Gene SERPING1 - ENSG00000149131 | NCBI Gene ID: 710

Details for: SERPING1

Gene ID: 710

Symbol: SERPING1

Ensembl ID: ENSG00000149131

Description: serpin family G member 1

Associated with

Complement cascade
(R-HSA-166658)
Defective serping1 causes hereditary angioedema
(R-HSA-9657689)
Defects of contact activation system (cas) and kallikrein/kinin system (kks)
(R-HSA-9651496)
Disease
(R-HSA-1643685)
Diseases of hemostasis
(R-HSA-9671793)
Formation of fibrin clot (clotting cascade)
(R-HSA-140877)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Intrinsic pathway of fibrin clot formation
(R-HSA-140837)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet degranulation
(R-HSA-114608)
Regulation of complement cascade
(R-HSA-977606)
Response to elevated platelet cytosolic ca2+
(R-HSA-76005)
Blood circulation
(GO:0008015)
Blood coagulation
(GO:0007596)
Blood microparticle
(GO:0072562)
Collagen-containing extracellular matrix
(GO:0062023)
Complement activation, classical pathway
(GO:0006958)
Endoplasmic reticulum lumen
(GO:0005788)
Extracellular exosome
(GO:0070062)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibrinolysis
(GO:0042730)
Innate immune response
(GO:0045087)
Negative regulation of complement activation, lectin pathway
(GO:0001869)
Negative regulation of endopeptidase activity
(GO:0010951)
Platelet alpha granule lumen
(GO:0031093)
Protein binding
(GO:0005515)
Serine-type endopeptidase inhibitor activity
(GO:0004867)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: fibroblast of lung (CL0002553)
Fold Change: 3.72
Marker Score: 9741
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 3.69
Marker Score: 3144
Cell Name: bronchus fibroblast of lung (CL2000093)
Fold Change: 3.48
Marker Score: 4780
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.45
Marker Score: 3684
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 3.29
Marker Score: 111952
Cell Name: hepatoblast (CL0005026)
Fold Change: 3.1
Marker Score: 10142
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 3.08
Marker Score: 1283
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 3.01
Marker Score: 1978
Cell Name: decidual cell (CL2000002)
Fold Change: 2.95
Marker Score: 12724
Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
Fold Change: 2.94
Marker Score: 4249
Cell Name: fibroblast of breast (CL4006000)
Fold Change: 2.88
Marker Score: 1641
Cell Name: inflammatory cell (CL0009002)
Fold Change: 2.87
Marker Score: 1233
Cell Name: supporting cell (CL0000630)
Fold Change: 2.84
Marker Score: 5345
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 2.73
Marker Score: 877
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 2.73
Marker Score: 14679
Cell Name: early promyelocyte (CL0002154)
Fold Change: 2.57
Marker Score: 2054
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.47
Marker Score: 63226
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 2.45
Marker Score: 21495
Cell Name: keratocyte (CL0002363)
Fold Change: 2.44
Marker Score: 562
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 2.42
Marker Score: 603
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 2.4
Marker Score: 603
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 2.36
Marker Score: 1260.5
Cell Name: fibroblast (CL0000057)
Fold Change: 2.3
Marker Score: 2225
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.28
Marker Score: 25624
Cell Name: skin fibroblast (CL0002620)
Fold Change: 2.17
Marker Score: 563
Cell Name: muscle cell (CL0000187)
Fold Change: 2.12
Marker Score: 601
Cell Name: theca cell (CL0000503)
Fold Change: 2.12
Marker Score: 1519
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 2.08
Marker Score: 2163
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.08
Marker Score: 13538
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 2.06
Marker Score: 1298
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 2.04
Marker Score: 5132
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 2.03
Marker Score: 1747
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 2.03
Marker Score: 5518
Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 2.03
Marker Score: 8746
Cell Name: preosteoblast (CL0007010)
Fold Change: 2.01
Marker Score: 568
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 2
Marker Score: 12858
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 1.99
Marker Score: 5054
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 1.98
Marker Score: 1409
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.98
Marker Score: 5303.5
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 1.97
Marker Score: 442
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 1.91
