Details for: TSPO
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 4.24
Marker Score: 237,207 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 3.67
Marker Score: 7,755 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 3.59
Marker Score: 22,917 - Cell Name: blood cell (CL0000081)
Fold Change: 3.57
Marker Score: 41,557 - Cell Name: lung macrophage (CL1001603)
Fold Change: 3.45
Marker Score: 3,947 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 3.36
Marker Score: 26,271 - Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 3.3
Marker Score: 6,425 - Cell Name: secretory cell (CL0000151)
Fold Change: 3.21
Marker Score: 5,852 - Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 3.2
Marker Score: 23,839 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.19
Marker Score: 7,782 - Cell Name: mucous neck cell (CL0000651)
Fold Change: 3.11
Marker Score: 7,063 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 3.09
Marker Score: 2,431 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 3.08
Marker Score: 7,664 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 3.04
Marker Score: 26,197 - Cell Name: cell in vitro (CL0001034)
Fold Change: 2.97
Marker Score: 102,748 - Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.96
Marker Score: 75,842 - Cell Name: mature T cell (CL0002419)
Fold Change: 2.95
Marker Score: 29,250 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 2.93
Marker Score: 4,853 - Cell Name: non-classical monocyte (CL0000875)
Fold Change: 2.87
Marker Score: 6,928 - Cell Name: classical monocyte (CL0000860)
Fold Change: 2.8
Marker Score: 11,645 - Cell Name: basophil (CL0000767)
Fold Change: 2.73
Marker Score: 1,296 - Cell Name: intestine goblet cell (CL0019031)
Fold Change: 2.69
Marker Score: 2,575 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.68
Marker Score: 17,151 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 2.64
Marker Score: 6,658 - Cell Name: basal cell (CL0000646)
Fold Change: 2.62
Marker Score: 3,377 - Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
Fold Change: 2.61
Marker Score: 1,533 - Cell Name: club cell (CL0000158)
Fold Change: 2.61
Marker Score: 3,049 - Cell Name: enterocyte (CL0000584)
Fold Change: 2.6
Marker Score: 12,490 - Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 2.6
Marker Score: 628 - Cell Name: elicited macrophage (CL0000861)
Fold Change: 2.59
Marker Score: 15,730 - Cell Name: myelocyte (CL0002193)
Fold Change: 2.58
Marker Score: 1,116 - Cell Name: lung secretory cell (CL1000272)
Fold Change: 2.58
Marker Score: 2,300 - Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 2.56
Marker Score: 3,704 - Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 2.55
Marker Score: 13,410 - Cell Name: type I pneumocyte (CL0002062)
Fold Change: 2.54
Marker Score: 3,065 - Cell Name: colon epithelial cell (CL0011108)
Fold Change: 2.54
Marker Score: 7,988 - Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 2.53
Marker Score: 10,835 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.52
Marker Score: 5,041 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.48
Marker Score: 16,177 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.45
Marker Score: 9,444 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.42
Marker Score: 3,568 - Cell Name: pro-T cell (CL0000827)
Fold Change: 2.39
Marker Score: 9,776 - Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 2.39
Marker Score: 2,421 - Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 2.37
Marker Score: 2,220 - Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 2.36
Marker Score: 2,033 - Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 2.36
Marker Score: 6,523 - Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 2.36
Marker Score: 2,073 - Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 2.36
Marker Score: 838 - Cell Name: pneumocyte (CL0000322)
Fold Change: 2.36
Marker Score: 3,787 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 2.35
Marker Score: 6,290 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.34
Marker Score: 5,327 - Cell Name: epithelial cell (CL0000066)
Fold Change: 2.33
Marker Score: 3,710 - Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 2.33
Marker Score: 739 - Cell Name: double negative T regulatory cell (CL0011024)
Fold Change: 2.32
Marker Score: 2,238 - Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 2.3
Marker Score: 1,666 - Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 2.3
Marker Score: 4,071 - Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
Fold Change: 2.26
Marker Score: 977 - Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 2.26
Marker Score: 119,368 - Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 2.26
Marker Score: 1,604 - Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
Fold Change: 2.25
Marker Score: 5,843 - Cell Name: reticular cell (CL0000432)
Fold Change: 2.25
Marker Score: 821 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.23
Marker Score: 22,637 - Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 2.22
Marker Score: 5,635 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: 2.21
Marker Score: 1,138 - Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 2.19
Marker Score: 911 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.18
Marker Score: 2,333 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.17
Marker Score: 2,288 - Cell Name: decidual cell (CL2000002)
Fold Change: 2.17
Marker Score: 9,345 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 2.17
