ACTG1 | ENSG00000184009 | NCBI 71

Details for: ACTG1

Gene ID: 71

Symbol: ACTG1

Ensembl ID: ENSG00000184009

Description: actin gamma 1

Associated with

Adherens junctions interactions
(R-HSA-418990)
Axon guidance
(R-HSA-422475)
Cell-cell communication
(R-HSA-1500931)
Cell-cell junction organization
(R-HSA-421270)
Cell-extracellular matrix interactions
(R-HSA-446353)
Cell junction organization
(R-HSA-446728)
Clathrin-mediated endocytosis
(R-HSA-8856828)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Eph-ephrin mediated repulsion of cells
(R-HSA-3928665)
Eph-ephrin signaling
(R-HSA-2682334)
Ephb-mediated forward signaling
(R-HSA-3928662)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Formation of annular gap junctions
(R-HSA-196025)
Gap junction degradation
(R-HSA-190873)
Gap junction trafficking
(R-HSA-190828)
Gap junction trafficking and regulation
(R-HSA-157858)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interaction between l1 and ankyrins
(R-HSA-445095)
L1cam interactions
(R-HSA-373760)
Leishmania infection
(R-HSA-9658195)
Leishmania phagocytosis
(R-HSA-9664417)
Map2k and mapk activation
(R-HSA-5674135)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Membrane trafficking
(R-HSA-199991)
Nervous system development
(R-HSA-9675108)
Oncogenic mapk signaling
(R-HSA-6802957)
Paradoxical activation of raf signaling by kinase inactive braf
(R-HSA-6802955)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Raf/map kinase cascade
(R-HSA-5673001)
Recycling pathway of l1
(R-HSA-437239)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Rhobtb2 gtpase cycle
(R-HSA-9013418)
Rhobtb gtpase cycle
(R-HSA-9706574)
Rho gtpase cycle
(R-HSA-9012999)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Rho gtpases activate iqgaps
(R-HSA-5626467)
Rho gtpases activate wasps and waves
(R-HSA-5663213)
Sensory perception
(R-HSA-9709957)
Sensory processing of sound
(R-HSA-9659379)
Sensory processing of sound by inner hair cells of the cochlea
(R-HSA-9662360)
Sensory processing of sound by outer hair cells of the cochlea
(R-HSA-9662361)
Signaling by braf and raf1 fusions
(R-HSA-6802952)
Signaling by high-kinase activity braf mutants
(R-HSA-6802948)
Signaling by moderate kinase activity braf mutants
(R-HSA-6802946)
Signaling by raf1 mutants
(R-HSA-9656223)
Signaling by ras mutants
(R-HSA-6802949)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signaling by vegf
(R-HSA-194138)
Signaling downstream of ras mutants
(R-HSA-9649948)
Signal transduction
(R-HSA-162582)
Translocation of slc2a4 (glut4) to the plasma membrane
(R-HSA-1445148)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Vesicle-mediated transport
(R-HSA-5653656)
Actin filament
(GO:0005884)
Angiogenesis
(GO:0001525)
Atp binding
(GO:0005524)
Axonogenesis
(GO:0007409)
Cell-cell junction
(GO:0005911)
Cell motility
(GO:0048870)
Cellular response to type ii interferon
(GO:0071346)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Extracellular space
(GO:0005615)
Hydrolase activity
(GO:0016787)
Identical protein binding
(GO:0042802)
Maintenance of blood-brain barrier
(GO:0035633)
Morphogenesis of a polarized epithelium
(GO:0001738)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Platelet aggregation
(GO:0070527)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of wound healing
(GO:0090303)
Postsynaptic actin cytoskeleton organization
(GO:0098974)
Profilin binding
(GO:0005522)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein localization to bicellular tight junction
(GO:1902396)
Regulation of focal adhesion assembly
(GO:0051893)
Regulation of stress fiber assembly
(GO:0051492)
Regulation of synaptic vesicle endocytosis
(GO:1900242)
Regulation of transepithelial transport
(GO:0150111)
Sarcomere organization
(GO:0045214)
Structural constituent of cytoskeleton
(GO:0005200)
Structural constituent of postsynaptic actin cytoskeleton
(GO:0098973)
Tight junction assembly
(GO:0120192)
Ubiquitin protein ligase binding
(GO:0031625)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 1622.6149
Cell Significance Index: -252.3900
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 793.8311
Cell Significance Index: -201.3500
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 670.4736
Cell Significance Index: -276.2000
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 625.7613
Cell Significance Index: -254.2200
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 588.0252
Cell Significance Index: -277.6200
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 545.4083
Cell Significance Index: -280.5500
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 414.6361
Cell Significance Index: -278.2300
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 271.7747
Cell Significance Index: -259.4800
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 207.7041
Cell Significance Index: -256.0900
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 70.9924
Cell Significance Index: -218.0500
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 67.2255
Cell Significance Index: -265.2800
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 36.8907
Cell Significance Index: -98.8300
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 24.9293
