BUB1B | ENSG00000156970 | NCBI 701

Details for: BUB1B

Gene ID: 701

Symbol: BUB1B

Ensembl ID: ENSG00000156970

Description: BUB1 mitotic checkpoint serine/threonine kinase B

Associated with

Activation of apc/c and apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176814)
Amplification of signal from the kinetochores
(R-HSA-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-HSA-141444)
Apc-cdc20 mediated degradation of nek2a
(R-HSA-179409)
Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Apc/c:cdc20 mediated degradation of mitotic proteins
(R-HSA-176409)
Apc:cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint
(R-HSA-179419)
Cdc20:phospho-apc/c mediated degradation of cyclin a
(R-HSA-174184)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Inactivation of apc/c via direct inhibition of the apc/c complex
(R-HSA-141430)
Inhibition of the proteolytic activity of apc/c required for the onset of anaphase by mitotic spindle checkpoint components
(R-HSA-141405)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Regulation of apc/c activators between g1/s and early anaphase
(R-HSA-176408)
Regulation of mitotic cell cycle
(R-HSA-453276)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Anaphase-promoting complex
(GO:0005680)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
Cell division
(GO:0051301)
Centrosome
(GO:0005813)
Chromatin remodeling
(GO:0006338)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Histone h2as1 kinase activity
(GO:0044024)
Kinetochore
(GO:0000776)
Meiotic sister chromatid cohesion, centromeric
(GO:0051754)
Metaphase/anaphase transition of mitotic cell cycle
(GO:0007091)
Mitotic checkpoint complex
(GO:0033597)
Mitotic spindle assembly checkpoint signaling
(GO:0007094)
Nucleus
(GO:0005634)
Outer kinetochore
(GO:0000940)
Perinuclear region of cytoplasm
(GO:0048471)
Phosphorylation
(GO:0016310)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein localization to chromosome, centromeric region
(GO:0071459)
Protein serine kinase activity
(GO:0106310)
Spindle
(GO:0005819)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 36.0024
Cell Significance Index: -5.6000
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 31.6586
Cell Significance Index: -8.0300
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 21.5076
Cell Significance Index: -8.8600
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 6.5209
Cell Significance Index: -8.0400
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.8417
Cell Significance Index: 17.4600
Cell Name: germ cell (CL0000586)
Fold Change: 0.7529
Cell Significance Index: 5.6900
Cell Name: salivary gland cell (CL0009005)
Fold Change: 0.7312
Cell Significance Index: 9.0800
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.5735
Cell Significance Index: 113.8100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.5567
Cell Significance Index: 31.2400
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.5131
Cell Significance Index: 55.8100
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4876
Cell Significance Index: 48.2400
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.4623
Cell Significance Index: 54.5200
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.3668
Cell Significance Index: 10.2500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3084
Cell Significance Index: 58.6900
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: 0.2130
Cell Significance Index: 3.0500
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.1913
Cell Significance Index: 22.2900
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 0.1908
Cell Significance Index: 5.6200
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 0.1729
Cell Significance Index: 1.8800
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.1708
Cell Significance Index: 4.5700
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1684
Cell Significance Index: 11.6500
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.1606
Cell Significance Index: 145.0000
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0964
Cell Significance Index: 52.6700
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0888
Cell Significance Index: 2.2200
Cell Name: mesangial cell (CL0000650)
Fold Change: 0.0826
Cell Significance Index: 1.0500
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.0791
Cell Significance Index: 4.7500
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0670
Cell Significance Index: 1.9300
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0515
Cell Significance Index: 1.6500
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.0485
Cell Significance Index: 1.3000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.0472
Cell Significance Index: 1.6400
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0376
Cell Significance Index: 0.8000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0347
Cell Significance Index: 1.8000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0319
Cell Significance Index: 6.3900
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0317
Cell Significance Index: 21.9000
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0283
Cell Significance Index: 12.5100
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.0272
Cell Significance Index: 0.5700
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0263
Cell Significance Index: 1.1900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0189
Cell Significance Index: 0.4100
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.0140
Cell Significance Index: 2.2800
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.0112
Cell Significance Index: 3.2200
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0026
Cell Significance Index: 0.0900
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.0005
Cell Significance Index: 0.0200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0018
Cell Significance Index: -3.4700
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0034
Cell Significance Index: -6.1900
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0040
Cell Significance Index: -6.1200
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0041
Cell Significance Index: -5.5500
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0063
Cell Significance Index: -0.7800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0084
Cell Significance Index: -1.5200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0108
Cell Significance Index: -3.8600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0109
Cell Significance Index: -7.9700
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0113
Cell Significance Index: -7.1800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0113
Cell Significance Index: -8.5700
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0126
Cell Significance Index: -9.3400
Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.0130
Cell Significance Index: -0.1800
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: -0.0151
Cell Significance Index: -0.1100
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0173
