLSQ 
PAAGGVLTCE AELGVEACRL TDTDAAIAED PPDAIAGLQA EWMQMSSLGT VDAPNFIVGN 
PWDDKLIFKL LSGLSKPVSS YPNTFEWQCK LPAIKPKTEF QLGSKLVYVH HLLGEGAFAQ 
VYEATQGDLN DAKNKQKFVL KVQKPANPWE FYIGTQLMER LKPSMQHMFM KFYSAHLFQN 
GSVLVGELYS YGTLLNAINL YKNTPEKVMP QGLVISFAMR MLYMIEQVHD CEIIHGDIKP 
DNFILGNGFL EQDDEDDLSA GLALIDLGQS IDMKLFPKGT IFTAKCETSG FQCVEMLSNK 
PWNYQIDYFG VAATVYCMLF GTYMKVKNEG GECKPEGLFR RLPHLDMWNE FFHVMLNIPD 
CHHLPSLDLL RQKLKKVFQQ HYTNKIRALR NRLIVLLLEC KRSRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.