Details for: C1QBP

Gene ID: 708

Symbol: C1QBP

Ensembl ID: ENSG00000108561

Description: complement C1q binding protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 295.0910
    Cell Significance Index: -45.9000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 178.7549
    Cell Significance Index: -45.3400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 152.8350
    Cell Significance Index: -62.9600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 138.5206
    Cell Significance Index: -56.2800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 131.2583
    Cell Significance Index: -61.9700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 123.2539
    Cell Significance Index: -63.4000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 92.6646
    Cell Significance Index: -62.1800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 59.7648
    Cell Significance Index: -57.0600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 45.7681
    Cell Significance Index: -56.4300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.9451
    Cell Significance Index: -62.9200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.5701
    Cell Significance Index: -41.6800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.2664
    Cell Significance Index: -32.8600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 5.8177
    Cell Significance Index: 155.6200
  • Cell Name: germ cell (CL0000586)
    Fold Change: 4.4930
    Cell Significance Index: 33.9300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 4.0023
    Cell Significance Index: 43.5100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.9148
    Cell Significance Index: 206.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.9108
    Cell Significance Index: 187.7900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.8594
    Cell Significance Index: 197.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.7371
    Cell Significance Index: 128.6400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.7161
    Cell Significance Index: 79.7700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.5992
    Cell Significance Index: 23.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.5375
    Cell Significance Index: 327.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.3750
    Cell Significance Index: 62.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.2945
    Cell Significance Index: 413.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.2506
    Cell Significance Index: 276.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.2173
    Cell Significance Index: 1210.9100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.1126
    Cell Significance Index: 249.1400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.0793
    Cell Significance Index: 48.0400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.0505
    Cell Significance Index: 42.9200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.8739
    Cell Significance Index: 828.5000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.7032
    Cell Significance Index: 46.3600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.6506
    Cell Significance Index: 123.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6444
    Cell Significance Index: 85.4200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.5310
    Cell Significance Index: 53.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.4707
    Cell Significance Index: 68.5700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.3802
    Cell Significance Index: 15.6800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3524
    Cell Significance Index: 185.7200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.0249
    Cell Significance Index: 13.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9519
    Cell Significance Index: 188.9000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.9490
    Cell Significance Index: 59.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.8909
    Cell Significance Index: 46.7800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.8623
    Cell Significance Index: 7.4100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7702
    Cell Significance Index: 98.7300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.7572
    Cell Significance Index: 20.2900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.7490
    Cell Significance Index: 5.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6222
    Cell Significance Index: 118.4100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.5955
    Cell Significance Index: 17.0700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5157
    Cell Significance Index: 13.7700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4889
    Cell Significance Index: 7.3300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4632
    Cell Significance Index: 8.1900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3264
    Cell Significance Index: 65.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3229
    Cell Significance Index: 55.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1958
    Cell Significance Index: 176.8000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1921
    Cell Significance Index: 31.2500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1556
    Cell Significance Index: 117.7900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1389
    Cell Significance Index: 4.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0770
    Cell Significance Index: 27.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0628
    Cell Significance Index: 46.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0287
    Cell Significance Index: 2.8400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0167
    Cell Significance Index: 0.2800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0048
    Cell Significance Index: -3.5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0240
    Cell Significance Index: -0.8500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0243
    Cell Significance Index: -45.8000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0304
    Cell Significance Index: -19.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0318
    Cell Significance Index: -3.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0343
    Cell Significance Index: -63.2200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0393
    Cell Significance Index: -60.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0443
    Cell Significance Index: -2.0100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0451
    Cell Significance Index: -61.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0630
    Cell Significance Index: -35.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0800
    Cell Significance Index: -50.8200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0847
    Cell Significance Index: -58.5900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1260
    Cell Significance Index: -3.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1264
    Cell Significance Index: -26.6300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1276
    Cell Significance Index: -57.9100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1350
    Cell Significance Index: -15.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1650
    Cell Significance Index: -19.2300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1741
    Cell Significance Index: -50.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1902
    Cell Significance Index: -4.0500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2499
    Cell Significance Index: -1.5100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.3282
    Cell Significance Index: -2.0200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3464
    Cell Significance Index: -9.6800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3554
    Cell Significance Index: -28.1500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3832
    Cell Significance Index: -19.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3900
    Cell Significance Index: -56.6900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4086
    Cell Significance Index: -25.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4405
    Cell Significance Index: -6.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4685
    Cell Significance Index: -11.7100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4951
    Cell Significance Index: -56.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5348
    Cell Significance Index: -35.9600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5744
    Cell Significance Index: -12.4500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6020
    Cell Significance Index: -62.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7303
    Cell Significance Index: -56.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7692
    Cell Significance Index: -47.1600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7702
    Cell Significance Index: -14.2400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.7878
    Cell Significance Index: -8.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.7932
    Cell Significance Index: -44.5100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.8825
    Cell Significance Index: -10.5200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.9664
    Cell Significance Index: -58.0200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0586
    Cell Significance Index: -31.1800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Cellular localization**: C1QBP is primarily localized to the cytoplasm and nucleus, with some expression in the mitochondria. 2. **Protein structure**: The protein consists of 4-5 domains, including a C1q-binding domain, a coiled-coil domain, and a transcriptional repression domain. 3. **Expression patterns**: C1QBP is expressed in various cell types, including CD14-low, CD16-positive monocytes, pro-T cells, erythroid progenitor cells, basal cells of prostate epithelium, and stratified epithelial cells. 4. **Function**: C1QBP acts as a negative regulator of several signaling pathways, including apoptosis, inflammation, and cell adhesion. **Pathways and Functions** 1. **Apoptosis**: C1QBP negatively regulates the intrinsic pathway of apoptosis, a process of programmed cell death. 2. **Immune response**: C1QBP inhibits the activation of the complement system, a key component of the innate immune response. 3. **Cell adhesion**: C1QBP regulates cell adhesion by inhibiting the activation of integrins and other adhesion molecules. 4. **Inflammation**: C1QBP negatively regulates the production of pro-inflammatory cytokines, such as IL-12 and IFN-α. 5. **Mitochondrial function**: C1QBP regulates mitochondrial translation and function, influencing the production of reactive oxygen species (ROS) and the mitochondrial permeability transition pore (mPTP). **Clinical Significance** 1. **Inflammatory diseases**: Alterations in C1QBP expression have been linked to various inflammatory diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. 2. **Cancer**: C1QBP has been implicated in the regulation of apoptosis and cell adhesion in cancer cells, suggesting its potential as a therapeutic target. 3. **Neurological disorders**: C1QBP has been linked to the regulation of apoptosis and inflammation in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Immunodeficiency**: Mutations in C1QBP have been associated with immunodeficiency disorders, highlighting the importance of this gene in the regulation of the immune response. In conclusion, the C1QBP gene plays a crucial role in regulating various cellular processes, including apoptosis, immune response, and cell adhesion. Its dysregulation has been linked to various diseases, making it a potential target for therapeutic intervention. Further research is needed to fully elucidate the mechanisms by which C1QBP regulates cellular processes and to explore its therapeutic potential.