Cell Significance Index: 264.8700
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 12.9554
Cell Significance Index: 165.9200
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 11.6933
Cell Significance Index: 244.7600
Cell Name: granulosa cell (CL0000501)
Fold Change: 11.4942
Cell Significance Index: 302.2400
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 10.7076
Cell Significance Index: 372.0900
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 10.5101
Cell Significance Index: 493.9700
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 9.6858
Cell Significance Index: 284.4600
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 8.8761
Cell Significance Index: 1046.7700
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 8.5152
Cell Significance Index: 1169.3800
Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: 8.2727
Cell Significance Index: 89.9400
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 8.0811
Cell Significance Index: 219.9600
Cell Name: early pro-B cell (CL0002046)
Fold Change: 7.9273
Cell Significance Index: 511.4300
Cell Name: lactocyte (CL0002325)
Fold Change: 7.6368
Cell Significance Index: 986.6200
Cell Name: odontoblast (CL0000060)
Fold Change: 7.1449
Cell Significance Index: 915.9300
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 7.0949
Cell Significance Index: 369.5700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 6.9837
Cell Significance Index: 366.6700
Cell Name: endothelial cell of venule (CL1000414)
Fold Change: 6.8747
Cell Significance Index: 78.1000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 6.6139
Cell Significance Index: 492.9300
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 6.4052
Cell Significance Index: 118.3900
Cell Name: cell in vitro (CL0001034)
Fold Change: 6.3905
Cell Significance Index: 3490.0100
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 6.3451
Cell Significance Index: 2805.3200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 5.7972
Cell Significance Index: 712.8200
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 5.3935
Cell Significance Index: 972.2900
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 5.0879
Cell Significance Index: 359.8400
Cell Name: oral mucosa squamous cell (CL1001576)
Fold Change: 4.9761
Cell Significance Index: 42.7600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 4.5668
Cell Significance Index: 212.9300
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 4.1327
Cell Significance Index: 73.0300
Cell Name: peg cell (CL4033014)
Fold Change: 4.1193
Cell Significance Index: 95.1700
Cell Name: kidney cell (CL1000497)
Fold Change: 4.0129
Cell Significance Index: 32.0400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 3.2986
Cell Significance Index: 563.2500
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 3.1136
Cell Significance Index: 506.3900
Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.9334
Cell Significance Index: 582.1500
Cell Name: colon goblet cell (CL0009039)
Fold Change: 2.3235
Cell Significance Index: 229.8500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.9748
Cell Significance Index: 56.6100
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.9435
Cell Significance Index: 109.0600
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.4506
Cell Significance Index: 75.3600
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 1.2779
Cell Significance Index: 145.8700
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.9815
Cell Significance Index: 28.2800
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.6907
Cell Significance Index: 138.5500
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: 0.6830
Cell Significance Index: 516.9600
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.3864
Cell Significance Index: 283.3100
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.3587
Cell Significance Index: 12.6100
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.2574
Cell Significance Index: 92.3300
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2504
Cell Significance Index: 471.5500
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2248
Cell Significance Index: 42.7800
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.2187
Cell Significance Index: 3.6600
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0974
Cell Significance Index: 2.6000
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0011
Cell Significance Index: -1.7100
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.0337
Cell Significance Index: -0.3100
Cell Name: theca cell (CL0000503)
Fold Change: -0.0426
Cell Significance Index: -0.2500
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0732
Cell Significance Index: -7.4800
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0845
Cell Significance Index: -114.9500
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0972
Cell Significance Index: -179.2000
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.1511
Cell Significance Index: -111.9300
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1955
Cell Significance Index: -122.1000
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.2584
Cell Significance Index: -164.0800
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.2707
