Details for: TSPO

Gene ID: 706

Symbol: TSPO

Ensembl ID: ENSG00000100300

Description: translocator protein

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.24
    Marker Score: 237206.5
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.67
    Marker Score: 7755
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.59
    Marker Score: 22916.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.57
    Marker Score: 41557
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.45
    Marker Score: 3947
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.36
    Marker Score: 26271
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.3
    Marker Score: 6425
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.21
    Marker Score: 5852
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.2
    Marker Score: 23839
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.19
    Marker Score: 7781.5
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.11
    Marker Score: 7063
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.09
    Marker Score: 2431
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 3.08
    Marker Score: 7664
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 3.04
    Marker Score: 26196.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.97
    Marker Score: 102748
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.96
    Marker Score: 75842
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.95
    Marker Score: 29250
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.93
    Marker Score: 4853
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.87
    Marker Score: 6928
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 2.8
    Marker Score: 11645
  • Cell Name: basophil (CL0000767)
    Fold Change: 2.73
    Marker Score: 1296
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.69
    Marker Score: 2575
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.68
    Marker Score: 17150.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.64
    Marker Score: 6658
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.62
    Marker Score: 3377
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.61
    Marker Score: 1533
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.61
    Marker Score: 3049
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.6
    Marker Score: 12490
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.6
    Marker Score: 628
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.59
    Marker Score: 15730
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 2.58
    Marker Score: 1116
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.58
    Marker Score: 2300
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 2.56
    Marker Score: 3704
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.55
    Marker Score: 13410
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.54
    Marker Score: 3064.5
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.54
    Marker Score: 7988
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.53
    Marker Score: 10834.5
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.52
    Marker Score: 5040.5
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.48
    Marker Score: 16177
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.45
    Marker Score: 9444
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.42
    Marker Score: 3568
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.39
    Marker Score: 9776
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.39
    Marker Score: 2421
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.37
    Marker Score: 2220
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 2.36
    Marker Score: 2033
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.36
    Marker Score: 6523
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.36
    Marker Score: 2072.5
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.36
    Marker Score: 838
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.36
    Marker Score: 3787
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.35
    Marker Score: 6290
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.34
    Marker Score: 5326.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.33
    Marker Score: 3710
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.33
    Marker Score: 739
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.32
    Marker Score: 2238
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.3
    Marker Score: 1665.5
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.3
    Marker Score: 4071
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.26
    Marker Score: 977
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.26
    Marker Score: 119368
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.26
    Marker Score: 1604
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.25
    Marker Score: 5843
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 2.25
    Marker Score: 821
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.23
    Marker Score: 22637
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 2.22
    Marker Score: 5635
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.21
    Marker Score: 1138
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.19
    Marker Score: 911
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.18
    Marker Score: 2333
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.17
    Marker Score: 2288
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.17
    Marker Score: 9345
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.17
    Marker Score: 625.5
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.16
    Marker Score: 1026
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.16
    Marker Score: 1078
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.15
    Marker Score: 860
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.11
    Marker Score: 2897
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.11
    Marker Score: 713
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.1
    Marker Score: 982
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.1
    Marker Score: 1224
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.1
    Marker Score: 1765
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.07
    Marker Score: 866
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.07
    Marker Score: 712
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 2.06
    Marker Score: 777
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.06
    Marker Score: 3168
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 2.03
    Marker Score: 707
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.02
    Marker Score: 6386
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.02
    Marker Score: 9934
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.02
    Marker Score: 753.5
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.02
    Marker Score: 764
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.02
    Marker Score: 995
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 2.01
    Marker Score: 443
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 2.01
    Marker Score: 438
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.01
    Marker Score: 900
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.01
    Marker Score: 2841
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.01
    Marker Score: 7123
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2
    Marker Score: 17552
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2
    Marker Score: 1638
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.99
    Marker Score: 1666
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.99
    Marker Score: 17259
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.99
    Marker Score: 637
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.98
    Marker Score: 2135
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.96
    Marker Score: 1761
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.96
    Marker Score: 4778

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Other Information

**Key characteristics:** * TSPO is a multi-functional protein that is involved in multiple cellular processes. * It is a member of the SLC2 family of solute transporters. * TSPO is a highly regulated protein that is involved in a variety of cellular functions. **Pathways and functions:** * TSPO is involved in the regulation of calcium and potassium transport. * It is also involved in the regulation of inflammation. * TSPO is a key regulator of the immune response. * It is involved in the trafficking of immune cells to sites of inflammation. * TSPO is also involved in the trafficking of drugs and other molecules into and out of cells. **Clinical significance:** * Mutations in the TSPO gene have been linked to a variety of diseases, including cancer and autoimmune disorders. * TSPO inhibitors are being investigated as a treatment for cancer and autoimmune disorders. * Understanding the role of TSPO in disease could lead to the development of new treatments for these disorders. **Additional notes:** * TSPO is a highly conserved protein that is found in organisms from yeast to humans. * It is a highly regulated protein that is controlled by a variety of factors, including hormones, cytokines, and other molecules. * TSPO is a versatile protein that can interact with a variety of different cellular proteins.