Genular Protein ID: 2822119728

Symbol: C1QBP_HUMAN

Name: Complement component 1 Q subcomponent-binding protein, mitochondrial

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8262387

Title: Cloning and expression of a cDNA covering the complete coding region of the P32 subunit of human pre-mRNA splicing factor SF2.

PubMed ID: 8262387

DOI: 10.1016/0378-1119(93)90108-f

PubMed ID: 8195709

Title: Isolation, cDNA cloning, and overexpression of a 33-kD cell surface glycoprotein that binds to the globular 'heads' of C1q.

PubMed ID: 8195709

DOI: 10.1084/jem.179.6.1809

PubMed ID: 11278463

Title: The human gC1qR/p32 gene, C1qBP. Genomic organization and promoter analysis.

PubMed ID: 11278463

DOI: 10.1074/jbc.m009064200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1830244

Title: Functional expression of cloned human splicing factor SF2: homology to RNA-binding proteins, U1 70K, and Drosophila splicing regulators.

PubMed ID: 1830244

DOI: 10.1016/0092-8674(91)90627-b

PubMed ID: 8662673

Title: Isolation and characterization of the kininogen-binding protein p33 from endothelial cells. Identity with the gC1q receptor.

PubMed ID: 8662673

DOI: 10.1074/jbc.271.22.13040

PubMed ID: 8567680

Title: Molecular cloning of human fibroblast hyaluronic acid-binding protein confirms its identity with P-32, a protein co-purified with splicing factor SF2. Hyaluronic acid-binding protein as P-32 protein, co-purified with splicing factor SF2.

PubMed ID: 8567680

DOI: 10.1074/jbc.271.4.2206

PubMed ID: 8900153

Title: The binding protein for globular heads of complement C1q, gC1qR. Functional expression and characterization as a novel vitronectin binding factor.

PubMed ID: 8900153

DOI: 10.1074/jbc.271.43.26739

PubMed ID: 8710908

Title: Identification of the zinc-dependent endothelial cell binding protein for high molecular weight kininogen and factor XII: identity with the receptor that binds to the globular 'heads' of C1q (gC1q-R).

PubMed ID: 8710908

DOI: 10.1073/pnas.93.16.8552

PubMed ID: 9191880

Title: The C1q-binding cell membrane proteins cC1q-R and gC1q-R are released from activated cells: subcellular distribution and immunochemical characterization.