Cell Significance Index: -13.6800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.3205
Cell Significance Index: -145.4800
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.3843
Cell Significance Index: -216.7100
Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.4403
Cell Significance Index: -18.0400
Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: -0.6110
Cell Significance Index: -3.7600
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.7478
Cell Significance Index: -157.5200
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.7759
Cell Significance Index: -16.9900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.9289
Cell Significance Index: -71.2900
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.9804
Cell Significance Index: -282.0800
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -1.0094
Cell Significance Index: -28.2100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -1.3795
Cell Significance Index: -158.0400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -1.4129
Cell Significance Index: -205.3800
Cell Name: pro-T cell (CL0000827)
Fold Change: -1.4268
Cell Significance Index: -36.4500
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -1.8726
Cell Significance Index: -218.2400
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.9014
Cell Significance Index: -119.8400
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -2.0430
Cell Significance Index: -161.8100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -2.1482
Cell Significance Index: -46.5400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -2.2374
Cell Significance Index: -71.6600
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -2.3469
Cell Significance Index: -244.3700
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -2.3523
Cell Significance Index: -106.6200
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -3.1472
Cell Significance Index: -42.9400
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -3.1854
Cell Significance Index: -47.7300
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -4.3315
Cell Significance Index: -74.2300
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -4.5199
Cell Significance Index: -277.1100
Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: -4.9465
Cell Significance Index: -41.5500
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -5.0152
Cell Significance Index: -147.7200
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -5.0241
Cell Significance Index: -86.6100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -5.5723
Cell Significance Index: -246.4800
Cell Name: germ cell (CL0000586)
Fold Change: -5.9299
Cell Significance Index: -44.7800
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -6.1679
Cell Significance Index: -226.4200
Cell Name: retinal rod cell (CL0000604)
Fold Change: -6.1691
Cell Significance Index: -73.5400
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -6.6002
Cell Significance Index: -216.0900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** The ACTG1 gene is a member of the actin family, which consists of six different isoforms (actin alpha, beta, gamma, delta, epsilon, and zeta). Actin gamma 1 is unique in that it is the only isoform that contains a myosin-binding domain, which allows it to interact with myosin motors and regulate actin dynamics. This interaction is essential for various cellular processes, including muscle contraction, cell migration, and cytoskeleton organization. The ACTG1 protein is also highly phosphorylated, which can regulate its activity and interactions with other proteins. **Pathways and Functions** The ACTG1 protein is involved in various signaling pathways, including: 1. **Cytoskeleton organization**: ACTG1 interacts with myosin motors to regulate actin dynamics and maintain cytoskeleton organization. 2. **Cell migration**: ACTG1 regulates cell migration by interacting with myosin motors and other signaling molecules. 3. **Adhesion**: ACTG1 regulates cell adhesion by interacting with integrins and other adhesion molecules. 4. **Signaling**: ACTG1 interacts with various signaling molecules, including Ras, Raf, and MAPK, to regulate cell signaling pathways. 5. **Phagocytosis**: ACTG1 regulates phagocytosis by interacting with actin-binding proteins and other signaling molecules. **Clinical Significance** The ACTG1 gene has been implicated in various diseases, including: 1. **Muscle disorders**: Mutations in the ACTG1 gene have been associated with muscle disorders, such as muscular dystrophy. 2. **Cancer**: The ACTG1 gene is overexpressed in various types of cancer, including leukemia and lymphoma. 3. **Immune system disorders**: The ACTG1 gene is involved in immune system disorders, such as autoimmune diseases and immunodeficiency disorders. 4. **Neurological disorders**: The ACTG1 gene has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the ACTG1 gene plays a crucial role in various cellular processes, including cytoskeleton organization, cell migration, adhesion, and signaling. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and regulation of the ACTG1 gene.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Actin, cytoplasmic 2

