Details for: ERC2 IT1

Gene ID: 711

Symbol: ERC2 IT1

Ensembl ID: ENSG00000281708

Description: ERC2 intronic transcript 1

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 3.6045
    Cell Significance Index: 51.3100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 2.9979
    Cell Significance Index: 44.2600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4640
    Cell Significance Index: 6.3300
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.2819
    Cell Significance Index: 3.9100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2454
    Cell Significance Index: 49.2200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2290
    Cell Significance Index: 39.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0929
    Cell Significance Index: 4.3300
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.0918
    Cell Significance Index: 1.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0606
    Cell Significance Index: 21.7500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0505
    Cell Significance Index: 0.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0314
    Cell Significance Index: 1.9300
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0218
    Cell Significance Index: 0.2800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0161
    Cell Significance Index: 0.2300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.0105
    Cell Significance Index: 0.2200
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.0062
    Cell Significance Index: 0.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0001
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0021
    Cell Significance Index: -1.5900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0021
    Cell Significance Index: -0.1100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0022
    Cell Significance Index: -0.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0032
    Cell Significance Index: -1.8200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0036
    Cell Significance Index: -0.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0079
    Cell Significance Index: -0.6100
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0087
    Cell Significance Index: -0.1200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0098
    Cell Significance Index: -2.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0145
    Cell Significance Index: -1.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0223
    Cell Significance Index: -1.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0298
    Cell Significance Index: -0.8100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0317
    Cell Significance Index: -0.7600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0320
    Cell Significance Index: -0.8000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0325
    Cell Significance Index: -0.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0336
    Cell Significance Index: -1.7500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0385
    Cell Significance Index: -1.3500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0428
    Cell Significance Index: -0.7400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0443
    Cell Significance Index: -1.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0473
    Cell Significance Index: -2.9000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0531
    Cell Significance Index: -1.6900
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0639
    Cell Significance Index: -1.3000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0671
    Cell Significance Index: -1.4500
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0673
    Cell Significance Index: -1.6800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0674
    Cell Significance Index: -3.1700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0688
    Cell Significance Index: -0.7500
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0712
    Cell Significance Index: -1.4300
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0740
    Cell Significance Index: -0.8800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0743
    Cell Significance Index: -1.2300
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0749
    Cell Significance Index: -0.7800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0818
    Cell Significance Index: -1.0200
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0872
    Cell Significance Index: -1.0600
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0872
    Cell Significance Index: -1.0900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0895
    Cell Significance Index: -1.7700
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0976
    Cell Significance Index: -1.9200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1017
    Cell Significance Index: -1.4600
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.1023
    Cell Significance Index: -1.0300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1054
    Cell Significance Index: -1.3300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1080
    Cell Significance Index: -1.8200
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.1113
    Cell Significance Index: -1.4700
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1139
    Cell Significance Index: -1.0800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1143
    Cell Significance Index: -2.2300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1166
    Cell Significance Index: -1.6800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1168
    Cell Significance Index: -1.4800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1177
    Cell Significance Index: -2.8500
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1186
    Cell Significance Index: -1.3000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1193
    Cell Significance Index: -1.4800
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.1196
    Cell Significance Index: -1.4800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.1200
    Cell Significance Index: -1.6000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1236
    Cell Significance Index: -1.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1243
    Cell Significance Index: -3.3200
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.1275
    Cell Significance Index: -1.7000
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: -0.1295
    Cell Significance Index: -1.6900
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: -0.1323
    Cell Significance Index: -1.4800
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.1400
    Cell Significance Index: -2.1000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1411
    Cell Significance Index: -3.2600
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1413
    Cell Significance Index: -1.8500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1417
    Cell Significance Index: -2.7700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1418
    Cell Significance Index: -1.6900
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.1440
    Cell Significance Index: -1.6700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1464
    Cell Significance Index: -2.9200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1518
    Cell Significance Index: -1.9600
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1523
    Cell Significance Index: -1.5500
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.1528
    Cell Significance Index: -1.7100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1599
    Cell Significance Index: -2.6900
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.1631
    Cell Significance Index: -1.9500
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: -0.1664
    Cell Significance Index: -1.8200
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.1714
    Cell Significance Index: -2.1400
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1714
    Cell Significance Index: -2.9300
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.1716
    Cell Significance Index: -1.8600
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.1738
    Cell Significance Index: -1.8000
  • Cell Name: immature NK T cell (CL0000914)
    Fold Change: -0.1766
    Cell Significance Index: -2.2600
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.1784
    Cell Significance Index: -1.8800
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.1809
    Cell Significance Index: -1.8600
  • Cell Name: goblet cell (CL0000160)
    Fold Change: -0.1824
    Cell Significance Index: -1.6500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.1856
    Cell Significance Index: -2.2500
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: -0.1864
    Cell Significance Index: -1.9700
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1870
    Cell Significance Index: -1.7000
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: -0.1892
    Cell Significance Index: -1.7800
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1915
    Cell Significance Index: -2.0200
  • Cell Name: pericyte (CL0000669)
    Fold Change: -0.1951
    Cell Significance Index: -2.3400
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.1964
    Cell Significance Index: -2.4700
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1969
    Cell Significance Index: -2.5700
  • Cell Name: plasma cell (CL0000786)
    Fold Change: -0.2005
    Cell Significance Index: -2.2400
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.2024
    Cell Significance Index: -2.3500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Profile:** ERC2 IT1 is expressed in a wide range of cell types, including those involved in the gastrointestinal tract and cardiovascular system. Its expression is not limited to specific cell types, but rather is a ubiquitous feature of various cell types. 2. **Intronic Transcript:** The ERC2 IT1 gene is an intronic transcript, meaning that it originates from a non-coding region of the genome. This characteristic suggests that ERC2 IT1 may play a regulatory role in gene expression. 3. **Cellular Localization:** ERC2 IT1 is predominantly expressed in the cytoplasm and nucleus of the cell, suggesting that it may be involved in various cellular processes, including transcriptional regulation and protein synthesis. **Pathways and Functions:** 1. **Immunological Regulation:** ERC2 IT1 may play a role in regulating the immune response by modulating the expression of genes involved in inflammation and immune cell activation. 2. **Cell Signaling:** ERC2 IT1 may be involved in cell signaling pathways, including those that regulate cell growth, differentiation, and survival. 3. **Transcriptional Regulation:** ERC2 IT1 may act as a transcriptional regulator, influencing the expression of genes involved in various cellular processes. 4. **Epigenetic Modulation:** ERC2 IT1 may also be involved in epigenetic regulation, influencing the expression of genes through mechanisms such as DNA methylation and histone modification. **Clinical Significance:** 1. **Cancer Association:** ERC2 IT1 is significantly expressed in neoplastic cells, suggesting that it may play a role in the development and progression of cancer. 2. **Inflammatory Diseases:** ERC2 IT1 is also expressed in cells involved in inflammation, suggesting that it may be involved in the pathogenesis of inflammatory diseases, such as inflammatory bowel disease. 3. **Cardiovascular Disease:** The expression of ERC2 IT1 in cardiac endothelial cells suggests that it may be involved in the pathogenesis of cardiovascular disease. 4. **Diagnostic and Therapeutic Applications:** Further research into the immunological functions of ERC2 IT1 may lead to the development of diagnostic and therapeutic strategies for diseases associated with its expression. In conclusion, the ERC2 IT1 gene is a complex transcript with a wide range of immunological functions. Further research into its expression profile, cellular localization, and potential applications is necessary to fully understand its significance in human disease.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.