PubMed ID: 9191880

DOI: 10.1006/clin.1997.4374

PubMed ID: 9299613

Title: P32/TAP, a cellular protein that interacts with EBNA-1 of Epstein-Barr virus.

PubMed ID: 9299613

DOI: 10.1006/viro.1997.8739

PubMed ID: 9305894

Title: p32 protein, a splicing factor 2-associated protein, is localized in mitochondrial matrix and is functionally important in maintaining oxidative phosphorylation.

PubMed ID: 9305894

DOI: 10.1074/jbc.272.39.24363

PubMed ID: 9233640

Title: Evidence that the two C1q binding membrane proteins, gC1q-R and cC1q-R, associate to form a complex.

PubMed ID: 9233640

PubMed ID: 9461517

Title: C1q-mediated chemotaxis by human neutrophils: involvement of gClqR and G-protein signalling mechanisms.

PubMed ID: 9461517

DOI: 10.1042/bj3300247

PubMed ID: 10479529

Title: Cytokeratin 1 and gC1qR mediate high molecular weight kininogen binding to endothelial cells.

PubMed ID: 10479529

DOI: 10.1006/clim.1999.4753

PubMed ID: 10022843

Title: The splicing factor-associated protein, p32, regulates RNA splicing by inhibiting ASF/SF2 RNA binding and phosphorylation.

PubMed ID: 10022843

DOI: 10.1093/emboj/18.4.1014

PubMed ID: 10747014

Title: gC1q-R/p32, a C1q-binding protein, is a receptor for the InlB invasion protein of Listeria monocytogenes.

PubMed ID: 10747014

DOI: 10.1093/emboj/19.7.1458

PubMed ID: 10722602

Title: Staphylococcus aureus protein A recognizes platelet gC1qR/p33: a novel mechanism for staphylococcal interactions with platelets.

PubMed ID: 10722602

DOI: 10.1128/iai.68.4.2061-2068.2000

PubMed ID: 11086025

Title: Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation.

PubMed ID: 11086025

DOI: 10.1172/jci10323

PubMed ID: 10823864

Title: Rubella virus capsid associates with host cell protein p32 and localizes to mitochondria.

PubMed ID: 10823864

DOI: 10.1128/jvi.74.12.5569-5576.2000

PubMed ID: 11493647

Title: Retargeting of the mitochondrial protein p32/gC1Qr to a cytoplasmic compartment and the cell surface.

PubMed ID: 11493647

DOI: 10.1242/jcs.114.11.2115

PubMed ID: 12411480

Title: GW domains of the Listeria monocytogenes invasion protein InlB are SH3-like and mediate binding to host ligands.

PubMed ID: 12411480

DOI: 10.1093/emboj/cdf558

PubMed ID: 11859136

Title: Cooperation of C1q receptors and integrins in C1q-mediated endothelial cell adhesion and spreading.

PubMed ID: 11859136

DOI: 10.4049/jimmunol.168.5.2441

PubMed ID: 12034482

Title: The N-terminal conserved domain of rubella virus capsid interacts with the C-terminal region of cellular p32 and overexpression of p32 enhances the viral infectivity.

PubMed ID: 12034482

DOI: 10.1016/s0168-1702(02)00030-8

PubMed ID: 12833064

Title: Human p32 protein relieves a post-transcriptional block to HIV replication in murine cells.

PubMed ID: 12833064

DOI: 10.1038/ncb1000

PubMed ID: 12574814

Title: Activation-dependent surface expression of gC1qR/p33 on human blood platelets.

PubMed ID: 12574814

DOI: 10.1267/THRO03020331

PubMed ID: 15031724

Title: Physical and functional interaction between BH3-only protein Hrk and mitochondrial pore-forming protein p32.

PubMed ID: 15031724

DOI: 10.1038/sj.cdd.4401418

PubMed ID: 15243141

Title: Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro.

PubMed ID: 15243141

DOI: 10.1093/nar/gkh692

PubMed ID: 16177118

Title: gC1q receptor ligation selectively down-regulates human IL-12 production through activation of the phosphoinositide 3-kinase pathway.

PubMed ID: 16177118

DOI: 10.4049/jimmunol.175.7.4706

PubMed ID: 16721827

Title: CDC2L5, a Cdk-like kinase with RS domain, interacts with the ASF/SF2-associated protein p32 and affects splicing in vivo.

PubMed ID: 16721827

DOI: 10.1002/jcb.20986

PubMed ID: 16537587

Title: Acetylated Tat regulates human immunodeficiency virus type 1 splicing through its interaction with the splicing regulator p32.

PubMed ID: 16537587

DOI: 10.1128/jvi.80.7.3189-3204.2006

PubMed ID: 16140380

Title: Chemotaxis of human monocyte-derived dendritic cells to complement component C1q is mediated by the receptors gC1qR and cC1qR.

