Details for: BYSL

Gene ID: 705

Symbol: BYSL

Ensembl ID: ENSG00000112578

Description: bystin like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 49.6962
    Cell Significance Index: -7.7300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 30.3576
    Cell Significance Index: -7.7000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 22.7456
    Cell Significance Index: -9.3700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 20.7573
    Cell Significance Index: -9.8000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 20.4058
    Cell Significance Index: -8.2900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 14.6269
    Cell Significance Index: -9.8200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.6564
    Cell Significance Index: -9.4400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 5.3582
    Cell Significance Index: 88.3000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 3.4706
    Cell Significance Index: 55.6800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.8370
    Cell Significance Index: -7.6000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.4886
    Cell Significance Index: -9.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6067
    Cell Significance Index: 158.9400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.0431
    Cell Significance Index: 11.3400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8172
    Cell Significance Index: 49.0600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6722
    Cell Significance Index: 73.1200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6543
    Cell Significance Index: 33.9900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5977
    Cell Significance Index: 539.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5128
    Cell Significance Index: 14.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5102
    Cell Significance Index: 82.9800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4940
    Cell Significance Index: 8.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4547
    Cell Significance Index: 20.6100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4462
    Cell Significance Index: 11.9600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.4180
    Cell Significance Index: 5.9900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3758
    Cell Significance Index: 10.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3552
    Cell Significance Index: 45.9000
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.3326
    Cell Significance Index: 3.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3311
    Cell Significance Index: 22.9000
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.3112
    Cell Significance Index: 2.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.3051
    Cell Significance Index: 22.7400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3029
    Cell Significance Index: 6.3400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2990
    Cell Significance Index: 8.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2502
    Cell Significance Index: 5.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2470
    Cell Significance Index: 17.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2200
    Cell Significance Index: 97.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2106
    Cell Significance Index: 115.0200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2035
    Cell Significance Index: 13.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1991
    Cell Significance Index: 4.2400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1989
    Cell Significance Index: 6.9100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1935
    Cell Significance Index: 2.6400
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.1921
    Cell Significance Index: 1.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1793
    Cell Significance Index: 24.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1741
    Cell Significance Index: 4.6500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1610
    Cell Significance Index: 10.1500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1582
    Cell Significance Index: 4.1600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1433
    Cell Significance Index: 4.5900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1361
    Cell Significance Index: 16.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1339
    Cell Significance Index: 26.5800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1303
    Cell Significance Index: 1.0400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.1251
    Cell Significance Index: 1.8800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1224
    Cell Significance Index: 14.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1196
    Cell Significance Index: 21.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1046
    Cell Significance Index: 4.9200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0726
    Cell Significance Index: 13.8200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0613
    Cell Significance Index: 1.8000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0388
    Cell Significance Index: 0.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0384
    Cell Significance Index: 7.7100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0358
    Cell Significance Index: 1.6700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0355
    Cell Significance Index: 0.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0313
    Cell Significance Index: 1.1000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0299
    Cell Significance Index: 0.3400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0179
    Cell Significance Index: 0.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0165
    Cell Significance Index: 0.4600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0092
    Cell Significance Index: 6.3600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0063
    Cell Significance Index: 0.8100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0012
    Cell Significance Index: 0.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0023
    Cell Significance Index: -1.7300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0043
    Cell Significance Index: -0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0044
    Cell Significance Index: -8.2900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0063
    Cell Significance Index: -1.0800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0065
    Cell Significance Index: -11.9700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0079
    Cell Significance Index: -12.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0090
    Cell Significance Index: -6.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0093
    Cell Significance Index: -3.3300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0093
    Cell Significance Index: -12.6200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0124
    Cell Significance Index: -9.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0130
    Cell Significance Index: -8.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0152
    Cell Significance Index: -1.5500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0160
    Cell Significance Index: -9.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0201
    Cell Significance Index: -12.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0210
    Cell Significance Index: -9.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0245
    Cell Significance Index: -7.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0293
    Cell Significance Index: -3.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0317
    Cell Significance Index: -3.6300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0527
    Cell Significance Index: -0.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0550
    Cell Significance Index: -11.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0608
    Cell Significance Index: -8.8400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0675
    Cell Significance Index: -0.8700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0853
    Cell Significance Index: -0.8900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0894
    Cell Significance Index: -0.5400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0940
    Cell Significance Index: -9.7900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1001
    Cell Significance Index: -5.6200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1044
    Cell Significance Index: -8.0100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1076
    Cell Significance Index: -5.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1106
    Cell Significance Index: -8.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1144
    Cell Significance Index: -2.9400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1160
    Cell Significance Index: -7.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1184
    Cell Significance Index: -7.2800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1266
    Cell Significance Index: -8.5100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1480
    Cell Significance Index: -2.2300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1494
    Cell Significance Index: -7.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The BYSL gene is a non-coding RNA gene, encoded by the BYST_HUMAN protein. It is significantly expressed in various cell types, including B-2 B cells, male germ cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, and intestinal epithelial cells. The gene's expression pattern suggests a widespread role in regulating cellular processes, particularly in the nucleus and cytosol. **Pathways and Functions:** The BYSL gene is involved in several critical pathways, including: 1. **Ribosome Biogenesis:** BYSL plays a crucial role in the maturation of small subunit precursors (SSU-RP) and large subunit precursors (LSU-RP) of ribosomes. This process is essential for protein synthesis and cellular growth. 2. **RNA Processing:** BYSL is involved in the regulation of RNA processing in the nucleus and cytosol, including the maturation of 5.8S rRNA and the processing of small nuclear RNAs (snRNAs). 3. **Protein Localization:** BYSL regulates the localization of proteins to the nucleolus, a critical organelle involved in ribosome biogenesis and RNA processing. 4. **Stem Cell Proliferation:** BYSL is expressed in stem cells, including intestinal crypt stem cells and primordial germ cells, suggesting its role in maintaining stem cell pluripotency. **Clinical Significance:** Dysregulation of the BYSL gene has been implicated in various diseases, including: 1. **Immune System Disorders:** Alterations in BYSL expression have been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, highlighting its role in immune system regulation. 2. **Cancer:** BYSL expression is often downregulated in cancer cells, suggesting its potential as a tumor suppressor gene. 3. **Neurological Disorders:** BYSL has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's, where its dysregulation may contribute to disease progression. In conclusion, the BYSL gene is a critical regulator of RNA processing and ribosome biogenesis, with significant implications for various cellular processes and diseases. Further research is necessary to fully elucidate the functions of BYSL and its role in human health and disease.