Marker Score: 561
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 1.91
Marker Score: 1255
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.9
Marker Score: 3804
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.9
Marker Score: 3222
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 1.84
Marker Score: 2602
Cell Name: Unknown (CL0002371)
Fold Change: 1.79
Marker Score: 1906
Cell Name: adventitial cell (CL0002503)
Fold Change: 1.75
Marker Score: 432
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 1.74
Marker Score: 2093
Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 1.73
Marker Score: 4251
Cell Name: pericyte (CL0000669)
Fold Change: 1.72
Marker Score: 1006
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 1.71
Marker Score: 1973
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 1.69
Marker Score: 1713
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.64
Marker Score: 1568
Cell Name: mesothelial cell (CL0000077)
Fold Change: 1.62
Marker Score: 650
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 1.62
Marker Score: 1731
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.62
Marker Score: 2347
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 1.61
Marker Score: 2671
Cell Name: alternatively activated macrophage (CL0000890)
Fold Change: 1.61
Marker Score: 669
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 1.59
Marker Score: 2067
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 1.58
Marker Score: 1949
Cell Name: mesodermal cell (CL0000222)
Fold Change: 1.55
Marker Score: 20388
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.54
Marker Score: 1637.5
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 1.53
Marker Score: 1107
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.53
Marker Score: 389
Cell Name: hepatocyte (CL0000182)
Fold Change: 1.52
Marker Score: 1036
Cell Name: lactocyte (CL0002325)
Fold Change: 1.49
Marker Score: 23909
Cell Name: lung microvascular endothelial cell (CL2000016)
Fold Change: 1.49
Marker Score: 316
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 1.48
Marker Score: 390
Cell Name: stromal cell (CL0000499)
Fold Change: 1.48
Marker Score: 1734
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.48
Marker Score: 1853
Cell Name: mural cell (CL0008034)
Fold Change: 1.45
Marker Score: 166865
Cell Name: vein endothelial cell (CL0002543)
Fold Change: 1.45
Marker Score: 1312
Cell Name: endothelial cell (CL0000115)
Fold Change: 1.45
Marker Score: 1299
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.45
Marker Score: 796
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.44
Marker Score: 742
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 1.43
Marker Score: 364
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 1.43
Marker Score: 313
Cell Name: cholangiocyte (CL1000488)
Fold Change: 1.42
Marker Score: 531.5
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 1.41
Marker Score: 1325
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.41
Marker Score: 9160.5
Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 1.4
Marker Score: 1412
Cell Name: reticular cell (CL0000432)
Fold Change: 1.36
Marker Score: 498
Cell Name: adipose microvascular endothelial cell (CL2000072)
Fold Change: 1.35
Marker Score: 402
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 1.34
Marker Score: 2202
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 1.34
Marker Score: 2056
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 1.33
Marker Score: 1434
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.32
Marker Score: 13260
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 1.31
Marker Score: 588
Cell Name: peritubular capillary endothelial cell (CL1001033)
Fold Change: 1.31
Marker Score: 304
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 1.29
Marker Score: 803
Cell Name: late promyelocyte (CL0002151)
Fold Change: 1.28
Marker Score: 321
Cell Name: megakaryocyte progenitor cell (CL0000553)
Fold Change: 1.26
Marker Score: 353
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 1.25
Marker Score: 3120
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 1.24
Marker Score: 4787
Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 1.24
Marker Score: 467
Cell Name: Kupffer cell (CL0000091)
Fold Change: 1.22
Marker Score: 1220
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 1.21
Marker Score: 353
Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.2
Marker Score: 584
Cell Name: pneumocyte (CL0000322)
Fold Change: 1.19
Marker Score: 1907
Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 1.19
Marker Score: 2281

Hover over a box to see details here...

