Details for: BUB1B
Associated with
Other Information
Genular Protein ID: 1653828806
Symbol: BUB1B_HUMAN
Name: Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9618306
Title: Identification of a novel gene -- SSK1 -- in human endothelial cells exposed to shear stress.
PubMed ID: 9618306
PubMed ID: 9660858
Title: The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase.
PubMed ID: 9660858
DOI: 10.1083/jcb.142.1.1
PubMed ID: 9763420
Title: Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1.
PubMed ID: 9763420
DOI: 10.1083/jcb.143.1.49
PubMed ID: 9521327
Title: Mutations of mitotic checkpoint genes in human cancers.
PubMed ID: 9521327
DOI: 10.1038/32688
PubMed ID: 9889005
Title: The mouse mitotic checkpoint gene bub1b, a novel bub1 family member, is expressed in a cell cycle-dependent manner.
PubMed ID: 9889005
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10593653
Title: BUBR1 phosphorylation is regulated during mitotic checkpoint activation.
PubMed ID: 10593653
PubMed ID: 10477750
Title: Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC.
PubMed ID: 10477750
PubMed ID: 11702782
Title: Mad2-independent inhibition of APC/Cdc20 by the mitotic checkpoint protein BubR1.
PubMed ID: 11702782
PubMed ID: 14706340
Title: Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability.
PubMed ID: 14706340
PubMed ID: 12925705
Title: Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss.
PubMed ID: 12925705
PubMed ID: 15020684
Title: Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression.
PubMed ID: 15020684
DOI: 10.1242/jcs.01006
PubMed ID: 16227576
Title: Caspase-mediated specific cleavage of BubR1 is a determinant of mitotic progression.
PubMed ID: 16227576
PubMed ID: 16760428
Title: Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1.
PubMed ID: 16760428
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 17981135
Title: Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1.
PubMed ID: 17981135
PubMed ID: 17785528
Title: Tension-sensitive Plk1 phosphorylation on BubR1 regulates the stability of kinetochore microtubule interactions.
PubMed ID: 17785528
DOI: 10.1101/gad.436007
PubMed ID: 17376779
Title: Polo-like kinase 1 facilitates chromosome alignment during prometaphase through BubR1.
PubMed ID: 17376779
PubMed ID: 19015317
Title: Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit.
PubMed ID: 19015317
PubMed ID: 18374647
Title: SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis.
PubMed ID: 18374647
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19411850
Title: Depletion of BubR1 promotes premature centrosomal localization of cyclin B1 and accelerates mitotic entry.
PubMed ID: 19411850
DOI: 10.4161/cc.8.11.8671
PubMed ID: 19625775
Title: Defects in chromosome congression and mitotic progression in KIF18A-deficient cells are partly mediated through impaired functions of CENP-E.
PubMed ID: 19625775
DOI: 10.4161/cc.8.16.9366
PubMed ID: 19407811
Title: BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis.
PubMed ID: 19407811
PubMed ID: 19503101
Title: BubR1 localizes to centrosomes and suppresses centrosome amplification via regulating Plk1 activity in interphase cells.
PubMed ID: 19503101
DOI: 10.1038/onc.2009.141
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 29162720
Title: Direct interactions of mitotic arrest deficient 1 (MAD1) domains with each other and MAD2 conformers are required for mitotic checkpoint signaling.
PubMed ID: 29162720
PubMed ID: 29883609
Title: PELI1 selectively targets kinase-active RIP3 for ubiquitylation-dependent proteasomal degradation.
PubMed ID: 29883609
PubMed ID: 33094908
Title: Premature aging syndrome showing random chromosome number instabilities with CDC20 mutation.
PubMed ID: 33094908
DOI: 10.1111/acel.13251
PubMed ID: 10366450
Title: Characterization of MAD2B and other mitotic spindle checkpoint genes.
PubMed ID: 10366450
PubMed ID: 15475955
Title: Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B.
PubMed ID: 15475955
DOI: 10.1038/ng1449
PubMed ID: 16411201
Title: Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome.
PubMed ID: 16411201
DOI: 10.1002/ajmg.a.31069
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 1050
- Mass: 119545
- Checksum: F7871103A56E6B46
- Sequence:
MAAVKKEGGA LSEAMSLEGD EWELSKENVQ PLRQGRIMST LQGALAQESA CNNTLQQQKR AFEYEIRFYT GNDPLDVWDR YISWTEQNYP QGGKESNMST LLERAVEALQ GEKRYYSDPR FLNLWLKLGR LCNEPLDMYS YLHNQGIGVS LAQFYISWAE EYEARENFRK ADAIFQEGIQ QKAEPLERLQ SQHRQFQARV SRQTLLALEK EEEEEVFESS VPQRSTLAEL KSKGKKTARA PIIRVGGALK APSQNRGLQN PFPQQMQNNS RITVFDENAD EASTAELSKP TVQPWIAPPM PRAKENELQA GPWNTGRSLE HRPRGNTASL IAVPAVLPSF TPYVEETARQ PVMTPCKIEP SINHILSTRK PGKEEGDPLQ RVQSHQQASE EKKEKMMYCK EKIYAGVGEF SFEEIRAEVF RKKLKEQREA ELLTSAEKRA EMQKQIEEME KKLKEIQTTQ QERTGDQQEE TMPTKETTKL QIASESQKIP GMTLSSSVCQ VNCCARETSL AENIWQEQPH SKGPSVPFSI FDEFLLSEKK NKSPPADPPR VLAQRRPLAV LKTSESITSN EDVSPDVCDE FTGIEPLSED AIITGFRNVT ICPNPEDTCD FARAARFVST PFHEIMSLKD LPSDPERLLP EEDLDVKTSE DQQTACGTIY SQTLSIKKLS PIIEDSREAT HSSGFSGSSA SVASTSSIKC LQIPEKLELT NETSENPTQS PWCSQYRRQL LKSLPELSAS AELCIEDRPM PKLEIEKEIE LGNEDYCIKR EYLICEDYKL FWVAPRNSAE LTVIKVSSQP VPWDFYINLK LKERLNEDFD HFCSCYQYQD GCIVWHQYIN CFTLQDLLQH SEYITHEITV LIIYNLLTIV EMLHKAEIVH GDLSPRCLIL RNRIHDPYDC NKNNQALKIV DFSYSVDLRV QLDVFTLSGF RTVQILEGQK ILANCSSPYQ VDLFGIADLA HLLLFKEHLQ VFWDGSFWKL SQNISELKDG ELWNKFFVRI LNANDEATVS VLGELAAEMN GVFDTTFQSH LNKALWKVGK LTSPGALLFQ
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.