Genular Protein ID: 3867935442

Symbol: BYST_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9560222

Title: A cytoplasmic protein, bystin, interacts with trophinin, tastin, and cytokeratin and may be involved in trophinin-mediated cell adhesion between trophoblast and endometrial epithelial cells.

PubMed ID: 9560222

DOI: 10.1073/pnas.95.9.5027

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17381424

Title: Bystin in human cancer cells: intracellular localization and function in ribosome biogenesis.

PubMed ID: 17381424

DOI: 10.1042/bj20061597

PubMed ID: 17360433

Title: Trophoblast cell activation by trophinin ligation is implicated in human embryo implantation.

PubMed ID: 17360433

DOI: 10.1073/pnas.0611516104

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 26711351

Title: Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells.

PubMed ID: 26711351

DOI: 10.1016/j.celrep.2015.11.061

Sequence Information:

  • Length: 437
  • Mass: 49601
  • Checksum: 1A8C5E5EB108DF1A
  • Sequence:
  • MPKFKAARGV GGQEKHAPLA DQILAGNAVR AGVREKRRGR GTGEAEEEYV GPRLSRRILQ 
    QARQQQEELE AEHGTGDKPA APRERTTRLG PRMPQDGSDD EDEEWPTLEK AATMTAAGHH 
    AEVVVDPEDE RAIEMFMNKN PPARRTLADI IMEKLTEKQT EVETVMSEVS GFPMPQLDPR 
    VLEVYRGVRE VLSKYRSGKL PKAFKIIPAL SNWEQILYVT EPEAWTAAAM YQATRIFASN 
    LKERMAQRFY NLVLLPRVRD DVAEYKRLNF HLYMALKKAL FKPGAWFKGI LIPLCESGTC 
    TLREAIIVGS IITKCSIPVL HSSAAMLKIA EMEYSGANSI FLRLLLDKKY ALPYRVLDAL 
    VFHFLGFRTE KRELPVLWHQ CLLTLVQRYK ADLATDQKEA LLELLRLQPH PQLSPEIRRE 
    LQSAVPRDVE DVPITVE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.