**Key characteristics:** * SERPING1 is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is a serine endopeptidase that inhibits the activation of the complement cascade. * SERPING1 is a key regulator of hemostasis, preventing excessive blood clotting and inflammation. * It is involved in the regulation of blood pressure, platelet aggregation, and inflammation. **Pathways and functions:** * SERPING1 inhibits the classical pathway of complement activation. * It acts as a competitive inhibitor of factor H, which is an essential protein in the classical pathway. * By binding to factor H, SERPING1 prevents it from interacting with other complement proteins, thereby inhibiting the activation of the classical pathway. * SERPING1 also plays a role in the negative regulation of complement activation. * It binds to complement proteins and prevents them from interacting with each other, thereby suppressing the complement cascade. **Clinical significance:** * Mutations in SERPING1 have been linked to hereditary angioedema, a condition characterized by abnormal swelling and pain in the face, ears, and throat. * SERPING1 is also involved in the pathogenesis of diseases such as sepsis, stroke, and heart disease. * Studies have shown that SERPING1 inhibitors can be used to treat these diseases by preventing the formation of blood clots and inflammation. **Additional notes:** * SERPING1 is a highly conserved protein with a wide expression in humans. * It is a critical regulator of blood homeostasis and hemostasis. * Mutations in SERPING1 have been associated with a number of human diseases, highlighting its importance in human health.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Plasma protease C1 inhibitor

Genular Protein ID: 2444783558

Symbol: IC1_HUMAN

Name: Plasma protease C1 inhibitor

UniProtKB Accession Codes:

P05155 A6NMU0 A8KAI9 B2R6L5 B4E1F0 B4E1H2 Q16304 Q547W3 Q59EI5 Q7Z455 Q96FE0 Q9UC49 Q9UCF9

Database IDs:

Citations:

PubMed ID: 3488058

Title: Isolation and analysis of a cDNA coding for human C1 inhibitor.

PubMed ID: 3488058

DOI: 10.1016/0006-291x(86)91123-x

PubMed ID: 3756141

Title: Human C1 inhibitor: primary structure, cDNA cloning, and chromosomal localization.

PubMed ID: 3756141

DOI: 10.1021/bi00363a018

PubMed ID: 3267220

Title: Genomic and cDNA cloning of the human C1 inhibitor. Intron-exon junctions and comparison with other serpins.

PubMed ID: 3267220

DOI: 10.1111/j.1432-1033.1988.tb13980.x

PubMed ID: 2026152

Title: Complete nucleotide sequence of the gene for human C1 inhibitor with an unusually high density of Alu elements.

PubMed ID: 2026152

DOI: 10.1111/j.1432-1033.1991.tb15911.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3393514

Title: Molecular cloning of the cDNA coding for human C1 inhibitor.

PubMed ID: 3393514

PubMed ID: 12773530

Title: The functional integrity of the serpin domain of C1-inhibitor depends on the unique N-terminal domain, as revealed by a pathological mutant.

PubMed ID: 12773530

DOI: 10.1074/jbc.m302977200

PubMed ID: 6416294

Title: Human C1 inhibitor: improved isolation and preliminary structural characterization.

PubMed ID: 6416294

DOI: 10.1021/bi00290a019

PubMed ID: 2154751

Title: Clusters of intragenic Alu repeats predispose the human C1 inhibitor locus to deleterious rearrangements.

PubMed ID: 2154751

DOI: 10.1073/pnas.87.4.1551

PubMed ID: 3089875

Title: Molecular cloning of human C1 inhibitor: sequence homologies with alpha 1-antitrypsin and other members of the serpins superfamily.

PubMed ID: 3089875

DOI: 10.1016/0378-1119(86)90230-1

PubMed ID: 8618290

Title: Molecular weights and isoelectric points of sperm antigens relevant to autoimmune infertility in men.

PubMed ID: 8618290

DOI: 10.1097/00005392-199606000-00030

PubMed ID: 3458172

Title: Human inhibitor of the first component of complement, C1: characterization of cDNA clones and localization of the gene to chromosome 11.

PubMed ID: 3458172

DOI: 10.1073/pnas.83.10.3161

PubMed ID: 7814636

Title: Crucial residues in the carboxy-terminal end of C1 inhibitor revealed by pathogenic mutants impaired in secretion or function.

