Nipbl | ENSMUSG00000022141 | NCBI 71175

Details for: Nipbl

Gene ID: 71175

Symbol: Nipbl

Ensembl ID: ENSMUSG00000022141

Description: NIPBL cohesin loading factor

Associated with

Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Cohesin loading onto chromatin
(R-MMU-2470946)
Mitotic telophase/cytokinesis
(R-MMU-68884)
M phase
(R-MMU-68886)
Brain development
(GO:0007420)
Cellular response to x-ray
(GO:0071481)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Chromatin remodeling
(GO:0006338)
Chromo shadow domain binding
(GO:0070087)
Cognition
(GO:0050890)
Cohesin loader activity
(GO:0061775)
Cytosol
(GO:0005829)
Developmental growth
(GO:0048589)
Digestive tract development
(GO:0048565)
Dna damage response
(GO:0006974)
Ear morphogenesis
(GO:0042471)
Embryonic cranial skeleton morphogenesis
(GO:0048701)
Embryonic digestive tract morphogenesis
(GO:0048557)
Embryonic forelimb morphogenesis
(GO:0035115)
Embryonic viscerocranium morphogenesis
(GO:0048703)
Establishment of mitotic sister chromatid cohesion
(GO:0034087)
Establishment of protein localization to chromatin
(GO:0071169)
External genitalia morphogenesis
(GO:0035261)
Eye morphogenesis
(GO:0048592)
Face morphogenesis
(GO:0060325)
Fat cell differentiation
(GO:0045444)
Forelimb morphogenesis
(GO:0035136)
Gallbladder development
(GO:0061010)
Heart development
(GO:0007507)
Heart morphogenesis
(GO:0003007)
Histone deacetylase binding
(GO:0042826)
Integrator complex
(GO:0032039)
Intracellular membrane-bounded organelle
(GO:0043231)
Maintenance of mitotic sister chromatid cohesion
(GO:0034088)
Mediator complex binding
(GO:0036033)
Mitotic cohesin loading
(GO:0061780)
Mitotic sister chromatid cohesion
(GO:0007064)
Mitotic sister chromatid segregation
(GO:0000070)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Outflow tract morphogenesis
(GO:0003151)
Positive regulation of multicellular organism growth
(GO:0040018)
Positive regulation of neuron migration
(GO:2001224)
Positive regulation of ossification
(GO:0045778)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Promoter-specific chromatin binding
(GO:1990841)
Protein binding
(GO:0005515)
Protein localization
(GO:0008104)
Regulation of developmental growth
(GO:0048638)
Regulation of embryonic development
(GO:0045995)
Regulation of hair cycle
(GO:0042634)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Replication-born double-strand break repair via sister chromatid exchange
(GO:1990414)
Scc2-scc4 cohesin loading complex
(GO:0090694)
Sensory perception of sound
(GO:0007605)
Smc loading complex
(GO:0032116)
Somatic stem cell population maintenance
(GO:0035019)
Transcription corepressor activity
(GO:0003714)
Uterus morphogenesis
(GO:0061038)

Other Information

Proteins

Nipped-B-like protein

Genular Protein ID: 1261206413

Symbol: NIPBL_MOUSE

Name: Nipped-B-like protein

UniProtKB Accession Codes:

Q6KCD5 Q6KC78 Q7TNS4 Q8BKV4 Q8CES9 Q9CUC6

Database IDs:

Citations:

PubMed ID: 15146185

Title: NIPBL, encoding a homolog of fungal Scc2-type sister chromatid cohesion proteins and fly Nipped-B, is mutated in Cornelia de Lange syndrome.

PubMed ID: 15146185

DOI: 10.1038/ng1363

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15146186

Title: Cornelia de Lange syndrome is caused by mutations in NIPBL, the human homolog of Drosophila melanogaster Nipped-B.

PubMed ID: 15146186

DOI: 10.1038/ng1364

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23967866

Title: Cohesin loading factor Nipbl localizes to chromosome axes during mammalian meiotic prophase.

PubMed ID: 23967866

DOI: 10.1186/1747-1028-8-12

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 24287868

Title: Localisation of the SMC loading complex Nipbl/Mau2 during mammalian meiotic prophase I.

PubMed ID: 24287868

DOI: 10.1007/s00412-013-0444-7

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 28041881

Title: Nipbl interacts with Zfp609 and the Integrator complex to regulate cortical neuron migration.