Genular Protein ID: 1692343408

Symbol: TSPO_HUMAN

Name: Translocator protein

UniProtKB Accession Codes:

P30536 Q53Y59 Q6ICF9 Q96TF6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EMBL 8 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 49 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 3 PIRSF 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1847678

Title: Molecular cloning and chromosomal localization of a human peripheral-type benzodiazepine receptor.

PubMed ID: 1847678

DOI: 10.1111/j.1432-1033.1991.tb15707.x

PubMed ID: 7721091

Title: Comparison of repetitive elements in the third intron of human and rodent mitochondrial benzodiazepine receptor-encoding genes.

PubMed ID: 7721091

DOI: 10.1016/0378-1119(94)00817-c

PubMed ID: 16189298

Title: Peripheral benzodiazepine receptor: characterization in human T-lymphoma Jurkat cells.

PubMed ID: 16189298

DOI: 10.1124/mol.105.015289

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9915832

Title: Cloning and characterization of PRAX-1. A new protein that specifically interacts with the peripheral benzodiazepine receptor.

PubMed ID: 9915832

DOI: 10.1074/jbc.274.5.2938

PubMed ID: 16822554

Title: Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function.

PubMed ID: 16822554

DOI: 10.1016/j.tips.2006.06.005

PubMed ID: 17143515

Title: Cellular expression, localization and interactions of the product of the human MOST-1 gene associated with breast and prostate cancers.

PubMed ID: 17143515

PubMed ID: 20600583

Title: Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states.

PubMed ID: 20600583

DOI: 10.1016/j.mce.2010.06.013

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24814875

Title: Targeting mitochondrial 18kDa translocator protein (TSPO) regulates macrophage cholesterol efflux and lipid phenotype.

PubMed ID: 24814875

DOI: 10.1042/cs20140047

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27641616

Title: TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood.

PubMed ID: 27641616

DOI: 10.1038/srep33516

PubMed ID: 11215759

Title: An association study between two missense variations of the benzodiazepine receptor (peripheral) gene and schizophrenia in a Japanese sample.

PubMed ID: 11215759

DOI: 10.1007/s007020070090

PubMed ID: 11304832

Title: No association of two missense variations of the benzodiazepine receptor (peripheral) gene and mood disorders in a Japanese sample.

PubMed ID: 11304832

DOI: 10.1002/ajmg.1194

PubMed ID: 19846611

Title: The spontaneous Ala147Thr amino acid substitution within the translocator protein influences pregnenolone production in lymphomonocytes of healthy individuals.

PubMed ID: 19846611

DOI: 10.1210/en.2009-0752

Sequence Information:

  • Length: 169
  • Mass: 18828
  • Checksum: 6DD741BF99AB89D9
  • Sequence:
    • MAPPWVPAMG FTLAPSLGCF VGSRFVHGEG LRWYAGLQKP SWHPPHWVLG PVWGTLYSAM 
GYGSYLVWKE LGGFTEKAVV PLGLYTGQLA LNWAWPPIFF GARQMGWALV DLLLVSGAAA 
ATTVAWYQVS PLAARLLYPY LAWLAFTTTL NYCVWRDNHG WRGGRRLPE

Genular Protein ID: 3726472169

Symbol: O76068_HUMAN

Name: N/A

UniProtKB Accession Codes:

O76068

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 GO 1 Gene3D 1 GenomeRNAi 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PeptideAtlas 1 Pfam 1 RefSeq 3 SAM 1

Sequence Information:

  • Length: 143
  • Mass: 16107
  • Checksum: DEAF74A8415C65A9
  • Sequence:
    • HGEGLRWYAG LQKPSWHPPH WVLGPVWGTL YSAMGYGSYL VWKELGGFTE KAVVPLGLYT 
GQLALNWAWP PIFFGARQMG WALVDLLLVS GAAAATTVAW YQVSPLAARL LYPYLAWLAF 
TTTLNYCVWR DNHGWRGGRR LPE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.