Cell Significance Index: -9.7800
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0174
Cell Significance Index: -10.8500
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0176
Cell Significance Index: -0.3000
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0180
Cell Significance Index: -8.1500
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0258
Cell Significance Index: -0.6900
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0290
Cell Significance Index: -1.7800
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0299
Cell Significance Index: -4.1100
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0371
Cell Significance Index: -5.3900
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0477
Cell Significance Index: -4.8800
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0487
Cell Significance Index: -10.2600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0556
Cell Significance Index: -9.5000
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0561
Cell Significance Index: -3.6200
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0566
Cell Significance Index: -4.0000
Cell Name: lactocyte (CL0002325)
Fold Change: -0.0641
Cell Significance Index: -8.2800
Cell Name: sensory neuron (CL0000101)
Fold Change: -0.0669
Cell Significance Index: -0.3800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0730
Cell Significance Index: -8.3600
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0807
Cell Significance Index: -8.4000
Cell Name: hepatoblast (CL0005026)
Fold Change: -0.0850
Cell Significance Index: -1.4300
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0959
Cell Significance Index: -7.3600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0962
Cell Significance Index: -5.9100
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.1033
Cell Significance Index: -2.6400
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -0.1059
Cell Significance Index: -2.6400
Cell Name: epidermal cell (CL0000362)
Fold Change: -0.1109
Cell Significance Index: -0.2500
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1144
Cell Significance Index: -5.9600
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1174
Cell Significance Index: -8.7500
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -0.1181
Cell Significance Index: -0.8000
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.1190
Cell Significance Index: -2.0400
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.1210
Cell Significance Index: -2.9300
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.1256
Cell Significance Index: -1.3000
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1271
Cell Significance Index: -8.5500
Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.1307
Cell Significance Index: -1.9700
Cell Name: medium spiny neuron (CL1001474)
Fold Change: -0.1326
Cell Significance Index: -1.7900
Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.1359
Cell Significance Index: -1.9100
Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
Fold Change: -0.1364
Cell Significance Index: -1.2400
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1412
Cell Significance Index: -7.4200
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.1428
Cell Significance Index: -9.0000
Cell Name: radial glial cell (CL0000681)
Fold Change: -0.1432
Cell Significance Index: -0.8500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1498
Cell Significance Index: -7.0400
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1564
Cell Significance Index: -4.0200
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.1576
Cell Significance Index: -7.3500
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: -0.1577
Cell Significance Index: -1.3400
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1635
Cell Significance Index: -7.2300
Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.1693
Cell Significance Index: -2.3800
Cell Name: proerythroblast (CL0000547)
Fold Change: -0.1724
Cell Significance Index: -2.4700
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1808
Cell Significance Index: -7.4100
Cell Name: neural progenitor cell (CL0011020)
Fold Change: -0.1809
Cell Significance Index: -1.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Serine/threonine kinase activity**: BUB1B is a serine/threonine kinase that phosphorylates and regulates the activity of various proteins involved in the mitotic checkpoint. 2. **Mitotic checkpoint complex**: BUB1B is a key component of the mitotic checkpoint complex, which ensures accurate chromosome segregation during cell division. 3. **Interaction with APC**: BUB1B interacts with the APC to regulate the degradation of mitotic proteins, ensuring proper chromosome segregation. 4. **Regulation of mitotic spindle assembly**: BUB1B regulates the assembly of the mitotic spindle, ensuring proper alignment and separation of chromosomes. 5. **Expression in various cell types**: BUB1B is expressed in various cell types, including germ cells, kidney epithelial cells, and immune cells. **Pathways and Functions** 1. **Activation of APC**: BUB1B phosphorylates and activates the APC, leading to the degradation of mitotic proteins and the promotion of anaphase. 2. **Amplification of signal from kinetochores**: BUB1B amplifies the signal from kinetochores, ensuring proper alignment and separation of chromosomes. 3. **Regulation of cell cycle checkpoints**: BUB1B regulates the cell cycle checkpoints, ensuring proper progression through the cell cycle. 4. **Inhibition of apoptosis**: BUB1B inhibits apoptosis by regulating the activity of pro-apoptotic proteins. 5. **Regulation of mitotic spindle assembly**: BUB1B regulates the assembly of the mitotic spindle, ensuring proper alignment and separation of chromosomes. **Clinical Significance** 1. **Cancer**: Abnormal expression or activity of BUB1B has been implicated in various cancers, including breast cancer, lung cancer, and leukemia. 2. **Neurodegenerative disorders**: BUB1B has been implicated in neurodegenerative disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 3. **Genetic disorders**: BUB1B mutations have been implicated in genetic disorders, including Fanconi anemia and Bloom syndrome. 4. **Reproductive disorders**: BUB1B has been implicated in reproductive disorders, including infertility and miscarriage. 5. **Therapeutic applications**: BUB1B inhibitors have been investigated as potential therapeutic agents for the treatment of various diseases, including cancer and neurodegenerative disorders. In conclusion, BUB1B is a crucial regulator of the mitotic checkpoint, ensuring accurate chromosome segregation during cell division. Abnormal expression or activity of BUB1B has been implicated in various diseases, including cancer, neurodegenerative disorders, and genetic disorders. Further research is needed to fully understand the role of BUB1B in human disease and to develop effective therapeutic strategies.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