PubMed ID: 28041881

DOI: 10.1016/j.neuron.2016.11.047

PubMed ID: 28914604

Title: Scc2/Nipbl hops between chromosomal cohesin rings after loading.

PubMed ID: 28914604

DOI: 10.7554/elife.30000

PubMed ID: 29094699

Title: Two independent modes of chromatin organization revealed by cohesin removal.

PubMed ID: 29094699

DOI: 10.1038/nature24281

PubMed ID: 29379197

Title: BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange-like syndrome.

PubMed ID: 29379197

DOI: 10.1038/s41588-018-0042-y

PubMed ID: 29440723

Title:

PubMed ID: 29440723

DOI: 10.1038/s41588-018-0069-0

PubMed ID: 31168063

Title:

PubMed ID: 31168063

DOI: 10.1038/s41588-019-0448-1

Sequence Information:

Length: 2798
Mass: 315450
Checksum: BC23B6E2C949C9B3
Sequence:

MNGDMPHVPI TTLAGIASLT DLLNQLPLPS PLPATTTKSL LFNSRIAEEV NCLLACRDDN 
LVSQLVHSLN QVSTDHIELK DNLGSDDPEG DIPVLLQAVL ARSPNVFREK SMQNRYVQSG 
MMMSQYKLSQ NSMHSSPASS NYQQTTISHS PSSRFVPPQT SSGNRFMPQQ NSPVPSPYAP 
QSPAGYMPYS HPSSYTTHPQ MQQASVSSPI VAGGLRNIHD NKVSGPLSGN SANHHADNPR 
HGSSDDYLHM VHRLSSDDGD SSTMRNAASF PLRSPQPVCS PAGSDGTPKG SRPPLILQSQ 
SLPCSSPRDV PPDILLDSPE RKQKKQKKIK LGKDEKDQNE KAAMYDIISS PTKDSTKLTL 
RLSRVRSSDM DQQDDMLSGM ENSNVSENDI PFNVQYPGQT SKTPITPQDV NRPLNAAQCL 
SQQEQTAFLP ANQVPVLQQN TSVATKQPQT SVVQNQQQVS QQGPIYDEVE LDALAEIERI 
ERESAIERER FSKEVQDKDK PLKKRKQDSY PQEAGGATGG NRPASQETGS TGNGSRPALM 
VSIDLHQAGR VDSQASITQD SDSIKKPEET KQCNDAPISV LQEDIVGSLK SIPENHPETP 
KKKSDPELSK SEMKQNESRL SESKPNENQL GESKSNESKL ETKTETPTEE LKQNENKTTE 
SKQSESAVVE PKQNENRPCD TKPNDNKQNN TRSENTKARP ETPKQKAESR PETPKQKSEG 
RPETPKQKGD GRPETPKQKS EGRPETPKQK GEGRPETPKH RHENRRDSGK PSTEKKPDVS 
KHKQDIKSDS PRLKSERAEA LKQRPDGRWE SLRRDHDSKQ KSDDRGESER HRGDQSRVRR 
PETLRSSSRN DHSTKSDGSK TEKLERKHRH ESGDSRDRPS GEQKSRPDSP RVKQGDTNKS 
RPGFKSPNSK DDKRTEGNRS KVDSNKAHTD NKAEFPSYLL GGRSGALKNF VIPKIKRDKD 
GNITQETKKM DMKGEQKDKV EKMGLVEDLN KGAKPVVVLQ KLSLDDVQKL IKDREEKSRS 
SLKSIKNKPS KSNKGSIDQS VLKELPPELL AEIESTMPLC ERVKMNKRKR STVNEKPKYA 
EISSDEDNDS DEAFESSRKR HKKDDDKAWE YEERDRRSSG DHRRSGHSHD GRRSSGGGRY 
RNRSPSDSDM EDYSPPPSLS EVARKMKKKE KQKKRKAYEP KLTPEEMMDS STFKRFTASI 
ENILDNLEDM DFTAFGDDDE IPQELLLGKH QLNELGSESA KIKAMGIMDK LSTDKTVKVL 
NILEKNIQDG SKLSTLLNHN NDTEEEERLW RDLIMERVTK SADACLTTIN IMTSPNMPKA 
VYIEDVIERV IQYTKFHLQN TLYPQYDPVY RVDPHGGGLL SSKAKRAKCS THKQRVIVML 
YNKVCDIVSS LSELLEIQLL TDTTILQVSS MGITPFFVEN VSELQLCAIK LVTAVFSRYE 
KHRQLILEEI FTSLARLPTS KRSLRNFRLN SSDVDGEPMY IQMVTALVLQ LIQCVVHLPS 
SEKDPNSEED SNKKVDQDVV ITNSYETAMR TAQNFLSIFL KKCGSKQGEE DYRPLFENFV 
QDLLSTVNKP EWPAAELLLS LLGRLLVHQF SNKSTEMALR VASLDYLGTV AARLRKDAVT 
