Details for: BYSL

Gene ID: 705

Symbol: BYSL

Ensembl ID: ENSG00000112578

Description: bystin like

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 1.21
    Marker Score: 1493
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.04
    Marker Score: 299
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71789
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48013
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.96
    Marker Score: 1206
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 490
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.92
    Marker Score: 621
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2725
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5062
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5268
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 311
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.74
    Marker Score: 1812
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 379
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.72
    Marker Score: 540
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 653
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.71
    Marker Score: 286
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.7
    Marker Score: 535
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.69
    Marker Score: 2967
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.68
    Marker Score: 2798
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.67
    Marker Score: 716
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.66
    Marker Score: 2607
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.66
    Marker Score: 950
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2756
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.64
    Marker Score: 679
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.62
    Marker Score: 1695
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.62
    Marker Score: 490
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.61
    Marker Score: 1164
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.61
    Marker Score: 9546
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.61
    Marker Score: 634
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.59
    Marker Score: 622
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.59
    Marker Score: 636
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.58
    Marker Score: 588
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 440
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.55
    Marker Score: 1113
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.54
    Marker Score: 347
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.54
    Marker Score: 567
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.53
    Marker Score: 18079
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.53
    Marker Score: 558
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.52
    Marker Score: 1096
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.52
    Marker Score: 1991
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.51
    Marker Score: 2529.5
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.51
    Marker Score: 250
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.51
    Marker Score: 321
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.5
    Marker Score: 251
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.5
    Marker Score: 287
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.49
    Marker Score: 330
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.48
    Marker Score: 1010
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.48
    Marker Score: 289
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.48
    Marker Score: 510
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.47
    Marker Score: 695
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.47
    Marker Score: 183
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.46
    Marker Score: 1101
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.46
    Marker Score: 434
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.44
    Marker Score: 746.5
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.44
    Marker Score: 741
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.44
    Marker Score: 240
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.43
    Marker Score: 1020
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.43
    Marker Score: 180
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 0.43
    Marker Score: 517
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.43
    Marker Score: 114
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.43
    Marker Score: 1049
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.42
    Marker Score: 223
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.42
    Marker Score: 409
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.42
    Marker Score: 141
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.41
    Marker Score: 103
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.41
    Marker Score: 171
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.41
    Marker Score: 103
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.41
    Marker Score: 132
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.41
    Marker Score: 4595
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.41
    Marker Score: 258
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.41
    Marker Score: 170
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.41
    Marker Score: 95
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.4
    Marker Score: 193
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 0.4
    Marker Score: 95
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.4
    Marker Score: 613
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.39
    Marker Score: 13595
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.39
    Marker Score: 3348
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.39
    Marker Score: 96
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.39
    Marker Score: 374
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.39
    Marker Score: 515
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.39
    Marker Score: 193
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.38
    Marker Score: 241
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.38
    Marker Score: 136
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.37
    Marker Score: 1386
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.37
    Marker Score: 246
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.37
    Marker Score: 104
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.36
    Marker Score: 968
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.35
    Marker Score: 2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.35
    Marker Score: 3583
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.34
    Marker Score: 108
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.34
    Marker Score: 156
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.33
    Marker Score: 223
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.33
    Marker Score: 152
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.33
    Marker Score: 369
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.32
    Marker Score: 2536

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Other Information

**Key characteristics:** - BYSL is a protein that is involved in the processing of rRNA. - It is expressed in a variety of cell types. - It is significantly expressed in B-2 B cell, male germ cell, cerebral cortex GABAergic interneuron, forebrain radial glial cell, absorptive cell, primordial germ cell, and tuft cell of colon. **Pathways and functions:** BYSL is involved in several pathways and functions, including: - The major pathway of rRNA processing in the nucleolus and cytosol - Membrane trafficking - Ribosome biogenesis - Rna binding - Rrna processing - Regulation of protein localization to nucleolus - Stem cell proliferation - Trophectodermal cell differentiation **Clinical significance:** BYSL is a promising target for cancer therapy. It is a highly expressed protein in cancer cells, and its inhibition leads to cell death. BYSL is currently being investigated as a potential treatment for a variety of cancers, including breast cancer, lung cancer, and leukemia.

Genular Protein ID: 3867935442

Symbol: BYST_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q13895 Q6P5W4 Q86W44 Q96IP8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EMDB 13 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 17 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 10 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SWISS-2DPAGE 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9560222

Title: A cytoplasmic protein, bystin, interacts with trophinin, tastin, and cytokeratin and may be involved in trophinin-mediated cell adhesion between trophoblast and endometrial epithelial cells.

PubMed ID: 9560222

DOI: 10.1073/pnas.95.9.5027

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17381424

Title: Bystin in human cancer cells: intracellular localization and function in ribosome biogenesis.

PubMed ID: 17381424

DOI: 10.1042/bj20061597

PubMed ID: 17360433

Title: Trophoblast cell activation by trophinin ligation is implicated in human embryo implantation.

PubMed ID: 17360433

DOI: 10.1073/pnas.0611516104

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 26711351

Title: Genome-wide RNAi Screening Identifies Protein Modules Required for 40S Subunit Synthesis in Human Cells.

PubMed ID: 26711351

DOI: 10.1016/j.celrep.2015.11.061

Sequence Information:

  • Length: 437
  • Mass: 49601
  • Checksum: 1A8C5E5EB108DF1A
  • Sequence:
    • MPKFKAARGV GGQEKHAPLA DQILAGNAVR AGVREKRRGR GTGEAEEEYV GPRLSRRILQ 
QARQQQEELE AEHGTGDKPA APRERTTRLG PRMPQDGSDD EDEEWPTLEK AATMTAAGHH 
AEVVVDPEDE RAIEMFMNKN PPARRTLADI IMEKLTEKQT EVETVMSEVS GFPMPQLDPR 
VLEVYRGVRE VLSKYRSGKL PKAFKIIPAL SNWEQILYVT EPEAWTAAAM YQATRIFASN 
LKERMAQRFY NLVLLPRVRD DVAEYKRLNF HLYMALKKAL FKPGAWFKGI LIPLCESGTC 
TLREAIIVGS IITKCSIPVL HSSAAMLKIA EMEYSGANSI FLRLLLDKKY ALPYRVLDAL 
VFHFLGFRTE KRELPVLWHQ CLLTLVQRYK ADLATDQKEA LLELLRLQPH PQLSPEIRRE 
LQSAVPRDVE DVPITVE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.