PubMed ID: 7814636

DOI: 10.1172/jci117663

PubMed ID: 8495195

Title: Chymotrypsin inhibitory activity of normal C1-inhibitor and a P1 Arg to His mutant: evidence for the presence of overlapping reactive centers.

PubMed ID: 8495195

DOI: 10.1002/pro.5560020504

PubMed ID: 10946292

Title: Proteolytic activities of two types of mannose-binding lectin-associated serine protease.

PubMed ID: 10946292

DOI: 10.4049/jimmunol.165.5.2637

PubMed ID: 12123444

Title: StcE, a metalloprotease secreted by Escherichia coli O157:H7, specifically cleaves C1 esterase inhibitor.

PubMed ID: 12123444

DOI: 10.1046/j.1365-2958.2002.02997.x

PubMed ID: 12754519

Title: Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry.

PubMed ID: 12754519

DOI: 10.1038/nbt827

PubMed ID: 15096536

Title: Potentiation of C1 esterase inhibitor by StcE, a metalloprotease secreted by Escherichia coli O157:H7.

PubMed ID: 15096536

DOI: 10.1084/jem.20030255

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16040958

Title: N-linked glycosylation at Asn3 and the positively charged residues within the amino-terminal domain of the c1 inhibitor are required for interaction of the C1 Inhibitor with Salmonella enterica serovar typhimurium lipopolysaccharide and lipid A.

PubMed ID: 16040958

DOI: 10.1128/iai.73.8.4478-4487.2005

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 19838169

Title: Enrichment of glycopeptides for glycan structure and attachment site identification.

PubMed ID: 19838169

DOI: 10.1038/nmeth.1392

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 23234360

Title: LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins.

PubMed ID: 23234360

DOI: 10.1021/pr300963h

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 17488724

Title: C1 inhibitor serpin domain structure reveals the likely mechanism of heparin potentiation and conformational disease.

PubMed ID: 17488724

DOI: 10.1074/jbc.m700841200

PubMed ID: 7749926

Title: What do dysfunctional serpins tell us about molecular mobility and disease?

PubMed ID: 7749926

DOI: 10.1038/nsb0295-96

PubMed ID: 3178731

Title: Dysfunctional C1-inhibitor(At), isolated from a type II hereditary-angio-oedema plasma, contains a P1 'reactive centre' (Arg444-->His) mutation.

PubMed ID: 3178731

DOI: 10.1042/bj2530615

PubMed ID: 2365061

Title: Identification of a new P1 residue mutation (444Arg-->Ser) in a dysfunctional C1 inhibitor protein contained in a type II hereditary angioedema plasma.

PubMed ID: 2365061

DOI: 10.1016/0014-5793(90)81494-9

PubMed ID: 2296585

Title: Type II hereditary angioneurotic edema that may result from a single nucleotide change in the codon for alanine-436 in the C1 inhibitor gene.

PubMed ID: 2296585

DOI: 10.1073/pnas.87.1.265

PubMed ID: 2118657

Title: Dysfunctional C1 inhibitor Ta: deletion of Lys-251 results in acquisition of an N-glycosylation site.

PubMed ID: 2118657

DOI: 10.1073/pnas.87.17.6786

PubMed ID: 1451784

Title: A dysfunctional C1 inhibitor protein with a new reactive center mutation (Arg-444-->Leu).

PubMed ID: 1451784

DOI: 10.1016/0014-5793(92)80204-t

PubMed ID: 1363816

Title: C1 inhibitor hinge region mutations produce dysfunction by different mechanisms.

PubMed ID: 1363816

DOI: 10.1038/ng0892-354

PubMed ID: 8172583

Title: Mutations in the C1 inhibitor gene that result in hereditary angioneurotic edema.

PubMed ID: 8172583

PubMed ID: 7883978

Title: Unique C1 inhibitor dysfunction in a kindred without angioedema. II. Identification of an Ala443-->Val substitution and functional analysis of the recombinant mutant protein.

