Details for: TSPO

Gene ID: 706

Symbol: TSPO

Ensembl ID: ENSG00000100300

Description: translocator protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 317.8497
    Cell Significance Index: -49.4400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 194.2097
    Cell Significance Index: -49.2600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 167.2463
    Cell Significance Index: -67.9500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 158.1581
    Cell Significance Index: -74.6700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 144.4054
    Cell Significance Index: -74.2800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 111.2631
    Cell Significance Index: -74.6600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 72.3441
    Cell Significance Index: -69.0700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 54.1544
    Cell Significance Index: -66.7700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 25.1868
    Cell Significance Index: -77.3600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.9152
    Cell Significance Index: -53.3500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 19.0849
    Cell Significance Index: -75.3100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.2786
    Cell Significance Index: -31.2500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 11.1418
    Cell Significance Index: 205.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 8.9032
    Cell Significance Index: 238.1600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 6.0199
    Cell Significance Index: 55.4400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 5.2132
    Cell Significance Index: 153.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.8097
    Cell Significance Index: 226.0500
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 3.7042
    Cell Significance Index: 31.8300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 3.6583
    Cell Significance Index: 41.5600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.5198
    Cell Significance Index: 634.5100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.4705
    Cell Significance Index: 80.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.4222
    Cell Significance Index: 420.7900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 3.3083
    Cell Significance Index: 20.3600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.2359
    Cell Significance Index: 1767.2100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.8614
    Cell Significance Index: 369.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.8298
    Cell Significance Index: 1251.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.8208
    Cell Significance Index: 146.5300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.7283
    Cell Significance Index: 127.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.6678
    Cell Significance Index: 172.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.3186
    Cell Significance Index: 172.8000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.2034
    Cell Significance Index: 38.9400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.9602
    Cell Significance Index: 251.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.9379
    Cell Significance Index: 100.9400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.8872
    Cell Significance Index: 133.4700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8362
    Cell Significance Index: 49.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.7364
    Cell Significance Index: 238.4600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.1032
    Cell Significance Index: 16.5300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9938
    Cell Significance Index: 117.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8443
    Cell Significance Index: 38.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7836
    Cell Significance Index: 54.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7662
    Cell Significance Index: 145.8200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5659
    Cell Significance Index: 14.8800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5543
    Cell Significance Index: 15.4900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4064
    Cell Significance Index: 66.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3813
    Cell Significance Index: 10.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1971
    Cell Significance Index: 149.2100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.1047
    Cell Significance Index: 1.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0888
    Cell Significance Index: 65.0900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0392
    Cell Significance Index: 4.0000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0265
    Cell Significance Index: 0.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0233
    Cell Significance Index: 0.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0218
    Cell Significance Index: -40.9700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0473
    Cell Significance Index: -87.1500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0568
    Cell Significance Index: -87.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0633
    Cell Significance Index: -6.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0695
    Cell Significance Index: -94.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0974
    Cell Significance Index: -61.8400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1105
    Cell Significance Index: -81.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1410
    Cell Significance Index: -88.0400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1491
    Cell Significance Index: -84.1100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1617
    Cell Significance Index: -73.4000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1720
    Cell Significance Index: -29.3700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1835
    Cell Significance Index: -1.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1971
    Cell Significance Index: -22.9700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1991
    Cell Significance Index: -71.4100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2117
    Cell Significance Index: -60.9100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2214
    Cell Significance Index: -25.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2726
    Cell Significance Index: -54.1000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2852
    Cell Significance Index: -7.1300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2877
    Cell Significance Index: -7.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.3500
    Cell Significance Index: -70.2100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.4138
    Cell Significance Index: -2.5000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4325
    Cell Significance Index: -9.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4437
    Cell Significance Index: -93.4500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4561
    Cell Significance Index: -66.3100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5394
    Cell Significance Index: -7.3600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5691
    Cell Significance Index: -45.0700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6176
    Cell Significance Index: -17.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6226
    Cell Significance Index: -38.2700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7239
    Cell Significance Index: -75.3800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.8318
    Cell Significance Index: -63.8300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -1.0549
    Cell Significance Index: -43.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.0569
    Cell Significance Index: -66.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2030
    Cell Significance Index: -73.7600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.2204
    Cell Significance Index: -82.0600
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.2628
    Cell Significance Index: -21.7700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -1.2740
    Cell Significance Index: -64.3900
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -1.3411
    Cell Significance Index: -8.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.3745
    Cell Significance Index: -28.7700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -1.3841
    Cell Significance Index: -34.5700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.4603
    Cell Significance Index: -76.6700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.4668
    Cell Significance Index: -50.9700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.4804
    Cell Significance Index: -83.0700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.5227
    Cell Significance Index: -12.7900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.5380
    Cell Significance Index: -45.3000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.5503
    Cell Significance Index: -25.9500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.5988
    Cell Significance Index: -42.6900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.7263
    Cell Significance Index: -63.3700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -1.7293
    Cell Significance Index: -33.8100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.7342
    Cell Significance Index: -76.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **TSPO structure:** The TSPO gene encodes a transmembrane protein that spans the mitochondrial outer membrane and interacts with the cytosol. 2. **Cellular expression:** TSPO is expressed in a wide range of cell types, including immune cells, non-immune cells, and cancer cells. 3. **Signaling pathways:** TSPO is involved in multiple signaling pathways, including those related to steroid hormone biosynthesis, cholesterol homeostasis, and cellular metabolism. 4. **Regulatory functions:** TSPO regulates various cellular processes, including immune response, cellular metabolism, and stress response. **Pathways and Functions:** 1. **Steroid hormone biosynthesis:** TSPO is involved in the biosynthesis of steroid hormones, including cortisol and progesterone. 2. **Cholesterol homeostasis:** TSPO regulates cholesterol homeostasis by modulating cholesterol transport and metabolism. 3. **Cellular metabolism:** TSPO is involved in cellular metabolism, including glucose and lipid metabolism. 4. **Immune regulation:** TSPO regulates immune response by modulating the activity of immune cells, such as monocytes and macrophages. 5. **Stress response:** TSPO is involved in the stress response, including the regulation of corticosterone secretion and the response to xenobiotics. **Clinical Significance:** 1. **Neuroinflammatory disorders:** TSPO has been implicated in neuroinflammatory disorders, including multiple sclerosis and Alzheimer's disease. 2. **Cancer:** TSPO is overexpressed in various types of cancer, including breast, lung, and prostate cancer. 3. **Metabolic disorders:** TSPO has been linked to metabolic disorders, including obesity and type 2 diabetes. 4. **Psychiatric disorders:** TSPO has been implicated in psychiatric disorders, including depression and anxiety. 5. **Immunotherapy:** TSPO is a potential target for immunotherapy, given its role in regulating immune response. In conclusion, the TSPO gene is a multifaceted gene that plays a crucial role in various cellular processes, including immune regulation, stress response, and cellular homeostasis. Further research is needed to fully understand the mechanisms by which TSPO regulates these processes and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 1692343408