Genular Protein ID: 1653828806

Symbol: BUB1B_HUMAN

Name: Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

UniProtKB Accession Codes:

O60566 B2R6U0 B4DL09 B4DLG3 O60501 O60627 O60758 O75389 Q59HH6 Q8WV50 Q96KM4

Database IDs:

Citations:

PubMed ID: 9618306

Title: Identification of a novel gene -- SSK1 -- in human endothelial cells exposed to shear stress.

PubMed ID: 9618306

DOI: 10.1006/bbrc.1998.8713

PubMed ID: 9660858

Title: The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase.

PubMed ID: 9660858

DOI: 10.1083/jcb.142.1.1

PubMed ID: 9763420

Title: Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1.

PubMed ID: 9763420

DOI: 10.1083/jcb.143.1.49

PubMed ID: 9521327

Title: Mutations of mitotic checkpoint genes in human cancers.

PubMed ID: 9521327

DOI: 10.1038/32688

PubMed ID: 9889005

Title: The mouse mitotic checkpoint gene bub1b, a novel bub1 family member, is expressed in a cell cycle-dependent manner.

PubMed ID: 9889005

DOI: 10.1006/geno.1998.5629

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10593653

Title: BUBR1 phosphorylation is regulated during mitotic checkpoint activation.

PubMed ID: 10593653

PubMed ID: 10477750

Title: Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC.

PubMed ID: 10477750

DOI: 10.1083/jcb.146.5.941

PubMed ID: 11702782

Title: Mad2-independent inhibition of APC/Cdc20 by the mitotic checkpoint protein BubR1.

PubMed ID: 11702782

DOI: 10.1016/s1534-5807(01)00019-3

PubMed ID: 14706340

Title: Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability.

PubMed ID: 14706340

DOI: 10.1016/s1535-6108(03)00302-7

PubMed ID: 12925705

Title: Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss.

PubMed ID: 12925705

DOI: 10.1083/jcb.200303167

PubMed ID: 15020684

Title: Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression.

PubMed ID: 15020684

DOI: 10.1242/jcs.01006

PubMed ID: 16227576

Title: Caspase-mediated specific cleavage of BubR1 is a determinant of mitotic progression.

PubMed ID: 16227576

DOI: 10.1128/mcb.25.21.9232-9248.2005

PubMed ID: 16760428

Title: Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1.

PubMed ID: 16760428

DOI: 10.1091/mbc.e06-03-0240

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17981135

Title: Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1.

PubMed ID: 17981135

DOI: 10.1016/j.devcel.2007.09.005

PubMed ID: 17785528

Title: Tension-sensitive Plk1 phosphorylation on BubR1 regulates the stability of kinetochore microtubule interactions.