PubMed ID: 7883978

DOI: 10.1172/jci117780

PubMed ID: 8529136

Title: A mutation unique in serine protease inhibitors (serpins) identified in a family with type II hereditary angioneurotic edema.

PubMed ID: 8529136

DOI: 10.1007/bf03401610

PubMed ID: 8755917

Title: Exhaustive mutation scanning by fluorescence-assisted mismatch analysis discloses new genotype-phenotype correlations in angiodema.

PubMed ID: 8755917

PubMed ID: 14635117

Title: Mutation screening of the C1 inhibitor gene among Hungarian patients with hereditary angioedema.

PubMed ID: 14635117

DOI: 10.1002/humu.9202

PubMed ID: 16409206

Title: Normal C1 inhibitor mRNA expression level in type I hereditary angioedema patients: newly found C1 inhibitor gene mutations.

PubMed ID: 16409206

DOI: 10.1111/j.1398-9995.2006.01010.x

PubMed ID: 22994404

Title: Mutational spectrum and geno-phenotype correlation in Chinese families with Hereditary Angioedema.

PubMed ID: 22994404

DOI: 10.1111/all.12024

PubMed ID: 24456027

Title: Mutational spectrum of the c1 inhibitor gene in a cohort of Italian patients with hereditary angioedema: description of nine novel mutations.

PubMed ID: 24456027

DOI: 10.1111/ahg.12052

Sequence Information:

Length: 500
Mass: 55154
Checksum: 8B5E874833EA6C05
Sequence:

MASRLTLLTL LLLLLAGDRA SSNPNATSSS SQDPESLQDR GEGKVATTVI SKMLFVEPIL 
EVSSLPTTNS TTNSATKITA NTTDEPTTQP TTEPTTQPTI QPTQPTTQLP TDSPTQPTTG 
SFCPGPVTLC SDLESHSTEA VLGDALVDFS LKLYHAFSAM KKVETNMAFS PFSIASLLTQ 
VLLGAGENTK TNLESILSYP KDFTCVHQAL KGFTTKGVTS VSQIFHSPDL AIRDTFVNAS 
RTLYSSSPRV LSNNSDANLE LINTWVAKNT NNKISRLLDS LPSDTRLVLL NAIYLSAKWK 
TTFDPKKTRM EPFHFKNSVI KVPMMNSKKY PVAHFIDQTL KAKVGQLQLS HNLSLVILVP 
QNLKHRLEDM EQALSPSVFK AIMEKLEMSK FQPTLLTLPR IKVTTSQDML SIMEKLEFFD 
FSYDLNLCGL TEDPDLQVSA MQHQTVLELT ETGVEAAAAS AISVARTLLV FEVQQPFLFV 
LWDQQHKFPV FMGRVYDPRA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: SERPING1

Associated with

Cells (max top 100)

Other Information

Isolation and analysis of a cDNA coding for human C1 inhibitor. PubMed ID: 3488058

Human C1 inhibitor: primary structure, cDNA cloning, and chromosomal localization. PubMed ID: 3756141

Genomic and cDNA cloning of the human C1 inhibitor. Intron-exon junctions and comparison with other serpins. PubMed ID: 3267220

Complete nucleotide sequence of the gene for human C1 inhibitor with an unusually high density of Alu elements. PubMed ID: 2026152

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Human chromosome 11 DNA sequence and analysis including novel gene identification. PubMed ID: 16554811

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular cloning of the cDNA coding for human C1 inhibitor. PubMed ID: 3393514

The functional integrity of the serpin domain of C1-inhibitor depends on the unique N-terminal domain, as revealed by a pathological mutant. PubMed ID: 12773530

Human C1 inhibitor: improved isolation and preliminary structural characterization. PubMed ID: 6416294

Clusters of intragenic Alu repeats predispose the human C1 inhibitor locus to deleterious rearrangements. PubMed ID: 2154751

Molecular cloning of human C1 inhibitor: sequence homologies with alpha 1-antitrypsin and other members of the serpins superfamily. PubMed ID: 3089875