Symbol: TSPO_HUMAN

Name: Translocator protein

UniProtKB Accession Codes:

P30536 Q53Y59 Q6ICF9 Q96TF6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 8 Ensembl 3 ExpressionAtlas 1 GO 50 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 3 PIRSF 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1847678

Title: Molecular cloning and chromosomal localization of a human peripheral-type benzodiazepine receptor.

PubMed ID: 1847678

DOI: 10.1111/j.1432-1033.1991.tb15707.x

PubMed ID: 7721091

Title: Comparison of repetitive elements in the third intron of human and rodent mitochondrial benzodiazepine receptor-encoding genes.

PubMed ID: 7721091

DOI: 10.1016/0378-1119(94)00817-c

PubMed ID: 16189298

Title: Peripheral benzodiazepine receptor: characterization in human T-lymphoma Jurkat cells.

PubMed ID: 16189298

DOI: 10.1124/mol.105.015289

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9915832

Title: Cloning and characterization of PRAX-1. A new protein that specifically interacts with the peripheral benzodiazepine receptor.

PubMed ID: 9915832

DOI: 10.1074/jbc.274.5.2938

PubMed ID: 16822554

Title: Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function.

PubMed ID: 16822554

DOI: 10.1016/j.tips.2006.06.005

PubMed ID: 17143515

Title: Cellular expression, localization and interactions of the product of the human MOST-1 gene associated with breast and prostate cancers.

PubMed ID: 17143515

PubMed ID: 20600583

Title: Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states.

PubMed ID: 20600583

DOI: 10.1016/j.mce.2010.06.013

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24814875

Title: Targeting mitochondrial 18kDa translocator protein (TSPO) regulates macrophage cholesterol efflux and lipid phenotype.

PubMed ID: 24814875

DOI: 10.1042/cs20140047

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27641616

Title: TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood.

PubMed ID: 27641616

DOI: 10.1038/srep33516

PubMed ID: 11215759

Title: An association study between two missense variations of the benzodiazepine receptor (peripheral) gene and schizophrenia in a Japanese sample.

PubMed ID: 11215759

DOI: 10.1007/s007020070090

PubMed ID: 11304832

Title: No association of two missense variations of the benzodiazepine receptor (peripheral) gene and mood disorders in a Japanese sample.

PubMed ID: 11304832

DOI: 10.1002/ajmg.1194

PubMed ID: 19846611

Title: The spontaneous Ala147Thr amino acid substitution within the translocator protein influences pregnenolone production in lymphomonocytes of healthy individuals.

PubMed ID: 19846611

DOI: 10.1210/en.2009-0752

PubMed ID: 37047353

Title: Sigma-2 Receptor Ligand Binding Modulates Association between TSPO and TMEM97.

PubMed ID: 37047353

DOI: 10.3390/ijms24076381

Sequence Information:

  • Length: 169
  • Mass: 18828
  • Checksum: 6DD741BF99AB89D9
  • Sequence:
    • MAPPWVPAMG FTLAPSLGCF VGSRFVHGEG LRWYAGLQKP SWHPPHWVLG PVWGTLYSAM 
GYGSYLVWKE LGGFTEKAVV PLGLYTGQLA LNWAWPPIFF GARQMGWALV DLLLVSGAAA 
ATTVAWYQVS PLAARLLYPY LAWLAFTTTL NYCVWRDNHG WRGGRRLPE

Genular Protein ID: 3726472169

Symbol: O76068_HUMAN

Name: N/A

UniProtKB Accession Codes:

O76068

Database IDs:

ARBA 12 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 GO 2 Gene3D 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PeptideAtlas 1 Pfam 1 RefSeq 3 SAM 1

Sequence Information:

  • Length: 143
  • Mass: 16107
  • Checksum: DEAF74A8415C65A9
  • Sequence:
    • HGEGLRWYAG LQKPSWHPPH WVLGPVWGTL YSAMGYGSYL VWKELGGFTE KAVVPLGLYT 
GQLALNWAWP PIFFGARQMG WALVDLLLVS GAAAATTVAW YQVSPLAARL LYPYLAWLAF 
TTTLNYCVWR DNHGWRGGRR LPE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.