Genular Protein ID: 1163596488

Symbol: ACTG_HUMAN

Name: Actin, cytoplasmic 2

UniProtKB Accession Codes:

P63261 A8K7C2 P02571 P14104 P99022 Q5U032 Q96E67

Database IDs:

Citations:

PubMed ID: 3737401

Title: Nucleotide sequence of the human gamma cytoskeletal actin mRNA: anomalous evolution of vertebrate non-muscle actin genes.

PubMed ID: 3737401

DOI: 10.1093/nar/14.13.5275

PubMed ID: 2837653

Title: Structure, chromosome location, and expression of the human gamma-actin gene: differential evolution, location, and expression of the cytoskeletal beta- and gamma-actin genes.

PubMed ID: 2837653

DOI: 10.1128/mcb.8.4.1775-1789.1988

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 3472224

Title: Gamma-actin: unusual mRNA 3'-untranslated sequence conservation and amino acid substitutions that may be cancer related.

PubMed ID: 3472224

DOI: 10.1073/pnas.84.9.2575

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19015515

Title: Connecting actin monomers by iso-peptide bond is a toxicity mechanism of the Vibrio cholerae MARTX toxin.

PubMed ID: 19015515

DOI: 10.1073/pnas.0808082105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23673617

Title: ALKBH4-dependent demethylation of actin regulates actomyosin dynamics.

PubMed ID: 23673617

DOI: 10.1038/ncomms2863

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 26228148

Title: ACD toxin-produced actin oligomers poison formin-controlled actin polymerization.

PubMed ID: 26228148

DOI: 10.1126/science.aab4090

PubMed ID: 30028079

Title: NAT6 acetylates the N-terminus of different forms of actin.

PubMed ID: 30028079

DOI: 10.1111/febs.14605

PubMed ID: 29581253

Title: NAA80 is actin's N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility.

PubMed ID: 29581253

DOI: 10.1073/pnas.1718336115

PubMed ID: 30626964

Title: SETD3 is an actin histidine methyltransferase that prevents primary dystocia.

PubMed ID: 30626964

DOI: 10.1038/s41586-018-0821-8

PubMed ID: 36173861

Title: Actin maturation requires the ACTMAP/C19orf54 protease.

PubMed ID: 36173861

DOI: 10.1126/science.abq5082

PubMed ID: 13680526

Title: Mutations in the gamma-actin gene (ACTG1) are associated with dominant progressive deafness (DFNA20/26).

PubMed ID: 13680526

DOI: 10.1086/379286

PubMed ID: 14684684

Title: A mutation in the gamma actin 1 (ACTG1) gene causes autosomal dominant hearing loss (DFNA20/26).

PubMed ID: 14684684

DOI: 10.1136/jmg.40.12.879

PubMed ID: 16773128

Title: A novel missense mutation in ACTG1 causes dominant deafness in a Norwegian DFNA20/26 family, but ACTG1 mutations are not frequent among families with hereditary hearing impairment.

PubMed ID: 16773128

DOI: 10.1038/sj.ejhg.5201670

PubMed ID: 18804074

Title: Novel ACTG1 mutation causing autosomal dominant non-syndromic hearing impairment in a Chinese family.

PubMed ID: 18804074

DOI: 10.1016/s1673-8527(08)60075-2

PubMed ID: 19477959

Title: In vivo and in vitro effects of two novel gamma-actin (ACTG1) mutations that cause DFNA20/26 hearing impairment.

PubMed ID: 19477959

DOI: 10.1093/hmg/ddp249

PubMed ID: 22366783

Title: De novo mutations in the actin genes ACTB and ACTG1 cause Baraitser-Winter syndrome.

PubMed ID: 22366783

DOI: 10.1038/ng.1091

PubMed ID: 22938506

Title: Targeted massive parallel sequencing: the effective detection of novel causative mutations associated with hearing loss in small families.

