TSPO | ENSG00000100300 | NCBI 706

Details for: TSPO

Gene ID: 706

Symbol: TSPO

Ensembl ID: ENSG00000100300

Description: translocator protein

Associated with

Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Metabolism of steroid hormones
(R-HSA-196071)
Metabolism of steroids
(R-HSA-8957322)
Pregnenolone biosynthesis
(R-HSA-196108)
Adrenal gland development
(GO:0030325)
Androgen binding
(GO:0005497)
Behavioral response to pain
(GO:0048266)
Benzodiazepine receptor activity
(GO:0008503)
C21-steroid hormone biosynthetic process
(GO:0006700)
Cellular hypotonic response
(GO:0071476)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to zinc ion
(GO:0071294)
Chloride transport
(GO:0006821)
Cholesterol binding
(GO:0015485)
Cholesterol homeostasis
(GO:0042632)
Cholesterol transfer activity
(GO:0120020)
Contact inhibition
(GO:0060242)
Cytosol
(GO:0005829)
Endoplasmic reticulum
(GO:0005783)
Extracellular exosome
(GO:0070062)
Glial cell migration
(GO:0008347)
Heme biosynthetic process
(GO:0006783)
Intermembrane lipid transfer
(GO:0120009)
Intracellular membrane-bounded organelle
(GO:0043231)
Maintenance of protein location in mitochondrion
(GO:0072656)
Mitochondrial outer membrane
(GO:0005741)
Mitochondrion
(GO:0005739)
Monoatomic anion transport
(GO:0006820)
Negative regulation of atp metabolic process
(GO:1903579)
Negative regulation of corticosterone secretion
(GO:2000853)
Negative regulation of glial cell proliferation
(GO:0060253)
Negative regulation of mitophagy
(GO:1901525)
Negative regulation of nitric oxide biosynthetic process
(GO:0045019)
Negative regulation of protein ubiquitination
(GO:0031397)
Negative regulation of tumor necrosis factor production
(GO:0032720)
Peripheral nervous system axon regeneration
(GO:0014012)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of calcium ion transport
(GO:0051928)
Positive regulation of glial cell proliferation
(GO:0060252)
Positive regulation of mitochondrial depolarization
(GO:0051901)
Positive regulation of programmed necrotic cell death
(GO:0062100)
Positive regulation of reactive oxygen species metabolic process
(GO:2000379)
Protein binding
(GO:0005515)
Protein targeting to mitochondrion
(GO:0006626)
Regulation of cell population proliferation
(GO:0042127)
Regulation of cholesterol transport
(GO:0032374)
Regulation of steroid biosynthetic process
(GO:0050810)
Response to acetylcholine
(GO:1905144)
Response to manganese ion
(GO:0010042)
Response to progesterone
(GO:0032570)
Response to testosterone
(GO:0033574)
Response to vitamin b1
(GO:0010266)
Response to xenobiotic stimulus
(GO:0009410)
Steroid metabolic process
(GO:0008202)
Sterol transport
(GO:0015918)
Transmembrane transporter binding
(GO:0044325)

Other Information

Proteins

Translocator protein
O76068_HUMAN

Genular Protein ID: 1692343408

Symbol: TSPO_HUMAN

Name: Translocator protein

UniProtKB Accession Codes:

P30536 Q53Y59 Q6ICF9 Q96TF6

Database IDs:

Citations:

PubMed ID: 1847678

Title: Molecular cloning and chromosomal localization of a human peripheral-type benzodiazepine receptor.

PubMed ID: 1847678

DOI: 10.1111/j.1432-1033.1991.tb15707.x

PubMed ID: 7721091

Title: Comparison of repetitive elements in the third intron of human and rodent mitochondrial benzodiazepine receptor-encoding genes.

PubMed ID: 7721091

DOI: 10.1016/0378-1119(94)00817-c

PubMed ID: 16189298

Title: Peripheral benzodiazepine receptor: characterization in human T-lymphoma Jurkat cells.

PubMed ID: 16189298

DOI: 10.1124/mol.105.015289

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9915832

Title: Cloning and characterization of PRAX-1. A new protein that specifically interacts with the peripheral benzodiazepine receptor.

PubMed ID: 9915832

DOI: 10.1074/jbc.274.5.2938

PubMed ID: 16822554

Title: Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function.