SKMDQGSIER ILKQVSGGED EIQQLQKALL DYLDENTETD PSLVFSRKFY IAQWFRDTTL 
ETEKAMKSQK DEESSDATHH AKELETTGQI MHRAENRKKF LRSIIKTTPS QFSTLKMNSD 
TVDYDDACLI VRYLASMRPF AQSFDIYLTQ ILRVLGENAI AVRTKAMKCL SEVVAVDPSI 
LARLDMQRGV HGRLMDNSTS VREAAVELLG RFVLCRPQLA EQYYDMLIER ILDTGISVRK 
RVIKILRDIC IEQPTFPKIT EMCVKMIRRV NDEEGIKKLV NETFQKLWFT PTPHNDKEAM 
TRKILNITDV VAACRDTGYD WFEQLLQNLL KSEEDSSYKP VKKACTQLVD NLVEHILKYE 
ESLADSDNKG VNSGRLVACI TTLFLFSKIR PQLMVKHAMT MQPYLTTKCS TQNDFMVICN 
VAKILELVVP LMEHPSETFL ATIEEDLMKL IIKYGMTVVQ HCVSCLGAVV NKVTQNFKFV 
WACFNRYYGA ISKLKSQHQE DPNNTSLLTN KPALLRSLFT VGALCRHFDF DLEDFKGNSK 
VNIKDKVLEL LMYFTKHSDE EVQTKAIIGL GFAFIQHPSL MFEQEVKNLY NSILSDKNSS 
VNLKIQVLKN LQTYLQEEDT RMQQADRDWK KVAKQEDLKE MGDVSSGMSS SIMQLYLKQV 
LEAFFHTQSS VRHFALNVIA LTLNQGLIHP VQCVPYLIAM GTDPEPAMRN KADQQLVEID 
KKYAGFIHMK AVAGMKMSYQ VQQAINTCLK DPVRGFRQDE SSSALCSHLY SMIRGNRQHR 
RAFLISLLNL FDDTAKTEVT MLLYIADNLA CFPYQTQEEP LFIMHHIDIT LSVSGSNLLQ 
SFKESMVKDK RKERKTSPAK ENESSESEEE VSRPRKSRKR VDSESDSDSE DDINSVMKCL 
PENSAPLIEF ANVSQGILLL LMLKQHLKNL CGFSDSKIQK YSPSESAKVY DKAINRKTGV 
HFHPKQTLDF LRSDMANSKL TEDVKRSIVR QYLDFKLLME HLDPDEEEEE GEVSASTNAR 
NKAITSLLGG GSPKNNTAAD TEDEESDGED RGGGTSGSLR RSKRNSDSTE LAAQMNESVD 
VMDVIAICCP KYKDRPQIAR VVQRTSSGVS VQWMAGSYSG SWTEAKRRDG RKLVPWVDTI 
KESDIIYKKI ALTSANKLTN KVVQTLRSLY AAKDGTSS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nipbl

Associated with

Other Information

NIPBL, encoding a homolog of fungal Scc2-type sister chromatid cohesion proteins and fly Nipped-B, is mutated in Cornelia de Lange syndrome. PubMed ID: 15146185

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cornelia de Lange syndrome is caused by mutations in NIPBL, the human homolog of Drosophila melanogaster Nipped-B. PubMed ID: 15146186

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Cohesin loading factor Nipbl localizes to chromosome axes during mammalian meiotic prophase. PubMed ID: 23967866

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Localisation of the SMC loading complex Nipbl/Mau2 during mammalian meiotic prophase I. PubMed ID: 24287868

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315

Nipbl interacts with Zfp609 and the Integrator complex to regulate cortical neuron migration. PubMed ID: 28041881

Scc2/Nipbl hops between chromosomal cohesin rings after loading. PubMed ID: 28914604

Two independent modes of chromatin organization revealed by cohesin removal. PubMed ID: 29094699

BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange-like syndrome. PubMed ID: 29379197