PubMed ID: 17785528

DOI: 10.1101/gad.436007

PubMed ID: 17376779

Title: Polo-like kinase 1 facilitates chromosome alignment during prometaphase through BubR1.

PubMed ID: 17376779

DOI: 10.1074/jbc.m611053200

PubMed ID: 19015317

Title: Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit.

PubMed ID: 19015317

DOI: 10.1083/jcb.200805163

PubMed ID: 18374647

Title: SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis.

PubMed ID: 18374647

DOI: 10.1016/j.molcel.2008.01.013

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19411850

Title: Depletion of BubR1 promotes premature centrosomal localization of cyclin B1 and accelerates mitotic entry.

PubMed ID: 19411850

DOI: 10.4161/cc.8.11.8671

PubMed ID: 19625775

Title: Defects in chromosome congression and mitotic progression in KIF18A-deficient cells are partly mediated through impaired functions of CENP-E.

PubMed ID: 19625775

DOI: 10.4161/cc.8.16.9366

PubMed ID: 19407811

Title: BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis.

PubMed ID: 19407811

DOI: 10.1038/emboj.2009.123

PubMed ID: 19503101

Title: BubR1 localizes to centrosomes and suppresses centrosome amplification via regulating Plk1 activity in interphase cells.

PubMed ID: 19503101

DOI: 10.1038/onc.2009.141

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 29162720

Title: Direct interactions of mitotic arrest deficient 1 (MAD1) domains with each other and MAD2 conformers are required for mitotic checkpoint signaling.

PubMed ID: 29162720

DOI: 10.1074/jbc.ra117.000555

PubMed ID: 29883609

Title: PELI1 selectively targets kinase-active RIP3 for ubiquitylation-dependent proteasomal degradation.

PubMed ID: 29883609

DOI: 10.1016/j.molcel.2018.05.016

PubMed ID: 33094908

Title: Premature aging syndrome showing random chromosome number instabilities with CDC20 mutation.

PubMed ID: 33094908

DOI: 10.1111/acel.13251

PubMed ID: 35217622

Title: Role of ubiquitin-protein ligase UBR5 in the disassembly of mitotic checkpoint complexes.

PubMed ID: 35217622

DOI: 10.1073/pnas.2121478119

PubMed ID: 10366450

Title: Characterization of MAD2B and other mitotic spindle checkpoint genes.

PubMed ID: 10366450

DOI: 10.1006/geno.1999.5831

PubMed ID: 15475955

Title: Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B.

PubMed ID: 15475955

DOI: 10.1038/ng1449

PubMed ID: 16411201

Title: Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome.

PubMed ID: 16411201

DOI: 10.1002/ajmg.a.31069

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 1050
Mass: 119545
Checksum: F7871103A56E6B46
Sequence:

MAAVKKEGGA LSEAMSLEGD EWELSKENVQ PLRQGRIMST LQGALAQESA CNNTLQQQKR 
AFEYEIRFYT GNDPLDVWDR YISWTEQNYP QGGKESNMST LLERAVEALQ GEKRYYSDPR 
FLNLWLKLGR LCNEPLDMYS YLHNQGIGVS LAQFYISWAE EYEARENFRK ADAIFQEGIQ 
QKAEPLERLQ SQHRQFQARV SRQTLLALEK EEEEEVFESS VPQRSTLAEL KSKGKKTARA 
PIIRVGGALK APSQNRGLQN PFPQQMQNNS RITVFDENAD EASTAELSKP TVQPWIAPPM 
PRAKENELQA GPWNTGRSLE HRPRGNTASL IAVPAVLPSF TPYVEETARQ PVMTPCKIEP 
SINHILSTRK PGKEEGDPLQ RVQSHQQASE EKKEKMMYCK EKIYAGVGEF SFEEIRAEVF 
RKKLKEQREA ELLTSAEKRA EMQKQIEEME KKLKEIQTTQ QERTGDQQEE TMPTKETTKL 
QIASESQKIP GMTLSSSVCQ VNCCARETSL AENIWQEQPH SKGPSVPFSI FDEFLLSEKK 
NKSPPADPPR VLAQRRPLAV LKTSESITSN EDVSPDVCDE FTGIEPLSED AIITGFRNVT 
ICPNPEDTCD FARAARFVST PFHEIMSLKD LPSDPERLLP EEDLDVKTSE DQQTACGTIY 
SQTLSIKKLS PIIEDSREAT HSSGFSGSSA SVASTSSIKC LQIPEKLELT NETSENPTQS 
PWCSQYRRQL LKSLPELSAS AELCIEDRPM PKLEIEKEIE LGNEDYCIKR EYLICEDYKL 
FWVAPRNSAE LTVIKVSSQP VPWDFYINLK LKERLNEDFD HFCSCYQYQD GCIVWHQYIN 
CFTLQDLLQH SEYITHEITV LIIYNLLTIV EMLHKAEIVH GDLSPRCLIL RNRIHDPYDC 
NKNNQALKIV DFSYSVDLRV QLDVFTLSGF RTVQILEGQK ILANCSSPYQ VDLFGIADLA 
HLLLFKEHLQ VFWDGSFWKL SQNISELKDG ELWNKFFVRI LNANDEATVS VLGELAAEMN 
GVFDTTFQSH LNKALWKVGK LTSPGALLFQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: BUB1B