PubMed ID: 16822554

DOI: 10.1016/j.tips.2006.06.005

PubMed ID: 17143515

Title: Cellular expression, localization and interactions of the product of the human MOST-1 gene associated with breast and prostate cancers.

PubMed ID: 17143515

PubMed ID: 20600583

Title: Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states.

PubMed ID: 20600583

DOI: 10.1016/j.mce.2010.06.013

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24814875

Title: Targeting mitochondrial 18kDa translocator protein (TSPO) regulates macrophage cholesterol efflux and lipid phenotype.

PubMed ID: 24814875

DOI: 10.1042/cs20140047

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27641616

Title: TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood.

PubMed ID: 27641616

DOI: 10.1038/srep33516

PubMed ID: 11215759

Title: An association study between two missense variations of the benzodiazepine receptor (peripheral) gene and schizophrenia in a Japanese sample.

PubMed ID: 11215759

DOI: 10.1007/s007020070090

PubMed ID: 11304832

Title: No association of two missense variations of the benzodiazepine receptor (peripheral) gene and mood disorders in a Japanese sample.

PubMed ID: 11304832

DOI: 10.1002/ajmg.1194

PubMed ID: 19846611

Title: The spontaneous Ala147Thr amino acid substitution within the translocator protein influences pregnenolone production in lymphomonocytes of healthy individuals.

PubMed ID: 19846611

DOI: 10.1210/en.2009-0752

Sequence Information:

Length: 169
Mass: 18828
Checksum: 6DD741BF99AB89D9
Sequence:

MAPPWVPAMG FTLAPSLGCF VGSRFVHGEG LRWYAGLQKP SWHPPHWVLG PVWGTLYSAM 
GYGSYLVWKE LGGFTEKAVV PLGLYTGQLA LNWAWPPIFF GARQMGWALV DLLLVSGAAA 
ATTVAWYQVS PLAARLLYPY LAWLAFTTTL NYCVWRDNHG WRGGRRLPE

Genular Protein ID: 3726472169

Symbol: O76068_HUMAN

Name: N/A

UniProtKB Accession Codes:

O76068

Database IDs:

Sequence Information:

Length: 143
Mass: 16107
Checksum: DEAF74A8415C65A9
Sequence:

HGEGLRWYAG LQKPSWHPPH WVLGPVWGTL YSAMGYGSYL VWKELGGFTE KAVVPLGLYT 
GQLALNWAWP PIFFGARQMG WALVDLLLVS GAAAATTVAW YQVSPLAARL LYPYLAWLAF 
TTTLNYCVWR DNHGWRGGRR LPE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TSPO

Associated with

Other Information

Molecular cloning and chromosomal localization of a human peripheral-type benzodiazepine receptor. PubMed ID: 1847678

Comparison of repetitive elements in the third intron of human and rodent mitochondrial benzodiazepine receptor-encoding genes. PubMed ID: 7721091

Peripheral benzodiazepine receptor: characterization in human T-lymphoma Jurkat cells. PubMed ID: 16189298

A genome annotation-driven approach to cloning the human ORFeome. PubMed ID: 15461802

The DNA sequence of human chromosome 22. PubMed ID: 10591208

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cloning and characterization of PRAX-1. A new protein that specifically interacts with the peripheral benzodiazepine receptor. PubMed ID: 9915832

Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. PubMed ID: 16822554

Cellular expression, localization and interactions of the product of the human MOST-1 gene associated with breast and prostate cancers. PubMed ID: 17143515

Regulation of translocator protein 18 kDa (TSPO) expression in health and disease states. PubMed ID: 20600583

Initial characterization of the human central proteome. PubMed ID: 21269460

Targeting mitochondrial 18kDa translocator protein (TSPO) regulates macrophage cholesterol efflux and lipid phenotype. PubMed ID: 24814875

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

TSPO ligands stimulate ZnPPIX transport and ROS accumulation leading to the inhibition of P. falciparum growth in human blood. PubMed ID: 27641616

An association study between two missense variations of the benzodiazepine receptor (peripheral) gene and schizophrenia in a Japanese sample. PubMed ID: 11215759

No association of two missense variations of the benzodiazepine receptor (peripheral) gene and mood disorders in a Japanese sample. PubMed ID: 11304832

The spontaneous Ala147Thr amino acid substitution within the translocator protein influences pregnenolone production in lymphomonocytes of healthy individuals. PubMed ID: 19846611