Details for: Ddo
Associated with
Other Information
Genular Protein ID: 1110643395
Symbol: OXDD_MOUSE
Name: D-aspartate oxidase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 16516413
Title: A physiological mechanism to regulate D-aspartic acid and NMDA levels in mammals revealed by D-aspartate oxidase deficient mice.
PubMed ID: 16516413
PubMed ID: 17469229
Title: Molecular cloning of a cDNA encoding mouse D-aspartate oxidase and functional characterization of its recombinant proteins by site-directed mutagenesis.
PubMed ID: 17469229
PubMed ID: 16141072
Title: The transcriptional landscape of the mammalian genome.
PubMed ID: 16141072
PubMed ID: 19468303
Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.
PubMed ID: 19468303
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7903300
Title: Biological role of D-amino acid oxidase and D-aspartate oxidase. Effects of D-amino acids.
PubMed ID: 7903300
PubMed ID: 16725213
Title: Behavioural alterations in male mice lacking the gene for D-aspartate oxidase.
PubMed ID: 16725213
PubMed ID: 16525061
Title: D-aspartate regulates melano in formation and function: behavioral alterations in D-aspartate oxidase-deficient mice.
PubMed ID: 16525061
PubMed ID: 18235994
Title: Hyperactive mutants of mouse D-aspartate oxidase: mutagenesis of the active site residue serine 308.
PubMed ID: 18235994
PubMed ID: 18314103
Title: D-Aspartate and D-aspartate oxidase show selective and developmentally dynamic localization in mouse retina.
PubMed ID: 18314103
PubMed ID: 20603179
Title: Thiolactomycin inhibits D-aspartate oxidase: a novel approach to probing the active site environment.
PubMed ID: 20603179
PubMed ID: 21183079
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
PubMed ID: 21183079
PubMed ID: 20567862
Title: Role of the active site residues arginine-216 and arginine-237 in the substrate specificity of mammalian D-aspartate oxidase.
PubMed ID: 20567862
PubMed ID: 20031274
Title: Persistent increase of D-aspartate in D-aspartate oxidase mutant mice induces a precocious hippocampal age-dependent synaptic plasticity and spatial memory decay.
PubMed ID: 20031274
PubMed ID: 25747990
Title: Characterization of the enzymatic and structural properties of human D-aspartate oxidase and comparison with those of the rat and mouse enzymes.
PubMed ID: 25747990
PubMed ID: 26058797
Title: Changes in D-aspartic acid and D-glutamic acid levels in the tissues and physiological fluids of mice with various D-aspartate oxidase activities.
PubMed ID: 26058797
PubMed ID: 25771393
Title: d-Aspartate oxidase influences glutamatergic system homeostasis in mammalian brain.
PubMed ID: 25771393
PubMed ID: 25979765
Title: D-aspartate dysregulation in Ddo(-/-) mice modulates phencyclidine-induced gene expression changes of postsynaptic density molecules in cortex and striatum.
PubMed ID: 25979765
PubMed ID: 25689573
Title: A role for D-aspartate oxidase in schizophrenia and in schizophrenia-related symptoms induced by phencyclidine in mice.
PubMed ID: 25689573
DOI: 10.1038/tp.2015.2
PubMed ID: 26658710
Title: The Effect of D-Aspartate on Spermatogenesis in Mouse Testis.
PubMed ID: 26658710
PubMed ID: 26961959
Title: Age-Related Changes in D-Aspartate Oxidase Promoter Methylation Control Extracellular D-Aspartate Levels and Prevent Precocious Cell Death during Brain Aging.
PubMed ID: 26961959
PubMed ID: 26707656
Title: Persistent elevation of D-Aspartate enhances NMDA receptor-mediated responses in mouse substantia nigra pars compacta dopamine neurons.
PubMed ID: 26707656
PubMed ID: 28393897
Title: Olanzapine, but not clozapine, increases glutamate release in the prefrontal cortex of freely moving mice by inhibiting D-aspartate oxidase activity.
PubMed ID: 28393897
DOI: 10.1038/srep46288
PubMed ID: 29292239
Title: Rat d-aspartate oxidase is more similar to the human enzyme than the mouse enzyme.
PubMed ID: 29292239
PubMed ID: 30822420
Title: Free d-aspartate triggers NMDA receptor-dependent cell death in primary cortical neurons and perturbs JNK activation, Tau phosphorylation, and protein SUMOylation in the cerebral cortex of mice lacking d-aspartate oxidase activity.
PubMed ID: 30822420
PubMed ID: 32185508
Title: Prenatal expression of D-aspartate oxidase causes early cerebral D-aspartate depletion and influences brain morphology and cognitive functions at adulthood.
PubMed ID: 32185508
PubMed ID: 32553892
Title: Biochemical characterization of mouse d-aspartate oxidase.
PubMed ID: 32553892
PubMed ID: 35915065
Title: D-aspartate oxidase gene duplication induces social recognition memory deficit in mice and intellectual disabilities in humans.
PubMed ID: 35915065
PubMed ID: 37189369
Title: D-Aspartate Depletion Perturbs Steroidogenesis and Spermatogenesis in Mice.
PubMed ID: 37189369
DOI: 10.3390/biom13040621
Sequence Information:
- Length: 341
- Mass: 37546
- Checksum: A80BC74CC44A601D
- Sequence:
MDTVCIAVVG AGVIGLSTAA CISQLVPGCT VTVISDRFTP DTTSNVAAGM LIPHTCADTP VPTQKRWFRE TFEHLSEIAK SAEAADAGVH LVSGWQIFRS VPAEEVPFWA DVVLGFRKMT EAELKRFPQY VFGQAFTTLK CETSAYLPWL ERRIKGSGGL LLTRRIEDLW ELQPSFDIVV NCSGLGSRRL VGDPMISPVR GQVLQARAPW VKHFIRDGGG LTYVYPGMSY VTLGGTRQKG DWNRSPDAEL SREIFSRCCT LEPSLHRAYD IKEKVGLRPS RPGVRLQKEI LVRGQQTLPV VHNYGHGSGG ISVHWGSALE ATRLVMECIH TLRTPASLSK L
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.