Associated with

Cells (max top 100)

Other Information

Identification of a novel gene -- SSK1 -- in human endothelial cells exposed to shear stress. PubMed ID: 9618306

The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase. PubMed ID: 9660858

Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1. PubMed ID: 9763420

Mutations of mitotic checkpoint genes in human cancers. PubMed ID: 9521327

The mouse mitotic checkpoint gene bub1b, a novel bub1 family member, is expressed in a cell cycle-dependent manner. PubMed ID: 9889005

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

BUBR1 phosphorylation is regulated during mitotic checkpoint activation. PubMed ID: 10593653

Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC. PubMed ID: 10477750

Mad2-independent inhibition of APC/Cdc20 by the mitotic checkpoint protein BubR1. PubMed ID: 11702782

Dual roles of human BubR1, a mitotic checkpoint kinase, in the monitoring of chromosomal instability. PubMed ID: 14706340

Centromere-associated protein-E is essential for the mammalian mitotic checkpoint to prevent aneuploidy due to single chromosome loss. PubMed ID: 12925705

Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression. PubMed ID: 15020684

Caspase-mediated specific cleavage of BubR1 is a determinant of mitotic progression. PubMed ID: 16227576

Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1. PubMed ID: 16760428

A probability-based approach for high-throughput protein phosphorylation analysis and site localization. PubMed ID: 16964243

Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1. PubMed ID: 17981135

Tension-sensitive Plk1 phosphorylation on BubR1 regulates the stability of kinetochore microtubule interactions. PubMed ID: 17785528

Polo-like kinase 1 facilitates chromosome alignment during prometaphase through BubR1. PubMed ID: 17376779

Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit. PubMed ID: 19015317

SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis. PubMed ID: 18374647

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Depletion of BubR1 promotes premature centrosomal localization of cyclin B1 and accelerates mitotic entry. PubMed ID: 19411850

Defects in chromosome congression and mitotic progression in KIF18A-deficient cells are partly mediated through impaired functions of CENP-E. PubMed ID: 19625775

BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis. PubMed ID: 19407811

BubR1 localizes to centrosomes and suppresses centrosome amplification via regulating Plk1 activity in interphase cells. PubMed ID: 19503101

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Direct interactions of mitotic arrest deficient 1 (MAD1) domains with each other and MAD2 conformers are required for mitotic checkpoint signaling. PubMed ID: 29162720

PELI1 selectively targets kinase-active RIP3 for ubiquitylation-dependent proteasomal degradation. PubMed ID: 29883609

Premature aging syndrome showing random chromosome number instabilities with CDC20 mutation. PubMed ID: 33094908

Role of ubiquitin-protein ligase UBR5 in the disassembly of mitotic checkpoint complexes. PubMed ID: 35217622

Characterization of MAD2B and other mitotic spindle checkpoint genes. PubMed ID: 10366450

Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B. PubMed ID: 15475955

Monoallelic BUB1B mutations and defective mitotic-spindle checkpoint in seven families with premature chromatid separation (PCS) syndrome. PubMed ID: 16411201

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846