Molecular weights and isoelectric points of sperm antigens relevant to autoimmune infertility in men. PubMed ID: 8618290

Human inhibitor of the first component of complement, C1: characterization of cDNA clones and localization of the gene to chromosome 11. PubMed ID: 3458172

Crucial residues in the carboxy-terminal end of C1 inhibitor revealed by pathogenic mutants impaired in secretion or function. PubMed ID: 7814636

Chymotrypsin inhibitory activity of normal C1-inhibitor and a P1 Arg to His mutant: evidence for the presence of overlapping reactive centers. PubMed ID: 8495195

Proteolytic activities of two types of mannose-binding lectin-associated serine protease. PubMed ID: 10946292

StcE, a metalloprotease secreted by Escherichia coli O157:H7, specifically cleaves C1 esterase inhibitor. PubMed ID: 12123444

Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry. PubMed ID: 12754519

Potentiation of C1 esterase inhibitor by StcE, a metalloprotease secreted by Escherichia coli O157:H7. PubMed ID: 15096536

Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. PubMed ID: 14760718

N-linked glycosylation at Asn3 and the positively charged residues within the amino-terminal domain of the c1 inhibitor are required for interaction of the C1 Inhibitor with Salmonella enterica serovar typhimurium lipopolysaccharide and lipid A. PubMed ID: 16040958

Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. PubMed ID: 16335952

Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. PubMed ID: 19159218

A strategy for precise and large scale identification of core fucosylated glycoproteins. PubMed ID: 19139490

Enrichment of glycopeptides for glycan structure and attachment site identification. PubMed ID: 19838169

Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD. PubMed ID: 22171320

LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins. PubMed ID: 23234360

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

C1 inhibitor serpin domain structure reveals the likely mechanism of heparin potentiation and conformational disease. PubMed ID: 17488724

What do dysfunctional serpins tell us about molecular mobility and disease? PubMed ID: 7749926

Dysfunctional C1-inhibitor(At), isolated from a type II hereditary-angio-oedema plasma, contains a P1 'reactive centre' (Arg444--&gt;His) mutation. PubMed ID: 3178731

Identification of a new P1 residue mutation (444Arg--&gt;Ser) in a dysfunctional C1 inhibitor protein contained in a type II hereditary angioedema plasma. PubMed ID: 2365061

Type II hereditary angioneurotic edema that may result from a single nucleotide change in the codon for alanine-436 in the C1 inhibitor gene. PubMed ID: 2296585

Dysfunctional C1 inhibitor Ta: deletion of Lys-251 results in acquisition of an N-glycosylation site. PubMed ID: 2118657

A dysfunctional C1 inhibitor protein with a new reactive center mutation (Arg-444--&gt;Leu). PubMed ID: 1451784

C1 inhibitor hinge region mutations produce dysfunction by different mechanisms. PubMed ID: 1363816

Mutations in the C1 inhibitor gene that result in hereditary angioneurotic edema. PubMed ID: 8172583

Unique C1 inhibitor dysfunction in a kindred without angioedema. II. Identification of an Ala443--&gt;Val substitution and functional analysis of the recombinant mutant protein. PubMed ID: 7883978

A mutation unique in serine protease inhibitors (serpins) identified in a family with type II hereditary angioneurotic edema. PubMed ID: 8529136

Exhaustive mutation scanning by fluorescence-assisted mismatch analysis discloses new genotype-phenotype correlations in angiodema. PubMed ID: 8755917

Mutation screening of the C1 inhibitor gene among Hungarian patients with hereditary angioedema. PubMed ID: 14635117

Normal C1 inhibitor mRNA expression level in type I hereditary angioedema patients: newly found C1 inhibitor gene mutations. PubMed ID: 16409206

Mutational spectrum and geno-phenotype correlation in Chinese families with Hereditary Angioedema. PubMed ID: 22994404

Mutational spectrum of the c1 inhibitor gene in a cohort of Italian patients with hereditary angioedema: description of nine novel mutations. PubMed ID: 24456027