PubMed ID: 16140380

DOI: 10.1016/j.molimm.2005.07.030

PubMed ID: 17881511

Title: HCV core protein interaction with gC1q receptor inhibits Th1 differentiation of CD4+ T cells via suppression of dendritic cell IL-12 production.

PubMed ID: 17881511

DOI: 10.1189/jlb.0507268

PubMed ID: 17693683

Title: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.

PubMed ID: 17693683

DOI: 10.1074/mcp.m700120-mcp200

PubMed ID: 17486078

Title: The autophagic inducer smARF interacts with and is stabilized by the mitochondrial p32 protein.

PubMed ID: 17486078

DOI: 10.1038/sj.onc.1210485

PubMed ID: 18191643

Title: Novel tyrosine phosphorylated and cardiolipin-binding protein CLPABP functions as mitochondrial RNA granule.

PubMed ID: 18191643

DOI: 10.1016/j.bbamcr.2007.12.009

PubMed ID: 18676636

Title: Human p32 is a novel FOXC1-interacting protein that regulates FOXC1 transcriptional activity in ocular cells.

PubMed ID: 18676636

DOI: 10.1167/iovs.07-1625

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19004836

Title: Evidence for inhibitory interaction of hyaluronan-binding protein 1 (HABP1/p32/gC1qR) with Streptococcus pneumoniae hyaluronidase.

PubMed ID: 19004836

DOI: 10.1074/jbc.m804246200

PubMed ID: 19164550

Title: Inhibition of RIG-I and MDA5-dependent antiviral response by gC1qR at mitochondria.

PubMed ID: 19164550

DOI: 10.1073/pnas.0811029106

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20810993

Title: An alternative role of C1q in cell migration and tissue remodeling: contribution to trophoblast invasion and placental development.

PubMed ID: 20810993

DOI: 10.4049/jimmunol.0903215

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 20950273

Title: Complement 1q-binding protein inhibits the mitochondrial permeability transition pore and protects against oxidative stress-induced death.

PubMed ID: 20950273

DOI: 10.1042/bj20101431

PubMed ID: 21536856

Title: Splicing factor 2-associated protein p32 participates in ribosome biogenesis by regulating the binding of Nop52 and fibrillarin to preribosome particles.

PubMed ID: 21536856

DOI: 10.1074/mcp.m110.006148

PubMed ID: 21544310

Title: Interaction of high-molecular-weight kininogen with endothelial cell binding proteins suPAR, gC1qR and cytokeratin 1 determined by surface plasmon resonance (BiaCore).

PubMed ID: 21544310

DOI: 10.1160/th10-09-0591

PubMed ID: 22700724

Title: DC-SIGN, C1q, and gC1qR form a trimolecular receptor complex on the surface of monocyte-derived immature dendritic cells.

PubMed ID: 22700724

DOI: 10.1182/blood-2011-07-369728

PubMed ID: 22238231

Title: Binding of cellular p32 protein to the rubella virus P150 replicase protein via PxxPxR motifs.

PubMed ID: 22238231

DOI: 10.1099/vir.0.038901-0

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 32958672

Title: Unusually efficient CUG initiation of an overlapping reading frame in POLG mRNA yields novel protein POLGARF.

PubMed ID: 32958672

DOI: 10.1073/pnas.2001433117

PubMed ID: 28942965

Title: Biallelic C1QBP mutations cause severe neonatal-, childhood-, or later-onset cardiomyopathy associated with combined respiratory-chain deficiencies.

PubMed ID: 28942965

DOI: 10.1016/j.ajhg.2017.08.015

PubMed ID: 31353207

Title: C1QBP promotes homologous recombination by stabilizing MRE11 and controlling the assembly and activation of MRE11/RAD50/NBS1 complex.

PubMed ID: 31353207

DOI: 10.1016/j.molcel.2019.06.023

PubMed ID: 10097078

Title: Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein.

PubMed ID: 10097078

DOI: 10.1073/pnas.96.7.3572

Sequence Information:

  • Length: 282
  • Mass: 31362
  • Checksum: 2F747FA73BB1314B
  • Sequence:
  • MLPLLRCVPR VLGSSVAGLR AAAPASPFRQ LLQPAPRLCT RPFGLLSVRA GSERRPGLLR 
    PRGPCACGCG CGSLHTDGDK AFVDFLSDEI KEERKIQKHK TLPKMSGGWE LELNGTEAKL 
    VRKVAGEKIT VTFNINNSIP PTFDGEEEPS QGQKVEEQEP ELTSTPNFVV EVIKNDDGKK 
    ALVLDCHYPE DEVGQEDEAE SDIFSIREVS FQSTGESEWK DTNYTLNTDS LDWALYDHLM 
    DFLADRGVDN TFADELVELS TALEHQEYIT FLEDLKSFVK SQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.