PubMed ID: 22938506

DOI: 10.1186/1750-1172-7-60

PubMed ID: 25388789

Title: Targeted genomic capture and massively parallel sequencing to identify novel variants causing Chinese hereditary hearing loss.

PubMed ID: 25388789

DOI: 10.1186/s12967-014-0311-1

PubMed ID: 28493397

Title: A recurrent de novo mutation in ACTG1 causes isolated ocular coloboma.

PubMed ID: 28493397

DOI: 10.1002/humu.23246

Sequence Information:

Length: 375
Mass: 41793
Checksum: 54D08F986964EFD5
Sequence:

MEEEIAALVI DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK DSYVGDEAQS 
KRGILTLKYP IEHGIVTNWD DMEKIWHHTF YNELRVAPEE HPVLLTEAPL NPKANREKMT 
QIMFETFNTP AMYVAIQAVL SLYASGRTTG IVMDSGDGVT HTVPIYEGYA LPHAILRLDL 
AGRDLTDYLM KILTERGYSF TTTAEREIVR DIKEKLCYVA LDFEQEMATA ASSSSLEKSY 
ELPDGQVITI GNERFRCPEA LFQPSFLGME SCGIHETTFN SIMKCDVDIR KDLYANTVLS 
GGTTMYPGIA DRMQKEITAL APSTMKIKII APPERKYSVW IGGSILASLS TFQQMWISKQ 
EYDESGPSIV HRKCF

Database document:

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Details for: ACTG1

Associated with

Cells (max top 100)

Other Information

Nucleotide sequence of the human gamma cytoskeletal actin mRNA: anomalous evolution of vertebrate non-muscle actin genes. PubMed ID: 3737401

Structure, chromosome location, and expression of the human gamma-actin gene: differential evolution, location, and expression of the cytoskeletal beta- and gamma-actin genes. PubMed ID: 2837653

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

Gamma-actin: unusual mRNA 3'-untranslated sequence conservation and amino acid substitutions that may be cancer related. PubMed ID: 3472224

Proteomic characterization of the human centrosome by protein correlation profiling. PubMed ID: 14654843

Connecting actin monomers by iso-peptide bond is a toxicity mechanism of the Vibrio cholerae MARTX toxin. PubMed ID: 19015515

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

ALKBH4-dependent demethylation of actin regulates actomyosin dynamics. PubMed ID: 23673617

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

ACD toxin-produced actin oligomers poison formin-controlled actin polymerization. PubMed ID: 26228148

NAT6 acetylates the N-terminus of different forms of actin. PubMed ID: 30028079

NAA80 is actin's N-terminal acetyltransferase and regulates cytoskeleton assembly and cell motility. PubMed ID: 29581253

SETD3 is an actin histidine methyltransferase that prevents primary dystocia. PubMed ID: 30626964

Actin maturation requires the ACTMAP/C19orf54 protease. PubMed ID: 36173861

Mutations in the gamma-actin gene (ACTG1) are associated with dominant progressive deafness (DFNA20/26). PubMed ID: 13680526

A mutation in the gamma actin 1 (ACTG1) gene causes autosomal dominant hearing loss (DFNA20/26). PubMed ID: 14684684

A novel missense mutation in ACTG1 causes dominant deafness in a Norwegian DFNA20/26 family, but ACTG1 mutations are not frequent among families with hereditary hearing impairment. PubMed ID: 16773128

Novel ACTG1 mutation causing autosomal dominant non-syndromic hearing impairment in a Chinese family. PubMed ID: 18804074

In vivo and in vitro effects of two novel gamma-actin (ACTG1) mutations that cause DFNA20/26 hearing impairment. PubMed ID: 19477959

De novo mutations in the actin genes ACTB and ACTG1 cause Baraitser-Winter syndrome. PubMed ID: 22366783

Targeted massive parallel sequencing: the effective detection of novel causative mutations associated with hearing loss in small families. PubMed ID: 22938506

Targeted genomic capture and massively parallel sequencing to identify novel variants causing Chinese hereditary hearing loss. PubMed ID: 25388789

A recurrent de novo mutation in ACTG1 causes isolated ocular coloboma. PubMed ID: 28493397