Marker Score: 626 - Cell Name: lung ciliated cell (CL1000271)
Fold Change: 2.16
Marker Score: 1,026 - Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 2.16
Marker Score: 1,078 - Cell Name: serous secreting cell (CL0000313)
Fold Change: 2.15
Marker Score: 860 - Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 2.11
Marker Score: 2,897 - Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 2.11
Marker Score: 713 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: 2.1
Marker Score: 982 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 2.1
Marker Score: 1,224 - Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
Fold Change: 2.1
Marker Score: 1,765 - Cell Name: peptic cell (CL0000155)
Fold Change: 2.07
Marker Score: 866 - Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 2.07
Marker Score: 712 - Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 2.06
Marker Score: 777 - Cell Name: enterocyte of colon (CL1000347)
Fold Change: 2.06
Marker Score: 3,168 - Cell Name: memory regulatory T cell (CL0002678)
Fold Change: 2.03
Marker Score: 707 - Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 2.02
Marker Score: 6,386 - Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 2.02
Marker Score: 9,934 - Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 2.02
Marker Score: 754 - Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 2.02
Marker Score: 764 - Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 2.02
Marker Score: 995 - Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
Fold Change: 2.01
Marker Score: 443 - Cell Name: progenitor cell of endocrine pancreas (CL0002351)
Fold Change: 2.01
Marker Score: 438 - Cell Name: granulocyte (CL0000094)
Fold Change: 2.01
Marker Score: 900 - Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 2.01
Marker Score: 2,841 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 2.01
Marker Score: 7,123 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 2
Marker Score: 17,552 - Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 2
Marker Score: 1,638 - Cell Name: keratinocyte (CL0000312)
Fold Change: 1.99
Marker Score: 1,666 - Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 1.99
Marker Score: 17,259 - Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 1.99
Marker Score: 637 - Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
Fold Change: 1.98
Marker Score: 2,135 - Cell Name: endothelial cell (CL0000115)
Fold Change: 1.96
Marker Score: 1,761 - Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 1.96
Marker Score: 4,778
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1692343408
Symbol: TSPO_HUMAN
Name: Translocator protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1847678
Title: Molecular cloning and chromosomal localization of a human peripheral-type benzodiazepine receptor.
PubMed ID: 1847678
PubMed ID: 7721091
Title: Comparison of repetitive elements in the third intron of human and rodent mitochondrial benzodiazepine receptor-encoding genes.
PubMed ID: 7721091
PubMed ID: 16189298
Title: Peripheral benzodiazepine receptor: characterization in human T-lymphoma Jurkat cells.
PubMed ID: 16189298
PubMed ID: 15461802
Title: A genome annotation-driven approach to cloning the human ORFeome.
PubMed ID: 15461802
PubMed ID: 10591208
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9915832
Title: Cloning and characterization of PRAX-1. A new protein that specifically interacts with the peripheral benzodiazepine receptor.
PubMed ID: 9915832
PubMed ID: 16822554
Title: Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function.
PubMed ID: 16822554
PubMed ID: 17143515
Title: Cellular expression, localization and interactions of the product of the human MOST-1 gene associated with breast and prostate cancers.
PubMed ID: 17143515
PubMed ID: 20600583
Title: Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states.
PubMed ID: 20600583
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 24814875
Title: Targeting mitochondrial 18kDa translocator protein (TSPO) regulates macrophage cholesterol efflux and lipid phenotype.
PubMed ID: 24814875
DOI: 10.1042/cs20140047
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27641616
Title: TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood.
PubMed ID: 27641616
DOI: 10.1038/srep33516
PubMed ID: 11215759
Title: An association study between two missense variations of the benzodiazepine receptor (peripheral) gene and schizophrenia in a Japanese sample.
PubMed ID: 11215759
PubMed ID: 11304832
Title: No association of two missense variations of the benzodiazepine receptor (peripheral) gene and mood disorders in a Japanese sample.
PubMed ID: 11304832
DOI: 10.1002/ajmg.1194
PubMed ID: 19846611
Title: The spontaneous Ala147Thr amino acid substitution within the translocator protein influences pregnenolone production in lymphomonocytes of healthy individuals.
PubMed ID: 19846611
DOI: 10.1210/en.2009-0752
Sequence Information:
- Length: 169
- Mass: 18828
- Checksum: 6DD741BF99AB89D9
- Sequence:
MAPPWVPAMG FTLAPSLGCF VGSRFVHGEG LRWYAGLQKP SWHPPHWVLG PVWGTLYSAM GYGSYLVWKE LGGFTEKAVV PLGLYTGQLA LNWAWPPIFF GARQMGWALV DLLLVSGAAA ATTVAWYQVS PLAARLLYPY LAWLAFTTTL NYCVWRDNHG WRGGRRLPE
Genular Protein ID: 3726472169
Symbol: O76068_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 143
- Mass: 16107
- Checksum: DEAF74A8415C65A9
- Sequence:
HGEGLRWYAG LQKPSWHPPH WVLGPVWGTL YSAMGYGSYL VWKELGGFTE KAVVPLGLYT GQLALNWAWP PIFFGARQMG WALVDLLLVS GAAAATTVAW YQVSPLAARL LYPYLAWLAF TTTLNYCVWR DNHGWRGGRR LPE
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.